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A Novel Krill Herd Based Random Forest Algorithm for Monitoring Patient Health

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Computers, Materials & Continua 2023年第5期75卷 4553-4571页

作者： Md.Moddassir Alam Md Mottahir Alam Muhammad Moinuddin Mohammad Tauheed ahmad Jabir Hakami Anis ahmad chaudhary Asif Irshad Khan Tauheed Khan Mohd Department of Health Information Management and Technology University of Hafr Al-BatinSaudi Arabia Department of Electrical and Computer Engineering Faculty of EngineeringKing AbdulazizJeddah21589Saudi Arabia Center of Excellence in Intelligent Engineering Systems King Abdul Aziz UniversityJeddahSaudi Arabia College of Medicine King Khalid UniversityAbhaSaudi Arabia Department of Physics College of ScienceJazan UniversityP.O.Box.114Jazan45142Saudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11623Saudi Arabia Computer Science Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Math and Computer Science Augustana CollegeIL61201United States

Artificial Intelligence(AI)is finding increasing application in healthcare *** learning systems are utilized for monitoring patient health through the use of IoT sensor,which keep track of the physiological state by way of various health ***,early detection of any disease or derangement can aid doctors in saving patients’***,there are some challenges associated with predicting health status using the common algorithms,such as time requirements,chances of errors,and improper *** propose an Artificial Krill Herd based on the Random Forest(AKHRF)technique for monitoring patients’health and eliciting an optimal prescription based on their health *** begin with,various patient datasets were collected and trained into the system using IoT *** a result,the framework developed includes four processes:preprocessing,feature extraction,classification,and result ***,preprocessing removes errors,noise,and missing values from the dataset,whereas feature extraction extracts the relevant ***,in the classification layer,we updated the fitness function of the krill herd to classify the patient’s health status and also generate a *** found that the results fromthe proposed framework are comparable to the results from other state-of-the-art techniques in terms of sensitivity,specificity,Area under the Curve(AUC),accuracy,precision,recall,and F-measure.

关键词： Healthcare system health monitoring clinical decision support internet of things artificial intelligence machine learning diagnosis

Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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BIOCELL 2022年第1期46卷 87-95页

作者： YANYAN LI SHAHANAVAJ KHAN ANIS ahmad chaudhary HASSAN AHMED RUDAYNI ABDUL MALIK ASHWAG SHAMI Department of Oncology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou450007China Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)Muzaffarnagar251001India Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)Riyadh11623Saudi Arabia Department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11617Saudi Arabia

Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate *** we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(ER)using in-silico approaches and their possible role in lung cancer *** predicted 48 proteins that target human ER,which may be associated with protein folding and protein-protein interactions during *** results showed *** proteins targeting human ER and their implications in lung cancer *** targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung ***,*** unfolded protein accumulation in the human ER possibly induces ER stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer *** current study showed the *** protein targeting in ER of host cell and their implication in lung cancer *** results may help researchers better manage lung cancer and establish a molecular mechanism for *** lung cancer association.

关键词： Bacterial infection C.pneumoniae Proteomes ER Lung cancer

Calcium supplementation in colorectal cancer prevention:A systematic meta-analysis of adverse events

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BIOCELL 2022年第3期46卷 759-767页

作者： XUE MEI LUO SHAHANAVAJ KHAN ABDUL MALIK FAHAD M.ALDAKHEEL ANIS ahmad chaudhary SHOUKI BAZARBASHI FATEMEH TABATABAIE Department of General Surgery Mianzhu People’s Hospital of SichuanMianzhuChina Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)MuzaffarnagarIndia Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)RiyadhSaudi Arabia Oncology Center King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Shiraz University of Medical Sciences ShirazIran

Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer,most of the associated adverse effects are not systematically *** aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic *** searched Medline,PubMed Central,EMBASE(Excerpta Medica database),Scopus,Cochrane Central Register of Controlled Trials,and Web of Science published in English from database inception up to 31 July *** the current systematic meta-analysis,we included human studies(including cohort studies,clinical trials,case-control studies)on supplementation of calcium in patients with or at risk of colorectal *** of the quality of included studies was performed by Jadad *** on the patient population,number of enrolled subjects in each group,dose of calcium supplementation,duration of calcium supplementation,and reported adverse events were *** data were pooled for incidence rates for any adverse event during the study period regardless of causality *** identified 6 studies,comprising 4583 participants that met the inclusion ***-analysis on pooled incidence rates for adverse event during study period showed no statistically significant increased risk for cancer(OR=0.92,95%CI:0.70–1.21,P=0.577;I^(2)=0.0%,P=0.731),coronary revascularization(OR=1.12,95%CI:0.79–1.59,P=0.492;I^(2)=0.0%,P=0.957),myocardial infarction(OR=0.81,95%CI:0.34–1.91,P=0.634;I^(2)=67.9%,P=0.047),stroke(OR=0.75,95%CI:0.42–1.33,P=0.332,I^(2)=0.00%,P=0.717),Transient Ischemic Attack(TIA)(OR=1.37,95%CI:0.28–6.51,P=0.692,I^(2)=81.9%,P=0.002),urolithiasis(OR=1.23,95%CI:0.75–2.01,P=0.410;I^(2)=0.0%,P=0.851),fracture(OR=0.98,95%CI:0.70–1.37,P=0.938;I^(2)=37.8%,P=0.152)and death(OR=1.05,95%CI:0.71–1.56,P=0.786,I^(2)=12.2%,P=0.317)in patients receiving calcium supplementation for colo

