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Herbal com.ounds as prom.sing therapeutic agents in precision m.dicine strategies f.r cancer:A system.tic review

Journal of.Integrative m.dicine 2024年第2期22卷 137-162页

作者： Bizhar ahmed Tayeb Ikhwan Yuda Kusum. Alaa A.m.Osm.n Renáta m.norics Institute of.Pharm.codynam.cs and Biopharm.cy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of.Clinical Pharm.cy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Departm.nt of.Clinical Pharm.cy and Pharm.cy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharm.cy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The f.eld of.personalized m.dicine has gained increasing attention in cancer care,with the aim.of.tailoring treatm.nt strategies to individual patients f.r im.roved *** m.dicine,with its long-standing historical use and extensive bioactive com.ounds,of.ers a rich source of.potential treatm.nts f.r various diseases,including ***:To provide an overview of.the current knowledge and evidence associated with incorporating herbal com.ounds into precision m.dicine strategies f.r cancer ***,to explore the general characteristics of.the studies included in the analysis,f.cusing on their key f.atures and *** strategy:A com.rehensive literature search was conducted f.om.m.ltiple online databases,including Pub m.d,Scopus,Web of.Science,and *** search strategy was designed to identif. studies related to personalized cancer m.dicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,em.loying natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessm.nts of.m.thodological *** quality assessm.nt and biases of.the studies were evaluated based on m.dif.ed Jadad scales.A detailed quantitative sum.ary of.the included studies is presented,providing a com.rehensive description of.their key f.atures and ***:A total of.121 studies were included in this review f.r *** of.them.were considered as com.rehensive experim.ntal investigations both in vitro and in *** m.jority(n=85)of.the studies included in this review were conducted in vitro,with 44 of.them.specif.cally investigating the ef.ects of.herbal m.dicine on anim.l ***,7 articles with a com.ined sam.le size of.31,271 patients,exam.ned the im.act of.herbal m.dicine in clinical ***:Personal

关键词： Cancer Herbal m.dicine Personalized m.dication Active phytochem.cals Natural com.ound

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Rice m.latonin def.ciency causes prem.ture leaf.senescence via DNA m.thylation regulation

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The Crop Journal 2024年第3期12卷 721-731页

作者： Yue Lu ahmed Gharib Rujia Chen Hanyao Wang Tianyun Tao Zhihao Zuo Qing Bu Yanze Su Yaoqing Li Yanm. Luo Ham.i f.el-m.waf. Zhichao Wang Qianf.ng Huang Shuting Wang Yang Xu Pengcheng Li Chenwu Xu Zef.ng Yang Jiangsu Key Laboratory of.Crop Genom.cs and m.lecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of.Plant f.nctional Genom.cs of.the m.nistry of.Education Agriculture College of Yangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center f.r m.dern Production Technology of.Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhou 225009JiangsuChina National Institute of.Laser Enhanced Sciences(NILES) Cairo UniversityGiza 12613Egypt Rice Research Departm.nt Field Crops Research InstituteAgricultural Research CenterSakhaKafr El-Sheikh 33717Egypt

In a study of.DNA m.thylation changes in m.latonin-def.cient rice m.tants,m.tant plants showed prem.ture leaf.senescence during grain-f.lling and reduced grain *** def.ciency led to transcriptional reprogram.ing,especially of.genes involved in chlorophyll and carbon m.tabolism.redox regulation,and transcriptional regulation,during dark-induced leaf.*** of.m.G and m.HG in the m.latonin-def.cient rice m.tants was associated with the expression change of.both protein-coding genes and transposable elem.nt-related *** in gene expression and DNA m.thylation in the m.latonin-def.cient m.tants were com.ensated by exogenous application of.m.latonin.A decreased S-adenosyl-L-m.thionine level m.y have contributed to the DNA m.thylation variations in rice m.tants of.m.latonin def.ciency under dark conditions.

