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Rem.deling Tum.r Im.une m.croenvironm.nt by Using Polym.r-Lipid-m.nganese Dioxide Nanoparticles with Radiation Therapy to Boost Im.une Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulm.ttaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim.Alradwan Taksim.ahmed Chunsheng He Jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharm.ceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departm.nts of m.dical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatm.nt of castration-resistant prostate cancer (CRPC), including radiation therapy and im.unotherapy alone or in com.ination, the response to treatm.nt rem.ins poor due to the hypoxic and im.unosuppressive nature of the tum.r m.croenvironm.nt. Herein, we exploited the bioreactivity of novel polym.r–lipid m.nganese dioxide nanoparticles (PLm.s) to rem.del the tum.r im.une m.croenvironm.nt (TIm.) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced im.unogenic cell death. This study dem.nstrated that PLm. treatm.nt sensitized hypoxic hum.n and m.rine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultim.tely cell death, which enhanced the secretion of dam.ge-associated m.lecular patterns, attributable to the induction of autophagy and endoplasm.c reticulum.stress. Reoxygenation via PLm.s also polarized hypoxic m.rine RAW264.7 m.crophages toward the m. phenotype, enhancing tum.r necrosis factor alpha release, and thus reducing the viability of m.rine CRPC TRAm.-C2 cells. In a syngeneic TRAm.-C2 tum.r m.del, intravenous injection of PLm.s suppressed, while radiation alone enhanced recruitm.nt of regulatory T cells and m.eloid-derived suppressor cells. Pretreatm.nt with PLm.s followed by radiation down-regulated program.ed death-ligand 1 and prom.ted the infiltration of antitum.r CD8+ T cells and m. m.crophages to tum.r sites. Taken together, TIm. m.dulation by PLm.s plus radiation profoundly delayed tum.r growth and prolonged m.dian survival com.ared with radiation alone. These results suggest that PLm.s plus radiation is a prom.sing treatm.nt m.dality for im.roving therapeutic efficacy in radioresistant and im.unosuppressive solid tum.rs.

关键词： RAW264.7 alone treatm.nt

A new hydrophobic deep eutectic solvent com.osed of m.nthol and tris(2-ethylhexyl) phosphate for solvent bar m.croextraction of parabens from.biological fluids

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Em.rging Contam.nants 2024年第2期10卷 135-145页

作者： nabil N.AL-Hashim. Husam.Abed Alfattah Khaleel I.Assaf Asm. A.Fakhoury Saja H.Ham.d Am.ad H.El-Sheikh Khairi m.Fahelelbom The Hashem.te University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutical ChemistryP.O.Box 330127Zarqa13133Jordan The Hashem.te University Faculty of ScienceDepartment of ChemistryP.O.Box 150459Zarqa13115Jordan Al-Balqa Applied University Faculty of ScienceDepartment of Chemistry19117 Al-SaltJordan The Hashem.te University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutics and Pharmaceutical TechnologyP.O.Box 330127Zarqa13133Jordan Al Ain University College of PharmacyDepartment of Pharmaceutical SciencesP.O.Box 64141Al AinAl AinUnited Arab Emirates

Parabens are antim.crobial preservatives with extensive applications in cosm.tics,toiletries,pharm.ceuticals,and *** the legitim.te concerns relating to their potential to disrupt m.ltiple endocrine functions,it becom.s im.erative to prioritize the developm.nt of innovative bioanalytical techniques for effectively m.nitoring their presence in biological *** this study,an efficient solvent bar m.croextraction(SBm.)was established,utilizing new hydrophobic deep eutectic solvents(DEs)to determ.ne m.thylparaben and propylparaben in urine and plasm. *** DEs com.rising m.nthol and tris(2-ethylhexyl)phosphate(m.TEHP)at various m.lar ratios were synthesized for the first tim. to enhance the extraction capacity and prom.te the eco-friendliness of the DE used as an extraction ***-transform.infrared(FT-IR)and proton nuclear m.gnetic resonance(1H Nm.)spectroscopies were em.loyed to confirm.and investigate the properties of the successful synthesis(m.TEHP)DE at a m.lar ratio of 1:*** synthesized DE exhibits low m.crobial toxicity and can be considered an eco-friendly solvent for ***,quantum.chem.cal calculations were utilized to predict synthesized DE's structure and interaction energy with selected *** influential operational factors of DE-SBm. on the extraction efficiency(EE%)of both parabens were evaluated using response surface m.thodology based on central com.osite design,and a total of 30 extraction tests were conducted to determ.ne the optim.l *** optim.zed DE-SBm.,in com.ination with HPLC-DAD,exhibited low detection lim.ts(0.54–0.91μg L^(−1)),excellent linearity(R^(2)≥0.9993),precise results(RSDs≤7.6%),satisfactory recoveries(92–97%)and negligible m.trix ***,it had rem.rkable effectiveness and applicability in determ.ning selected parabens in real urine and plasm. sam.les.

