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Clinical relevance of circulating non-coding RNAs in metabolic diseases:Emphasis on obesity,diabetes,cardiovascular diseases and metabolic syndrome

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Genes & Diseases 2023年第6期10卷 2393-2413页

作者： Abdullahi Dandare Muhammad Jawad Khan Aisha naeem Afrose Liaquat Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Biochemistry Usmanu Danfodiyo UniversitySokoto 840104Nigeria Ministry of Public Health POB42DohaQatar Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA Shifa College of Medicine Shifa Tameer-E-Millat UniversityIslamabad 45550Pakistan

Non-coding RNAs(ncRNAs)participate in the regulation of several cellular processes including transcription,RNA processing and genome *** aberrant expression of ncRNAs is associated with several pathological *** this review,we focused on recent information to elucidate the role of various regulatory ncRNAs i.e.,micro RNAs(miRNAs),circular RNAs(circRNAs)and long-chain non-coding RNAs(lncRNAs),in metabolic diseases,e.g.,obesity,diabetes mellitus(DM),cardiovascular diseases(CVD)and metabolic syndrome(MetS).The mechanisms by which ncRNAs participated in disease pathophysiology were also *** regulate the expression of genes at transcriptional and translational *** modulate the regulation of gene expression via miRNA sponging activity,interacting with RNA binding protein and polymerase II transcription *** regulate the expression of genes by acting as a protein decoy,miRNA sponging,miRNA host gene,binding to miRNA response elements(MRE)and the recruitment of transcriptional element or chromatin *** examined the role of ncRNAs in the disease pathogenesis and their potential role as molecular markers for diagnosis,prognosis and therapeutic *** showed the involvement of ncRNAs in the onset of obesity and its progression to MetS and ***-192,miRNA-122,and miRNA-221 were dysregulated in all these metabolic *** ncRNAs,implicated in at least three diseases include miRNA-15a,miRNA-26,miRNA-27a,miRNA-320,and *** of ncRNAs increased the risk of development of DM and MetS and its progression to CVD in obese ***,these molecules are potential targets to arrest or delay the progression of metabolic diseases.

关键词： Biomarkers CircRNAs LncRNAs Metabolic diseases miRNAs Non-coding RNAs Therapeutic targets

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Optimization of Abrasive Water Jet Cutting of Ductile Materials

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Journal of Wuhan University of Technology(Materials Science) 2011年第1期26卷 88-92页

作者： Asif IQBAL naeem U DAR Ghulam HUSSAIN Department of Mechanical Engineering Eastern Mediterranean University Department of Mechanical Engineering University of Engineering & Technology

Full factorial design of experiments was developed in order to investigate the effects of jet pressure, abrasive mixing rate, cutting feed, and plate thickness upon three response variables, surface finish of cutting wear zone, percentage proportion of striation free area, and maximum width of cut. The set of sixteen experiments was performed on each of the following two ductile materials： AISI 4340 （high strength low alloy steel, hardened to 49HRc） and Aluminum 2219. Analysis of Variance （ANOVA） was performed on experimental data in order to determine the significance of effects of different parameters on the performance measures. It was found that cutting feed and thickness were highly influential parameters, while abrasive mixing rate is influential upon surface roughness only. Strong interaction was found between jet pressure and workpiece material. Multi-criteria numerical optimization was performed in order to simultaneously maximize/minimize different combinations of performance measures.

关键词： abrasive jet cutting ductile metals material processing striations optimization

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Spherical uncertain linguistic Hamacher aggregation operators and their application on achieving consistent opinion fusion in group decision making

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International Journal of Intelligent Computing and Cybernetics 2021年第4期14卷 550-579页

作者： Muhammad Qiyas Saleem Abdullah Muhammad naeem Mathematics Abdul Wali Khan UniversityMardanPakistan Abdul Wali Khan University MardanPakistanand Department of Preparatory Year Umm Al-Qura UniversityMakkahSaudi Arabia

Purpose-The aim of this research is to establish a new type of aggregation operator based on Hamacher operational law of spherical uncertain linguistic numbers(SULNs).Design/methodology/approach-First,the authors define spherical uncertain linguistic sets and develop some operational laws of ***,the authors extended these operational laws to the aggregation operator and developed spherical uncertain linguistic Hamacher averaging and geometric aggregation ***-The authors were limited in achieving a consistent opinion on the fusion in group decision-making problem with the SULN ***/value-In order to give an application of the introduced operators,the authors first constrict a system of multi-attribute decision-making algorithm.

