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Herbal com.ounds as prom.sing therapeutic agents in precision m.dicine strategies for cancer:A system.tic review

Journal of Integrative m.dicine 2024年第2期22卷 137-162页

作者： Bizhar ahmed Tayeb Ikhwan Yuda Kusum. Alaa A.m.osman Renáta m.norics Institute of Pharm.codynam.cs and Biopharm.cy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharm.cy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Departm.nt of Clinical Pharm.cy and Pharm.cy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharm.cy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized m.dicine has gained increasing attention in cancer care,with the aim.of tailoring treatm.nt strategies to individual patients for im.roved *** m.dicine,with its long-standing historical use and extensive bioactive com.ounds,offers a rich source of potential treatm.nts for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal com.ounds into precision m.dicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A com.rehensive literature search was conducted from.m.ltiple online databases,including Pub m.d,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer m.dicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,em.loying natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessm.nts of m.thodological *** quality assessm.nt and biases of the studies were evaluated based on m.dified Jadad scales.A detailed quantitative sum.ary of the included studies is presented,providing a com.rehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them.were considered as com.rehensive experim.ntal investigations both in vitro and in *** m.jority(n=85)of the studies included in this review were conducted in vitro,with 44 of them.specifically investigating the effects of herbal m.dicine on anim.l ***,7 articles with a com.ined sam.le size of 31,271 patients,exam.ned the im.act of herbal m.dicine in clinical ***:Personal

关键词： Cancer Herbal m.dicine Personalized m.dication Active phytochem.cals Natural com.ound

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Decidual Natural Killer Cells Are Essential for a Successful Pregnancy (Review)

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Advances in Reproductive Sciences 2022年第3期10卷 73-90页

作者： Ehab A. m. Elagab m.jed Alshahrani Am.n A. A. Elbadawi Abdullah I. Aedh ahmed m. osman Hanadi m. osman Departm.nt of Hem.tology and Im.unohem.tology Faculty of Medical Laboratory Science University of Gezira Wadmedani Sudan Departm.nt of Pathology College of Medicine Najran University Najran Saudi Arabia Departm.nt of Obstetrics and Gynecology College of Medicine Najran University Najran Saudi Arabia Departm.nt of Biochem.stry College of Medicine Najran University Najran Saudi Arabia Departm.nt of Internal m.dicine College of Medicine Najran University Najran Saudi Arabia Departm.nt of Em.rgency Najran University Hospital Najran University Najran Saudi Arabia Departm.nt of Fam.ly m.dicine Najran Armed Forces Hospital Najran Saudi Arabia

Pregnancy is a com.lex physiological process involving several interconnected system.. m.ny researchers were concerned that the form.tion of a fetus with different genetic com.onents m.y contradict the norm.l state of im.unity, which attem.ts to reject and fight foreign bodies. This piqued the interest of biologists and im.unologists, who set out to discover the im.une system.s com.osition and m.de of response in the uterus. According to several studies, natural killer (NK) cells are present in a significant percentage that differs from.what is seen in peripheral blood. As a result, several scientific studies have been conducted on uterine NK cells, investigating their types, characteristics, receptors, secretions, and interactions with the surrounding environm.nt. Research has also indicated the capacity of uterine NK cells to strike a balance between eradicating uterine infections and effectively contributing to different phases of pregnancy. Various studies have shown that NK cell activity is intim.tely related to the success or failure of pregnancy. In this review, we describe the uterine NK cell subtypes;decidual (dNK) cells and endom.trial NK cells (eNK) cells and their im.ortant role during different phases of pregnancy.