关键词： Colorectal cancer Calcium Supplement Adverse event Systematic reviewed Meta-analysis

Discovery and evaluation of a novel ^(18)F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4014-4027页

作者： Junqi Hu Yinlong Li Chenchen Dong Huiyi Wei Kai Liao Junjie Wei Chunyu Zhao ahmad chaudhary Jiahui Chen Hao Xu Ke Zhong Steven H.Liang Lu Wang Weijian Ye Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine&Key Laboratory of Basic and Translational Research on Radiopharmaceuticalsthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiology and Imaging Sciences Emory UniversityAtlant1GA 30322USA Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

The arginine-vasopressin(AVP)hormone plays a pivotal role in regulating various physiological processes,such as hormone secretion,cardiovascular modulation,and social *** studies have highlighted the V1a receptor as a promising therapeutic ***-depth insights into V1a receptor-related pathologies,attained through in vivo imaging and quantification in both peripheral organs and the central nervous system(CNS),could significantly advance the development of effective V1a *** address this need,we develop a novel V1a-targeted positron emission tomography(PET)ligand,[^(18)F]V1A-2303([^(18)F]8),which demonstrates favorable in vitro binding affinity and selectivity for the V1a *** tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies,autoradiography,biodistribution ***,[^(18)F]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity,whole-body distribution,and kinetic *** research indicated[^(18)F]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs,and as a foundational element for the development of next-generation,brain-penetrant ligands specifically designed for the CNS.

关键词： Vasopressin Autism V1a receptor Positron emission tomography PET imaging Radiolabeling Fluorine 18 Kinetic modeling

Assessment of Metals Concentration and Ecotoxicology of the Sediment Core of Rehri Creek, Karachi Coast, Pakistan

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1434-1443页

作者： Muhammad Z. chaudhary Nasir ahmad Azhar MASHIATULLAH Sajjad MUNIR Tariq JAVED Isotope Application Division Pakistan Institute of Nuclear Science and Technology (PINSTECH) Institute of Geology University of the Punjab Department of Earth & Environmental Sciences Bahria University Islamanad

Trace metal concentrations were investigated in a recent sediment core collected from the Rehri Creek area of the Karachi coast, Sindh - Pakistan. The core was sliced horizontally at 2.5-cm intervals to determine grain size, sediment composition, pH, organic matter, and acid-leachable trace metals： cadmium, chromium, copper, lead, and zinc. The trace metals were analyzed by ICP. To separate anthropogenic from geogenic input, several approaches were made, including comparison with sediment quality guidelines--ecotoxicological sense of heavy metal contamination and classification by quantitative indexes. Grain-size analysis and sediment composition of core sample show a sandy nature with neutral pH. Elemental sequence （ES） of the trace metals is in the order of Zn （19.2-109.56 ppm）〉 Si （66.46-101.71 ppm）〉 Ba （12.05-26.86 ppm）〉 As （8.18-17.36 ppm）〉 Ni （4.2- 14.69 ppm）〉 Cr （3.02-9.62 ppm）〉 Pb （2.79-6.83 ppm）〉 Cu （2.2-5.29 ppm）〉 Co （0.9-2.05 ppm）. Thus it is likely that the area may face a serious threat of metal pollution with the present deposition rates unless stringent pollution control norms are adopted. The Sediment Geo-accumulation Index shows that there is no Cr, Cu, Ni, Pb, Zn, or Fe pollution; however, the former index and the Pollution Load Index indicate arsenic pollution in the sediments.

关键词： trace elements lake sedimentation sediment quality guidelines pollution shale values

Three-phase AC-DC Converter for Direct-drive PMSG-based Wind Energy Conversion System

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 589-598页

作者： Kumar Abhishek Singh Ayushi chaudhary Kalpana chaudhary Department of Electrical Engineering Indian Institute TechnologyVaranasiIndia Department of Electrical Engineering Indian Institute TechnologyKanpurIndia

In this paper,a wind energy conversion system(WECS)is presented for the electrification of rural areas with wind energy availability.A three-phase AC-DC converter based on a bridgeless Cuk converter is used for power extraction from the permanent magnet synchronous generator(PMSG).The bridgeless topology enables the elimination of the front-end diode bridge rectifier(DBR).Moreover,the converter has fewer components,simple control,and high efficiency,making it suitable for a small-scale WECS.A squirrel cage induction motor(SCIM)is used to emulate a MOD-2 wind turbine to implement the PMSG-based WECS.A direct-drive eight-pole PMSG is used in this study;thus,a low-input-voltage system is *** converter is designed to operate in the discontinuous inductor current mode(DICM)for inherent power factor correction(PFC)and the maximum power point tracking(MPPT)is achieved through the tip-speed ratio(TSR)*** performance of the developed system is analyzed through simulation,and a 500 W hardware prototype is developed and tested in different wind speed conditions.