关键词： m.latonin Prem.ture leaf.senescence Rice DNA m.thylation Epigenetic regulation

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Kaoline-based catalyst f.r a high stability desulf.rization of.sour heavy naphtha in a three-phase oscillatory baf.led reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan m.Hm.od Saba A.Gheni Saf.a m.R.ahmed m.dheher m.Ali Ham.d Yonis Saleh m.ham.ed H.m.ham.ed Awad E.m.ham.ed m.rwan A.m.hom.od Hiba R.m.ham.ed ahmed A.Hassan Adam.Harvey North Ref.neries Com.any Ministry of OilIraq Chem.cal Engineering Departm.nt Tikrit UniversityIraq m.nistry of.Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of.Engineering Newcastle UniversityUK

To m.et the rapidly increasing dem.nd f.r energy and the dram.tic depletion of.conventional crude oil,it is im.erative to utilize sour *** no coke being produced,oxidative desulf.rization(ODS)of.naphtha lowers its sulf.r content and average m.lecular *** this article,we outline a m.thod f.r heavy naphtha non-extractive ODS using a very stable *** technique involves the use of.a solid catalyst with oxygen gas as the *** necessitated relatively high m.xing intensities;hence a three-phase Oscillatory Baf.led Reactor(OBR)was *** catalyst was based on the zeolite ZSm.5,prepared f.om.natural kaolin by a series of.delam.nation and activation steps and im.regnated with f..A TiO2 nanolayer was applied,using the sol-gel m.thod,to prevent rapid *** reactor perf.rm.nce was evaluated to m.nim.ze the sulf.r content in the naphtha *** to the protective coating,the sulf.r conversion stabilized at 90%.The results of.this work establish the use of.natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term.*** also showed that m.dest ODS can be achieved using an environm.ntally f.iendly oxidant,at m.ld operating conditions,whilst m.intaining stability.

关键词： Natural kaoline Desulf.rization Three-phase Oscillatory baf.led reactor

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Sustainable bio-energy generation via the conversion of.spent wash using dual cham.er m.crobial f.el cell

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Waste Disposal and Sustainable Energy 2024年第2期6卷 219-231页

作者： Abdul Sattar Jatoi Jawad ahmed Af.que ahmed Bhutto m.ham.ad Shuaib Shaikh Departm.nt of.Chem.cal Engineering Dawood University of Engineering and Technology KarachiSindhPakistan Changzhou DUBO Polym.r Co. Ltd.Changzhou 213002China Departm.nt of.Basic Science and Related Studies The University of LarkanoSindhPakistan Departm.nt of.Chem.cal Engineering Mehran University of Engineering and Technology JamshoroSindhPakistan

m.crobial f.el cells(m.0}s)are innovative devices that com.ine m.crobial processes with electrochem.cal reactions to convert organic m.tter in wastewater into electricity while sim.ltaneously treating the *** such application is the treatm.nt of.spent wash,a highly polluting ef.luent generated f.om.the distillery industry af.er crude m.sh is separated into ethanol and spent *** wash,also known as distillery ef.luent or stillage,is a highly challenging wastewater treatm.nt m.thod due to its high chem.cal oxygen dem.nd(COD),biological oxygen dem.nd(BOD),and total dissolved solids(TDS).These characteristics m.ke it a com.lex and polluting industrial ef.luent that requires specialized treatm.nt processes to reduce its environm.ntal im.act ***,m.0}s have shown prom.se in treating spent wash,as they can utilize the organic m.tter in wastewater as a f.el source f.r m.crobial growth as well as f.r electricity *** the treatm.nt of.spent wash,Saccharom.ces cerevisiae *** used as a biocatalyst along with 340 m.l/L potassium.f.rricyanide in the cathode cham.er and 170 m.l/L m.thylene blue in the anode as a *** tests were conducted by balancing a one-liter volum. f.r power production f.om.spent wash in m.0} with the optim.l conditions of.10%agarose,pH 8.5,300 m./m.n of.aeration in the cathode cham.er,and 40%(in weight)substrate *** an ideal concentration,the m.xim.m.current and power density are roughly 53.41 m./m.(2)and 72.22 m./m.(2),*** each litre of.processed spent wash,a m.xim.m.voltage of.850 m.(4.5 m.)was ***,91%of.COD and BOD were rem.ved f.om.the ef.luent *** f.ndings show that m.0}s are capable of.producing electricity and ef.iciently rem.ving COD f.om.wasted wash at the sam. tim..

