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Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： Martin-Paul Agbaga Mohiuddin ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

Simultaneous removal of copper and zinc ions by low cost natural snail shell/hydroxyapatite/chitosan composite

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Chinese Journal of Chemical Engineering 2021年第5期34卷 221-230页

作者： Abbas Bambaeero Reza Bazargan-lari Department of Materials Science&Engineering Marvdasht BranchIslamic Azad UniversityMarvdashtIran

In this work,the snail shell/hydroxyapatite/chitosan composite was prepared as *** adsorption potential of the composite was studied for simultaneous sorption behavior of Zn(Ⅱ)and Cu(Ⅱ)ions in a batch *** and hydroxyapatite(HAP)were extracted from shrimp shell and bone ash,respectively,so this is a low cost natural *** prepare the composite,chitosan was dissolved in acetic acid,then HAP and snail shell powders were added to the chitosan *** morphology and characterization of the composite was studied by SEM and EDX *** adsorption was used to measure the amount of the *** parameters were optimized with Design Expert Software and five parameters such as the concentration of ions,pH,adsorbent amount and contact time were studied at room *** value for the parameters of Zn(Ⅱ)and Cu(Ⅱ)concentrations,pH,adsorbent dose,and contact time were 3.01 mg·L^(-1),5.5,0.02 g and 95 min,*** adsorption isotherms for Zn(Ⅱ)and Cu(Ⅱ)showed Langmuir and Tempkin,*** and equilibrium studies showed the experimental data of Zn(Ⅱ)and Cu(Ⅱ)ions were best described by the pseudo-second-order *** on thermodynamic show the adsorption process were physical and spontaneous.

关键词： Hydroxyapatite Chitosan Composite Adsorbent

Multiplex qPCR for serodetection and serotyping of hepatitis viruses: A brief review

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World Journal of Gastroenterology 2016年第20期22卷 4824-4834页

作者： Mohammad Irshad Priyanka Gupta Dhananjay Singh Mankotia Mohammad ahmad ansari Clinical biochemistry division Department of Laboratory Medicine All India Institute of Medical Sciences New Delhi 110029 India

The present review describes the current status of multiplex quantitative real time polymerase chain reaction(q PCR) assays developed and used globally for detection and subtyping of hepatitis viruses in body fluids. Several studies have reported the use of multiplex q PCR for the detection of hepatitis viruses, including hepatitis A virus(HAV), hepatitis B virus(HBV), hepatitis C virus(HCV), hepatitis D virus(HDV), and hepatitis E virus(HEV). In addition, multiplex q PCR has also been developed for genotyping HBV, HCV, and HEV subtypes. Although a single step multiplex q PCR assay for all six hepatitis viruses, i.e., A to G viruses, is not yet reported, it may be available in the near future as the technologies continue to advance. All studies use a conserved region of the viral genome as the basis of amplification and hydrolysis probes as the preferred chemistries for improved detection. Based on a standard plot prepared using varying concentrations of template and the observed threshold cycle value, it is possible to determine the linear dynamic range and to calculate an exact copy number of virus in the specimen. Advantages of multiplex q PCR assay over singleplex or other molecular techniques in samples from patients with co-infection include fast results, low cost, and a single step investigation process.

关键词： Co-infection Viral genome Quantitative real-time polymerase chain reaction Genotyping techniques Serotyping Hepatitis viruses

A Review of Image Steganography Based on Multiple Hashing Algorithm

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Computers, Materials & Continua 2024年第8期80卷 2463-2494页

作者： Abdullah Alenizi Mohammad Sajid Mohammadi ahmad A.Al-Hajji Arshiya Sajid ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Engineering and Information TechnologyOnaizah CollegesQassim56312Saudi Arabia

Steganography is a technique for hiding secret messages while sending and receiving communications through a cover *** ancient times to the present,the security of secret or vital information has always been a significant *** development of secure communication methods that keep recipient-only data transmissions secret has always been an area of ***,several approaches,including steganography,have been developed by researchers over time to enable safe data *** this review,we have discussed image steganography based on Discrete Cosine Transform(DCT)algorithm,*** have also discussed image steganography based on multiple hashing algorithms like the Rivest–Shamir–Adleman(RSA)method,the Blowfish technique,and the hash-least significant bit(LSB)*** this review,a novel method of hiding information in images has been developed with minimal variance in image bits,making our method secure and effective.A cryptography mechanism was also used in this *** encoding the data and embedding it into a carry image,this review verifies that it has been ***,embedded text in photos conveys crucial signals about the *** review employs hash table encryption on the message before hiding it within the picture to provide a more secure method of data *** the message is ever intercepted by a third party,there are several ways to stop this operation.A second level of security process implementation involves encrypting and decrypting steganography images using different hashing algorithms.

