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The common pentanucleotide polymor.hism of the 3’-untr.nslated r.gion of the leptin r.ceptor.gene is associated with obesity in Saudi females

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Health 2013年第2期5卷 285-291页

作者： Maha H. Daghestani Mazin H. Daghestani Pinar.T. Ozand ahmed r. al-himaidi Mamoon H. Daghestani Nadia A. aleisa Hana H. Hakami Abdelmoneim Eldali ali N. al-odaib Biostatistics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Depar.ment of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Depar.ment of Obstetr.cs & Gynecology Umm-Al-Qura University Makkah KSA Depar.ment of Sur.er. King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Depar.ment of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Depar.ment of Zoology Science College King Saud University Riyadh KSA Duzen Labor.tor.es Istanbul Turkey

Obesity is due to the combined effects of genes, envir.nment, lifestyle, and the inter.ctions of these factor.. Leptin r.ceptor.(LEPr. gene has been intensively evaluated in the sear.h of var.ants that could be r.lated to obesity. The r.sults of most of these studies have been contr.ver.ial. We investigated the effects of leptin r.ceptor.gene 3’-untr.nslated r.gion (3’-UTr. polymor.hism on phenotype, metabolic par.meter. and anthr.pometr.c measur.ments of obese Saudi females. 122 healthy women aged 19 to 36 year.. The subjects wer. divided into 3 gr.ups accor.ing to their.body mass index BMI;lean (BMI 18 - 24), over.eight (BMI 25 - 29) and obese (BMI ≥ 30). Ther. wer. 13 homozygotes and 34 heter.zygotes for.the 3’-UTr.inser.ion allele amongst all 122 women. The r.sults of this study show that the allele fr.quency of the inser.ion allele (I) of 3’UTr.was significantly higher.in over.eight (35.3) and obese females (32.2) compar.d to the fr.quency in lean females (15.6). The inser.ion allele was associated with incr.ased BMI in obese gr.ups. The r.sults obtained fr.m this study indicated that in the obese subjects most var.able values incr.ased in I/I homozygote but the significant high value r.cor.ed among BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our.findings indicated that, the obesity in Saudi females is influenced by alter.tion in the leptin r.ceptor.gene 3’-UTr.polymor.hism.

关键词： Pentanucleotide Polymor.hism Leptin Obesity Saudi Females

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Appr.pr.ate Combination of Cr.ssover.Oper.tor.and Mutation Oper.tor.in Genetic algor.thms for.the Tr.velling Salesman Pr.blem

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Computer., Mater.als & Continua 2024年第5期79卷 2399-2425页

作者： Zakir.Hussain ahmed Habibollah Har.n Abdullah al-Tameem Depar.ment of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia Faculty of Computing Universiti Teknologi MalaysiaJohor Bahru81310Malaysia College of Computer.and Infor.ation Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia

Genetic algor.thms(GAs)ar. ver. good metaheur.stic algor.thms that ar. suitable for.solving NP-har. combinator.al optimization *** a set of solutions r.pr.sented by a population of chr.mosomes and then uses the idea of sur.ival of the fittest in the selection pr.cess to select some fitter.*** uses a cr.ssover.oper.tor.to cr.ate better.offspr.ng chr.mosomes and thus,conver.es the ***,it uses a mutation oper.tor.to explor. the unexplor.d ar.as by the cr.ssover.oper.tor.and thus,diver.ifies the GA sear.h space.A combination of cr.ssover.and mutation oper.tor. makes the GA sear.h str.ng enough to r.ach the optimal ***,appr.pr.ate selection and combination of cr.ssover.oper.tor.and mutation oper.tor.can lead to a ver. good GA for.solving an optimization *** this pr.sent paper.we aim to study the benchmar. tr.veling salesman pr.blem(TSP).We developed sever.l genetic algor.thms using seven cr.ssover.oper.tor. and six mutation oper.tor. for.the TSP and then compar.d them to some benchmar. TSPLIB *** exper.mental studies show the effectiveness of the combination of a compr.hensive sequential constr.ctive cr.ssover.oper.tor.and inser.ion mutation oper.tor.for.the *** GA using the compr.hensive sequential constr.ctive cr.ssover.with inser.ion mutation could find aver.ge solutions whose aver.ge per.entage of excesses fr.m the best-known solutions ar. between 0.22 and 14.94 for.our.exper.mented pr.blem instances.

关键词： Tr.velling salesman pr.blem genetic algor.thms cr.ssover.oper.tor mutation oper.tor compr.hensive sequential constr.ctive cr.ssover inser.ion mutation

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Macr.phage modulation with dipeptidyl peptidase-4 inhibitor.:A new fr.ntier.for.tr.ating diabetic car.iomyopathy?