关键词： Multi-attribute group decision making Spherical fuzzy set Spherical uncertain linguistic Hamacher averaging operators Spherical uncertain linguistic Hamacher geometric operators

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A novel extended Portuguese of Interactive and Multi-Criteria Decision Making and Archimedean Bonferroni mean operators based on prospect theory to select green supplier with complex q-rung orthopair fuzzy information

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CAAI Transactions on Intelligence Technology 2023年第1期8卷 177-191页

作者： Zeeshan Ali Tahir Mahmood Jeonghwan Gwak naeem Jan Department of Mathematics&Statistics International Islamic University IslamabadIslamabadPakistan Department of Software Korea National University of TransportationChungjuKorea Department of Biomedical Engineering Korea National University of TransportationChungjuKorea Department of AI Robotics Engineering Korea National University of TransportationChungjuKorea Department of IT&Energy Convergence(BK21 FOUR) Korea National University of TransportationChungjuKorea

The word sustainable or green supply chain refers to the concept of incorporating sustainable environmental procedures into the traditional supply *** supply chain management gives a chance to revise procedures,materials and operational *** the fuzziness of assessing data and the spiritual situations of experts in the decision-making procedure are two important *** main contribution of this analysis is to derive the theory of Archimedean Bonferroni mean operator for complex qrung orthopair fuzzy(CQROF)information,called the CQROF Archimedean Bonferroni mean and CQROF weighted Archimedean Bonferroni mean operators which are very valuable,dominant and classical type of aggregation operators used for examining the interrelationship among the finite number of attributes in modern data fusion *** and well-used properties of the initiated theories are also diagnosed with some special ***,the theory of extended TODIM tool using the prospect theory based on CQROF information was discovered,which play an essential and critical role in the environment of fuzzy set ***,a real life problem by computing a green supply chain management based on the initiated CQROF operators was evaluated and fully illustrating the feasibility and efficiency of the diagnosed work with the help of a comparison between existing and prevailing theories.

关键词： fuzzy set fuzzy sets

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Multi-person vision tracking approach based on human body localization features

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Advances in Manufacturing 2021年第4期9卷 496-508页

作者： Ao-Lei Yang Hai-Yan Ren Min-Rui Fei Wasif naeem School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People’s Republic of China School of Electronics Electrical Engineering and Computer ScienceQueen’s University BelfastBelfast BT71NNNorthern IrelandUK

This paper presents a multi-person vision tracking approach based on human body localization features to address the problem of interactive object localization and tracking in a home monitoring ***,the human body localization model is used to obtain the 3D position of the human body,which is then used to construct the human body motion model based on the Kalman filter *** the same time,the human appearance model is constructed by fusing human color features and features of the histogram of oriented gradient to better characterize the human ***,the human body observation model is constructed based on the human body motion model and appearance model to measure the similarities between the human body state sequence in the historical frame and the human body observation result in the current frame,and the cost matrix is then ***,the Hungarian maximum matching algorithm is employed to match each human body in the current and historical frames,and the exception detection mechanism is simultaneously constructed to further reduce the probability of human tracking and matching ***,a multi-person vision tracking verification platform was constructed,and the achieved average accuracy was 96.6%in the case of human body overlapping,occlusion,disappearance,and appearance;this verifies the feasibility and effectiveness of the proposed method.

