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东革阿里中活性成分宽缨酮的提取及纯化工艺研究

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中国药学杂志 2016年第14期51卷 1169-1175页

作者：李红亮于秀颖马崇鸣 Kiew Lik-Voon Mohammad rais Mustafa 李卫国田景奎浙江大学生物医学工程与仪器科学学院杭州310027 南京理工大学泰州科技学院江苏泰州225300 马来亚大学医学院药学系马来西亚吉隆坡50603 常熟求是科技有限公司江苏常熟215500

目的优选东革阿里的提取纯化工艺。方法以宽缨酮Eurycomanone(EN)的转移率为考察指标,综合采用单因素实验和正交实验,通过对乙醇浓度、提取时间、溶剂用量、提取次数的考察,优选东革阿里合理的提取工艺;在静态吸附和解吸实验筛选树脂的... 详细信息

目的优选东革阿里的提取纯化工艺。方法以宽缨酮Eurycomanone(EN)的转移率为考察指标,综合采用单因素实验和正交实验,通过对乙醇浓度、提取时间、溶剂用量、提取次数的考察,优选东革阿里合理的提取工艺;在静态吸附和解吸实验筛选树脂的基础上,结合单因素和正交实验优选东革阿里采用大孔树脂纯化的工艺。结果东革阿里的最佳提取工艺为:加20倍量水回流提取2次,第一次2h,第二次1h;最佳纯化工艺为:采用HPD100型大孔树脂,以70%饱吸附量上样,上样液质量浓度0.25 g生药·m L-1,上样流速3 BV·h-1,洗脱乙醇体积分数30%,洗脱流速3B V·h-1。结论优选出的工艺操作简单、稳定可行、重复性好,可推广于工业化生产应用。

关键词：东革阿里宽缨酮正交实验提取工艺纯化工艺

Tamoxifen Treatment and Risk of Endometrial Cancer： An Overview

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Journal of Health Science 2016年第1期4卷 1-7页

作者： Fadila Kouhen Fadoua rais Naoual Benhmidou Mohammed Afif Sanaa Elmajjaoui Hanan Elkacemi Tayeb Kebdani Noureddine Benjaafar Department of Radiotherapy National Institute of Oncology Mohammed Vuniversity in Rabat Rabat Morocco

For several decades, tamoxifen has proven effective in reducing recurrence and mortality for early and metastatic breast cancer with positive estrogen receptors, and has been proven to be beneficial in preventing breast cancer in high-risk women. However, tamoxifen has been associated with an increased risk of endometrial cancer by its agonist effects on the endometrium in postmenopausal women. The purpose of this article, through an exhaustive summary of literature, is to provide a better understanding of this relationship and its impact on managed care on patients.

关键词： Tamoxifen endometrial cancer screening.

Removal of Aniline Blue from Aqueous Solutions Using Ce1-xBixCrO3 (x = 0, 0.5, 1)

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Open Journal of Inorganic Non 2018年第1期8卷 1-10页

作者： Labib A. Awin Mahmoud A. El-rais Abdunnaser M. Etorki Najat A. Mohamed Wesal A. Makhlof Department of Chemistry Faculty of Science University of Tripoli Tripoli Libya Department of Chemistry School of Basic Sciences Libyan Academy Tripoli Libya

The removal of aniline blue dye from aqueous solutions using the A-site doped perovskite Ce1-xBixCrO3 (x = 0, 0.5, 1) was investigated. The perovskite oxides were synthesised using Sol-Gel method and characterised by conventional powder X-ray diffraction technique. The X-ray diffraction measurements suggested that doping with Bismuth Ion influences both the crystal structure and the particle size of the oxides, and consequently affects the adsorption properties. It was found that both CeCrO3 and Ce0.5Bi0.5CrO3 compounds are orthorhombic and have approximate particle size of 87 and 36 nm respectively, whereas BiCrO3 oxide has rhombohedral space group symmetry and the particle sizes are less than 49 nm. The batch mode study demonstrated that the removal capacities of Aniline Blue at 150 min and pH = 4.3 for Ce0.5Bi0.5CrO3, CeCrO3 and BiCrO3 are 779.67, 705.45 and 440.18 mg/g respectively. The results reflect the influence of the A site doping on the adsorption properties of the oxides. The removal of Aniline Blue was found to be negatively correlated with temperature and pH.

