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Epicardial adipose tissue in obesity with heart failure with preserved ejection fraction: Cardiovascular magnetic resonance biomarker study

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World Journal of Cardiology 2024年第3期16卷 149-160页

作者： Ju-Wei Shao Bing-Hua Chen kamil Abu-Shaban ahmad Baiyasi Lian-Ming Wu Jing Ma Department of Radiology The Affiliated Hospital of Yunnan UniversityKunming 650021Yunnan ProvinceChina Department of Radiology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Radiology University of Toledo College of MedicineToledoOH 43623United States Department of Radiology Wayne State University School of MedicineDetroitMI 48201United States Department of Endocrinology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

BACKGROUND Obesity has become a serious public health issue,significantly elevating the risk of various *** is a well-established contributor to Heart failure with preserved ejection fraction(HFpEF).Evaluating HFpEF in obesity is *** adipose tissue(EAT)has emerged as a valuable tool for validating prognostic biomarkers and guiding treatment ***,assessing EAT is of paramount *** magnetic resonance(CMR)imaging is acknowledged as the gold standard for analyzing cardiac function and *** hope to use CMR to assess EAT as a bioimaging marker to evaluate HFpEF in obese *** To assess the diagnostic utility of CMR for evaluating heart failure with preserved ejection fraction[HFpEF;left ventricular(LV)ejection fraction≥50%]by measuring the epicardial adipose tissue(EAT)volumes and EAT mass in obese *** Sixty-two obese patients were divided into two groups for a case-control study based on whether or not they had heart failure with *** two groups were defined as HFpEF+and HFpEF-.LV geometry,global systolic function,EAT volumes and EAT mass of all subjects were obtained using cine magnetic resonance *** Forty-five patients of HFpEF-group and seventeen patients of HFpEF+group were *** mass index(g/m2)of HFpEF+group was higher than HFpEF-group(P<0.05).In HFpEF+group,EAT volumes,EAT volume index,EAT mass,EAT mass index and the ratio of EAT/[left atrial(LA)left-right(LR)diameter]were higher compared to HFpEF-group(P<0.05).In multivariate analysis,Higher EAT/LA LR diameter ratio was associated with higher odds ratio of *** EAT/LA LR diameter ratio is highly associated with HFpEF in obese *** is plausible that there may be utility in CMR for assessing obese patients for HFpEF using EAT/LA LR diameter ratio as a diagnostic *** prospective studies,are needed to validate these proof-of-concept findings.

关键词： Heart failure with preserved ejection fraction Epicardial adipose tissue Obesity Cardiac magnetic resonance

Etiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study

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Asian Pacific Journal of Tropical Medicine 2020年第3期13卷 115-122页

作者： Alif Adlan Mohd Thabit Mohd Hatta Abdul Mutalip Wan Mohd Rasis Wan ahmad kamil Mohd RamadhanMohd Din Mohan Arumugam Siti Sanaa Wan Azman Roslinda Jaafar Sathvinder Singh Gian Singh RafidahAbdullah Eida Nurhadzira Muhammad Nor Asiah Muhamad Department of Medicine Hospital Bentong BentongPahangMalaysia Institute for Public Health National Institute of HealthMalaysiaMinistry of Health MalaysiaSelangorMalaysia Department of Medicine Hospital Sultan Haji ahmad Shah TemerlohPahangMalaysia Department of Pathology Hospital Sultan Haji ahmad Shah TemerlohPahangMalaysia Department of Medicine Hospital Kuala Lipis Kuala LipisPahangMalaysia

Objective: To determine the etiologies of tropical acute febrile illness(TAFI) in West Pahang, Malaysia and to investigate morbidity and mortality factors in relation to TAFI. Methods: A multicenter prospective cohort study was conducted between January and June 2016 in six district hospitals throughout the western part of Pahang State in Peninsular Malaysia. A total of 336 patients answered a standardized questionnaire and blood samples were collected for laboratory confirmation of infectious etiology. Descriptive analysis and logistic regression were performed to identify factors associated with TAFI. Results: A total of 336 patients were included. The patients were mainly Malays(70.2%), males(61.3%), aged(44.6±17.4) years, with more than half(58.9%) presenting with gastrointestinal symptoms. The majority were diagnosed with dengue(35.7%) while malaria(4.5%) was the least frequent. The in-hospital mortality due to TAFI was 9.2%. Patients with meliodosis had five times higher mortality [Adjusted OR: 5.002, 95% CI:(1.233, 20.286)]. Patients with comorbidities such as cardiovascular symptoms(P<0.001) and renal replacement therapy initiation(P<0.001) were significantly associated with in-hospital mortality in all TAFI. Conclusions: The etiology of TAFI in the western Pahang includes dengue, leptospirosis, malaria and melioidosis, which carry the highest risk of in-hospital mortality. The presence of cardiovascular symptoms may be used to assess the disease severity in TAFI, but more studies are needed in the future.