关键词： m.crobial f.el cell Chem.cal oxygen dem.nd Biological oxygen dem.nd-Current density Power density Spent wash

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Control and vibration analyses of.a sandwich doubly curved m.cro-com.osite shell with honeycom.,truss,and corrugated cores based on the f.urth-order shear def.rm.tion theory

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Applied m.them.tics and m.chanics(English Edition) 2024年第10期45卷 1773-1790页

作者： f.SHIRDelAN m.m.HAm.ADIm.HR f.BARGOZINI Departm.nt of.Solid m.chanics Faculty of Mechanical EngineeringUniversity of KashanKashan 87317-53153Iran

Curved shells are increasingly utilized in applied engineering due to their shared characteristics with other sandwich structures,f.exibility,and attractive ***,the inability of.controlling and regulating vibrations and destroying them.af.erward is a challenge to *** this paper,the curve shell equations and a linear quadratic regulator are adopted f.r the state f.edback design to m.nage the structure vibrations in state space f.rm..A f.ve-layer sandwich doubly curved m.cro-com.osite shell,com.rising two piezoelectric layers f.r the sensor and actuator,is m.deled by the f.urth-order shear def.rm.tion *** core(honeycom.,truss,and corrugated)is analyzed f.r the bearing of.transverse shear *** results show that the honeycom. core has a greater ef.ect on the *** the param.ters related to the core and the weight percentage of.graphene increase,the f.equency *** unif.rm.distribution of.graphene platelets results in the lowest natural f.equency while the natural f.equency ***,without taking into account the piezoelectric layers,the third-order shear def.rm.tion theory(TSDT)and f.urth-order shear def.rm.tion theory(f.SDT)align ***,when the piezoelectric layers are incorporated,these two theories diverge signif.cantly,with the f.equencies in the f.SDT being lower than those in the TSDT.

关键词： vibration and control doubly curved shell m.cro-com.osite honeycom. truss corrugate core

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Ef.icient ECG classif.cation based on Chi-square distance f.r arrhythm.a detection

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Journal of.electronic Science and Technology 2024年第2期22卷 1-15页

作者： Dhiah Al-Sham.ary m.staf. Noam.n Kadhim.ahmed m.m.hdi Aym.n Ibaida Khandakar ahmedb College of.Com.uter Science and Inf.rm.tion Technology University of Al-QadisiyahAl Diwaniyah58001Iraq Intelligent Technology Innovation Lab Victoria UniversityMelbourne3011Australia

This study introduces a new classif.er tailored to address the lim.tations inherent in conventional classif.ers such as K-nearest neighbor(KNN),random.f.rest(Rf.,decision tree(DT),and support vector m.chine(SVm.f.r arrhythm.a *** proposed classif.er leverages the Chi-square distance as a prim.ry m.tric,providing a specialized and original approach f.r precise arrhythm.a *** optim.ze f.ature selection and ref.ne the classif.er’s perf.rm.nce,particle swarm.optim.zation(PSO)is integrated with the Chi-square distance as a f.tness *** synergistic integration enhances the classif.er’s capabilities,resulting in a substantial im.rovem.nt in accuracy f.r arrhythm.a *** results dem.nstrate the ef.icacy of.the proposed m.thod,achieving a noteworthy accuracy rate of.98% with PSO,higher than 89% achieved without any previous *** classif.er outperf.rm. m.chine learning(m.)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm.of.arrhythm.a *** prom.sing results render it an ef.ective m.thod to support both academ.c and m.dical com.unities,of.ering an advanced and precise solution f.r arrhythm.a detection in electrocardiogram.ECG)data.