关键词： Removal Aniline Blue Perovskite Oxides

Enhanced Multi-Objective Grey Wolf Optimizer with Lévy Flight and Mutation Operators for Feature Selection

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Computer Systems Science & Engineering 2023年第11期47卷 1937-1966页

作者： Qasem Al-Tashi Tareq M Shami Said Jadid Abdulkadir Emelia Akashah Patah Akhir Ayed Alwadain Hitham Alhussain Alawi Alqushaibi Helmi MD rais Amgad Muneer Maliazurina B.Saad Jia Wu Seyedali Mirjalili Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Electronic Engineering University of YorkYorkYO105DDUK Computer and Information Sciences Department Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Computer Science Department Community CollegeKing Saud UniversityRiyadhP.O.Box 145111Saudi Arabia Torrens University Australia BrisbaneQLDAustralia Yonsei Frontier Lab Yonsei UniversitySeoulKorea University Research and Innovation Center Obuda UniversityBudapest1034Hungary

The process of selecting features or reducing dimensionality can be viewed as a multi-objective minimization problem in which both the number of features and error rate must be *** it is a multi-objective problem,current methods tend to treat feature selection as a single-objective optimization *** paper presents enhanced multi-objective grey wolf optimizer with Lévy flight and mutation phase(LMuMOGWO)for tackling feature selection *** proposed approach integrates two effective operators into the existing Multi-objective Grey Wolf optimizer(MOGWO):a Lévy flight and a mutation *** Lévy flight,a type of random walk with jump size determined by the Lévy distribution,enhances the global search capability of MOGWO,with the objective of maximizing classification accuracy while minimizing the number of selected *** mutation operator is integrated to add more informative features that can assist in enhancing classification *** feature selection is a binary problem,the continuous search space is converted into a binary space using the sigmoid *** evaluate the classification performance of the selected feature subset,the proposed approach employs a wrapper-based Artificial Neural Network(ANN).The effectiveness of the LMuMOGWO is validated on 12 conventional UCI benchmark datasets and compared with two existing variants of MOGWO,BMOGWO-S(based sigmoid),BMOGWO-V(based tanh)as well as Non-dominated Sorting Genetic Algorithm II(NSGA-II)and Multi-objective Particle Swarm Optimization(BMOPSO).The results demonstrate that the proposed LMuMOGWO approach is capable of successfully evolving and improving a set of randomly generated solutions for a given optimization ***,the proposed approach outperforms existing approaches in most cases in terms of classification error rate,feature reduction,and computational cost.

关键词： Feature selection multi-objective optimization grey wolf optimizer Lévy flight mutation classification

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

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Translational Neurodegeneration 2023年第1期12卷 70-89页

作者： Carolyn Tallon Benjamin J.Bell Medhinee M.Malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren Ajit G.Thomas Kristen R.Hollinger Arindom Pal Maja Mustapic Meixiang Huang Kaleem Coleman Tawnjerae R.Joe Rana rais Norman J.Haughey Dimitrios Kapogiannis Barbara S.Slusher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cell Biology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavioral Science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramural Research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University School of Medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphorylated tau(pTau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelinase2(nSMase2)-mediated cleavage of *** report,for the first time,that human tau expression elevates brain ceramides and nSMase2 *** To determine the therapeutic benefit of inhibiting this elevation,we evaluated PDDC,the first potent,selective,orally bioavailable,and brain-penetrable nSMase2 inhibitor in the transgenic PS19 AD mouse ***,we directly evaluated the effect of PDDC on tau propagation in a mouse model where an adeno-associated virus(AAV)encoding P301L/S320F double mutant human tau was stereotaxically-injected unilaterally into the *** contralateral transfer of the double mutant human tau to the dentate gyrus was *** examined ceramide levels,histopathological changes,and pTau content within EVs isolated from the mouse *** Similar to human AD,the PS19 mice exhibited increased brain ceramide levels and nSMase2 activity;both were completely normalized by PDDC *** PS19 mice also exhibited elevated tau immunostaining,thinning of hippocampal neuronal cell layers,increased mossy fiber synaptophysin immunostaining,and glial activation,all of which were pathologic features of human *** treatment reduced these *** plasma of PDDC-treated PS19 mice had reduced levels of neuronal-and microglial-derived EVs,the former carrying lower pTau levels,compared to untreated *** the tau propagation model,PDDC normalized the tau-induced increase in brain ceramides and significantly reduced the amount of tau propagation to the contralateral *** PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nSMase2 activity,leading to the slo