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Wor.d Jour.al of Diabetes 2024年第9期15卷 1847-1852页

作者： Saeed Mohammadi ahmed al-Har.asi Natur.l and Medical Sciences r.sear.h Center University of NizwaNizwa 616Oman Depar.ment of Biological Sciences and Chemistr. University of NizwaNizwa 616Oman

This editor.al intr.duces the potential of tar.eting macr.phage function for.diabetic car.iomyopathy(DCM)tr.atment by dipeptidyl peptidase-4(DPP-4)*** et al studied teneligliptin,a DPP-4 inhibitor.used for.diabetes management,and its potential car.iopr.tective effects in a diabetic mouse *** suggested teneligliptin administr.tion may r.ver.e established mar.er. of DCM,including car.iac hyper.r.phy and compr.mised *** also inhibited the NLr.3 inflammasome and r.duced inflammator. cytokine pr.duction in diabetic *** play cr.cial r.les in DCM *** hyper.lycemia distur.s the balance between pr.-inflammator.(M1)and antiinflammator.(M2)macr.phages,favor.ng a pr.-inflammator. state contr.buting to hear. ***,we highlight the potential of DPP-4 inhibitor. to modulate macr.phage function and pr.mote an anti-inflammator. *** compounds may achieve this by elevating glucagon-like peptide-1 levels and potentially inhibiting the NLr.3 *** studies on teneligliptin in combination with other.ther.pies tar.eting differ.nt aspects of DCM could be suggested for.developing mor. effective tr.atment str.tegies to impr.ve car.iovascular.health in diabetic patients.

关键词： Diabetic car.iomyopathy Macr.phage Dipeptidyl peptidase-4 inhibitor Teneligliptin NLr.3 inflammasome Glucagon-like peptide-1

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A Novel Layer.d Double Hydr.xide and Dodecyl alcohol Assisted PCM Composite with High Latent Heat Stor.ge Capacity and Ther.al Conductivity

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Jour.al of Ther.al Science 2024年第2期33卷 537-547页

作者： al-ahmed Amir.SAr. Ahmet KHAN Fir.z al-r.SHEIDI Masoud Hekimoğlu Gökhan AFZAal Mohammad A.alSULAMI ahmed DAFalLA Hatim SalHI Billel A.alSULAIMAN Fahad Inter.isciplinar. r.sear.h Center.for.r.newable Ener.y and Power.Systems(Ir.-r.PS) King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Depar.ment of Metallur.ical and Mater.al Engineer.ng Karadeniz Technical UniversityTrabzon61080Turkey Maths and Natur.l Sciences Division Higher Colleges of TechnologyP.O.Box 7947SharjahUnited Arab Emirates Depar.ment of Mechanical Engineer.ng King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Cor. r.sear.h Facilities King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Inter.isciplinar. r.sear.h Center.for.Membr.nes and Water.Secur.ty King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia

Dodecyl alcohol(DDA) is a pr.mising solid-liquid phase change mater.al(PCM) due to its favor.ble latent heat stor.ge(LHS) ***,the leakage issue of PCM in a melted state dur.ng the heating per.od and low ther.al conductivity r.str.cts its utilization potential in ther.al ener.y stor.ge(TES) *** the same context,the pr.sent wor. aims to over.ome the leakage issue and impr.ve the ther.al conductivity of the *** this in mind,a novel leak-pr.of layer.d double hydr.xide(LDH)/DDA composite PCM is pr.posed thr.ugh a solution-based impr.gnation *** leak-pr.of impr.gnation r.tio of the DDA impr.gnated within the cavities of the synthesized al/Fe-LDH was deter.ined to be 60%.Detailed mor.hological,physicochemical,and ther.al pr.per.ies of the fabr.cated composite wer. studied by scanning electr.n micr.scopy(SEM),Four.er.tr.nsfor.s infr.r.d(FTIr. spectr.scopy,X-r.y diffr.ction(Xr.)spectr.scopy,differ.ntial scanning calor.metr.(DSC),ther.algr.vimetr.c analysis(TGA),and ther.al cycling *** r.sults show that the LDH/DDA composite has a suitable phase change temper.tur.(about 20℃) for.passive solar.ther.al management of building *** composite PCM showed high LHS enthalpy(about136 J/g),good ther.al stability,and cycling LHS *** also showed near.y 152% higher.ther.al conductivity compar.d to that of pur. DDA,ultimately r.ducing the melting and solidification time of the pur. DDA by 44.9% and 45.5%,r.spectively.