关键词： Permanent magnet synchronous generator(PMSG) three-phase AC-DC converter wind energy conversion system(WECS) wind turbine emulator

Synthesis and catalytic activity of SBA-15 supported catalysts for styrene oxidation

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1300-1306页

作者： Vasu chaudhary Sweta Department of Chemical Engineering and Technology Indian Institute of Technology(BHU)

Cu(II) and Mn(II) metals embedded on mesoporous SBA-15 were synthesized by co-precipitation *** support and catalysts were characterized by SEM–EDX,TEM,BET,XRD and ICP-AES *** catalytic activity of these catalysts was evaluated for styrene oxidation at various reaction conditions such as styrene to TBHP mole ratio,temperature,catalyst amount by using TBHP as an oxidizing *** reaction products were styrene oxide and benzaldehyde and highest styrene conversion(97.3%) was observed at styrene to TBHP mole ratio of 1:4,temperature at 80 °C and 20 mg of ***,the recyclability of the catalysts was observed and found that they can be recycled three times without major loss in their activity and selectivity.

关键词： SBA-15 Styrene Styrene oxide Benzaldehyde Oxidation Catalytic oxidation

Influence of site conditions on seismic design parameters for foundations as determined via nonlinear site response analysis

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Frontiers of Structural and Civil Engineering 2021年第1期15卷 275-303页

作者： Muhammad Tariq A.chaudhary Civil Engineering Department Kuwait UniversityKhalidya 13060Kuwait

Site conditions,including geotechnical properties and the geological setting,influence the near-surface response of strata subjected to seismic *** geotechnical parameters required for the design of foundations include mass density(ρ),damping ratio(β_(s)),shear wave velocity(V_(s)),and soil shear modulus(G_(s)).The values of the last three parameters are sensitive to the level of nonlinear strain induced in the strata due to seismic ground *** this study,the effect of variations in soil properties,such as plasticity index(PI),effective stress(σ′),over consolidation ratio(OCR),impedance contrast ratio(ICR)between the bedrock and the overlying strata,and depth of soil strata over bedrock(H),on seismic design parameters(β_(s),V_(s),and G_(s))was investigated for National Earthquake Hazards Reduction Program(NEHRP)site classes C and D,through 1D nonlinear seismic site response *** Morris one-at-a-time(OAT)sensitivity analysis indicated thatβ_(s),V_(s),and G_(s)were significantly influenced by variations in PI,while ICR affectedβ_(s)more than it affected V_(s)and G_(s).However,the influence of H on these parameters was less *** was also found that variations in soil properties influenced seismic design parameters in soil type D more significantly than in soil type *** relationships forβ_(s),V_(s),and G_(s)were derived based on the 1D seismic site response analysis and sensitivity analysis ***β_(s),V_(s),and G_(s)values obtained from the analysis were compared with the corresponding values in NEHRP to determine the similarities and differences between the two sets of *** need to incorporate PI and ICR in the metrics for determiningβ_(s),V_(s),and G_(s)for the seismic design of foundations was highlighted.

关键词： site effects 1D seismic site response analysis sensitivity analysis foundations shear wave velocity soil shear modulus

Multiple Response Optimization of Dimensional Accuracy of Nimonic Alloy Miniature Gear Machined on Wire Edm Using Entropy Topsis Andpareto Anova

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Computer Modeling in Engineering & Sciences 2021年第1期126卷 241-259页

作者： Tina chaudhary Arshad Noor Siddiquee Arindam Kumar Chanda Shafi ahmad Irfan Anjum Badruddin Zahid A.Khan Department of Mechanical and Automation Engineering Indira Gandhi Delhi Technical University for WomenKashmere Gate110006India Department of Mechanical Engineering Jamia Millia Islamia(A Central University)New Delhi110025India Department of Mechanical and Automation Engineering G.B.Pant Engineering CollegeNew Delhi110020India Mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha-61421AsirSaudi Arabia

The purpose of this research is to obtain the optimum cutting parameters to achieve the dimensional accuracy of Nimonic alloy miniature gear manufactured using Wire *** cutting parameters investigated in this study are current,pulse on time(PON),pulse off time(POFF),wire tension(WT)and dielectric *** glycol,nanopowder of alumina and oxygen are mixed to demineralized water to prepare novel dielectric *** in inner diameter,deviation in outer diameter,deviation in land and deviation in tooth width are considered to check the dimensional *** L_(16) is employed for experimental design and multiple response optimization is performed using Entropy TOPSIS and Pareto *** indicate that pulse on time is the most notable parameter for good dimensional accuracy followed by dielectric fluid,current,pulse off time and wire *** glycol mixed demineralized water is preferred for low dimensional *** optimum WEDM parameters are pulse on time at 20μs,Ethylene glycol mixed demineralized water dielectric fluid,current at 3 A,pulse off time at 4μs,and wire tension at 18 N.

关键词： Miniature gear multiple optimization dimensional accuracy entropy TOPSIS Pareto ANOVA