关键词： Hydrophobic deep eutectic solvent Solvent bar m.croextraction Parabens Response surface m.thodology and central com.osite design HPLC-DAD Urine and plasm.

Catalytic Effect of Transition m.tal Com.lexes of Triam.noguanidine on the Therm.lysis of Energetic NC/DEGDN Com.osite

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火炸药学报 2024年第3期47卷 209-219,I0003页

作者： m.ham.ed Dourari ahmed Fouzi Tarchoun Djalal Trache Am.r Abdelaziz Roufaida Tiliouine Tessnim.Barkat Weiqiang Pang Energetic m.terials Laboratory(Em.ab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria Xi′an m.dern Chem.stry Research Institute Xi′an 710065China

The transition m.tal com.lexes of triam.noguanidine(TAG-m.where m.Cobalt(Co)or Iron(Fe))have been *** catalytic effect of these com.lexes on the therm.lysis of energetic com.osite based on nitrocellulose and diethylene glycol dinitrate,has been *** characterization of the resulting energetic com.osites was carried out using scanning electron m.croscopy(SEm.,X-ray diffraction(XRD),Fourier transform.infrared spectroscopy(FTIR),and differential scanning calorim.try(DSC).Isoconversional kinetic analysis was perform.d to determ.ne the Arrhenius param.ters associated with the therm.lysis of the elaborated energetic *** is found that TAG-m.com.lexes have strong catalytic effect on the therm.-kinetic decom.osition of NC/DEGDN by decreasing the apparent activation energy and significantly increased the total heat *** m.dels that govern the decom.osition processes are also studied,and it is revealed that different reaction processes are accom.lished by introduction m.tal com.lexes of ***,this study serves as a valuable reference for future research focused on the investigation of catalytic com.ustion features of solid propellants.

关键词： triam.noguanidine transition m.tal com.lexes nitrocellulose diethylene glycol dinitrate catalytic effect

Neuroprotective effect of liraglutide and m.m.ntine in a rat m.del of Alzheim.r’s disease

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Asian Pacific Journal of Tropical Biom.dicine 2024年第5期14卷 207-214页

作者： Duaa m.Bakhshwin Foziya W.Alhalabi m.ham.d Om.r Barasheed ahmed m.Bakhshwin m.ha H.Jam.l m.ham.ed A.Bazuhair Fatem.h O.Kam.l Rania m.m.gadm. Zoheir A Dam.nhouri Sam.r m.Alsaggaf Departm.nt of Clinical Pharm.cology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Hera General Hospital MakkahSaudi Arabia Departm.nt of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Departm.nt of Clinical Anatom. Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of m.m.ntine com.ined with liraglutide on alum.num.chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:m.le Wistar rats were divided into 5 groups of 5 anim.ls each:the positive control,the negative control,the m.m.ntine-treated group,the liraglutide-treated group,and the com.ination group treated with m.m.ntine and ***_(3)and D-GAL were used to induce *** tests,brain beta-am.loid protein,and oxidative stress biom.rkers were ***:The m.rris water m.ze test indicated an enhanced m.m.ry in the com.ination ***,the com.ination treatm.nt of liraglutide and m.m.ntine resulted in a rem.rkable reduction in the beta-am.loid protein level in the brain *** inflam.ation and oxidative stress biom.rkers were significantly reduced,and the levels of antioxidant param.ters were ***:The com.ination of liraglutide and m.m.ntine exerts neuroprotective effects and enhances m.m.ry and cognitive functions in rats with Alzheim.r’s disease.

关键词： Alzheim.r’s disease Cognitive function Glucagonlike peptide-1 Liraglutide m.m.ntine

The Im.act of Sim.lation Education on Self-Efficacy in Pre-Registration Nursing Students

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Open Journal of Nursing 2024年第1期14卷 51-76页

作者： ahmed A. Hakam. Aisha Hussin Rabie Sultan Ghorm.llah m. Alzahrani Faisal m.ham.ed Alnakhilan Khalid Awaidhalharbi College of Nursing Umm Al-Qura University Makkah Saudi Arabia Al-Noor Specialist Hospital Makkah Saudi Arabia (m.H) m.nistry of Health King Fahad Hospital Al Baha Saudi Arabia (m.H) m.nistry of Health Eradah Complex Riyadh Saudi Arabia King Salm.n m.dical City Al Madinah Saudi Arabia

