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Symptomatic male with subclinical varicocele found on ultrasound evaluation

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Asian Journal of Andrology 2016年第2期18卷 313-314页

作者： Ahmad Majzoub Edmund Sabanegh Jr. Department of Urology Glickman Urological and Kidney Institute Cleveland Clinic Foundation CLeveland Ohio USA.

Scrotal pain is a commonly encountered complaint in urology practice. It occurs in around 2%-10% of patients with varicocele.Despite a relatively common association, the effect ofvaricocele on pain is much less investigated than its relation with infertility. Biggers and Soderdahl were the first to explore surgical treatment for pain attributed to a clinical varicocele in 1981, reporting an improvement rate of 48% after surgery.

关键词： SCROTAL CONTENT PAIN INTERNAL SPERMATIC VEIN CHRONIC ORCHIALGIA CORD MICRODENERVATION DENERVATION LIGATION

Correlation of oxidation reduction potential and total motile sperm count:its utility in the evaluation of male fertility potential

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Asian Journal of Andrology 2020年第3期22卷 317-322页

作者： Ahmad Majzoub Mohamed Arafa Walid El Ansari Mohammed Mahdi Ashok Agarwal Sami Al-Said Haitham Elbardisi Department of Urology Hamad Medical CorporationDoha 00974Qatar Department of Urology Weill Cornell Medicine-QatarDoha 00974Qatar Department of Andrology Cairo UniversityCairo 12613Egypt Department of Surgery Hamad Medical CorporationDoha 00974Qatar College of Medicine Qatar UniversityDoha 00974Qatar School of Health and Education University of SkovdeSkovde 54128Sweden department of Urology Glickman Urology and Kidney InstituteCleveland Clinic FoundationOH 44195USA.

Oxidative stress(OS)is detri me ntal to sperm fun ctio ns,and the oxidation reductio n pote ntial(ORP)is a good measure of OS as it considers the balance betwee n oxidants and reducta nts.Total motile sperm count(TMSC)is viewed as the single most im porta nt semen analysis parameter that can predict male infertility severity,and its correlation with ORP has never been undertaken.The objectives of this study were to assess the correlation between ORP and TMSC,to identify the ORP cutoff value based on the TMSC result,and to compare this cutoff value with previously reported ORP cutoff values in literature.One thousand one hundred and sixty-eight infertile patients and 100 fertile controls were enrolled.Demographic and semen data of the participants were retrieved and analyzed.Wilcox on's rank-sum test compared variables betwee n infertile men and fertile controls;Spearman's correlation assessed the static ORP(sORP)-TMSC relationship for the whole sample and among each group individually.Using a 20×10^6TMSC threshold,receiver operator characteristic(ROC)analysis determined the sORP cutoff associated with the highest predictive values.TMSC was significantly negatively correlated with sORP across all participants(r=0.86,P<0.001),among infertile patients(r=0.729,P<0.001),and among fertile controls(r=0.53,P<0.001).A 20-million TMSC threshold determined an sORP cutoff value of 2.34 mV/106sperm/ml to be associated with 82.9%sensitivity,82.8%specificity,91.5%positive predictive value(PPV),68.5%negative predictive value(NPV),and 82.9%overall accuracy.Compared with previously reported cutoff values in searched literature,the 2.34 mV/10^6sperm/ml cutoff value identified in our study yielded the highest overall diagnostic accuracy in the evaluation of in fertile men.

关键词： male in fertility oxidati on reduction pote ntial oxidative stress total motile sperm

46 XX karyotype during male fertility evaluation; case series and literature review

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Asian Journal of Andrology 2017年第2期19卷 168-172页

作者： Ahmad Majzoub Mohamed Arafa Christopher Starks Haitham Elbardisi Sami A1 Said Edmund Sabanegh Jr Cleveland Clinic Foundation Department of Urology Cleveland Ohio USA Hamad Medical Corporation Department of Urology Qatar Cairo University Department of Andrology Giza Egypt Reston Hospital Department of Urology Virginia USA

Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man＇s fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients＇ clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using ＂46 XX man＂ as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients＇ mean age _＋ s.d. was 34 ＋ 10 years and their mean height ＋ s.d. was 166 ＋ 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% （4120）, 25.8% （8/31）, and 42% （13131） of the patients, respectively. The SRYgene was detected in 36 （83.7%） and was absent in the remaining seven （16.3%） patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption.