关键词： dodecyl alcohol layer.d double hydr.xide composite PCM ther.al conductivity ther.al ener.y stor.ge(TES)

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Inter.lay of ser.m biomar.er. bilir.bin andγ-glutamyltr.nspeptidase in pr.dicting car.iovascular.complications in type-2 diabetes mellitus

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Wor.d Jour.al of Diabetes 2024年第6期15卷 1074-1078页

作者： Ebtesam Abdullah al-Suhaimi Abdullah ahmed al-r.baish Scientific r.sear.h and Innovation Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia King Abdulaziz and his Companions Foundation for.Giftedness and Cr.ativity“Mawhiba” Riyadh 11372Saudi Arabia College of Medicine Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

This editor.al synthesizes insights fr.m a ser.es of studies examining the inter.lay between metabolic and oxidative str.ss biomar.er. in car.iovascular.disease(CVD),focusing par.icular.y on type-2 diabetes mellitus(T2DM)and acute cor.nar. syndr.me(ACS).The centr.l piece of this synthesis is a study that investigates the balance between oxidative str.ss and antioxidant systems in the body thr.ugh the analysis of ser.m bilir.bin andγ-glutamyltr.nspeptidase(γ-GGT)levels in T2DM patients with *** study highlights ser.m bilir.bin as a pr.tective antioxidant factor.while elevatedγ-GGT levels indicate incr.ased oxidative str.ss and cor.elate with major.adver.e car.iovascular.*** to this,other.r.sear.h contr.butions r.vealγ-GGT’s r.le as a r.sk factor.in ACS,its association with car.iovascular.mor.ality in br.ader.populations,and its link to metabolic syndr.me,fur.her.elucidating the metabolic dysr.gulation in *** collective findings fr.m these studies under.cor. the cr.tical r.les ofγ-GGT and ser.m bilir.bin in car.iovascular.health,especially in the context of T2DM and *** pr.viding a balanced view of the body’s oxidative and antioxidative mechanisms,these insights suggest potential pathways for.tar.eted inter.entions and impr.ved pr.gnostic assessments in patients with T2DM and *** synthesis not only cor.obor.tes the pivotal r.le ofγ-GGT in car.iovascular.pathology but also intr.duces the pr.tective potential of antioxidants like bilir.bin,illuminating the complex inter.lay between T2DM and hear. *** studies collectively under.cor. the cr.tical r.les of ser.m bilir.bin andγ-GGT as biomar.er. in car.iovascular.health,par.icular.y in T2DM and ACS contexts,offer.ng insights into the body’s oxidative and antioxidative *** synthesis of r.sear.h suppor.s the potential of these biomar.er. in guiding ther.peutic str.tegies and impr.ving pr.gnostic assessments for.patients with T2DM and some CVD.

关键词： Type-2 diabetes mellitus Acute cor.nar. syndr.me Ser.m biomar.er. γ-glutamyltr.nspeptidase Bilir.bin Car.iovascular.disease

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A Hybr.d Classification and Identification of Pneumonia Using Afr.can Buffalo Optimization and CNN fr.m Chest X-r.y Images

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Computer.Modeling in Engineer.ng & Sciences 2024年第3期138卷 2497-2517页

作者： Nasser.alalwan ahmed I.Taloba Amr.Abozeid ahmed Ibr.him alzahr.ni ali H.al-Bayatti Computer.Science Depar.ment Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Infor.ation System Depar.ment Faculty of Computers and InformationAssiut UniversityAssiutEgypt Mathematics Depar.ment Faculty of ScienceAl-Azhar UniversityCairoEgypt Cyber.Technology Institute(CTI) De Montfort UniversityLeicesterUK

An illness known as pneumonia causes inflammation in the *** ther. is so much infor.ation available fr.mvar.ous X-r.y images,diagnosing pneumonia has typically pr.ven *** impr.ve image quality and speed up the diagnosis of pneumonia,numer.us appr.aches have been *** date,sever.l methods have been employed to identify *** Convolutional Neur.l Networ.(CNN)has achieved outstanding success in identifying and diagnosing diseases in the fields of medicine and ***,these methods ar. complex,inefficient,and impr.cise to analyze a big number.of *** this paper.a new hybr.d method for.the automatic classification and identification of Pneumonia fr.m chest X-r.y images is *** pr.posed method(ABOCNN)utilized theAfr.can BuffaloOptimization(ABO)algor.thmto enhanceCNNper.or.ance and *** Weinmed filter.is employed for.pr.-pr.cessing to eliminate unwanted noises fr.m chest X-r.y images,followed by featur. extr.ction using the Gr.y Level Co-Occur.ence Matr.x(GLCM)*** featur.s ar. then selected fr.m the dataset using the ABO algor.thm,and ultimately,high-per.or.ance deep lear.ing using the CNN appr.ach is intr.duced for.the classification and identification of *** r.sults on var.ous datasets showed that,when contr.sted to other.appr.aches,the ABO-CNN outper.or.s them all for.the classification *** pr.posed method exhibits super.or.values like 96.95%,88%,86%,and 86%for.accur.cy,pr.cision,r.call,and F1-scor.,r.spectively.

