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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar ahmed Tayeb Ikhwan Yuda Kusuma Alaa A.m.Osman Renáta minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan m.Hmood Saba A.Gheni Safaa m.R.ahmed mudheher m.Ali Hamid Yonis Saleh mohammed H.mohammed Awad E.mohammed marwan A.mahomood Hiba R.mohammed ahmed A.Hassan Adam Harvey North Refineries Company Ministry of OilIraq Chemical Engineering Department Tikrit UniversityIraq ministry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To meet the rapidly increasing demand for energy and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSm-5,prepared from natural kaolin by a series of delamination and activation steps and impregnated with Fe.A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally friendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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Sustainable bio-energy generation via the conversion of spent wash using dual chamber microbial fuel cell

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Waste Disposal and Sustainable Energy 2024年第2期6卷 219-231页

作者： Abdul Sattar Jatoi Jawad ahmed Afaque ahmed Bhutto muhammad Shuaib Shaikh Department of Chemical Engineering Dawood University of Engineering and Technology KarachiSindhPakistan Changzhou DUBO Polymer Co. Ltd.Changzhou 213002China Department of Basic Science and Related Studies The University of LarkanoSindhPakistan Department of Chemical Engineering Mehran University of Engineering and Technology JamshoroSindhPakistan

microbial fuel cells(mFCs)are innovative devices that combine microbial processes with electrochemical reactions to convert organic matter in wastewater into electricity while simultaneously treating the *** such application is the treatment of spent wash,a highly polluting effluent generated from the distillery industry after crude mesh is separated into ethanol and spent *** wash,also known as distillery effluent or stillage,is a highly challenging wastewater treatment method due to its high chemical oxygen demand(COD),biological oxygen demand(BOD),and total dissolved solids(TDS).These characteristics make it a complex and polluting industrial effluent that requires specialized treatment processes to reduce its environmental impact ***,mFCs have shown promise in treating spent wash,as they can utilize the organic matter in wastewater as a fuel source for microbial growth as well as for electricity *** the treatment of spent wash,Saccharomyces cerevisiae *** used as a biocatalyst along with 340 mol/L potassium ferricyanide in the cathode chamber and 170 mol/L methylene blue in the anode as a *** tests were conducted by balancing a one-liter volume for power production from spent wash in mFC with the optimal conditions of 10%agarose,pH 8.5,300 mL/min of aeration in the cathode chamber,and 40%(in weight)substrate *** an ideal concentration,the maximum current and power density are roughly 53.41 mA/m^(2)and 72.22 mW/m^(2),*** each litre of processed spent wash,a maximum voltage of 850 mV(4.5 mA)was ***,91%of COD and BOD were removed from the effluent *** findings show that mFCs are capable of producing electricity and efficiently removing COD from wasted wash at the same time.

关键词： microbial fuel cell Chemical oxygen demand Biological oxygen demand-Current density Power density Spent wash

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Efficient ECG classification based on Chi-square distance for arrhythmia detection

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Journal of electronic Science and Technology 2024年第2期22卷 1-15页

作者： Dhiah Al-Shammary mustafa Noaman Kadhim ahmed m.mahdi Ayman Ibaida Khandakar ahmedb College of Computer Science and Information Technology University of Al-QadisiyahAl Diwaniyah58001Iraq Intelligent Technology Innovation Lab Victoria UniversityMelbourne3011Australia

This study introduces a new classifier tailored to address the limitations inherent in conventional classifiers such as K-nearest neighbor(KNN),random forest(RF),decision tree(DT),and support vector machine(SVm)for arrhythmia *** proposed classifier leverages the Chi-square distance as a primary metric,providing a specialized and original approach for precise arrhythmia *** optimize feature selection and refine the classifier’s performance,particle swarm optimization(PSO)is integrated with the Chi-square distance as a fitness *** synergistic integration enhances the classifier’s capabilities,resulting in a substantial improvement in accuracy for arrhythmia *** results demonstrate the efficacy of the proposed method,achieving a noteworthy accuracy rate of 98% with PSO,higher than 89% achieved without any previous *** classifier outperforms machine learning(mL)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm of arrhythmia *** promising results render it an effective method to support both academic and medical communities,offering an advanced and precise solution for arrhythmia detection in electrocardiogram(ECG)data.

