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Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response

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World Journal of Gastroenterology 2015年第39期21卷 11141-11151页

作者： Mazen Naga Mona Amin Dina Algendy ahmed elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed Samia Gabal Manal Kamal Division of Gastro-enterology Department of Internal Medicine Faculty of Medicine Cairo University Department of Biochemistry Faculty of Medicine Cairo University Department of Pathology Faculty of Medicine Cairo University Department of Clinical and Chemical pathology Faculty of Medicine Cairo University

AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) ***: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all ***: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.

关键词： Hepatitis C virus Genetic polymorphisms Low-densit

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Cardio-Protective Effects of Oral Nicorandil in Patients Undergoing Cardiac Valve Surgery

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World Journal of Cardiovascular Diseases 2019年第10期9卷 707-717页

作者： Mohamed A. W. Ezzat Essam elbadry Hashim Mohamed Ayman Mohamed Abdel Ghaffar Abdelhady ahmed Helmy Wesam Abdelgalil Aboelwafa Eman Mohammad Ali Internal Medicine and Cardiology Department Sohag Faculty of Medicine Sohag University Sohag Egypt Cardiothoracic Surgery Department Sohag Faculty of Medicine Sohag University Sohag Egypt Anesthesia and Intensive Care Department Sohag Faculty of Medicine Sohag University Sohag Egypt Pharmacology Department Sohag Faculty of Medicine Sohag University Sohag Egypt

Background: Reduction of myocardial reperfusion injury during cardiopulmonary bypass is an essential requirement for increasing the success rate, decreasing morbidity and mortality of open-heart surgery. Aim: To study the role of pre-operative oral nicorandil in decreasing reperfusion cardiac injury in patients subjected to cardiac valve surgery. Patients and Methods: The study included 62 patients, who were equally randomized into two groups: nicorandil group and control group. Pre-operative, intra-operative and post- operative data were reported and analyzed. Left Ventricle Ejection Fraction (LVEF) was estimated pre-operatively and postoperatively for both groups. Troponin I, creatine kinase-muscle/brain (CK-MB), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were measured before surgery by 24 hours then 4, 12 and 48 hours after aortic cross clamp removal. Results: Nicorandil considerably decreased TNF-α and IL-6 after 4 and 12 hours following the removal of aortic clamping. It also reduced troponin-I and CKMB at the same time points. However, there were no important changes in IL-6, TNF-α, troponin-I and CK-MB levels in control group in comparison to nicorandil group in the next 48 hours following the removal of aortic clamping. Conclusions: Pre-operative oral nicorandil expressively decreased myocardial reperfusion damage during open heart valve operations, this evidenced by the decrease in the postoperative use of inotropic drugs, considerable reduction of postoperative elevation of cardiac enzymes and inflammatory cytokines with no reported complications.

关键词： Nicorandil for Myocardial Protection Cardiopulmonary Bypass Ischemia-Reperfusion Injury Inflammatory Cytokines Cardiac Valvular Surgery

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