关键词： Multi-person vision tracking Human body positioning Motion model Body observation model

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Numerical Simulation of Reiner–Rivlin Nanofluid Flow under the Influence of Thermal Radiation and Activation Energy over a Rotating Disk

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1669-1692页

作者： Arfan Shahzad Muhammad Imran Muhammad Nawaz naeem Mohsan Raza Department of Mathematics Government College University FaisalabadFaisalabad38000Pakistan Department of Sciences&Humanities National University of Computer and Emerging SciencesChiniot-Faisalabad CampusFaisalabad38000Pakistan

In current study,the numerical computations of Reiner–Rivlin nanofluid flow through a rotational disk under the influence of thermal radiation and Arrhenius activation energy is *** innovative physical situations,the motile microorganisms are incorporated *** multiple slip effects are considered in the boundary *** bioconvection of motile microorganism is utilized alongside nanofluids to provide stability to enhanced thermal *** Bioconvection pattern in various nanoparticles accredits novel applications of biotechnology like the synthesis of biological polymers,biosensors,fuel cells,petroleum engineering,and the natural *** deploying some suitable similarity transformation functions,the governing partial differential equations(PDEs)of the flow problem are rehabilitated into dimensionless *** accomplished ordinary differential equations(ODEs)are solved numerically through the bvp4c scheme via a built-in function in computational MATLAB *** upshots of some prominent physical and bioconvection parameters including wall slip parameters,thermophoresis parameter,Brownian motion parameter,Reiner–Revlin nanofluid parameter,Prandtl number,Peclet number,Lewis number,bioconvection Lewis number,and the mixed convection parameter against velocity,temperature,nanoparticles concentration,and density of motile microorganism profiles are dichotomized and pondered through graphs and *** presented computations show that the velocity profiles are de-escalated by the wall slip parameters while the thermal and solutal fields are upgraded with augmentation in thermophoresis number and wall slip *** presence of thermal radiation enhances the temperature profile of *** concentration profile of nanoparticles is boosted by intensification in activation ***,the increasing values of bioconvection Lewis number and Peclet number decay the motile microorganisms’field.

关键词： Reiner-Rivlin nanofluid bioconvection motile swimming microorganisms rotational disk multiple slip conditions bvp4c

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Unregulated emissions from a diesel engine equipped with vanadium-based urea-SCR catalyst

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Journal of Environmental Sciences 2010年第4期22卷 575-581页

作者： Lei Jiang Yunshan Ge Asad naeem Shah Chao He Zhihua Liu School of Mechanical Engineering Beijing Institute of Technology Beijing 100081 China. Department of Mechanical Engineering University of Engineering and Technology Lahore 54000 Pakistan School of Transportation Machinery and Civil Engineering Southwest Forestry College Kunming 650224 China

The present work is aimed at the study of number-size distribution of particles, volatile organic compounds （VOCs）, and carbonyl compounds （CC） or carbonyls emitted from a 4-cylinder turbocharged diesel engine equipped with a vanadium-based urea selective catalytic reduction catalyst. The engine was run on an electric dynamometer in accordance with the European steady-state cycle. Pollutants were analyzed using an electric low pressure impactor, a gas chromatograph/mass spectrometer, and a high performance liquid chromatography system for the number-size distribution of particles, VOCs, and CC emissions, respectively. Experimental results revealed that total number of particles were decreased, and their number-size distributions were moved from smaller sizes to larger sizes in the presence of the catalyst. The VOCs were greatly reduced downstream of the catalyst. There was a strong correlation between the conversion of styrene and ethyl benzene. The conversion rate of benzene increased with increase of catalyst temperature. Formaldehyde, acetaldehyde, acrolein and acetone were significantly reduced, resulting in a remarkable abatement in carbonyls with the use of the vanadium-based urea-SCR system.

关键词： diesel engine selective catalytic reduction particulate volatile organic compounds carbonyls

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Recent advancements in applications of chitosan-based biomaterials for skin tissue engineering

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Journal of Bioresources and Bioproducts 2021年第1期6卷 11-25页

作者： Ahmed Madni Rozina Kousar Naveera naeem Fazli Wahid Department of Biotechnology COMSATS University IslamabadAbbottabad Campus 22060Pakistan Department of Pharmacy Women Institute of LearningAbbottabadPakistan Department of Biomedical Sciences Pak-Austria Fachhochschule:Institute of Applied Sciences and TechnologyMangKhanpur RoadHaripurPakistan