关键词： Comorbidities Mortality Tropical acute febrile illness

Coordinated Voltage Control in Distribution Network with Renewable Energy based Distributed Generation

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Engineering（科研） 2013年第1期5卷 208-214页

作者： Mohd Khairun Nizam Mohd Sarmin Worawat Nakawiro MohdZamriChe Wanik Mohd FadzilMohd Siam ZahrulFaizi Hussien ahmad Asrul Ibrahim ahmad kamil Mat Hussin Green Technology Section TNB Research Malaysia Malaysia Power system research group UniversitiKebangsaan Malaysia Malaysia Smart Grid Section TNB Research Malaysia Malaysia

This paper presentsa voltage control strategy for power distribution systems with interconnected renewable energy based distributed generators (DGs). The control strategy coordinating conventional voltage control devices and reactive power from DG.A mixed-integer nonlinear programming problem was formulated and solved by particle swarm optimization (PSO). The code is written using DigSILENT programming language (DPL) and implemented inside DigSILENT power factory simulation software. All system constraints and operating limits are considered. The optimal power flow based approach can incorporate various uncertainties such as intermittent power characteristics and varying load demand. The proposed method is tested using real distribution network to demonstrate its effectiveness. The merits of the proposed method over the classical local-based control are presented in the simulation results. It is demonstrated that the proposed method is capable of keeping the system voltage within operating limit. Power losses is at the same time is minimized in comparison to the losses using conventional method.

关键词： Photovoltaic Distributed Generation Particle Swarm Optimisation DigSILENT Coordinated Control

Green hydrogen production from photovoltaic power station as a road map to climate change mitigation

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Clean Energy 2024年第2期8卷 156-167页

作者： Kehinde Ridwan kamil Bassey Okon Samuel Umar Khan Department of Computer Science and Engineering Edge Hill UniversityUK Enel Green Power Rome Italy Materials Research Laboratory Steelagon Engineering LimitedKaduna StateNigeria

The increasing recognition of hydrogen as a critical element in the global net-zero transition and its clear role in decarbonizing challenging sectors coincide with the growing urgency to address climate ***'s favourable renewable-energy capacity,ranging from 28%to 36%for solar,has been reported by the global solar irradiance ***,the majority of hydrogen production today relies on fossil fuels(96%),with only a small fraction(4%)being produced through water *** though there have been many studies on climate change mitigation with a focus on Africa,a green hydrogen production from a photovoltaic power station approach has not been ***,literature with a focus on Nigeria is *** study focuses on the African green hydrogen production industry,utilizing Nigeria as a case study to explore the feasibility of generating clean hydrogen vectors from a percentage of photovoltaic power output in various regions of the country through stand-alone solar grid electrification *** of the usage and effectiveness of the produced hydrogen fuel in each region are carried out,with the highest region having an annual output of 12247278 kg of green hydrogen and 8573094 kg of ammonia and the lowest region having an output of 511245 kg of green hydrogen and 357871 kg of ammonia,and the expected production from the proposed usage of 50%of the power generation output of the installed 1.6-MWp and 80-kWp solar power minigrids in the regions is *** analyses were repeated for the other considered regions in the *** results showcased the enormous advantages of the electrolytic production of hydrogen and how the greener economy project can play a major role in mitigating climate change effects and overreliance on fossil fuels as the driver of the economy in many African countries.

