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Phytochemical Analysis,Estimation of Quercetin,and in Vitro Anti-Diabetic Potential of Stevia Leaves Samples Procured from Two Geographical Origins

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Phyton-International Journal of Experimental Botany 2022年第10期91卷 2349-2365页

作者： Kuntal Das Syed mohammed Basheeruddin Asdaq M.Saifulla Khan Sravani Singirikonda Abdulhakeem S.alamri Walaa F.Alsanie Majid Alhomrani Sreeharsha Nagaraja Katharigatta N.Venugopala Department of Pharmacognosy and Phytochemistry Krupanidhi College of PharmacyVarthurHobliBengaluru560035India Department of Pharmacy Practice College of PharmacyAlMaarefa UniversityDariyahRiyadh13713Saudi Arabia Department of Clinical Laboratory Sciences The Faculty of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Centre of Biomedical Sciences Research(CBSR) Deanship of Scientific ResearchTaif UniversityTaif21944Saudi Arabia Department of Pharmaceutical Sciences College of Clinical PharmacyKing Faisal UniversityAl-HofufAl-Ahsa31982Saudi Arabia Department of Pharmaceutics Vidya Siri College of PharmacyBangalore560035India Department of Biotechnology and Food Science Faculty of Applied SciencesDurban University of TechnologyDurban4001South Africa

The current study used RP-HPLC to compare phytochemicals and estimate the bioactive constituents found in Stevia rebaudiana Bert.(SRB)leaves collected from two different geographical *** leaves were collected from Bangalore,Karnataka,India,and Reduit,*** were prepared using ethanol and aqueous sol*** analysis was used to evaluate moisture content,ash values,crude fibers,and extractive *** that,preliminary phytochemical screening was done on both ethanol leaves extracts,and subsequently total flavonoid content was *** addition,TLC chromatograms and RP-HPLC studies were performed on both plant extracts to determine the presence of flavonoid components in both leaves extracts,followed by in vitro anti-diabetic activity was performed with alpha amylase and alpha glucosidase enzymes against Acarbose as *** revealed that both the extracts from two different geographical sources varied significantly with the yield,content of chemicals,and presence of quercetin(flavonoid)content when estimated through the RP-HPLC standardized ***,flavonoids,proteins,steroids,saponins,terpenoids,and phenols were found in various concentrations during phytochemical *** both zones,the ethanol leaves extract of SRB taken from Mauritius had a greater content of phytochemicals and a higher yield than other extracts due to the soil *** Mauritius sample had greater total flavonoid levels as well as more quercetin(0.92±0.011)than the other *** that,ethanol extract inhibited enzymes(alpha amylase,alpha glucosidases)more than aqueous extract,and this inhibition was dose *** them,the Mauritius ethanol sample showed higher anti-diabetic efficacy than the Indian sample,but this difference was not ***,SRB ethanol leaves extracts outperformed other leaves extracts in terms of yield,phytoconstituents,and total flavo***,both SRB samples had high querce

关键词： Antidiabetic activity Stevia rebaudiana phytochemicals proximate analysis TLC RP-HPLC

Actual Practical Attitude and Knowledge of Dental Implants among Senior Dental Students and General Dentists Graduated from Some Saudi and Non-Saudi Dental Schools

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International Journal of Clinical Medicine 2023年第1期14卷 1-19页

作者： mohammed M. A. Abdullah Al-Abdaly Sami Yahya alamri Ghadeer mohammed mohammed Al-Abdaly Ayed Abdulrahman Abdullah Periodontics and Community Dental Sciences College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia Faculty of Dentistry Sana’a University Sana’a Republic of Yemen

Objective: To assess the actual practical attitude and knowledge of dental implants among senior dental students and general dentists graduated from some Saudi and Non-Saudi dental schools. Methods: A total of 300 senior dental students and general dentists participated in the study. Hard copies of the self-designed, multiple-choice questionnaires were distributed to all participants. The questionnaire consisted of 31 questions in five parts. Data were collected and analyzed using Chi-square test and t-test, where p Results: There is a statistically significant relationship between the participants’ answers, and their dental schools. Participants’ general knowledge, training, and teaching of dental implants, as well as information about restorations retained for the dental implants, were higher among participants from Saudi dental schools than participants from non-Saudi dental schools, while the information about dental implants was higher among participants from non-Saudi dental schools than participants from Saudi dental schools. Conclusion: We conclude that the actual practical attitude and knowledge of dental implants among participants in the current study was insufficient. Therefore, dental implant education in the undergraduate curricula of dental schools surveyed should be updated to include teaching, laboratory training, and preclinical and clinical training.

