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Risk Factors of Liver Cirrhosis in Chad: Large Proportion of Cases without Clear Etiology

Open Journal of Gastroenterology 2023年第11期13卷 339-350页

作者： Ali Mahamat Moussa Pascal Pineau Mayanna habkreo Moussa hassan Elefi Tahir Mahamat Saleh Maire Dehainsala Mahamat Ali hachim Adama ahmed N’Gare Adoum Abderrazak Fouda Bessimbaye Nadlaou Adawaye Chatté Service de Médecine Interne et Gastroentérologie Centre Hospitalier Universitaire La Référence Nationale Ndjamena Tchad Unité “Organisation Nucléaire et Oncogenèse” Institut National de la Santé et de la Recherche Médicale U993 Paris France Service de Medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Programme de Lutte contre le VIh et SIDA Hépatites et Infectins Sexuellement Transmissibles Ministère de la Santé Publique N’Djamena Tchad Service de Laboratoire Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad

Background: In comparison to other forms of chronic liver diseases, cirrhosis is generally poorly studied in sub Saharan Africa. In Chad, more particularly, no data are available despite the burden of liver diseases considered as the first cause of hospitalizations in the country. Methods: We conducted a retrospective analysis of 268 patients with liver cirrhosis attending care at the University Reference hospital between 2007 and 2016. Results: This series of liver cirrhoses was characterized by a weak mal predominance (M:F = 1.7). The age of onset occurs significantly earlier in women than in men (40.6 ± 12.0 vs. 44.4 ± 13.4, p = 0.0171). The principal risk factor was persistent infection with hepatitis B virus (49% of cases) followed distantly by infection with hepatitis C virus (13%) and excessive alcohol consumption (10%). Men were more frequently carrying hBV surface antigen than women (65.6% vs 35.9% p = 0.0019). hBV-associated liver cirrhosis was overall more severe than diseases from other causes. A large proportion of cirrhosis (30%), observed primarily in women (48.1% vs 24.1%, p = 0.0036), was considered are cryptogenic. Conclusions: The etiological spectrum of liver cirrhosis remains to be properly defined in Chad. This lack of knowledge prevents the implementation of an efficient policy of prevention. A significant effort should be secured to characterize hitherto neglected infectious, lifestyle or genetic risk factors responsible of this form of terminal disease and improve subsequently liver health of local populations.

关键词： Chad Liver Cirrhosis hepatitis Viruses Alcohol Cryptogenic

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Educational Program for Pregnant Women Regarding Obstetrics Dangerous Signs in Rural Areas

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Open Journal of Obstetrics and Gynecology 2021年第5期11卷 529-552页

作者： Mai ahmed Gobran Marwa Tharwat Abdel Fatah Mohamed S. h. Ramadan Ghada A. Amer M. Mahmoud Rabeh Rofida M. Elshafei Almandouh hussein Bosilah hala hassan Saied Khalil Sharbat Thabet hassanine Manal Mansour Mostafa Mohamed Sobhy Bakry Safaa A. Ibrahim Eman Ramadan Abd El Fattah Abeer M. Abdelbary Pathology Faculty of Medicine Zagazig University Zagazig Egypt Anatomy Faculty of Medicine Zagazig University Zagazig Egypt Obstetrics & Gynecology Faculty of Medicine Zagazig University Zagazig Egypt Zoology (Physiology) Department Faculty of Science Zagazig University Zagazig Egypt Stem Sharqiai Zagazig Egypt Nursing Faculty of Medicine Fayoum University Fayoum Egypt Obstetrics & Gynecology Faculty of Medicine Fayoum University Fayoum Egypt

Background: Complications linked to postpartum & pregnancy are one of the major causes of female death. In order to understand the causes of complications and encourage women to take sufficient action in order to receive emergency treatment, a critical step should therefore be taken to minimize complications related to pregnancy, in order to ensure the safety of both women and newborns. Aim of the work: Evaluate the effectiveness of the education programs for pregnant women on obstetric danger signs in rural areas and help minimize the incidence of pregnancy loss and comorbidities. Methods: A quasi-experimental design on 70 women from a population of through 372 women in six-month in antenatal clinics recruited from the previously mentioned settings with pre- and post-test was conducted at antenatal clinics (M.C.h centers) affiliated to the available geographical health zones in EL-fayoum rural area including: Al-sheikh hassan at sanorse. We collected the data of women characteristics by a self-administered interview q

关键词： Obstetric Danger Signs Knowledge Practice Obstetric Complications

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Anaemia in Waldmann's disease: A rare presentation of a rare disease

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World Journal of Gastrointestinal Endoscopy 2015年第5期7卷 567-572页

作者： Shahira A El-Etreby ahmed Y Altonbary Mohamed El Sorogy Wagdi Elkashef Jehan A Mazroa Monir h Bahgat Divisions of hepatology and Gastroenterology Pathology and Diagnostic Radiology Specialized Medical Hospital and Gastrointestinal Surgery Center