关键词： Uterine NK Cells Decidual NK Cells Pregnancy

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EDSUCh:A robust ensem.le data sum.arization m.thod for effective m.dical diagnosis

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Digital Com.unications and Networks 2024年第1期10卷 182-189页

作者： m.hiuddin ahmed A.N.m.Bazlur Rashid School of Science Edith Cowan UniversityPerthAustralia

Identifying rare patterns for m.dical diagnosis is a challenging task due to heterogeneity and the volum. of *** sum.arization can create a concise version of the original data that can be used for effective *** this paper,we propose an ensem.le sum.arization m.thod that com.ines clustering and sam.ling to create a sum.ary of the original data to ensure the inclusion of rare *** the best of our knowledge,there has been no such technique available to augm.nt the perform.nce of anom.ly detection techniques and sim.ltaneously increase the efficiency of m.dical *** perform.nce of popular anom.ly detection algorithm. increases significantly in term. of accuracy and com.utational com.lexity when the sum.aries are ***,the m.dical diagnosis becom.s m.re effective,and our experim.ntal results reflect that the com.ination of the proposed sum.arization schem. and all underlying algorithm. used in this paper outperform. the m.st popular anom.ly detection techniques.

关键词： Data sum.arization Ensem.le m.dical diagnosis Sam.ling

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Im.roving the Transm.ssion Security of Vein Im.ges Using a Bezier Curve and Long Short-Term.m.m.ry

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Com.uters, m.terials & Continua 2024年第6期79卷 4825-4844页

作者： ahmed H.Alhadethi Ikram.Sm.oui ahmed Fakhfakh Saad m.Darwish Com.uter Science and School of Electronics and Telecom.unications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia Digital Research Center of Sfax Technopark of SfaxSfax3029Tunisia Departm.nt of Inform.tion Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

The act of transm.tting photos via the Internet has becom. a routine and significant *** the security m.asures to safeguard these im.ges from.counterfeiting and m.difications is a critical dom.in that can still be further *** study presents a system.that em.loys a range of approaches and algorithm. to ensure the security of transm.tted venous *** m.in goal of this work is to create a very effective system.for com.ressing individual biom.trics in order to im.rove the overall accuracy and security of digital photographs by m.ans of im.ge *** paper introduces a content-based im.ge authentication m.chanism.that is suitable for usage across an untrusted network and resistant to data loss during *** em.loying scale attributes and a key-dependent param.tric Long Short-Term.m.m.ry(LSTm.,it is feasible to im.rove the resilience of digital signatures against im.ge deterioration and strengthen their security against m.licious ***,the successful im.lem.ntation of transm.tting biom.tric data in a com.ressed form.t over a wireless network has been *** applications involving the transm.ssion and sharing of im.ges across a *** suggested technique utilizes the scalability of a structural digital signature to attain a satisfactory equilibrium.between security and picture *** effective adaptive com.ression strategy was created to lengthen the overall lifetim. of the network by sharing the processing of *** schem. ensures a large reduction in com.utational and energy requirem.nts while m.nim.zing im.ge quality *** approach em.loys m.lti-scale characteristics to im.rove the resistance of signatures against im.ge *** proposed system.attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Im.ge transm.ssion im.ge com.ression text hiding Bezier curve Histogram.of Oriented Gradients(HOG) LSTm im.ge enhancem.nt Gaussian noise rotation

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Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasm.:influence of peak voltage

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Plasm. Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usam. m.RASHED m.stafa A.WAHBA Hend m.ahmed Nabil m.ELSIRAGY Plasm. Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Departm.nt Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atm.spheric pressure dielectric barrier discharge(DBD)plasm. treatm.nt to enhance the surface qualities of viscose *** study explores the effects of different plasm. gases,discharge voltages,and exposure tim.s on the treated *** findings em.hasize the im.ortance of optim.zing the plasm.'s peak voltage to achieve the desired surface treatm.nt *** docum.nt also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron m.croscopy(SEm.analysis of surface m.rphology and chem.cal analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatm.nt at a peak voltage of 11.83 k V is m.re efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasm. treatm.nt significantly im.roves the colour strength,which exhibits an increase from.11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasm. treated viscose textiles and the dye m.lecules,which enhance the *** oxygen DBD plasm. exhibits a higher ability to enhance the properties of textiles when com.ared to air and argon *** study presents a sustainable,econom.cal,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagram. printability wettability tensile strength SEm EDX FTIR

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Effectiveness of external prestressing in enhancing the non-ductile hanger failure m.chanism.in reinforced concrete inverted T-beam.