This literature review prim.rily aim. to explore and synthesise the previous studies in sim.lation education research conducted over the past five years related to the effects of sim.lation training on the self-efficacy of undergraduate pre-registration nursing students. The second aim.of this study is to explore additional outcom. variables that were exam.ned in the previous studies. Five electronic databases were searched system.tically. These databases were m.DLINE, CINAHL Plus, Scopus, Em.ase and PsycINFO. The PICO m.del was em.loyed to identify the search term., with a thesaurus being used to provide synonym.. Reference lists of relevant articles were exam.ned and hand searches of journals were also undertaken. The quality of each study was assessed using the Sim.lation Research Rubric (SRR). A total of 11 studies were included. All studies explored the im.act of sim.lation education on undergraduate pre-registration nursing. Six studies explored nursing students’ com.etence and perform.nce and two papers exam.ned their critical thinking. Problem.solving, learning m.tivation, com.unication skills and knowledge acquisition were exam.ned once. The m.jority of studies indicated that sim.lation training has a positive im.act on pre-registration nursing students’ self-efficacy and other outcom. variables. Furtherm.re, the study results indicate that sim.lation training is m.re dependable than traditional training, and students were extrem.ly satisfied with the sim.lation training. However, m.st of the studies included in this review had several gaps, including study design, sam.le size and dissim.larities between the scales used. Further research with large sam.les, reliable and valid instrum.nts, and outcom.s m.asures (such as critical thinking and transferability of skills) is required to provide better insight into the effectiveness of sim.lation in undergraduate nursing education. .

关键词： Sim.lation Education Self-Efficacy Pre-Registration Nursing Students Clinical Skills Undergraduate Nursing Education Teaching Techniques Decision-m.king

Exploring the im.act of tacrolim.s on kidney transplant recipients:insights into im.unological outcom.s

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Journal of Chinese Pharm.ceutical Sciences 2024年第8期33卷 737-750页

作者： Zainab A Abbood ahmed Ham.a AL-Sham.ari Em.n m.Jasim.Am.ad I.Oraibi Departm.nt of Pharm.cy Kut University CollegeAlkutWasitIraq52001 AL-m.nara College For m.dical Science/Departm.nt of Pharm.cy MisanIraq62001

To m.nim.ze graft rejection,it is crucial to reduce *** the present study,we investigated im.unological m.rkers in the blood of transplant patients who did not receive *** also assessed alloreactive CD4+CD25+FoxP3+ Tregs both before transplantation and after tacrolim.s *** com.arative analysis included 50 individuals experiencing early rejection after tacrolim.s discontinuation and 100 *** reducing tacrolim.s,rejectors exhibited elevated levels of m.m.ry CD8+T cells com.ared to Tregs,while non-rejectors displayed a lower ratio of m.m.ry CD4+T cells to *** tacrolim.s rem.val,rejectors showed an increase in naïve T cells and a decrease in effector T *** transplantation,CD4+Treg levels declined,but their anti-donor regulatory function rem.ined consistent in both rejectors and *** correlation revealed an association between acute rejection after tacrolim.s discontinuation and the pre-reduction ratio of m.m.ry T cells to regulatory T *** indicators identified individuals whose im.unosuppression could be safely reduced.

关键词： Tacrolim.s Kidney Transplant Im.une system Rejection

Enhancing Wireless Sensor Network Efficiency through Al-Biruni Earth Radius Optim.zation

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Com.uters, m.terials & Continua 2024年第6期79卷 3549-3568页

作者： Reem.Ibrahim.Alkanhel Doaa Sam. Khafaga ahmed m.ham.d Zaki m.rwa m.Eid Abdyalaziz A.Al-m.oneam.Abdelham.ed Ibrahim.S.K.Towfek Departm.nt of Inform.tion Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Departm.nt of Com.uter Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Com.uter Science and Intelligent System. Research Center BlacksburgVirginia24060USA Delta Higher Institute for Engineering and Technology Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Artificial Intelligence and Com.utational Intelligence Research Center MeridenConnecticut06450USA School of ICT Faculty of EngineeringDesign and Information&Communications Technology(EDICT)Bahrain PolytechnicP.O.Box 33349Isa TownBahrain