The use of polymer based composites in the treatment of skin tissue damages,has got huge attention in clinical demand,which enforced the scientists to improve the methods of biopolymer designing in order to obtain highly efficient system for complete restoration of damaged *** last few decades,chitosan-based biomaterials have major applications in skin tissue engineering due to its biocompatible,hemostatic,antimicrobial and biodegradable *** article overviewed the promising biological properties of chitosan and further discussed the various preparation methods involved in chitosan-based *** addition,this review also gave a comprehensive discussion of different forms of chitosan-based biomaterials including membrane,sponge,nanofiber and hydrogel that were extensively employed in skin tissue *** review will help to form a base for the advanced applications of chitosan-based biomaterials in treatment of skin tissue damages.

关键词： Biological properties of chitosan Chitosan biomaterials Hydrogel Nanofiber Preparation method Skin tissue engineering

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Earthquake Risk Assessment Approach Using Multiple Spatial Parameters for Shelter Demands

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Computers, Materials & Continua 2022年第2期70卷 3763-3780页

作者： Wenquan Jin naeem Iqbal Hee-Cheal Kang Dohyeun Kim Big Data Research Center Jeju National UniversityJeju63243Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea Infomind Jeju63243Korea

The earthquake is considered one of the most devastating disasters in any area of the world due to its potentially destructive *** on the various earthquake-related parameters,the risk assessment is enabled in advance to prevent future earthquake *** this paper,for providing the shelter space demands to reduce the damage level and prevention costs,an earthquake risk assessment approach is proposed for deriving the risk index based on multiple spatial parameters in the gridded *** proposed assessment approach is comprised of pre-processing,methodologymodel,and data *** risk index model derives the earthquake risk index by multiple spatial parameters including indexes of earthquake,danger,shelter,and building for blocks in the quantitative gridded *** parameters are provided based onmathematicalmodels and combinedwith the risk index that presents the earthquake risk assessment result for each ***,the gridding approach is proposed to provide the elements of the risk assessment area that are used in the spatial *** gridded map is developed for the selected area to visualize risk index parameters associated with each risk *** on the derived result of the proposed earthquake risk indexmodel,emergency shelter requirements are provided according to the risk index for each location,which supports safety measures in advance to prevent future earthquake disasters.

关键词： Risk analysis risk index earthquake shelter demand data analysis

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High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation

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Journal of Environmental Sciences 2021年第9期33卷 160-170页

作者： Jiangyuan Han Yan Hu Yongmei Qi Cong Yuan Sajid naeem Dejun Huang Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution School of Life SciencesLanzhou UniversityLanzhou 730000China.

Elevated temperature could influence the sex differentiation by altering the expression of sex-related genes in ***, the underlying mechanisms by which the gene expression is altered remain poorly ***, we aimed to explore the role of DNA methylation in sex differentiation of zebrafish(Danio rerio) in response to elevated *** results showed that high temperature(33℃) exposure of fish from 20 to 30 days post fertilization(dpf), compared to normal temperature(28℃), resulted in male-biased sex ratio and decreased expression of female-related genes including cyp19a1a, sox9b and ***, the expressions of DNA methyltransferases dnmt3a1 and dnmt3a2, and the DNA methylation levels in sox9b and esr1 promoter were significantly increased by high temperature, strongly implying that DNA methylation is involved in high temperature-induced masculinization of ***-treatment with 5-aza-2-deoxycytidine(a DNA methylation inhibitor) attenuated the high temperature-induced masculinizing effect, recovered the expression of esr1 and sox9b, suppressed the transcription of dnmt3a1 and dnmt3a2, and decreased the methylation of esr1 and sox9b promoter, further confirming that DNA methylation plays an important role in high temperature-induced masculinization of ***, the methylation of sox9b promoter decreased the enrichment of transcription factor CREB(cAMP-responsive element binding proteins).Overall, these findings suggest that high temperature induce masculinization of zebrafish by down-regulation of femalerelated genes via DNA methylation, providing a new insight in understanding the epigenetic mechanism of thermal-mediated sex differentiation in fish.

关键词： Temperature Sex ratio Masculinization DNA methylation

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