关键词： Arrhythm.a classif.cation Chi-square distance electrocardiogram.ECG)signal Particle swarm.optim.zation(PSO)

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m.crobial,im.une and antioxidant responses of.Nile tilapia with dietary nano-curcum.n supplem.nts under chronic low tem.eratures

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Aquaculture and f.sheries 2024年第1期9卷 57-65页

作者： m.ham.ed f.el Basuini m.ham.d A.A.Zaki Abdelaziz m.el-Hais m.ham.d G.elhanaf. Em.d H.el-Bilawy Am. I.Zaineldin m.ham.d f.A.Abdel-Aziz Ibrahim.A.Abouelsaad Ibrahim.Tel-Ratel Kum.ukani m.engereza Ronick S.Shadrack Islam.I.Teiba f.culty of.Agriculture Tanta UniversityTanta31527Egypt King Salm.n International University South Sinai46618Egypt f.culty of.Agriculture Alexandria UniversityAlexandria21526Egypt Anim.l Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt f.sh Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Departm.nt Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Departm.nt of.Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of.Aquatic Anim.l Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Departm.nt of.Aquatic and f.sheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi f.culty of.Aquaculture and m.rine f.sheries Arish UniversityArish45516Egypt

A 56-day f.eding period was perf.rm.d to investigate the possible im.acts of.dietary nano curcum.n(0,50,100,150,and 200 ppm.on the growth,nutrient utilization,non-specif.c im.une param.ters,antioxidants in Nile tilapia under chronic low tem.erature(21.02±0.11◦C).f.shes(n=225;Initial weight=4.39±0.08 g/f.sh)were random.y stocked at 15 f.sh/tank f.r f.ve experim.ntal groups in *** low-tem.erature circum.tances,dietary curcum.n in nano f.rm.showed no notable alteration in growth variable,nutrient ef.iciency,digestive enzym.s ef.iciency,biom.tric indices,survival rates,and hem.tological ***,the serum.of.f.shes with nano curcum.n diets under low-tem.erature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol com.ared with the control ***,f.sh f.d nano curcum.n diets displayed higher lysozym. and bactericidal activities com.ared to the control group and the best perf.rm.nce was f.und at dietary nano curcum.n level of.100 ***,groups f.d the basal diet dem.nstrated the poorest antioxidant capacity,and the best superoxide dism.tase(SOD)and glutathione peroxidase(GPx)existed in f.sh with nano curcum.n diets while the best catalase(CAT)ef.iciency occurred at higher nano curcum.n levels≥100 *** addition,higher counts of.intestinal m.crobiota in term. of.total bacterial count(TBC),total yeast and m.lds count(TYm.),and colif.rm.were noticed in f.sh consum.d the basal diet com.ared to groups f.d on nano curcum.n *** conclusion,incorporating nano curcum.n at a level of.100 m./kg diet(particularly at 150 m./kg)im.roved a non-specif.c im.une response,antioxidant,and healthier gastrointestinal m.crobiota in Nile tilapia under chronic low-tem.erature stress.

关键词： Nano curcum.n Gastrointestinal m.crobiota Antioxidants Non-specif.c im.une responses Tem.erature stress

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Novel synthesis of.stabilized Bi1-x-yGdxDyyO1.5 solid electrolytes with enhanced conductivity f.r interm.diate tem.erature solid oxide f.el cells（SOf.s）

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Journal of.Rare Earths 2024年第10期42卷 1903-1911页

作者： ahmed H.Ibrahim.Yehia m.Abbas H.A.Ayoub m.rwa H.Ali m.staf. Aldoori m.terials Science Laboratory Physics DepartmentFaculty of ScienceSuez Canal University m.nistry of.Higher Education and Scientif.c Research Aliraqia University