关键词： Knowledge Dental Implants Dental Schools Non-Saudi Practical Attitude Saudi

Assessment of Breast Cancer Prevention Practices among Women Attending Primary Health Care in Abha City, Aseer Region, Saudi Arabia

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International Journal of Clinical Medicine 2024年第2期15卷 31-54页

作者： Sabah mohammed Asiri Sultan Yahia Alfifii Tagreed Khairan Al-Rashidi Sager Misfer Alqahtani Faiz Abdulrahman Alshafa Fayez Mari alamri Amal mohammed Asiri Fatima mohammed Ali Almagadi Thuraya mohammed Asiri Department of Therapeutic Assistance Management General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Health Affairs General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Kidney King Khaled Hospital Hail Saudi Arabia Department of Nursing Sarat Abida Hospital Aseer Saudi Arabia Department of Radiation Oncology King Faisal Medical City Abha Saudi Arabia Department of Health Affairs KSA MOH Department of Kidney Dialysis Centers General Directorate of Health Affairs Aseer Region Abha Saudi Arabia Department of Operation Ahad Rafidah Hospital General Directorate of Health Affairs in Asseer Region Abha Saudi Arabia South Qunfudah General Hospital Jizan Saudi Arabia Armed Forces Southern Region Hospital Aseer Saudi Arabia

Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for 15.9% of all cancers reported among Saudi nationals and 28.7% of all cancers reported among females of all ages. Early detection of breast cancer could decrease the risks, have a better prognosis, and have better outcomes/more successful treatments. Prevalence of breast cancer reached more than 25% of all diagnosed cancer in the kingdom among women. Aim: This study aims to assess the knowledge and performance of women attending primary care centers about breast self-examination and mammogram screening for prevention and early detection of breast cancer in Abha city primary healthcare centers, Kingdom of Saudi Arabia. Research Method: cross sectional design was conducted by using questionnaire, which was distributed to primary care center nurses. The collected data was statistically analyzed using the Statistical Package for Social Sciences, version 25. Results: The study found that participants had poor awareness and knowledge about breast self-examination, risk factors for breast cancer, and trends and practices in early diagnosis of breast cancer. Conclusion and Recommendations: It recommends increasing awareness campaigns and providing educational programs to improve knowledge and practices.

关键词： Assessment Breast Cancer Prevention Practices Women Attending Health Care Centers Abha City

Injury Pattern among Road Traffic Accidents’ Victims in Najran City, Saudi Arabia

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International Journal of Clinical Medicine 2018年第4期9卷 270-280页

作者： Mahdi Yahya Al-Zamanan Abdullah Saleh Al-Yami Ali Abdullah Al-Najrani Mansour Yousef Al-Asmari Abdulrahman alamri Manaa Awad mohammed Al-Qahtani mohammed Helmy Faris Shalayel Abdulhadi Mohamed Elbashir Saeed Ali Alsareii College of Medicine Najran University Najran Saudi Arabia Department of Surgery College of Medicine Najran University Najran Saudi Arabia Department of Surgery College of Medicine Najran University Najran Saudi Arabia Department of Family and Community Medicine College of Medicine Najran University Najran Saudi Arabia

Traffic accidents constitute the substantial cause of disability and mortality in the young Saudi individuals reaching horrible figures. The aim of this study was to review and identify the pattern of injury among road traffic accident (RTA) victims as well as the peak time of accidents and their implications. This retrospective hospital-based cross-sectional study was carried out in the period between April 2016 to March 2017 in King Khalid Hospital, Maternity and Children Hospital and Najran General Hospital, Najran, Saudi Arabia. All RTA victims admitted to the emergency departments of the pre-mentioned hospitals. Data collected from 435 Saudis and non-Saudis’ files were statistically analyzed with regard to age, gender, the timing of road traffic accidents, injury pattern, and neurological deficits incidence. Most of the RTAs’ cases (92%) were male victims with the highest peak in the age group 20 - 29 years. 58% of the RTAs happened in the evening (6:00 PM-9:00 PM) while 20% occurred in the morning. Head injury represented the most frequent pattern (36%) followed by the spinal injury (23%), lower limb injury (23%), upper limb injury (20%), thoracic injury (17%), pelvic injury and abdominal injury (8%). 4.4% of RTAs resulted in death whilst 9% of cases experienced neurological deficits. In conclusion, young male drivers in Najran recorded the highest frequency of RTAs. Initiation of road safety education and expansion of speed detectors (Saher) system deployment is highly recommended.