关键词： Arrhythmia classification Chi-square distance electrocardiogram(ECG)signal Particle swarm optimization(PSO)

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Novel synthesis of stabilized Bi1-x-yGdxDyyO1.5 solid electrolytes with enhanced conductivity for intermediate temperature solid oxide fuel cells（SOFCs）

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Journal of Rare Earths 2024年第10期42卷 1903-1911页

作者： ahmed H.Ibrahim Yehia m.Abbas H.A.Ayoub marwa H.Ali mustafa Aldoori materials Science Laboratory Physics DepartmentFaculty of ScienceSuez Canal University ministry of Higher Education and Scientific Research Aliraqia University

Herein,we report the synthesis of a Dy-Gd co-doped cubic phase-stabilized Bi2O3solid electrolyte system via solid-state processing under atmospheric *** with Dy3+and Gd3+has been observed to significantly enhance the densification process during sintering for stabilization purposes,thereby improving the electrical properties of δ-Bi2O3-type *** synthesized ceramics were characterized using X-ray diffraction（XRD）,field emission scanning electron microscopy-energy dispersive X-ray spectroscopy（FESEm-EDX）,thermal gravimetry/differential thermal analysis（TG/DTA）,and the four-point probe technique（4PPT）.XRD analysis reveals that the samples Bi1-x-yGdxDyyO1.5（y=0.05/x=0.05,0.10,0,15,and 0.20,and x=0.05/y=0.10,0.15,and 0.20） exhibit a stable face-centered cubic δ-phase and a mixed-phase crystallographic *** XRD analysis of the stabilized δ-phase suggests that the prepared oxides show a face-centered cubic（FCC） structure with a space group of *** micrographs reveal that the composition Bi0.90Gd0.05Dy0.05O1.5has no significant ***,an evident increase in the pore formation is observed as the amount of Gd2O3increases until it reaches 20%.This finding suggests that dense pellets are formed during the sintering process at 900-1000℃.The DTA analyses were performed to verify the phase stability,which agrees with the XRD *** electrochemical performance of the synthesized Dy-Gd co-doped Bi2O3solid electrolyte system was evaluated and analyzed in detail by using the electrochemical impedance spectroscopy（EIS） technique,Based on EIS and conductivity measurements,Bi0.75Gd0.20Dy0.05O1.5exhibits the lowest activation energy of 0.519 eV and the highest conductivity value of 0.398 S/cm at 627℃compared to the other samples;this composition can be used as a solid electrolyte for intermediatetemperature solid oxide fuel cells（SOFCs）.

关键词： electrochemical impedance spectroscopy (EIS) Fast Fourier transform (FFT) Rare earths Rietveld Solid oxide fuel cells (SOFCs) Solid-state processing

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Phytochemical analysis,antioxidant,acetylcholinesterase,andα-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese medicine 2024年第3期44卷 496-504页

作者： Naila Sher mushtaq ahmed Nadia mushtaq Department of Biotechnology University of Science and Technology Bannu-KPK 28100Pakistan Department of Botany University of Science and Technology Bannu-KPK 28100Pakistan

OBJECTIVE:To investigate the effects of Hippeastrum hybridum(HH)as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase(α-amylase)and acetylcholinesterase(AChE).mETHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be(78.52±0.69)mg GAE/g,(2.01±0.04)mg RUE/g,and(58.12±0.23)mg TAE/g of plant extract respectively.28.02%±0.02%alkaloid and 2.02%±0.05%saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50(50%inhibition)of(151.01±0.13)(HH),(79.01±0.04)(Ascorbic acid)for ferric reducing,(91.48±0.13)(HH),(48.02±0.11)(Ascorbic acid)against Ammonium molybdenum,(156.02±0.31)(HH),(52.38±0.21)(Ascorbic acid)against DPPH,136.01±0.21(HH),52.02±0.31(Ascorbic acid)against H_(2)O_(2),and 154.12±0.03(HH),(40.05±0.15)(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition ofα-amylase(V_(max)remained constant and Km increases from 10.65 to84.37%)while Glucophage caused the un-competitive type of inhibition i-e both Km and V_(max)decreased from40.49 to 69.15%and 38.86 to 69.61%*** K_(i),(inhibition constant);K_(I),(dissociation constant),K_(m),(michaelis-menten constant),and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while V_(max)decreases from 60.5%to74.1%.The calculated K_(i),K_(I),K_(m),and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidant

关键词： Hippeastrum hybridum phytochemicals antioxidant alpha-amylase acetylcholinesterase

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Fuel cell stack design and modelling with a double-stage boost converter coupled to a single-phase inverter

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Clean Energy 2024年第1期8卷 188-196页

作者： Basem E.elnagi ahmed m.Ismaiel Hany S.E.mansour m.N.Abd-Alwahab electrical Engineering Department Faculty of EngineeringSuez Canal UniversityIsmailia 41522Egypt

A comprehensive proton-exchange membrane fuel cell stack model was developed and integrated with a two-stage DC/DC boost *** was directly coupled to a single-phase(two levels-four pulses)inverter without a *** pulse-width modu-lation signal was used to independently regulate every converter *** converter was modelled using a mATLAB®/Simulink®environment and an appropriate voltage control *** analysis features of the suggested circuit were created and,through established experiments,the simulation results were verified.A single-phase(two levels-four pulses)inverter control circuit was tested and it produced a pure sinusoidal waveform with voltage *** matches the voltage of the network in terms of amplitude and frequency.A sinusoidal pulse-width modulation approach was performed using a single-phase(two levels-four pulses)pulse-width modulation *** results demonstrated an enhancement in the standard of the output wave and tuned the dead time with a reduction of 63μs compared with 180μs in conventional techniques.

关键词： PEm fuel cell pulse-width modulation single-phase inverter and double-stage DC/DC boost converter

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Intelligent Fractional-Order Controller for SmES Systems in Renewable Energy-Based microgrid

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Computer modeling in Engineering & Sciences 2024年第8期140卷 1807-1830页

作者： Aadel m.Alatwi Abualkasim Bakeer Sherif A.Zaid Ibrahem E.Atawi Hani Albalawi ahmed m.Kassem electrical Engineering Department Faculty of EngineeringUniversity of TabukTabuk47913Saudi Arabia Industrial Innovation and Robotic Center(IIRC) University of TabukTabuk47731Saudi Arabia Department of electrical Engineering Faculty of EngineeringAswan UniversityAswan81542Egypt Renewable Energy and Environmental Technology Centre University of TabukTabuk47913Saudi Arabia electrical Engineering Department Faculty of EngineeringSohag UniversitySohag82524Egypt

An autonomous microgrid that runs on renewable energy sources is presented in this *** has a supercon-ducting magnetic energy storage(SmES)device,wind energy-producing devices,and an energy storage ***,because such microgrids are nonlinear and the energy they create varies with time,controlling and managing the energy inside them is a difficult ***-order proportional integral(FOPI)controller is recommended for the current research to enhance a standalone microgrid’s energy management and *** suggested dedicated control for the SmES comprises two loops:the outer loop,which uses the FOPI to regulate the DC-link voltage,and the inner loop,responsible for regulating the SmES current,is constructed using the intelligent FOPI(iFOPI).The FOPI+iFOPI parameters are best developed using the dandelion optimizer(DO)approach to achieve the optimum *** suggested FOPI+iFOPI controller’s performance is contrasted with a conventional PI controller for variations in wind speed and microgrid *** optimal FOPI+iFOPI controller manages the voltage and frequency of the *** behavior of the microgrid as a reaction to step changes in load and wind speed was measured using the proposed *** simulations were used to evaluate the recommended system’s *** results of the simulations showed that throughout all interruptions,the recommended microgrid provided the load with AC power with a constant amplitude and *** addition,the required load demand was accurately ***,the microgrid functioned incredibly well despite SmES and varying wind *** obtained under identical conditions were compared with and without the best FOPI+iFOPI *** utilizing the optimal FOPI+iFOPI controller with SmES,it was found that the microgrid performed better than the microgrid without SmES.

关键词： Fractional-order proportional integral(FOPI) intelligent controller renewable energy resources superconducting magnetic energy storage optimization

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Fever assessment in children under five: Are we following the guidelines?