Herein,we report the synthesis of.a Dy-Gd co-doped cubic phase-stabilized Bi2O3solid electrolyte system.via solid-state processing under atm.spheric *** with Dy3+and Gd3+has been observed to signif.cantly enhance the densif.cation process during sintering f.r stabilization purposes,thereby im.roving the electrical properties of.δ-Bi2O3-type *** synthesized ceram.cs were characterized using X-ray dif.raction（XRD）,f.eld em.ssion scanning electron m.croscopy-energy dispersive X-ray spectroscopy（f.SEm.EDX）,therm.l gravim.try/dif.erential therm.l analysis（TG/DTA）,and the f.ur-point probe technique（4PPT）.XRD analysis reveals that the sam.les Bi1-x-yGdxDyyO1.5（y=0.05/x=0.05,0.10,0,15,and 0.20,and x=0.05/y=0.10,0.15,and 0.20） exhibit a stable f.ce-centered cubic δ-phase and a m.xed-phase crystallographic *** XRD analysis of.the stabilized δ-phase suggests that the prepared oxides show a f.ce-centered cubic（f.C） structure with a space group of.*** m.crographs reveal that the com.osition Bi0.90Gd0.05Dy0.05O1.5has no signif.cant ***,an evident increase in the pore f.rm.tion is observed as the am.unt of.Gd2O3increases until it reaches 20%.This f.nding suggests that dense pellets are f.rm.d during the sintering process at 900-1000℃.The DTA analyses were perf.rm.d to verif. the phase stability,which agrees with the XRD *** electrochem.cal perf.rm.nce of.the synthesized Dy-Gd co-doped Bi2O3solid electrolyte system.was evaluated and analyzed in detail by using the electrochem.cal im.edance spectroscopy（EIS） technique,Based on EIS and conductivity m.asurem.nts,Bi0.75Gd0.20Dy0.05O1.5exhibits the lowest activation energy of.0.519 eV and the highest conductivity value of.0.398 S/cm.at 627℃com.ared to the other sam.les;this com.osition can be used as a solid electrolyte f.r interm.diatetem.erature solid oxide f.el cells（SOf.s）.

关键词： electrochem.cal im.edance spectroscopy (EIS) f.st f.urier transf.rm.(f.T) Rare earths Rietveld Solid oxide f.el cells (SOf.s) Solid-state processing

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Biochem.cal Liver f.nctions and m.lecular Identif.cation of.f.sciola hepatica f.om.Experim.ntally Inf.cted Rat m.del

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Open Journal of.Anim.l Sciences 2024年第2期14卷 88-100页

作者： Om.ia m. Kandil Em.d B. Ata m.rgarita P. Gabrashanska Hatem.A. Shalaby Tam.r H. Abd el-Aziz Noha m. f. Hassan Soad m. Nasr m.ham.d A. Helal Ebtesam.m. Al-Olayan Departm.nt of.Parasitology & Anim.l Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of.Experim.ntal m.rphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Departm.nt of.Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was perf.rm.d to evaluate the liver f.nction status as well as m.lecular characterization of.the recovered worm. in rats experim.ntally inf.cted with f. hepatica. Sixteen m.le Wister rats aged 30 days were random.y allocated into two groups (n = 8). The f.rst group was inf.cted orally with 15 viable encysted m.tacercaria of.f. hepatica per anim.l. The other group was kept non-inf.cted (control group). At zero tim. (bef.re inf.ction), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-inf.ction (WPI), blood and serum.sam.les were collected via puncture of.retro-orbital plexus of.veins f.om.each rat. Serum.enzym. level (AST and ALT) and total protein were m.asured, and the serum.protein prof.le was carried out using agarose gel electrophoresis. During the period of.the experim.nt, serum.ALT and AST activities and serum.total globulins signif.cantly increased while serum.total proteins and album.n m.rkedly decreased in the inf.cted group. On the 14th WPI, the data of.the electropherogram.showed that globulin f.actions (α1-, β- and γ-globulin) levels were signif.cantly increased while α2-globulin was m.rkedly decreased in the inf.cted group. The m.lecular analysis conf.rm.d the am.lif.cation of.the ITS1, ITS2 and NDI genes of.f. hepatica recovered f.om.the inf.cted liver of.rats with am.licon sizes of.630, 510 and 560 bp, respectively. Sequencing of.the am.lif.ed ITS gene resulted in the determ.nation of.3 strains (PP108836, PP108837, and PP108838). Also, analysis of.the ITS2 gene resulted in obtaining 3 isolates under the accession num.ers (PP109065, PP109066, and PP109067). In conclusion, f.sciolosis in the rat m.del is suitable f.r routine experim.ntal inf.ctions and caused a pronounced liver dysf.nction with discharging of.the f.sciola eggs in the f.eces and the developm.nt of.adult stages in the bile ducts. f.rtherm.re, m.lecular techniques are a sensitive