关键词： renewable energy photovoltaic climate change green hydrogen vector fossil fossil fuels decarbonization electrolysis

Zinc-doped hydroxyapatite-zeolite/polycaprolactone composites coating on magnesium substrate for enhancing in-vitro corrosion and antibacterial performance

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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 123-133页

作者： Nida IQBAL Saman IQBAL Tanveer IQBAL H.R.BAKHSHESHI-RAD Ahmed ALSAKKAF ahmad kamil Mohammed Rafiq ABDUL KADIR Mohd Hasbullah IDRIS H.Balaji RAGHAV Biomedical Engineering Centre University of Engineering and TechnologyKala Shah Kaku(KSK)CampusLahorePakistan Department of Physics University of the PunjabQuaid-e-Azam CampusLaborePakistan Department of Chemical Polymer&Composite Material Engineering University of Engineering and TechnologyKala Shah Kaku(KSK)New CampusLahorePakistan Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran School of Mechanical Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia Kulliyyah of Science International Islamic University MalaysiaBandar Indera Mahkota CampusJalan Sultan Ahmad Shah25200 KuantanPahang Darul MakmurMalaysia School of Biomedical Engineering and Health Sciences Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia Tissue Engineering Group(TEG) National Orthopaedic Centre of Excellence in Research and Learning(NOCERAL)Department of Orthopaedic SurgeryFaculty of MedicineUniversity of Malaya50603 Lembah PantaiKuala LumpurMalaysia

This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn HA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial ***-coating technique was used to coat Zn HA-Zeo/PCL on the Mg substrate at room *** samples were subjected to field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Fourier transform infrared(FTIR),energy dispersive X-ray spectroscopy(EDX)and antimicrobial *** demonstrated that composite coatings consist of HA,scholzite,zeolite,and PCL *** spectra indicated the presence of calcium(Ca),silicon(Si),aluminum(Al),zinc(Zn),phosphorus(P)and oxygen(O).The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260μ***-doped HA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic *** Zn HA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the *** as compared to HA-Zeo *** these results showed that the Zn HA-Zeo coatings not only improved the corrosion resistance,but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.

关键词： biodegradable magnesium bioceramics coating corrosion resistance antimicrobial activity

Inhibition mechanisms of secretome proteins from Paenibacillus polymyxa Kp10 and Lactococcus lactis Gh1 against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 483-494页

作者： Nurul Hana Zainal Baharin Nur Fadhilah Khairil Mokhtar Mohd Nasir Mohd Desa Nurul Diana Dzaraly AbdulRahman Muthanna Mazen M.Jamil Al-Obaidi Mohd Hafis Yuswan Sahar Abbasiliasi Norasfaliza Rahmad Wan ahmad kamil Wan Nur Ismah Amalia Mohd Hashim Shuhaimi Mustafa Laboratory of Halal Science Research Halal Products Research InstituteUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Science University of Technology and Applied SciencesRustaq 10 P.C.329Oman Agro-Biotechnology Institute MalaysiaNational Institutes of Biotechnology Malaysia43400 UPM SerdangSelangorMalaysia Department of Microbiology Faculty of Biotechnology and Biomolecular ScienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Objective:To determine the inhibition mechanisms of secretome protein extracted from Paenibacillus polymyxa Kp10(Kp10)and Lactococcus lactis Gh1(Gh1)against methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococcus(VRE).Methods:The sensitivity and viability of MRSA and VRE treated with secretome proteins of Kp10 and Gh1 were determined using minimal inhibitory concentration,minimum bactericidal concentration,and time-to-kill *** morphological changes were observed using scanning electron microscopy and transmission electron *** elucidate the antimicrobial mechanism of secretome protein of Kp10 and Gh1 against MRSA and VRE,2D gel proteomic analysis using liquid chromatography-mass spectrometry was run by comparing upregulated and downregulated proteins,and the proton motive force study including the efflux of ATP,pH gradient,and the membrane potential study were ***:MRSA and VRE were sensitive to Kp10 and Gh1 secretome protein extracts and displayed apparent morphological and internal composition *** proteins associated with cellular component functions were either downregulated or upregulated in treated MRSA and VRE by changing the membrane potential ***:Kp10 and Gh1 secretome proteins reduce the growth of VRE and MRSA by damaging the cell *** division,cell wall biosynthesis,and protein synthesis are involved in the inhibition mechanism.

