检索结果-南通市图书馆

The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

引用

Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUssEF ahmed EL-sEBAIE sHERIF REFAAT AFAF EL-sAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(AsA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,psphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

stripping of aggregate from mortar in waste concrete heated by microwave:Mechanisms of differential-temperature stress and vapor expansion pressure

引用

Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 538-558页

作者： Yanping sheng Xiao Huan Peizhen Hu Liangliang Li ahmed Abdulakeem Zhoujing Ye Linbing Wang Yanping Yin school of Materials science and Engineering Chang'an UniversityXi'an 710064China Engineering Research Center of Transportation Materials Ministry of EducationChang'an UniversityXi'an 710064China National Center for Materials service safety University of Science and Technology BeijingBeijing 100083China school of Environmental CivilAgricultural and Mechanical EngineeringCollege of EngineeringUniversity of GeorgiaAthensGA 30602USA

Microwave heating,which is used for pre-treatment of concrete before it is comminuted,stands as a strong candidate for selective liberation of multiphase materials like *** paper is concerned with the selective liberation of concrete's raw constituents(particularly aggregate)for recycling by considering the water content of concrete as a parameter of microwave heating for the first *** deterioration law of the concrete's performance was characterized by the variation in the splitting tensile strength and relative dynamic modulus after heating by microwave at different water ***,tests were conducted to evaluate the performance of the interface transition zone(ITZ)between aggregate and mortar as well as to investigate the reasons for the stripping behavior of aggregate-mortar,which included the interface tensile strength test,temperature measurement,and porosity *** deterioration law of splitting tensile strength and relative dynamic modulus revealed that the performance of concrete was subject to different degrees of damage depending on the water ***,experimental results showed that interface bonding strength between aggregate and mortar was dramatically impaired,and a large temperature difference was generated between the aggregate and mortar during microwave ***,the permeable pores increased considerably even when the specimens were *** the presence of water,the intactness of ITZ between aggregate and mortar was destroyed by microwave heating,and its performance was significantly lowered,which led to the occurrence of stripping behavior between aggregate and *** was reaffirmed by the microstructure presented by scanning electron ***,the newly developed microwave pretreatment improved by providing appropriate water contents for concrete corresponding to different strength grades is a promising method for recycling aggregate from waste concrete.

关键词： Waste concrete Recycled aggregate Microwave heating stripping behavior Differential-temperature stress Vapor expansion pressure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in saudi Arabia

引用

Asian Journal of Urology 2024年第1期11卷 26-32页

作者： Awad Elsid Osman sahar Alharbi Atif Ali ahmed Asim Ali Elbagir Pathology and Clinical Laboratory Management Department(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Department of Pathology and Laboratory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (sNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in saudi males is low but is probably familial or genetically ***: To identify any possible association of sNP with PCa development in saudi patients, we investigated a group of sNPs in saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen sNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction ***: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (ps16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 sNP with PCa in saudi males. such findings have important implications in the PCa diagnosis and in screening unaffected family members of saudi patients.

关键词： Prostatecancer saudi singlenucleotide polymorphism Allele

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LsTM Based Neural Network Model for Anomaly Event Detection in Care-Independent smart Homes

引用

Computer Modeling in Engineering & sciences 2024年第9期140卷 2689-2706页

作者： Brij B.Gupta Akshat Gaurav Razaz Waheeb Attar Varsha Arya ahmed Alhomoud Kwok Tai Chui Department of Computer science and Information Engineering Asia UniversityTaichung413TaiwanChina symbiosis Centre for Information Technology(sCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Computer Engineering Ronin InstituteMontclairNJ 07043USA Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Business Administration Asia UniversityTaichung413TaiwanChina Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon Department of Computer sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia school of science and Technology Hong Kong Metropolitan University(HKMU)Hong KongChina

This study introduces a long-short-term memory(LsTM)-based neural network model developed for detecting anomaly events in care-independent smart homes,focusing on the critical application of elderly fall *** balances the dataset using the synthetic Minority Over-sampling Technique(sMOTE),effectively neutralizing bias to address the challenge of unbalanced datasets prevalent in time-series classification *** proposed LsTM model is trained on the enriched dataset,capturing the temporal dependencies essential for anomaly *** model demonstrated a significant improvement in anomaly detection,with an accuracy of 84%.The results,detailed in the comprehensive classification and confusion matrices,showed the model’s proficiency in distinguishing between normal activities and *** study contributes to the advancement of smart home safety,presenting a robust framework for real-time anomaly monitoring.