A 32-year-old female presented with 5-year history of iron deficiency anemia, marked pallor and edema of both lower limbs. Laboratory investigations including complete blood count, blood film, iron studies, lipid profile, ascitic fluid analysis, test of stool for occult blood and alpha 1 anti-trypsin. Upper, lower gastrointestinal(GIT) endoscopies, and enteroscopy were performed. Imaging techniques as abdominal ultrasonography and computed tomography were done. Echocardiography, lymph node biopsy and bone marrow examination were normal. The case was diagnosed as Waldmann's disease with protein losing enteropathy and recurrent GIT bleeding. Management started with low fat diet with medium chain triglyceride, octreotide 200 μg twice a day, tranexamic acid and blood transfusion. Then, exploratory laparotomy with pathological examination of resected segment was done when recurrent GIT bleeding occurred and to excluded malignant transformation.

关键词： Waldmann's disease Lymphangiectasia Gastrointestinal bleeding Iron deficiency anemia

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hyperuricemia in Patients with Chronic Renal Failure in the General hospital of National Reference of N’Djamena (Chad)

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Open Journal of Nephrology 2017年第1期7卷 9-18页

作者： Guillaume Mahamat Abderraman Ibrahim hamat Zeinabou Maiga Moussa Tondi ahmed Tall Lemrabott Maria Faye Cisse Mouhamadou Moustapha Kossi Akomola Sabi Ka Elhaj Fary Ka Niang Abdou Diouf Boucar hemodialysis Unit H&#244pital Général de Référence Nationale (HGRN) N’Djamena Tchad Medical Department FSS/ Université Abdou Moumouni de Niamey Service de Néphrologie et Hémodialyse H&#244pital National Lamordé de Niamey Niamey Niger Nephrology service H&#244pital Aristide Le Dantec de Dakar Dakar Sénégal Nephrology and hemodialysis Service CHU SO Lomé Lomé Togo

Introduction: hyperuricemia is defined as a level of serum uric acid greater than or equal to 70 mg/l (420 μmol/l) in men and 60 mg/l (360 μmol/l) in women. Several studies have shown that it is a risk factor or a factor of progression of chronic kidney disease. Recent experimental and epidemiological data correlate the association of hyperuricemia with chronic kidney disease (CKD), arterial hypertension and cardiovascular diseases, thus raising the question of the usefulness of therapeutics in the prevention of renal diseases. The objective of this study is to seek a link between chronic kidney disease and hyperuricemia. Materials and Methods: This is a descriptive and analytical study conducted at hemodialysis unit and cardiology service of General hospital of National reference of N’Djamena (Chad) from 1th January to 1th October 2013 (10 months). We included all chronic kidney disease patients hospitalized in hemodialysis unit and cardiology service who presented associated hyperuricemia. Results: There were 712 CKD patients who were hospitalized. Among them, there were 108 patients who were included in the study and who had hyperuricemia as a prevalence of 15.20%. The average age of patients was 35.5 years and the sex ratio was 3/1. The age group between 40 to 60 years represented 54.6%. There were 41.7% of traders. hypertensive patients accounted for 49.1%;association of diabetes and hypertension was noted in 12.90%. Renal insufficiency was moderate in 43.5% of patients. hyperuricemia was present in more than 90% of patients. Profession, age, hematuria, proteinuria and hypertension were statistically positively related to hyperuricemia. Treatment consisted of prescribing allopurinol in 84% of patients. In more than 11% of patients the progression was unfavorable. Conclusion: The implication of hyperuricemia in chronic kidney disease has been proved in several recent studies. however, randomized studies at very long scales have to be carried out to conclude from

关键词： Component Formatting Style Styling

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<i>β</i>-Oxoanilides in heterocyclic Synthesis: Synthesis and Antimicrobial Activity of Pyridines, Pyrans, Pyrimidines and Azolo, Azinopyrimidines Incorporating Antipyrine Moiety

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International Journal of Organic Chemistry 2012年第4期2卷 341-351页

作者： Abdel haleem M. hussein Mohamed A. M. Gad-Elkareem Abu-Bakr A. A. M. El-Adasy ahmed A. Khames Ismail M. M. Othman Department of Chemistry Faculty of Science Al-Azhar University Assiut Egypt

Condensation of β-Oxoanilide 1 with active methylene derivatives 2a,bafforded the pyridine derivative 5, and with crotononitrile afforded the pyridine 8. Compounds 9 and 11a-c were obtained by reaction of 1 with malononitrile dimer and arylidinemalononitrile 10a-10c. In contrast, when compound 1 reacted with ethoxymethylen malononitrile afforded the pyridine derivative 13. On the other hand, treatment of 1 with anthranilic acid gave the quinoline derivative 14. Also, reactions of 1 with isothiocyanate derivatives afforded compounds 16-18. The reaction of 1 with chalcone derivative afforded the pyridine derivative 22. Treatment of compound 1 with thiourea produced pyrimidine derivative 23. Furthermore, compound 1 converted into pyrimidinethione 24a and pyrimidinone 24b on treatment with a mixture of aromatic aldehydes and thiourea or urea respectively. Reaction of 24a with hydrazonyl halide, thiosemicarbazide and arylidinecyanothioacetamide afforded compounds 26, 28 and 29. Compound 29 was treated with chloroacetonitrile to afford compound 30. Six compounds from the newly synthesized were screened for antibacterial and antifungal activity against bacteria staphylococcus aureus, bacillus cereus and klebsiella pneumonia and fungi aspergillus flavus and aspergillus ochraceous, respectively. Some of the tested compounds showed significant antimicrobial activity. IR, 1h NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.

关键词： β-Oxoanilides Pyridines Pyrans Pyrimidines Azolo Azinopyrimidines

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快眼动睡眠行为障碍与额叶癫痫的鉴别及两者对睡眠参数影响的分析

快眼动睡眠行为障碍与额叶癫痫的鉴别及两者对睡眠参数影响的分析

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中国睡眠研究会第十五届全国学术年会

作者： NIMAN ahmed MUSE 孙晴晴王颖王栋王赞吉林大学第一医院

目的:鉴别快眼动睡眠行为障碍(RBD)和额叶癫痫(FLE),分析两者对睡眠相关参数的影响。方法:收集吉大一院睡眠中心的FLE和RBD患者及年龄性别相匹配的正常对照组共36例,通过分析24h EEG和PSG,比较其行为学特点及神经电生理差异。结果:RBD...

目的:鉴别快眼动睡眠行为障碍(RBD)和额叶癫痫(FLE),分析两者对睡眠相关参数的影响。方法:收集吉大一院睡眠中心的FLE和RBD患者及年龄性别相匹配的正常对照组共36例,通过分析24h EEG和PSG,比较其行为学特点及神经电生理差异。结果:RBD患者及FLE患者之间发病年龄有显著的统计学差异。RBD组患者表现为R期与梦境相关的喊叫和拍打(3例),下肢运动(9例),上肢摆动(8例)睡眠中含糊讲话7例;癫痫组表现为睡眠2期发作性觉醒夜间过度运动发作(6例),睡眠中坐起(5例),意识障碍(12例)。RBD组显示PSG的RSWA, FLE组24hEEG表现为额区和额颞区的尖波和尖慢波,有1例患者FLE共病RBD患者的电生理检查可见24h EEG即显示尖慢波和PSG中的RSWA。病例组与对照组之间的比较的结果显示,病例组和对照组之间SE,N1,WASO存在显著差异,微觉醒指数,AhI和PLM指数也存在显著差异。RBD与FLE组的组间比较结果显示,RBD组觉醒指数及N1时间高于癫痫组;RBD组的AhI及PLMD值高于癫痫组。通过临床特征及PSG和24h-EEG相结合的方法可以有效鉴别RBD和额叶癫痫病。RBD组对睡眠质量的影响大于额叶癫痫对其影响,RBD常伴有睡眠呼吸暂停低通气和睡眠中周期性肢体运动障碍。

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国际疾病分类第9次修订码中先兆子痫诊断的准确性

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 12-13页

作者： Geller S.E. ahmed S. Brown M.L. 成夜霞 Dept. of Obstetrics an d Gynecology College of MedicineUniv. Illinois Chicago Ill D. Chicago IL United States Dr.

Objective The purpose of this study was to evaluate the accuracy of t he Intern ational Classification of Diseases-9th revision codes for preeclampsia and ecla mpsia. Study design The University of Illinois Medical Center at Chicago dischar ge database was used to identify 135 women from 1999 through 2001 whose disease was coded as having preeclampsia or eclampsia. With American College of Obstetri cs and Gynecology criteria as the gold standard, the diagnosis that was determin ed through chart review was compared with the International Classification of Di seases-9th revision code that was present in the discharge database. Patients w ere classified as true cases if the International Classification of Diseases-9t h revision code matched the American College of Obstetricians and Gynecologists diagnosis; the positive predictive value of the code was then calculated. Result s The overall positive predictive value for the complete sample was only 54%, b ut the positive predictive value for severe preeclampsia was 84.8%, which was h igh compared with mild preeclampsia (45.3%) and eclampsia (41.7%). Diagnostic (clinician) error was the most common reason for miscoding error. Conclusion The findings suggest that International Classification of Diseases-9th revision co des for preeclampsia/eclampsia vary greatly in their accuracy of diagnosis. Ther efore, a review of medical records is required when data are being gathered on t he incidence of preeclampsia and eclampsia.