关键词： Antimicrobial Proteins Secretome proteins Antibiotic-resistance Paenibacillus polymyxa Kp10 Lactococcus lactis Gh1 Vancomycin-resistant Enterococcus Methicillin-resistant Staphylococcus aureus Mechanism

Harmonic Measurement and Analysis during Electric Vehicle Charging

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Engineering（科研） 2013年第1期5卷 215-220页

作者： MohdZamriChe Wanik Mohd FadzilMohd Siam Afida Ayob Subi yanto Azah Mohamed Abu HanifahAzit Saharuddin Sulaiman Mohamed Azrin Mohamed Ali Zahrul Faizi Hussein ahmad kamil MatHussin Malaysian Green Technology Corporation Bandar BaruBangi Malaysia Power System Research Group UniversitiKebangsaan Malaysia Malaysia TNB Distribution Malaysia Malaysia TNB Research Malaysia Malaysia

This paper presentsand describes harmonic measurement and analysis of studying harmonic propagation during electric vehicle (EV) charging. The measurement study is performed on a golf cart and two modern type of EVs. Harmonics from a single EV charging and a group of EV charging was measured. The voltage and current waveform during the charging was captured and analyzed to investigate the harmonic components that exist in the electrical system. Total current harmonic distortion (THDi) and total voltage harmonic distortion (THDi) were both calculated. Modern electric vehicles are found to release low THDi but higher THDv compared to a golf cart. On the measurement study during charging of? a group of EV, it is found that the summation of THD is not linear with a number of vehicles. The finding of the study reveals that harmonic contamination from EV charging on electrical grid is not as critical as thought by most of power system researchers and engineers.

关键词： Electric Vehicle Total Harmonic Distortion Electric Vehicle Charging Harmonic Power Quality

Assessment of ecotoxicity of tellurium in soils of contrasting properties

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Emerging Contaminants 2024年第3期10卷 250-259页

作者： Sergey Kolesnikov Natalia Evstegneeva Tatiana Minnikova Alena Timoshenko Natalia Tsepina kamil Kazeev Southern Federal University Rostov-on-Don344090Russia

The ecotoxicity of tellurium(Te)compounds(oxide and nitrate)is assessed by changing the biological properties of soils of contrasting properties:Haplic Chernozem(Loamic),Eutric Cambisol,and Eutric *** stability was assessed by the most sensitive and informative biological indicators:microbiological(total number of bacteria),biochemical(catalase and dehydrogenase activity),and phytotoxic(changes in the length of wheat roots and shoots).Te contamination was simulated at concentrations of 0.5,1,3,10,and 30 possible permissible concentrations(PPC).It has been established that already at minimum concentrations of Te(0.5 and 1 PPC),the biological indicators of soils *** a rule,a direct relationship between Te concentration and the degree of deterioration of the studied soil properties was *** nitrate showed higher ecotoxicity than oxide.A stronger negative effect of Te contamination was manifested 10 and 30 days after *** 90 days,the restoration of the biological properties of the soils was *** Chernozem(Loamic)showed greater resistance to Te contamination than Haplic Cambisols Eutric and Eutric *** obtained results can be used to predict environmental risks from soil contamination with Te and to develop maximum permissible concentrations of Te in soils of contrasting properties.

关键词： Pollution Heavy metals Haplic chernozem(Loamic) Haplic Cambisols Eutric Eutric Arenosol Biotesting Stability

AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

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Science China(Life Sciences) 2024年第7期67卷 1468-1478页

作者： Jiang Deng Jia-Cheng Yang Yue Feng Ze-Jing Xu kamil Kuča Meng Liu Lv-Hui Sun State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic

Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic *** hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1to the highly toxic exo-AFB1-8,9-epoxide(AFBO)in ***,the transcriptional regulation mechanism of these CYP genes in the liver of chicks in AFB1metabolism remains ***-luciferase reporter assay,bioinformatics and site-directed mutation results indicated that specificity protein 1(SP1)and activator protein-1(AP-1)motifs were located in the core region-1,063/-948,-606/-541 of the CYP1A1 promoter as well as-636/-595,-503/-462,-147/-1 of the CYP2A6 ***,overexpression and decoy oligodeoxynucleotide technologies demonstrated that SP1 and AP-1 were pivotal transcriptional activators regulating the promoter activity of CYP1A1 and ***,bioactivation of AFB1to AFBO could be increased by upregulation of CYP1A1 and CYP2A6 expression,which was trans-activated owing to the upregulation of AP-1,rather than SP1,stimulated by AFB1-induced reactive oxygen ***,nano-selenium could reduce ROS,downregulate AP-1 expression and then decrease the expression of CYP1A1 and CYP2A6,thus alleviating the toxicity of *** conclusion,AP-1 and SP1 played important roles in the transactivation of CYP1A1 and CYP2A6 expression and further bioactivated AFB1to AFBO in chicken liver,which could provide novel targets for the remediation of aflatoxicosis in chicks.

关键词： aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation