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Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

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Science China Life Sciences 2025年第1期 306-308页

作者： aziz Ul Ikram Yanping Jing Huan Chen Jian Chen International Genome Center Jiangsu University Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

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Single cell whole-genome sequencing of brain cells:age-and cell-type specific mutational profiles

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3544-3545页

作者： Melania Capasso N.ahmad aziz Immune Regulation German Center for Neurodegenerative Diseases(DZNE)BonnGermany Population and Clinical Neuroepidemiology German Center for Neurodegenerative Diseases(DZNE)BonnGermany Department of Neurology Faculty of MedicineUniversity of BonnBonnGermany

In a recent study published in Cell,Ganz et *** new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome sequencing with single-nucleus chromatin accessibility and gene expression analysis,they profiled somatic mutations in 86 OLs from 13 neurotypical individuals,spanning in age from infants to *** investigated were 56,derived from 19(including 12 overlapping)individuals(Fig.1).

关键词： landscape cytes

Structure and Thermal Parameters of Ni_(20)Pd_(80) Alloy

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Journal of Materials Science & Technology 2009年第2期25卷 208-210页

作者： S. ahmad A.B. Ziya A. aziz Z.I. Zafar Department of Physics Bahauddin Zakariya University Department of Chemistry Bahauddin Zakariya University

The structure and thermal parameters of Ni20Pd80 alloy were studied by X-ray diffraction（XRD）. The diffraction experiments performed in the temperature range of 308-1100 K revealed that the alloy formed a face centered cubic （fcc） Al-type structure. The temperature dependence of the lattice parameters was investigated by using the Bragg line displacement method showing that the lattice parameter increases with the increase of temperature. The mean linear thermal expansion （MLTE（%））, coefficient of thermal expansion （CTE, α）, the characteristic Debye temperature （（θD） and mean square amplitudes of vibration were determined from XRD data. The value of Debye temperature was found to be 253 K. It was found that temperature factor was independent of the static displacements.

关键词： Alloys Structure Thermal parameters X-ray diffraction (XRD)

Potential use of nanofiltration like-forward osmosis membranes for copper ion removal

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Chinese Journal of Chemical Engineering 2020年第2期28卷 420-428页

作者： Wan Nur Ain Shuhada Abdullah Sirinan Tiandee Woeijye Lau Farhana aziz ahmad Fauzi Ismail Advanced Membrane Technology Research Centre(AMTEC) Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia School of Chemical and Energy Engineering Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia Faculty of Science and Industrial Technology Prince of Songkla UniversitySurat Thani Campus84000 Surat ThaniThailand

The discharge of industrial effluent containing heavy metal ions would cause water pollution if such effluent is not properly *** this work,the performance of emerging nanofiltration(NF)like-forward osmosis(FO)membrane was evaluated for its efficiency to remove copper ion from ***,copper ion is removed from aqueous solution via adsorption and/or ion-exchange *** engineered osmosis method as proposed in this work considered four commercial NF membranes(i.e.,NF90,DK,NDX and PFO)where their separation performances were accessed using synthetic water sample containing 100 mg·L-1 copper ion under FO and pressure retarded osmosis(PRO)*** findings indicated that all membranes could achieve almost complete removal of copper regardless of membrane orientation without applying external driving *** high removal rates were in good agreement with the outcomes of the membranes tested under pressuredriven mode at 1 *** use of appropriate salts as draw solutes enabled the NF membranes to be employed in engineered osmosis process,achieving a relatively low reverse solute *** findings showed that the best performing membrane is PFO membrane in which it achieved N 99.4%copper rejection with very minimum reverse solute flux of<1 g·m-2·h-1.

关键词： Nanofiltration Forward osmosis Copper Divalent salt Water flux

Effects of Tualang honey in modulating nociceptive responses at the spinal cord in offspring of prenatally stressed rats

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Journal of Integrative Medicine 2019年第1期17卷 66-70页

作者： Che Badariah Abd aziz Siti Qusyasyiah ahmad Suhaimi Hidani Hasim Asma Hayati ahmad Idris Long Rahimah Zakaria Department of Physiology School of Medical Sciences Health Campus Universiti Sains Malaysia School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: This study was done to determine whether Tualang honey could prevent the altered nociceptive behaviour, with its associated changes of oxidative stress markers and morphology of the spinal cord,among the offspring of prenatally stressed ***: Pregnant rats were divided into three groups: control, stress, and stress treated with Tualang honey. The stress and stress treated with Tualang honey groups were subjected to restraint stress from day 11 of pregnancy until delivery. Ten week old male offspring(n = 9 from each group) were given formalin injection and their nociceptive behaviours were recorded. After 2 h, the rats were sacrificed, and their spinal cords were removed to assess oxidative stress activity and morphology. Nociceptive behaviour was analysed using repeated measures analysis of variance(ANOVA), while the levels of oxidative stress parameters and number of Nissl-stained neurons were analysed using a one-way ***: This study demonstrated that prenatal stress was associated with increased nociceptive behaviour, changes in the oxidative stress parameters and morphology of the spinal cord of offspring exposed to prenatal stress; administration of Tualang honey reduced the alteration of these ***: This study provides a preliminary understanding of the beneficial effects of Tualang honey against the changes in oxidative stress and neuronal damage in the spinal cord of the offspring of prenatally stressed rats.

关键词： Prenatal stress Nociceptive responses Tualang honey Spinal cord

Epigenetic basis of cancer drug resistance

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Cancer Drug Resistance 2020年第1期3卷 113-116页

作者： Moammir H.aziz Aamir ahmad James H.Quillen VA Medical Center Johnson CityTN 37604USA School of Medicine University of Alabama at BirminghamBirminghamAL 35205USA

Cancer is a deadly disease and resistance to therapies is a major reason that renders it particularly lethal.A majority of research thus far has focused on genetic factors that form the basis of cancer drug ***,it is increasingly being realized that epigenetic regulation plays a very important role in determining the resistance of individual tumors to certain *** novel drugs that target epigenetic events are under investigation,thus serving as a testimony to the enormous potential of exploiting epigenetics in tackling the problem of cancer drug *** forward,a focus on epigenetics will be critical for a better understanding of the phenomenon of cancer drug resistance and for the design of novel therapies.

关键词： drug cancer drugs

Dosimetric Characteristics of a LKB:Cu,Mg Solid Thermoluminescence Detector

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Chinese Physics Letters 2013年第1期30卷 191-194页

作者： Yasser Saleh Mustafa Alajerami Suhairul Hashim ahmad Termizi Ramli Muneer aziz Saleh ahmad Bazlie Bin Abdul Kadir Mohd.Iqbal Saripan Department of Physics Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia Department of Medical Radiography Al-Azhar UniversityGaza StripPalestine Secondary Standard Dosimetery Laboratory Malaysian Nuclear Agency4300 Kajang SelangorMalaysia Faculty of Engineering Universiti Putra Malaysia43400 SerdangSelangorMalaysia

We present the main thermoluminescence characteristics of a newly borate glass dosimeter modified with lithium and potassium carbonate(LKB)and co-doped with CuO and *** enhancement of about three times has been shown with the increment of 0.1mol%MgO as a co-dopant *** effects of dose linearity,storage capacity,effective atomic number and energy dose response are *** proposed dosimeter shows a simple glow curve,good linearity up to 10^(3) Gy,close effective atomic number and photon energy *** current results suggest using the proposed dosimeter in different dosimetric applications.