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World Journal of Clinical Pediatrics 2024年第1期13卷 62-72页

作者： Hasan m Isa ahmed J Isa murtadha A Alnasheet mahmood m mansoor Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of General Surgery Salmaniya Medical ComplexManama 26671Bahrain

BACKGROUND Fever is a common cause of medical consultation and hospital admission,particularly among ***,the United Kingdom’s National Institute for Health and Care Excellence(NICE)updated its guidelines for assessing fever in children under five years of *** efficient assessment and management of children with fever are crucial for improving patient *** To evaluate fever assessment in hospitalized children and to assess its adherence with the NICE Fever in under 5s *** We conducted a retrospective cohort review of the electronic medical records of children under five years of age at the Department of Pediatrics,Salmaniya medical Complex,Bahrain,between June and July *** data,vital signs during the first 48 h of admission,route of temperature measurement,and indications for admission were *** was defined according to the NICE *** children were divided into five groups according to their age(0-3 months,>3-6 months,>6-12 months,>12-36 months,and>36-60 months).Patients with and without fever were compared in terms of demography,indication for admission,route of temperature measurement,and other vital *** with the NICE Fever in the under 5s guideline was *** compliance was defined as>95%,partial compliance as 70%-95%,and minimal compliance as≤69%.Pearson’sχ^(2),Student’s t test,the mann-Whitney U test,and Spearman’s correlation coefficient(rs)were used for *** Of the 136 patients reviewed,80(58.8%)were *** median age at admission was 14.2[interquartile range(IQR):1.7-44.4]months,with the most common age group being 36-60 ***-six(26.4%)patients had fever,and 100(73.6%)were *** commonest age group for febrile patients(>12-36 months)was older than the commonest age group for afebrile patients(0-3 months)(P=0.027).The median weight was 8.3(IQR:4.0-13.3)*** with fever had higher weight than those without fever[10.2(IQR:7.3-13.0)vs 7

关键词： Fever Pediatrics Admission patterns Temperature measurement Guidelines Bahrain

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Does dutasteride reduce the bleeding in transurethral resection of the prostate in patients on antiplatelet drugs?

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Current Urology 2024年第3期18卷 194-198页

作者： ahmed m.Rammah Alaa meshref Ebram Soliman Islam Nasser Abd elaziz Enmar Habib ahmed Yehia Abdelaziz ahmed H.Abozamel Department of Urology Kasr Alainy HospitalFaculty of MedicineCairo UniversityCairoEgypt el Sahel Teaching Hospital CairoEgypt

Background The aim of this study was to assess the effect of a 4-week dutasteride treatment on reducing the intraoperative and postoperative bleeding,as well as the amount and duration of irrigation required to clear the urine after transurethral resection of the prostate(TURP)≥50 g in men receiving the antiplatelet drug(APD).materials and methods This double-blind randomized clinical trial included patients with a prostate size≥50 g who were indicated for TURP and were already receiving *** study was conducted in the Urology Department of Cairo University over a 12-month *** preoperative laboratory investigations were performed in all ***,baseline prostate size,serum prostate-specific antigen level,and International Prostate Symptom Score were *** patients were randomly divided into 2 equal groups(groups A and B).Group A,the dutasteride group,received dutasteride(0.5 mg)once daily for 4 *** B,the placebo group,received a placebo capsule once daily for 4 *** groups underwent bipolar *** patients were excluded from the study;9 patients from group A and 6 patients from group B,either due to drug intolerability or loss *** The mean blood loss was insignificant between the 2 groups immediately after and 24 hours after surgery(Δhemoglobin:1.41±0.63 g/dL vs.1.48±0.54 g/dL,2.12±0.70 g/dL vs.2.31±0.78 g/dL,respectively,p=0.631,p=0.333;Δhematocrit:2.97%±1.51%vs.3.16%±1.36%,4.96%±1.87%vs.5.73%±4.39%,respectively,p=0.610,p=0.380).However,there were significant differences in duration of indwelling urethral catheter(5.10±0.55 days vs.5.80±1.79 days,p=0.048),duration of bladder irrigation(13.60±2.85 hours vs.16.33±6.62 hours,p=0.044),and the amount of saline used for bladder irrigation(11.03±2.30 L vs.13.87±6.13 L,p=0.046)between group A and group *** Treatment with dutasteride for 4 weeks before TURP in men receiving APD did not significantly reduce intraoperative or postoperativ

关键词： Dutasteride Transurethral resection of the prostate Postprostatectomy bleeding Antiplatelet drugs

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