关键词： Road Traffic Accidents (RTA) Road Traffic Injuries (RTIs) Disability

Epidemiological Pattern of Breast Diseases among Females in the South-Western Region, Saudi Arabia

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International Journal of Clinical Medicine 2020年第5期11卷 257-269页

作者： Abdulrahman Manaa alamri Saeed Ali Alsareii Hajr Al-Wadei Awad mohammed Al-Qahtani Salem Ali Alatef Sultan Sara Ali Alshamrani Ahmed Hamzah Almakrami Abdullah Ahmed Daiel Ahlam Yahya Alyami Ashwaq Mousa Hommadi Yagoub mohammed Tahir Ali Department of Surgery College of Medicine Najran University Najran KSA Department of Community Medicine Faculty of Medicine Najran University Najran KSA College of Medicine Najran University Najran KSA Department of General surgery King Khalid Hospital Najran KSA

Background: Breast diseases cover several conditions. The majority of breast diseases are noncancerous. Some of these lesions are clinically unremarkable, which needed minimal intervention. However, some symptoms may be of clinical value and attract the attention of both the patient and the attending physician, especially when they become persistent. The study aimed to assess the prevalence, pattern, types, and clinical profile of breast diseases among females in the South-western region, during the period from 2018-2020. Methods: A retrospective record-based descriptive approach was used through reviewing medical records of all cases with breast disease attended King Khalid Hospital during the period from January 2018 to January 2020. Data extracted throng pre-structured questionnaire. Results: The study included 211 cases whose ages ranged from 18 to 58 years old with a mean age of 28.9 ± 12.8 years. Breast mass was the most recorded complaint (95.1%) followed with breast pain (32%), skin changes. Benign findings based on the final pathology report were recorded for more than two thirds of the cases, with the most common finding were fibroadenoma. Excisional biopsy and modified radical mastectomy were the most reported surgical interventions. Conclusions: In conclusion, the study revealed that the majority of the cases had benign breast disease (BBD), where fibroadenoma was the most frequent.

关键词： Breast Disease Females Incidence Pattern Predictors Epidemiolo-gylesions Biopsy

Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia

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International Journal of Clinical Medicine 2022年第12期13卷 590-649页

作者： Abdulrahman Alshaikh Ahmed Aljedai Assim Alfadda Abdulrahman Alrobayan Abdulwahab Bawahab Shaza Abou Ouf Ali Sultan Amani Alhozali mohammed Bawazeer Eman Sheshah Fahad Alqahtani Hala Mosli Hussein Elbadawi Khaled alamri Khalid Alshali mohammed Aldawish mohammed Alsofiani Raed Aldahash Rasha Alfawaz Reem Alamoudi Wessam Jamal Hajer Almudaiheem Emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia King Saud University Medical City Riyadh Saudi Arabia Prince Sultan Military Medical City Riyadh Saudi Arabia King Fahad General Hospital Jeddah Saudi Arabia International Medical Center Jeddah Saudi Arabia King Salman Hospital Riyadh Saudi Arabia King Fahad Medical Center Riyadh Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Saudi Centre for Disease Prevention and Control Riyadh Saudi Arabia Aslam Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

Obesity and overweight are prevalent in Saudi Arabia (24.95% & 31.80%). Also, childhood obesity in the country is a challenge, with 6% - 10% of preschool and school-age children. The burden of being overweight and obese is disastrous. Therefore, the Saudi Diabetes Scientific Society constituted a team to develop a guideline. The team reviewed the local Clinical Practice Guidelines for the Prevention and Management of Obesity in Saudi Arabia;and conducted a rigorous review of relevant evidence-based scientific literature. After a thorough assessment, a consensus was reached to use the Australian guideline as the main guideline to be adapted and localized to be suitable for the Saudi people. To avoid duplication of efforts, the team adopted the grading of evidence used by the Australian guideline. The updated version was presented in a workshop, and the recommendation of the participants was included. The final draft was distributed for review, and comments were included. This document presents the result of such an effort as a local guideline.

关键词： Obesity Overweight Disease Burden Management Guideline Saudi Arabia