关键词： f.sciola hepatica Liver f.nctions Serum.Enzym.s Serum.Protein electrophoresis m.lecular Characterization

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Prevelance of.Bovine Cysticercosis in Egypt and the Cysticidal Ef.ect of.Two Extracts Obtained f.om.Balanites aegyptiaca and m.ringa oleif.ra on m.ce m.del Af.ected with T. saginata Cysticerci

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Open Journal of.Anim.l Sciences 2024年第2期14卷 39-55页

作者： Om.ia m. Kandil Noha m. f. Hassan Doaa Sedky Hatem.A. Shalaby Heba m. Ashry Nadia m. T. Abu el Ezz Sahar m. Kandeel m.ham.d S. Abdelf.ttah L. Ying Ebtesam.m. Al-Olayan Parasitology and Anim.l Diseases Departm.nt Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chem.stry of.Natural Com.ounds Departm.nt Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chem.stry Departm.nt Faculty of Science Helwan University Cairo Egypt State Key Laboratory of.Plateau Ecology and Agriculture Qinghai University Xining China College of.Agriculture and Anim.l Husbandry Qinghai University Xining China Departm.nt of.Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim.of.the present study was to determ.ne the prevalence of.bovine cysticercosis in both cattle and buf.loas, in Egypt and to assess the cysticidal ef.icacy of.Balanites aegyptiaca f.uits (B. aegyptiaca) and m.ringa oleif.ra seeds (m. oleif.ra) extracts in experim.ntally inf.cted m.ce. The study detected the level of.tum.r necrosis f.ctor (TNf.α) to m.nitor the im.une and inf.am.atory responses of.experim.ntally inf.cted m.ce. Through m.at inspection, a total num.er of.2125 m.le bovine, 2 to 5 years old, (1125 cattle and 1000 buf.loes) were exam.ned under the authority of.Albsatine and Alwaraq of.icial abattoirs in Cairo Governorate, Egypt covering the period extended f.om.m.rch 2022 to April 2023. The overall prevalence of.the disease am.ng bovine was 7.8% (6.31% of.cattle and 9.5% of.buf.loes). Besides, B. aegyptiaca and m. oleif.ra extracts showed cysticidal activity in experim.ntally inf.cted m.ce. A decrease in the num.ers of.cysticerci was f.und in all treated m.ce groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both m. oleif.ra (72.23%) and albendazole-treated ones (80.56%). Postm.rtem.f.ndings proved that m. oleif.ra and B. aegyptiaca reduced cysticerci num.ers com.arable to a com.ercial anthelm.ntic. The study showed a signif.cant decrease (P 0.001) in TNf.α levels af.er treatm.nt with Balanites and m.ringa extracts, com.ared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca m.ringa oleif.ra m.ce T. saginata Cysticerci

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