关键词： hypogonadism infertility male sex-determining region XX disorders of sex development

Specialized sperm function tests in varicocele ant Ihe future of andrology laboratory

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Asian Journal of Andrology 2016年第2期18卷 205-212,J0003,J0004页

作者： Ahmad Majzoub Sandro C Esteves Jaime Gosalvez Ashok Agarwal Glickman Urological and Kidney Institute Cleveland Clinic Foundation Cleveland Ohio USA Androfert Andrology and Human Reproduction Clinic Referral Center for Male Reproduction Av. Dr. Heitor Penteaclo 1464 Campinas SP 13075-460Brazil Genetics Unit Department of Biology universidad Autonoma de MadridMadrid.Spain American Center for Reproductive Medicine Cleveland Clinic Cleveland OH USA.

Varicocele is a common medical condition entangled with many controversies. Though it is highly prevalent in men with infertility, still it marks its presence in males who do have normal fertility. Determining which patients are negatively affected by varicocele would enable clinicians to better select those men who benefitted the most from surgery. Since conventional semen analysis has been limited in its ability to evaluate the negative effects of varicocele on fertility, a multitude of specialized laboratory tests have emerged. In this review, we examine the role and significance of specialized sperm function tests with regards to varicocele. Among the various tests, analysis of sperm DNA fragmentation and measurements of oxidative stress markers provide an independent measure of fertility in men with varicocele. These diagnostic modalities have both diagnostic and prognostic information complementary to, but distinct from conventional sperm parameters. Test results can guide management and aid in monitoring intervention outcomes. Proteomics, metabolomics, and genomics are areas; though still developing, holding promise to revolutionize our understanding of reproductive physiology, including varicocele.

关键词： male infertility oxidative stress semen analysis sperm DNA fragmentation sperm function varicocele varicocelectomy

Bibliometrics： tracking research impact by selecting Lhe appropriate metrics

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Asian Journal of Andrology 2016年第2期18卷 296-309,J0008页

作者： Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri American Center for Reproductive Medicine Cleveland Clinic Cleveland OH USA Faculty of Medicine Universiti Teknologi MARA Selangor Malaysia Case Western Reserve University Cleveland OH USA Androfert Andrology and Human Reproduction Clinic Campinas Brazil Department of Obstetrics and Gynecology Soroka University Medical Center Ben Gurion University of the Negev Beersheba Israel Department of Medical Bioscience University of the Western Cape Bellville South Africa Department of Life Science and Bioinformatics Assam University Silchar Assam India Andrology Solutions London UK IVF Laboratory Instituto Universitario IVI Valencia Valencia Spain Department of Urology Unwersity of Miami Miller School of Medicine Miami Florida USA Texas A and M Health Science Center College of Medicine Bryan Texas USA Department of Animal Physiology Slovak University of Agricuiture Nitra Siovakia Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah KSA School of Life Sciences Jaipur National UnJversity Jaipur Rajasthan India Department of Health Services Saint Joseph's University Philadelphia PA USA Department of Medical Laboratory Sciences Jordan university of science and Technology Irbid Jordan Department of Urology Loma Linda University School of Medicine Loma Linda California USA Department of Biology Genetics Unit Autonomous University of Madrid MadridSpain Maternal-Fetal Medicine and Ultrasound Soroka University Medical Center Ben-Gurion University of the NegevBeersheba Israel.

Traditionally, the success of a researcher is assessed by the number of publications he or she publishes in peer-reviewed, indexed, high impact journals. This essential yardstick, often referred to as the impact of a specific researcher, is assessed through the use of various metrics. While researchers may be acquainted with such matrices, many do not know how to use them to enhance their careers. In addition to these metrics, a number of other factors should be taken into consideration to objectively evaluate a scientist＇s profile as a researcher and academician. Moreover, each metric has its own limitations that need to be considered when selecting an appropriate metric for evaluation. This paper provides a broad overview of the wide array of metrics currently in use in academia and research. Popular metrics are discussed and defined, including traditional metrics and article-level metrics, some of which are applied to researchers for a greater understanding of a particular concept, including varicocete that is the thematic area of this Special Issue of Asian Journal of Andrology. We recommend the combined use of quantitative and qualitative evaluation using judiciously selected metrics for a more objective assessment of scholarly output and research impact.

关键词： article-level metrics bibliometrics citation counts h-index impact factor research databases research impact research productivity traditional metrics