关键词：国际疾病分类先兆子痫阳性预测值间记录有显著性差异金标准诊断标准大学医学中心临床医生诺斯

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Statistical Time Series Forecasting Models for Pandemic Prediction

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Computer Systems Science & Engineering 2023年第10期47卷 349-374页

作者： ahmed ElShafee Walid El-Shafai Abeer D.Algarni Naglaa F.Soliman Moustafa h.Aly Department of Electrical Engineering Faculty of EngineeringAhram Canadian University6th October CityGizaEgypt Security Engineering Lab Computer Science DepartmentPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Electronics and Electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Electronics and Communications Engineering Department College of Engineering and TechnologyArab Academy for ScienceTechnology and Maritime TransportAlexandria1029Egypt

COVID-19 has significantly impacted the growth prediction of a pandemic,and it is critical in determining how to battle and track the disease *** this case,COVID-19 data is a time-series dataset that can be projected using different ***,this work aims to gauge the spread of the outbreak severity over ***,data analytics and Machine Learning(ML)techniques are employed to gain a broader understanding of virus *** have simulated,adjusted,and fitted several statistical time-series forecasting models,linearML models,and nonlinear ML *** of these models are Logistic Regression,Lasso,Ridge,ElasticNet,huber Regressor,Lasso Lars,Passive Aggressive Regressor,K-Neighbors Regressor,Decision Tree Regressor,Extra Trees Regressor,Support Vector Regressions(SVR),AdaBoost Regressor,Random Forest Regressor,Bagging Regressor,AuoRegression,MovingAverage,Gradient Boosting Regressor,Autoregressive Moving Average(ARMA),Auto-Regressive Integrated Moving Averages(ARIMA),SimpleExpSmoothing,Exponential Smoothing,holt-Winters,Simple Moving Average,Weighted Moving Average,Croston,and naive ***,our suggested methodology includes the development and evaluation of ensemble models built on top of the best-performing statistical and ML-based prediction methods.A third stage in the proposed system is to examine three different implementations to determine which model delivers the best ***,this best method is used for future forecasts,and consequently,we can collect the most accurate and dependable predictions.

关键词： Forecasting COVID-19 predictive models medical viruses mathematical model market research diseases

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Nat Med:靶向两分子或有助于彻底治愈白血病

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： Meenu Kesarwani, Zachary Kincaid, ahmed Gomaa, Erika huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, h Leighton Grimes Mohammad Azam Tahir Latif Ming Xu h Leighton Grimes Mohammad Azam Division of Experimental hematology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Department of Medicine University of Cincinnati Cincinnati Ohio USA Department of Anesthesia and Critical Care University of Chicago Chicago Illinois USA Division of Immunobiology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Division of Pathology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA.

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能... 详细信息

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。

关键词：白血病治愈 Nat Med 分子信号蛋白治疗效果国际学术期刊

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流产布鲁菌LysR家族转录调控子LTTR8缺失株的构建及其生物学特性分析

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中国动物传染病学报 2023年第5期31卷 7-13页

作者：李子晨尹伊成志敏左东胡海 hosny ahmed Abdelgawad 管祥王少辉李涛祁晶晶田明星于圣青中国农业科学院上海兽医研究所上海200241 山东农业大学动物科技学院泰安271018

布鲁菌是一种重要的人畜共患病病原,兼性胞内寄生,无典型毒力因子,毒力相关基因的研究对阐明布鲁菌持续感染的机制具有重要意义。本研究以流产布鲁菌S2308为亲本株,通过同源重组的方法,构建流产布鲁菌LysR家族转录调控子基因bab_RS2467... 详细信息

布鲁菌是一种重要的人畜共患病病原,兼性胞内寄生,无典型毒力因子,毒力相关基因的研究对阐明布鲁菌持续感染的机制具有重要意义。本研究以流产布鲁菌S2308为亲本株,通过同源重组的方法,构建流产布鲁菌LysR家族转录调控子基因bab_RS24670缺失株ΔlttR8,基于广宿主质粒pBBR1MCS构建成互补株ΔlttR8-Com。免疫印迹试验表明:ΔlttR8为光滑型菌株;体外培养分析发现lttR8缺失不影响布鲁菌的生长;细胞感染试验发现lttR8缺失不影响布鲁菌黏附、入侵细胞和胞内存活的能力。耐受性试验分析发现:lttR8缺失不影响布鲁菌对过氧化氢(h2O2)和多粘菌素B(polymyxin B)的敏感性。小鼠感染试验分析发现lttR8缺失显著减弱流产布鲁菌的毒力。综上所述,本研究发现一个新的与流产布鲁菌致病性相关的转录调控子,为布鲁菌致病机制研究提供参考。

关键词：流产布鲁菌 LysR家族转录调控子 lttR8 毒力

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