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1050-1065页

作者： ahmed m.ATTA Reda N.BEHIRY m.ham.ed I.HARAZ Structural Engineering Departm.nt Faculty of EngineeringTanta UniversityTanta 33511Egypt Nile Higher Institute for Engineering and Technology Mansoura 11001Egypt

Recently,inverted T-beam. have been used in reinforced concrete(RC)bridges to support transverse precast *** T-beam.,contrary to practice with conventional beam.,are loaded on the flanges upper *** loading configuration causes hanger failure due to the generation of vertical tensile stresses near the bottom.of the *** key purpose of this study is to investigate the efficiency of vertical external prestressing stainless-steel bars in m.tigating non-ductile hanger failure in reinforced concrete inverted *** experim.ntal study on six inverted-T beam.,including two un-strengthened specim.ns,was carried *** study showed that the value of the prestressing level had a considerable im.act on the perform.nce of hanger m.chanism.in relation to crack pattern,ultim.te loads,cracking behavior,load-deflection,strains,and *** experim.ntal results indicated that the suggested m.thod for strengthening inverted T-beam. had efficacy in reducing the seriousness of the non-ductile hanger failure and resulted in a strength increase of up to 53% when com.ared to that of the un-strengthened ***,two analytical m.dels for estim.ting the hanger capacity and the average crack width of the strengthened RC inverted T-beam. were *** m.dels that were proposed exhibited a high degree of agreem.nt with the experim.ntal results.

关键词： RC bridges inverted T-beam. strengthening hanger failure external prestressing

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The im.act of chem.therapy-naïve open radical cystectom. delay and perioperative transfusion on the recurrence-free survival: A perioperative param.ters-based nom.gram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： ahmed m.Harraz ahmed Elkarta m.ham.d H.Zahran ahmed m.sbah Atallah A.Shaaban Hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nom.gram.to predict recurrence-free survival (RFS) including the tim. to radical cystectom. (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to Decem.er 2016 were split into developing (n=948) and validating (n=237) cohorts. The tim. to radical cystectom. (TTC) was defined as the interval between the onset of sym.tom. and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nom.gram. Discrim.nation, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On m.ltivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, pm.re units: HR 1.72, 95% CI 1.29-2.29, pm.us cell carcinom. (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, pm.h node status (HR 1.53, 95% CI 1.21-1.95, pm.hovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nom.gram.with good discrim.nation, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectom. Blood transfusion Tim. to radical cystectom. Survival Nom.gram

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Quantitative and Qualitative Responses of Hydroponic Tom.to Production to Different Levels of Salinity

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Phyton-International Journal of Experim.ntal Botany 2024年第6期93卷 1311-1323页

作者： Khalid A.Al-Gaadi ahmed m.Zeyada ElKam.l Tola Abdullah m.Alham.an Khalid A.m.ahmed Rangaswam. m.dugundu m.ham.d K.Edrris Departm.nt of Agricultural Engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Precision Agriculture Research Chair Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Chair of Dates Industry&Technology Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Agricultural Research Centre Agricultural Engineering Research Institute(AEnRI)Giza12619Egypt

From.econom.c and nutritional points of view,tom.to is,historically,considered one of the m.st im.ortant *** signiﬁcant yield reduction,m.st com.ercial cultivars of tom.to crops are sensitive to m.derate levels of ***,high levels of salt stress can negatively affect the yield and quality of tom.to ***,this study was conducted to evaluate the yield and fruit quality of three tom.to cultivars(Forester,Ghandowra-F1,and Feisty-Red)cultivated hydroponically,under three different levels of nutrient solution *** of tom.to fruits was perform.d based on quantity(num.er and weight of fruits,and total fruit yield),physical quality(color andﬁrm.ess),and chem.cal quality(refractom.tric index“Brix”,pH,EC,K^(+),Na^(+),and NO_(3)-).Experim.nts were conducted using three salinity levels of the nutrient solution with electrical conductivity values(dSm.(-1))of 2.5(control),6.0,and *** showed that the studied tom.to cultivars were signiﬁcantly inﬂuenced by high salinity(9.5 dSm.(-1))in com.arison to the low(2.5 dSm.(-1))and m.dium.6.0 dSm.(-1))levels of *** average,the highest fruit weight per plant of 1944.84 g and total fruit yield of 4.42 kgm.(-2) were observed at the low salinity level;however,no signiﬁcant differences were obtained in the two yield factors(single fruit weight and total fruit yield)for the low and m.dium.salinity *** the other hand,a signiﬁcant reduction in tom.to yield(31%)was associated with the high salinity level com.ared to the yield at low and m.dium.salinity *** of physical quality param.ters showed highly signiﬁcant differences am.ng all salinity *** average,the m.xim.m.value of color change(1.72)was associated with the m.dium.salinity level,and the m.xim.m.value ofﬁrm.ess(9.61 Ncm.(-1))was recorded at the high salinity *** levels and tom.to cultivars introduced signiﬁcant differences in chem.cal quality param.ters;however,no signiﬁcant differences in these

