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Health 2013年第2期5卷 339-343页

作者： Faris Q. Alenzi Fahad G. B. alanazi Abdulaziz D. Al-Faim Mohamed W. Al-Rabea Waleed Tamimi Bassel Tarakji Omar Kujan Ali Al-Jabri Richard K. H. Wyse College of Applied Medical Sciences Salman bin Abdulaziz University Al-Kharj Saudi Arabia College of Medicine King Abdulaziz University Jeddah Saudi Arabia Department of Microbiol & Immunology College of Medicine Sultan Qaboos University Muscat Oman Department of Pathology and Laboratory Medicine King Abdulaziz Medical City Riyadh Saudi Arabia Department of Pathology Al-Farabi Medical College Riyadh Saudi Arabia Department of Pharmacy Ministry of Health Riyadh Saudi Arabia Department of Preventive Medicine Ministry of Health Riyadh Saudi Arabia Imperial College of Medicine London UK

Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-responsiveness, wheezing, breathlessness and coughing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% - 10% of the population and the number of worldwide cases is approximately 300 milliones. The incidence of this disease is increasing particulry in western countries [1]. It is the cause of a huge economic burden to national healthcare services. In a minority of cases, asthma is potentially fatal. After a period when fatalities appeared to be increasing [2], in recent years asthma-related mortality has progressively declined due to the develop- ment of specific asthma disease management programs, as well as the extensive use of in- haled corticosteroids [3]. Inflammation of the airways is a central component in asthma. In- flammation is associated with infliltration of the airway wall with eosinophiles and or neutron- philes mast cell degranulation and T cell active- tion. Other pathological features include, sub- basement membrane thickening, loss of epithet- lial cell integrity, goblet cells hyperplasia In- crease in airway smooth muscle mass. Eosino- phils are thought to be vital in the development of airway hyperreactivity, with the eosinophil cationic protein playing a crucial role [4]. The fact that treatment of asthma with corticos-teroids reduces eosinophils numbers and decreases airway reactivity further supports this hypothesis.

关键词： Eosinophils Asthma

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