关键词： LsTM neural networks anomaly detection smart home health-care elderly fall prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing Lexicons for Enhanced sentiment Analysis in software Engineering:An Innovative Multilingual Approach for social Media Reviews

引用

Computers, Materials & Continua 2024年第5期79卷 2771-2793页

作者： Zohaib Ahmad Khan Yuanqing Xia ahmed Khan Muhammad sadiq Mahmood Alam Fuad AAwwad Emad A.A.Ismail school of Automation Beijing Institute of TechnologyBeijing100081China Department of Computer science and Technology University of Science and Technology BannuKPKBannu28100Pakistan school of Computer science and Engineering Central South UniversityChangsha410083China Department of Quantitative Analysis College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh11587Saudi Arabia

sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significantsource of user-generated content. The development of sentiment lexicons that can support languages other thanEnglish is a challenging task, especially for analyzing sentiment analysis in social media reviews. Most existingsentiment analysis systems focus on English, leaving a significant research gap in other languages due to limitedresources and tools. This research aims to address this gap by building a sentiment lexicon for local languages,which is then used with a machine learning algorithm for efficient sentiment analysis. In the first step, a lexiconis developed that includes five languages: Urdu, Roman Urdu, Pashto, Roman Pashto, and English. The sentimentscores from sentiWordNet are associated with each word in the lexicon to produce an effective sentiment score. Inthe second step, a naive Bayesian algorithm is applied to the developed lexicon for efficient sentiment analysis ofRoman Pashto. Both the sentiment lexicon and sentiment analysis steps were evaluated using information retrievalmetrics, with an accuracy score of 0.89 for the sentiment lexicon and 0.83 for the sentiment analysis. The resultsshowcase the potential for improving software engineering tasks related to user feedback analysis and productdevelopment.

关键词： Emotional assessment regional dialects sentiWordNet naive bayesian technique lexicons software engineering user feedback

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MXenes and heterostructures-based electrocatalysts for hydrogen evolution reaction:Recent developments and future outlook

引用

Journal of Energy Chemistry 2024年第5期92卷 176-206页

作者： Abdul Hanan Hafiz Taimoor ahmed Awan Faiza Bibi Raja Rafidah Raja sulaiman Wai Yin Wong Rashmi Walvekar seema singh Mohammad Khalid sunway Centre for Electrochemical Energy and sustainable Technology(sCEEsT) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversitiBandar Sunway47500 Petaling JayaSelangorMalaysia Fuel Cell Institute Universiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Innovation and Technology School of EngineeringChemical Engineering ProgrammeNo.1 Jalan Taylor’sTaylor’s University Malaysia47500 Subang JayaSelangorMalaysia Chitkara Centre for Research and Development Chitkara UniversityHimachal Pradesh 174103India school of Applied and Life sciences Uttaranchal UniversityDehradunUttarakhand 248007India Manipal Institute of Technology Manipal Academy of Higher EducationManipal 576104KarnatakaIndia Centre of Research Impact and Outcome Chitkara UniversityPunjab 140401India

The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and *** materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER *** discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical ***,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical *** review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..

关键词： MXenes Electrocatalyst Water splitting Hydrogen Generation Clean Energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=s and se）:A first-principles study

引用

Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas A.ahmed Jisha Annie Abraham Zeinhom M.El-Bahy Mumtaz Manzoor sajad Ahmad Dar Ramesh sharma Department of Basic science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（s/se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（s/se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2s4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor semiconductors Thermoelectric

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Contrast Normalization strategies in Brain Tumor Imaging:From Preprocessing to Classification

引用

Computer Modeling in Engineering & sciences 2024年第8期140卷 1539-1562页

作者： samar M.Alqhtani Toufique A.soomro Faisal Bin Ubaid ahmed Ali Muhammad Irfan Abdullah A.Asiri Department of Information systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Electronic Engineering The University of LarkanoLarkanaSindh75660Pakistan Computer science Department Sukkur IBA UniversitySukkurSindh65200Pakistan Eletrical Engineering Department Sukkur IBA UniversitySukkurSindh65200Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Radiological sciences Department College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia

Cancer-related to the nervous system and brain tumors is a leading cause of mortality in various *** resonance imaging(MRI)and computed tomography(CT)are utilized to capture brain *** plays a crucial role in the diagnosis of brain tumors and the examination of other brain ***,manual assessment of MRI images by radiologists or experts is performed to identify brain tumors and abnormalities in the early stages for timely ***,early diagnosis of brain tumors is intricate,necessitating the use of computerized *** research introduces an innovative approach for the automated segmentation of brain tumors and a framework for classifying different regions of brain *** proposed methods consist of a pipeline with several stages:preprocessing of brain images with noise removal based on Wiener Filtering,enhancing the brain using Principal Component Analysis(PCA)to obtain well-enhanced images,and then segmenting the region of interest using the Fuzzy C-Means(FCM)clustering technique in the third *** final step involves classification using the support Vector Machine(sVM)*** classifier is applied to various types of brain tumors,such as meningioma and pituitary tumors,utilizing the Contrast-Enhanced Magnetic Resonance Imaging(CE-MRI)*** proposed method demonstrates significantly improved contrast and validates the effectiveness of the classification framework,achieving an average sensitivity of 0.974,specificity of 0.976,accuracy of 0.979,and a Dice score(DsC)of ***,this method exhibits a shorter processing time of 0.44 s compared to existing *** performance of this method emphasizes its significance when compared to state-of-the-art methods in terms of sensitivity,specificity,accuracy,and *** enhance the method further in the future,it is feasible to standardize the approach by incorporating a set of classifiers to increase the robustness of the brain classi

关键词： Brain tumor magnetic resonance imaging principal component analysis fuzzy c-clustering support vector machine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A WORK IN PROGREss

引用

Beijing Review 2024年第24期67卷 22-23页

作者： ahmed Moustafa Asia Center for studies and Translation

China-Arab cooperation is a dynamic and multifaceted/rapport that has evolved over the past decades and today transcends *** 1Oth Ministerial Conference of the China-Arab states Cooperation Forum(CAsCF),held in Beijing on May 30,marked a renewed commitment to cooperation in different sectors,including trade,investment,infrastructure,energy and *** two decades since the forum's launch have seen a significant rise in bilateral trade,significant infrastructure projects and increased cultural exchange.

关键词： investment PROGREss cooperation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimized Phishing Detection with Recurrent Neural Network and Whale Optimizer Algorithm

引用

Computers, Materials & Continua 2024年第9期80卷 4895-4916页

作者： Brij Bhooshan Gupta Akshat Gaurav Razaz Waheeb Attar Varsha Arya ahmed Alhomoud Kwok Tai Chui Department of Computer science and Information Engineering Asia UniversityTaichung413Taiwan symbiosis Centre for Information Technology(sCIT) Symbiosis International UniversityPuneMaharashtra411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Ronin Institute MontclairNJ 07043USA Management Department College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Business Administration Asia UniversityTaichung413Taiwan Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon Department of Computer sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia Department of Electronic Engineering and Computer science Hong Kong Metropolitan University(HKMU)HomantinHong KongChina

Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection *** machine learning approaches to phishing detection have relied heavily on feature engineering and have often fallen short in adapting to the dynamically changing patterns of phishingUniformResource Locator(URLs).Addressing these challenge,we introduce a framework that integrates the sequential data processing strengths of a Recurrent Neural Network(RNN)with the hyperparameter optimization prowess of theWhale Optimization Algorithm(WOA).Ourmodel capitalizes on an extensive Kaggle dataset,featuring over 11,000 URLs,each delineated by 30 *** WOA’s hyperparameter optimization enhances the RNN’s performance,evidenced by a meticulous validation *** results,encapsulated in precision,recall,and F1-score metrics,surpass baseline models,achieving an overall accuracy of 92%.This study not only demonstrates the RNN’s proficiency in learning complex patterns but also underscores the WOA’s effectiveness in refining machine learning models for the critical task of phishing detection.

关键词： Phishing detection Recurrent Neural Network(RNN) Whale Optimization Algorithm(WOA) cybersecurity machine learning optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：