关键词： independence increment potassium

Establishing a breast cancer center in Herat,Afghanistan:an implementation study

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Global Health Journal 2021年第4期5卷 204-208页

作者： aziz-ur-Rahman Niazi aziz ahmad Jami ahmad Zia Shams ahmad Saeed Mahmoodi Eckart Krapfl Stephan Falk Alexander Buia Ernst Hanisch Faculty of Medicine Herat UniversityHeratAfghanistan Afghanistan Surgeons Society-West Andisha buidingEast of Herat Stadium7 Ahmad Shah Bada RoadHeratAfghanistan Kimia Hospital Qomandani Amniya StreetHeratAfghanistan German Cancer Research Center Im Neuenheimer Feld 280Heidelberg 69120Germany Interdisziplinäres Brustzentrum Asklepios Klinik LangenRöntgenstraβe 20Langen 63225Germany Center for Histology Cytology and Molecular Diagnostics TrierMax-Planck-Str.5Trier 54296Germany Department of General Visceral and Thoracic Surgery Asklepios Klinik LangenRöntgenstraβe 20Langen 63225Germany

Objective:Breast cancer is the most common cancer in women,causing significant mortality in the world,which contributed 11.7%to the overall cancer-related mortality in *** 2018,3062 new breast cancer cases were reported accounting for 29.7%of all cancers in women in the ***,a comprehensive diagnostic and therapeutic system is lacking in *** this paper,we reported the implementation of a project aiming to establish a comprehensive breast cancer center in Herat province of ***:From July 2017,a two-year-program initiated at Kimia Hospital in *** first free diagnostic and therapeutic breast cancer project planned by the Afghanistan Surgeons Society-West and the Verein für Afghanistan-Förderung e.V.,as well supported by three international *** target populations of this project were women presenting with breast problems at Kimia Hospital in Herat and healthcare staff involved in breast cancer diagnosis and ***:A group of six medical personnel chosen to represent the breast cancer core team for breast cancer diagnosis and management were trained in *** caregivers established the breast cancer service and tumor *** a period of 20 months,a total of 632 women with breast problems presented to Kimia Hospital of whom 44(7.0%)were diagnosed with breast *** was established by a physical examination,ultrasonography,mammography,biopsy and *** included surgery,radiotherapy and *** seminars for 512 healthcare workers,1000 brochures and a movie were prepared for awareness-raising *** continuation of this project,potential resource providers were identified.A database was developed to record project ***:Implementation of this comprehensive breast cancer project resulted in significant achievements in healthcare staff capacity building,diagnosis and management of breast cancer patients in Herat *** obtai

关键词： Breast cancer Implementation Heart Afghanistan

Impedance analysis of Labisia pumila plant water status

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Information Processing in Agriculture 2015年第3期2卷 161-168页

作者： Diyana Jamaludin Samsuzana Abd aziz Desa ahmad Hawa Z.E.Jaafar Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Crop Science Faculty of AgricultureUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Labisia pumila(Kacip fatimah)is a popular medicinal plant in *** constituents of this plant have been reported to possess anticancer,antioxidant and anti-inflammatory *** growth and production of *** is greatly influenced by the plant water *** techniques to measure plant water status are generally based on the plant soil moisture,which apparently did not indicate the real water content inside the *** are other techniques to measure directly on the plant such as based on leaf water potential(LWP)and relative water content(RWC).However,these techniques are destructive and time *** this study,four levels of evapotranspiration replacement(ER)treatment which were 100%ER,75%ER,50%ER and 25%ER was applied to 30 polybags of *** *** plant water status was measured using an impedance spectroscopy technique.A pair of electrocardiogram(ECG)electrode connected to an impedance analyzer board was used to measure the impedance value of the leaf samples *** water status parameters such as LWP,RWC,volumetric moisture content(VMC),and leaf thickness were measured using standard *** results show that after 20 weeks of treatment,25%ER had the highest impedance value ranged from 0.10 MX to 0.15 MX at the frequency of 70–100 *** resistance of 100%ER at 20 weeks of treatment increased from 0.70 kX to 1.23 kX as the reactance decreased from 0.51 kX to 0.28 ***,the resistance of 25%ER increased from 1 kX to 1.10 kX as the reactance decreased from 0.88 kX to 0.83 *** polynomial regression of impedance measurements with plant water status parameters(VMC,leaf thickness,LWP and RWC)shows that LWP and RWC had the highest R2(0.78,0.73).The results show that impedance measurement technique is auspicious to evaluate plant water status.

关键词： Impedance spectroscopy Plant water status Labisia pumila Impedance Reactance Resistance