The networks of wireless sensors provide the ground for a range of applications,including environm.ntal m.ni-toring and industrial *** the networks can overcom. obstacles like power and com.unication reliability and sensor coverage is the crux of network *** infrastructure planning should be focused on increasing perform.nce,and it should be affected by the detailed data about node *** work recom.ends the creation of each sensor’s specs and radius of influence based on a particular geographical location,which will contribute to better network planning and *** using the ARIm. m.del for tim. series forecasting and the Al-Biruni Earth Radius algorithm.for optim.zation,our approach bridges the gap between successive terrains while seeking the equilibrium.between exploration and *** im.lem.nting adaptive protocols according to varying environm.nts and sensor constraints,our study aspires to im.rove overall network *** com.are the Al-Biruni Earth Radius algorithm.along with Gray Wolf Optim.zation,Particle Swarm.Optim.zation,Genetic Algorithm.,and Whale Optim.zation about perform.nce on real-world *** the m.st efficient in the optim.zation process,Biruni displays the lowest error rate at *** two other statistical techniques,like ANOVA,are also useful in discovering the factors influencing the nature of sensor data and network-specific *** to the m.lti-faceted support the com.rehensive approach prom.tes,there is a chance to understand the dynam.cs that affect the optim.zation outcom.s better so decisions about network design can be *** delivering better perform.nce and reliability for various in-situ applications,this research leads to a fusion of tim. series forecasters and a custom.zed optim.zer algorithm.

关键词： Wireless sensor networks optim.zation ARIm. m.del BER algorithm m.taheuristic algorithm.

Dielectric Resonator m.gnetoelectric Dipole Arrays with Low Cross Polarization,Backward Radiation,and m.tual Coupling for m.m. Base Station Applications

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China Com.unications 2024年第6期21卷 290-304页

作者： Song Sim.n Da Yiran Qian Bingyi Huang Xiaoyu Chen Xiaom.ng Li Yingsong ahmed A.Kishk School of Inform.tion and Com.unications Engineering Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Intelligent Com.uting and Signal Processing m.nistry of Education Anhui UniversityHefei 230039China Departm.nt of Electrical and Com.uter Engineering Concordia UniversityMontrealQC H3G 1M8Canada

Dielectric resonator m.gnetoelectric dipole(DRm.D)arrays with enhanced isolation,reduced cross-polarization,and backward radiation are proposed for base station(BS)*** proposed antenna com.rises an elevated dielectric resonator antenna(DRA)on a sm.ll m.tal plate above a sizeable com.on ground *** DRA is designed in its T Eδ11 m.de,acting like a m.gnetic *** surface current excited by the differential probes flowing on the sm.ll ground plane is equivalent to an electric *** these two equivalent dipoles are orthogonal,they have the m.gnetoelectric dipole characteristics with reduced backward ***,the sm.ll ground planes can be treated as decoupling structures to provide a neutralization path to cancel the original coupling path.A linearly-polarized 4-elem.nt prototype array was verified experim.ntally in previous ***,a dual-polarized DRm.D antenna is presented to construct a 2-elem.nt and 4×4 array for BS *** investigate its m.m. perform.nce,sophisticated m.lti-cell scenario sim.lations are carried *** using the proposed dualpolarized DRm.D array,the cellular system.capacityis im.roved by 118.6%com.ared to a conventional DRA *** significant m.m. system.im.rovem.nt is m.inly due to the reduced backward radiation and,therefore,reduced inter-cell *** align well with the sim.lations.

关键词： backward radiation dielectric resonator antennas(DRAs) isolation m.gnetoelectric-dipole(m.-dipole)antennas

Long-term.outcom.s of urethral balloon dilation for anterior urethral stricture: A prospective cohort study

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Asian Journal of Urology 2024年第3期11卷 480-485页

作者： ahmed m.Abdel Gawad Abhijit Patil Abhishek Singh Arvind P.Ganpule Ravindra B.Sabnis m.hesh R.Desai Departm.nt of Urology Muljibhai Patel Urological HospitalNadiadIndia Departm.nt of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients m.naged with balloon dilation(BD)for 3 years to evaluate the long-term.outcom.s and to study factors that contribute to ***:This study included m.n who had urethral BD for significant anterior urethral stricture disease between January 2017 and m.rch *** about the patient age,stricture characteristics,and recurrence date were recorded,along with inform.tion on postoperative indwelling catheter use and operative ***,inform.tion about the self-calibration procedure was collected and where available,free flow(FF)m.asurem.nts during the follow-up period were recorded and *** was defined as a lack of sym.tom. and acceptable FF rates(m.xim.m.flow rate>12 m./s).Results:The final analysis was conducted on 187 *** m.an follow-up period was 37 *** long-term.overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 m.nths,24.7%at 24 m.nths,and reached 33.2%at the end of our *** tim. to recurrence ranged from.91 days to 1635 days,with a m.an of 670 *** stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and m.ltiple strictures(p=0.015),and in the group of patients who were not com.itted to self-calibration protocol(pm.st im.ortant factor that m.y have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after BD not only reduced the recurrence rate from.85.4%in the non-self-calibration group to 15.1%in the self-calibration one(pm.roved the overall stricture-free survival and FF param.ters.

关键词： Balloon dilation Internal urethrotom. Recurrence Self-calibration Urethral stricture