关键词： Image steganography multiple hashing algorithms Hash-LSB approach RSA algorithm discrete cosine transform(DCT)algorithm blowfish algorithm

Impact of time between meniscal injury and isolated meniscus repair on post-operative outcomes:A systematic review

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World Journal of Clinical Cases 2025年第7期13卷 39-45页

作者： Kashif Javid Xavier Akins Nicole G Lemaster Amer ahmad Austin V Stone Department of Orthopaedic Surgery and Sports Medicine University of KentuckyLexingtonKY 40504United States

BACKGROUND Meniscal tears are one of the most common knee *** the diagnosis of a meniscal tear has been made,there are several factors physicians use to guide clinical *** influence of time between injury and isolated meniscus repair on patient outcomes is not well *** this relationship is important as it may influence clinical decision-making and can add to the preoperative patient education *** hypothesized that increasing the time from injury to meniscus surgery would worsen postoperative *** To investigate the current literature for data on the relationship between time between meniscus injury and repair on patient *** PubMed,Academic Search Complete,MEDLINE,CINAHL,and SPORTDiscus were searched for studies published between January 1,1995 and July 13,2023 on isolated meniscus *** criteria included concomitant ligament surgery,incomplete outcomes or time to surgery data,and *** demographics,time to injury,and postoperative outcomes from each study were abstracted and *** Five studies met all inclusion and exclusion *** were 204(121 male,83 female)patients *** of five(60%)studies determined that time between injury and surgery was not statistically significant for postoperative Lysholm scores(P=0.62),Tegner scores(P=0.46),failure rate(P=0.45,P=0.86),and International Knee Documentation Committee scores(P=0.65).Two of five(40%)studies found a statistically significant increase in Lysholm scores with shorter time to surgery(P=0.03)and a statistically significant association between progression of medial meniscus extrusion ratio(P=0.01)and increasing time to *** Our results do not support the hypothesis that increased time from injury to isolated meniscus surgery worsens postoperative ***-making primarily based on injury interval is thus not recommended.

关键词： Meniscus Meniscal Meniscus repair Meniscectomy Patient reported outcomes Postoperative outcomes Time to surgery Injury interval

Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

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World Journal of Gastroenterology 2021年第7期27卷 592-608页

作者： Mushtaq ahmad ansari Mohammad Raish Yousef A Bin Jardan Ajaz ahmad Mudassar Shahid SheikhFayaz ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer *** mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue *** To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in *** Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal *** was administered orally once daily starting 7 d before LPS/D-GalN *** Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model ***,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling *** In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.

关键词： Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis Antioxidant Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

Comparative study of living donor kidney transplants:Right vs left

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World Journal of Transplantation 2025年第1期15卷 115-123页

作者： Taqi Khan Nadeem ahmad Qaisar Iqbal Muneeb Hassan Lajward Asnath Naveed Khan Sajid Shakeel Kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan Department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

Synthesis,Structural and Optical Properties of Mn-Doped Ceria Nanoparticles:A Promising Catalytic Material

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Acta Metallurgica Sinica(English Letters) 2016年第3期29卷 265-273页

作者： Anees A.ansari Joselito P.Labis Manawwer Alam Shahid M.Ramay Naushad ahmad Asif Mahmood King Abdullah Institute for Nanotechnology King Saud University Research Center College of ScienceKing Saud University Department of Physics King Saud University College of Engineering Department of Chemical EngineeringKing Saud University

The structure,the morphology and the thermal,optical and the surface properties of nanocrystalline CeO_2 doped with Mn have been studied by X-ray diffraction（XRD）,field-emission transmission electron microscopy（FE-TEM）,energy-dispersive X-ray analysis,thermogravimetric analysis,UV–Vis absorption spectroscopy and Fourier transform infrared *** XRD results confirmed the successful incorporation of Mn into the CeO_2 lattice through the formation of nanoscale face-centered cubic solid *** FE-TEM observations supported the nanocrystalline nature of the solid *** presence of structural defects and their role on the band gap have been discussed on the basis of absorption spectral *** structural differences correlate with results from temperature-programmed reaction（TPR）experiments with H_2 *** TPR measurements showed an enhanced bulk reduction at much lower temperatures,indicating increased oxygen mobility in the samples,which enable to enhanced oxygen diffusion at lower temperatures.

关键词： Cerium oxide nanoparticle Manganese Band gap energy Redox property

Atrocious Impinging of COVID-19 Pandemic on Software Development Industries

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Computer Systems Science & Engineering 2021年第2期36卷 323-338页

作者： Wajdi Alhakami Ahmed Binmahfoudh Abdullah Baz Hosam Alhakami Md Tarique Jamal ansari Raees ahmad Khan Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Engineering College of Computer and Information SystemsUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Computer Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025India

COVID-19 is the contagious disease transmitted by *** majority of people diagnosed with COVID-19 may suffer from moderate-tosevere respiratory illnesses and stabilize without preferential *** who are most likely to experience significant infections include the elderly as well as people with a history of significant medical issues including heart disease,diabetes,or chronic breathing *** novel Coronavirus has affected not only the physical and mental health of the people but also had adverse impact on their emotional *** months on end now,due to constant monitoring and containment measures to combat COVID-19,people have been forced to live in isolation and maintain the norms of social distancing with no community *** ties,experiences,and partnerships are not only integral part of work life but also form the basis of human ***,COVID-19 brought all such communication to a grinding *** interactions have failed to support the fervor that one enjoys in face-to-face *** COVID-19 disease outbreak has triggered dramatic changes in many sectors,and the main among them is the software *** paper aims at assessing COVID-19’s impact on Software *** impact of the COVID-19 disease outbreak has been measured on the basis of some predefined criteria for the demand of different software applications in the software *** the stated analysis,we used an approach that involves the application of the integrated Fuzzy ANP and TOPSIS strategies for the assessment of the impact of COVID-19 on the software *** of this research study indicate that Government administration based software applications were severely affected,and these applications have been the major apprehensions in the wake of the pandemic’s ***,COVID-19 has had a considerable impact on software industry,yet the damage is not irretrievable and the world’s societies can emerge out

关键词： Coronavirus software industry safety COVID-19 monitoring fuzzy ANP-TOPSIS