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Anti-inflammatory and anti-cancer potential of pterostilbene:A review

Asian Pacific Journal of Tropical Biomedicine 2023年第12期13卷 497-506页

作者： Omchit Surien Siti Fathiah Masre Dayang Fredalina Basri ahmad rohi ghazali Centre for Toxicology and Health Risk Studies(CORE) Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia Centre of Diagnostic Therapeutic&Investigative Studies(CODTIS)Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia

Pterostilbene is a natural compound that can be found in various food plants such as blueberries,grapes,and peanuts.It has also been reported to be extracted from Pterocarpus indicus,a tree species native to India and Southeast Asia.Pterostilbene exhibits various pharmacological activities such as antioxidants,anti-proliferation,anti-microbial,and anti-inflammatory activities with favorable pharmacokinetic properties,such as high oral bioavailability and longer half-life.The anti-inflammatory effect of pterostilbene has been reported to contribute to its therapeutic effects in many chronic inflammatory diseases.Besides,pterostilbene has anti-cancer activity on various types of cancers due to its ability to induce cell cycle arrest and apoptosis.Hence,in this review,we discuss the anti-inflammatory and anti-cancer activities of pterostilbene in preclinical studies.

关键词： Pterostilbene Anti-cancer NF-κB Anti-inflammation Natural product Pterocarpus indicus

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Genotoxic Potential of Shrimp Pastes (Belacan) Extracts Using <i>Umu</i>Test

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Food and Nutrition Sciences 2012年第4期3卷 522-525页

作者： ahmad rohi ghazali Yvonne Sipain Nor Fadilah Rajab Siew Ee Ling Norain Ramli Rozaini Abdullah Zaliha Harun Firdaus Kamarulzaman Biomedical Science Program Faculty of Health Sciences School of Diagnostic and Applied Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Environmental Health Program Faculty of Health Sciences School of Diagnostic and Applied Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia.

This study was conducted to observe the genotoxic effects of aqueous, methanol, hexane and dichloromethane extracts of “belacan” (shrimp paste) taken from three local districts in Melaka, Malaysia (Kelemak, Batang Tiga & Pantai Puteri). The umu test which was used as the screening test was conducted with and without the presence of metabolic activation system. Without the presence of metabolic activation system, aqueous extracts from Kelemak showed mutagenicity activity at 5 mg/ml with IR (Induction Rate) = 1.52 ± 0.57 and the methanol extracts showed mutagenic activities at 0.625 mg/ml and 5 mg/ml, which the IR was the highest at 5 mg/ml (2.08 ± 0.09). On the other hand, samples from Batang Tiga, Melaka showed mutagenic effects at all five concentrations for the dichloromethane extract, with IR = 2.09 ± 0.64 as the highest value at 1.25 mg/ml. Methanol extracts also showed positive results at 1.25 mg/ml and 2.5 mg/ml with IR = 1.70 ± 0.33 and IR = 2.12 ± 0.51 respectively, and aqueous extract at 0.625 mg/ml with IR = 1.54 ± 0.48 and 5 mg/ml with IR = 1.74 ± 0.50. There was a significant difference of the mean values of IR between the four different types of “belacan” extracts from Batang Tiga (p < 0.05). All four “belacan” extracts from Pantai Puteri, Melaka did not show any mutagenic effect. With the presence of metabolic activation system, there was no mutagenic effect observed in all four extracts from the three districts. Further study to analyze the contents in the food samples should be done in the future to determine the possible contents in the food samples that might be responsible for the mutagenic activities.

关键词： Shrimp Pastes Mutagenicity Umu Test Melaka Genotoxicity

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