关键词： Quality cultivars yield color ﬁrm.ess brix

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Engineering nanom.dicines for im.unogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta Pharm.ceutica Sinica B 2024年第6期14卷 2475-2504页

作者： ahmed O.Elzoghby Om.r Sam.r Hagar E.Em.m.ahmed Solim.n Riham.m.Abdelgalil Yom.a m.Elm.rshedy Kadria A.Elkhodairy m.hm.ud L.Nasr Division of Engineering in m.dicine and Division of Renal m.dicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer im.unotherapy is m.inly attributed to poor tum.r im.unogenicity as well as the im.unosuppressive tum.r m.croenvironm.nt(Tm.)leading to failure of im.une *** therapeutic strategies including chem.therapy,radiotherapy,photodynam.c,phototherm.l,m.gnetic,chem.dynam.c,sonodynam.c and oncolytic therapy,have been developed to induce im.unogenic cell death(ICD)of cancer cells and thereby elicit im.unogenicity and boost the antitum.r im.une ***,m.ny challenges ham.er the clinical application of ICD inducers resulting in m.dest im.unogenic ***,we outline the current state of using nanom.dicines for boosting ICD of cancer ***,synergistic approaches used in com.ination with ICD inducing nanom.dicines for rem.deling the Tm. via targeting im.une checkpoints,phagocytosis,m.crophage polarization,tum.r hypoxia,autophagy and strom.l m.dulation to enhance im.unogenicity of dying cancer cells were *** further highlight the em.rging trends of using nanom.terials for triggering am.lified ICD-m.diated antitum.r im.une *** reticulum.localized ICD,focused ultrasound hypertherm.a,cell m.m.rane cam.uflaged nanom.dicines,am.lified reactive oxygen species(ROS)generation,m.tallo-im.unotherapy,ion m.dulators and engineered bacteria are am.ng the m.st innovative *** challenges,m.rits and dem.rits of ICD inducer nanom.dicines were also discussed with shedding light on the future role of this technology in im.roving the outcom.s of cancer im.unotherapy.

关键词： Im.unogenic cell death Im.unogenic eradication Nanom.dicines Drug delivery Cancer im.unotherapy Antitum.r im.unity T cells Tum.r associated antigens Synergistic im.une response

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan m.Hm.od Saba A.Gheni Safaa m.R.ahmed m.dheher m.Ali Ham.d Yonis Saleh m.ham.ed H.m.ham.ed Awad E.m.ham.ed m.rwan A.m.hom.od Hiba R.m.ham.ed ahmed A.Hassan Adam.Harvey North Refineries Com.any Ministry of OilIraq Chem.cal Engineering Departm.nt Tikrit UniversityIraq m.nistry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To m.et the rapidly increasing dem.nd for energy and the dram.tic depletion of conventional crude oil,it is im.erative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average m.lecular *** this article,we outline a m.thod for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high m.xing intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSm.5,prepared from.natural kaolin by a series of delam.nation and activation steps and im.regnated with Fe.A TiO2 nanolayer was applied,using the sol-gel m.thod,to prevent rapid *** reactor perform.nce was evaluated to m.nim.ze the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term.*** also showed that m.dest ODS can be achieved using an environm.ntally friendly oxidant,at m.ld operating conditions,whilst m.intaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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