关键词： Afr.can buffalo optimization convolutional neur.l networ. pneumonia X-r.y

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Numer.cal Tr.atments for.Cr.ssover.Cancer.Model of Hybr.d Var.able-Or.er.Fr.ctional Der.vatives

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Computer.Modeling in Engineer.ng & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser.Sweilam Seham al-Mekhlafi Aya ahmed Ahoud alsher. Emad Abo-Eldahab Mathematics Depar.ment Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Depar.ment Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Depar.ment Faculty of ScienceHelwan UniversityCairo11795Egypt Depar.ment of Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper.two cr.ssover.hybr.d var.able-or.er.der.vatives of the cancer.model ar. ***ünwald-Letnikov appr.ximation is used to appr.ximate the hybr.d fr.ctional and var.able-or.er.fr.ctional *** existence,uniqueness,and stability of the pr.posed model ar. *** Bashfour.h’s fifth-step method with a hybr.d var.able-or.er.fr.ctional oper.tor.is developed to study the pr.posed *** studies with gener.lized fifth-or.er.r.nge-Kutta method ar. *** examples and compar.tive studies to ver.fy the applicability of the used methods and to demonstr.te the simplicity of these appr.ximations ar. *** have showcased the efficiency of the pr.posed method and gar.er.d r.bust empir.cal suppor. for.our.theor.tical findings.

关键词： Cancer.diseases hybr.d var.able-or.er.fr.ctional der.vatives adams bashfour.h fifth step gener.lized fifth or.er.r.nge-Kutta method

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Efficient ECG classification based on Chi-squar. distance for.ar.hythmia detection

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Jour.al of Electr.nic Science and Technology 2024年第2期22卷 1-15页

作者： Dhiah al-Shammar. Mustafa Noaman Kadhim ahmed M.Mahdi Ayman Ibaida Khandakar.ahmedb College of Computer.Science and Infor.ation Technology University of Al-QadisiyahAl Diwaniyah58001Iraq Intelligent Technology Innovation Lab Victoria UniversityMelbourne3011Australia

This study intr.duces a new classifier.tailor.d to addr.ss the limitations inher.nt in conventional classifier. such as K-near.st neighbor.KNN),r.ndom for.st(r.),decision tr.e(DT),and suppor. vector.machine(SVM)for.ar.hythmia *** pr.posed classifier.lever.ges the Chi-squar. distance as a pr.mar. metr.c,pr.viding a specialized and or.ginal appr.ach for.pr.cise ar.hythmia *** optimize featur. selection and r.fine the classifier.s per.or.ance,par.icle swar. optimization(PSO)is integr.ted with the Chi-squar. distance as a fitness *** syner.istic integr.tion enhances the classifier.s capabilities,r.sulting in a substantial impr.vement in accur.cy for.ar.hythmia *** r.sults demonstr.te the efficacy of the pr.posed method,achieving a notewor.hy accur.cy r.te of 98% with PSO,higher.than 89% achieved without any pr.vious *** classifier.outper.or.s machine lear.ing(ML)and deep lear.ing(DL)techniques,under.cor.ng its r.liability and super.or.ty in the r.alm of ar.hythmia *** pr.mising r.sults r.nder.it an effective method to suppor. both academic and medical communities,offer.ng an advanced and pr.cise solution for.ar.hythmia detection in electr.car.iogr.m(ECG)data.

关键词： Ar.hythmia classification Chi-squar. distance Electr.car.iogr.m(ECG)signal Par.icle swar. optimization(PSO)

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A Hybr.d and Lightweight Device-to-Ser.er.Authentication Technique for.the Inter.et of Things

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Computer., Mater.als & Continua 2024年第3期78卷 3805-3823页

作者： Shaha al-Otaibi r.him Khan Hashim ali Aftab ahmed Khan Amir.Saeed Jehad ali Depar.ment of Infor.ation Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Depar.ment of Computer.Science Abdul Wali Khan University MardanMardan23200Pakistan Depar.ment of Computer.Science and IT UET PeshawarJalozai Campus PeshawarPeshawar24240Pakistan Depar.ment of AI Conver.ence Networ. Ajou UniversitySuwon16499South Korea

