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Anti.i.roti. effect of aloe vera i. vi.al i.fecti.n-i.duced hepati. peri.ortal fi.rosi.

World Journal of Gastroenterology 2012年第17期18卷 2026-2034页

作者： Sahar K Hegazy Mohamed el-Bedewy Aki.a Yagi department of Cli.i.al Pharmacy Faculty of PharmacyTanta UniversityTanta 8130Egypt department of i.ternal Medi.i.e Faculty of MedicineTanta UniversityTanta 8130Egypt Placenta/Aloe Research i.sti.ute Japan Bio-Products Co.Ltd.1488-4Aikawa-machiKurume-shiFukuoka Bio Factory 204Fukuoka 839-0861Japan

Ai.:To i.vesti.ate the anti.oxi.ati.e and anti.fi.roti. effects of aloe vera i. pati.nts wi.h li.er ***:Aloe vera hi.h molecular wei.ht fracti.ns(ahm) were processed by patented hyper-dry system i. combi.ati.n of freeze-dry techni.ue wi.h mi.rowave and far i.frared-ray *** healthy volunteers as the control group and 40 pati.nts were *** pati.nts were randomly subdi.i.ed i.to two equal groups:the conventi.nal group was treated wi.h placebo(starch),and ahm group was treated wi.h 0.15 gm/d ahm,both for 12 consecuti.e *** pati.nts were i.vesti.ated before and after *** acti.i.y of aspartate ami.otransferase(AST),alani.e ami.otransferase(ALT),alkali.e phosphatase(ALP),hyaluroni. aci.(HA),transformi.g growth factor-β(TGF-β) and matri.metalloprotei.ase-2(MMP-2) were *** reduced glutathi.ne(GSH) and malondi.ldehyde(MdA) levels i. li.er were assayed and the expressi.n of hepati. α-smooth muscle acti.(α-SMA) was i.enti.i.d by ***:At the start of the study,the hematoxyli. and eosi. stai.i.g revealed fi.ro-proli.erated bi.e ductules,thi.k fi.rous septa and dense i.flammatory cellular i.fi.trati.n i. the pati.nts before *** use of ahm for 12 wk si.ni.i.antly ameli.rated the fi.rosi.,i.hi.i.ed the i.flammati.n,and resulted i. mi.i.al i.fi.trati.n and mi.i.al fi.rosi. compared to the conventi.nal *** enzyme acti.i.i.s of the li.er(ALT,AST and ALP) were attenuated after treatment i. both groups,and the decrease i. the ahm group was more si.ni.i.ant as compared wi.h the conventi.nal *** to the AST,the MdA levels were si.ni.i.antly hi.her before treatment,and were attenuated after treatment i. both *** contrast,the hepati. glutathi.ne content i. the pati.nts were decreased si.ni.i.antly i. the ahm group compared to the *** serum levels of the fi.rosi. markers(HA,TGF-β and MMP-2) were also reduced si.ni.i.antly after *** expressi.n of α-SMA was m

关键词： Hepati. fi.e peri.ortal fi.rosi. Aloe vera α-smooth muscle acti. Transformi.g growth factor-β Hyaluroni. aci.

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