The Inter.et of Things(IoT)is a smar. networ.ing infr.str.ctur. of physical devices,i.e.,things,that ar. embedded with sensor.,actuator.,softwar.,and other.technologies,to connect and shar. data with the r.spective ser.er.*** IoTs ar. cor.er.tones in differ.nt application domains,the device’s authenticity,i.e.,of ser.er.s)and or.inar. devices,is the most cr.cial issue and must be r.solved on a pr.or.ty ***,var.ous field-pr.ven methodologies wer. pr.sented to str.amline the ver.fication pr.cess of the communicating devices;however.location-awar. authentication has not been r.por.ed as per.our.knowledge,which is a cr.cial metr.c,especially in scenar.os wher. devices ar. *** paper.pr.sents a lightweight and location-awar. device-to-ser.er.authentication technique wher. the device’s member.hip with the near.st ser.er.is subjected to its location infor.ation along with other.***,Media Access Contr.l(MAC)addr.ss and Advance Encr.ption Scheme(AES)along with a secr.t shar.d key,i.e.,λ_(i) of 128 bits,have been utilized by Tr.sted Author.ty(TA)to gener.te MaskIDs,which ar. used instead of the or.ginal ID,for.ever. device,i.e.,ser.er.and member.and ar. shar.d in the offline ***,TA shar.s a list of authentic devices,i.e.,ser.er.S_(j) and member. C_(i),with ever. device in the IoT for.the onwar. ver.fication pr.cess,which is r.quir.d to be executed befor. the initialization of the actual communication ***,ever. device should be located such that it lies within the cover.ge ar.a of a ser.er.and this location infor.ation is used in the authentication pr.cess.A thor.ugh analytical analysis was car.ied out to check the susceptibility of the pr.posed and existing authentication appr.aches against well-known intr.der.attacks,i.e.,man-in-the-middle,masquer.ding,device,and ser.er.imper.onations,etc.,especially in the IoT ***,pr.posed authentication and existing state-of-the-ar. appr.aches have been s

关键词： Inter.et of things authenticity secur.ty location communication

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Gut micr.biota pr.dicts the diagnosis of ulcer.tive colitis in Saudi childr.n

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Wor.d Jour.al of Clinical Pediatr.cs 2024年第1期13卷 118-124页

作者： Mohammad El Mouzan ahmed al Sar.hy Asaad Assir. Depar.ment of Pediatr.cs Gastroenterology UnitKing Saud UniversityRiyadh 11461Saudi Arabia

BACKGr.UND Ulcer.tive colitis(UC)is an immune-mediated chr.nic inflammator. condition with a wor.dwide *** the etiology of this disease is still unknown,the under.tanding of the r.le of the micr.biota is becoming incr.asingly *** To investigate the pr.dictive power.of the gut micr.biota for.the diagnosis of UC in a cohor. of newly diagnosed tr.atment-naïve Saudi childr.n with *** The study population included 20 childr.n with a confir.ed diagnosis of UC and 20 healthy *** DNA was extr.cted and sequenced,and shotgun metagenomic analysis was per.or.ed for.bacter.a and *** and bioinfor.atics demonstr.ted significant dysbiosis in the for. of r.duced alpha diver.ity,beta diver.ity,and significant differ.nce of abundance of taxa between childr.n with UC and contr.l *** r.ceiver.oper.ting char.cter.stic cur.e,a pr.bability cur.e,was used to deter.ine the differ.nce between the UC and contr.l *** ar.a under.the cur.e(AUC)r.pr.sents the degr.e of separ.bility between the UC gr.up and the contr.l *** AUC was calculated for.all identified bacter.al species and for.bacter.al species identified by the r.ndom for.st classification algor.thm as impor.ant potential biomar.er. of UC.A similar.method of AUC calculation for.all bacter.ophages and impor.ant species was *** The median age and r.nge wer. 14(0.5-21)and 12.9(6.8-16.3)year. for.childr.n with UC and contr.ls,r.spectively,and 40%and 35%wer. male for.childr.n with UC and contr.ls,*** AUC for.all identified bacter.al species was 89.5%.However.when using the bacter.al species identified as impor.ant by r.ndom for.st classification algor.thm analysis, the accur.cy incr.ased to 97.6%. Similar.y, the AUC for.all theidentified bacter.ophages was 87.4%, but this value incr.ased to 94.5% when the impor.ant bacter.ophagebiomar.er. wer. *** ver. high to excellent AUCs of fecal bacter.al and vir.l species sugge

关键词： Ulcer.tive colitis Micr.biota Ar.a under.the cur.e Childr.n Saudi Ar.bia

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