关键词： Alzheimer’s disease Extracellular vesicles Neutral sphingomyelinase 2 Tau Ceramide

Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature

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World Journal of Gastrointestinal Endoscopy 2022年第7期14卷 455-466页

作者： Kaouthar rais Oumayma El Eulj Najoua El Moutaoukil Imane Kamaoui Amal Bennani Ghizlane Kharrasse Abdelkrim Zazour Wafaa Khannoussi Zahi Ismaili Department of Hepatogastroenterology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Radiology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco Department of Anatomo-Pathology Mohammed Ⅵ University Hospital CenterDigestive Disease Research LaboratoryMedical SchoolMohammed Ⅰ UniversityOujda 60000Morocco

BACKGROUND Pancreatic metastases from squamous cell lung carcinoma(SCLC)are *** lesions are often asymptomatic and detected incidentally or during followup investigations,occasionally several years after removal of the primary *** SUMMARY A 56-year-old male with SCLC developed jaundice 1 mo after the cancer *** abdominal computed tomography(CT)scan showed a mass in the pancreatic head with distention of both intra-and extrahepatic biliary *** retrograde cholangiopancreatography and sphincterotomy were performed first,culminating with plastic biliary stent *** examination of the pancreatic mass sample collected by fine-needle aspiration(FNA)under endoscopic ultrasound(EUS)guidance revealed the presence of malignant cells compatible with well-differentiated squamous cell *** liver function normalized,chemotherapy was initiated with carboplatin and paclitaxel;however,4 d later,the patient presented ***-thoracoabdominal CT showed tracheoesophageal fistula and stent *** replacement with a 10 cm/10 mm uncovered metallic biliary stent and treatment of the tracheoesophageal fistula with a fully covered esophageal stent,the patient was able to start oral feeding *** died 9 mo after the initial *** The diagnosis of pancreatic metastasis from SCLC is challenging for ***-FNA is the primary exam for confirmatory diagnosis.

关键词： Squamous cell lung carcinoma Pancreatic metastasis Jaundice Esotracheal fistula Ultrasound endoscopy Case report

Adult Langerhans Cell Histiocytosis: A Rare Etiology of Spinal Cord Compression

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Open Journal of Internal Medicine 2015年第3期5卷 21-28页

作者： Fadila Kouhen Naoual Benhmiddou Mohammed Afif Fadoua rais Youssef Mahdi Basma Khannoussi Khadija Bellahamou Ibrahim Ghissassi Khouloud Boussouni Hanan Elkacemi Sanaa Elmajjaoui Tayeb Kebdani Noureddine Benjaafar Department of Radiotherapy National Institute of Oncology Rabat Morocco Department of Pathology National Institute of Oncology Rabat Morocco Department of Medical Oncology National Institute of Oncology Rabat Morocco Department of Radiology National Institute of Oncology Rabat Morocco

Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. Clinical presentation is variable, ranging from a single location in the bone to severe multivisceral involvement. Moreover, spinal involvement causing myelopathy is even rare and unusual. We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution.

关键词： Langerhans Cell Histiocytosis Adults Spinal Cord Compression

Towards a Remote Sensing and GIS-Based Technique to Study Population and Urban Growth: A Case Study of Multan

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Advances in Remote Sensing 2018年第3期7卷 245-258页

作者： Atif Ali Anam Khalid Muhammad Atif Butt Rashid Mehmood Syed Amer Mahmood Javed Sami Jahanzeb Qureshi Kashif Shafique Asdullah Khan Ghalib Rizwan Waheed Farhan Ali rais Mukhtar Muhammad Azhar Department of Space Science University of the Punjab Lahore Pakistan

In recent decades, the migration rates of the large cities of Punjab have been risen up to a considerable level due to the lack of employment opportunities as well as lack of facilities in the rural areas of the province. It has caused an unprecedented and unplanned urbanization across the urban areas of the province. This study has been undertaken to perform fractal analysis about the sprawl in rapidly growing city. GIS and remote sensing data have been used in this study as an emerging technology which is cost effective as well as accurate at the same time. Landsat images have been taken for the study and the sprawl has been calculated with the analysis of the data of each decade for past more than 40 years. It has been observed that the built up area is 47.8 to 141.12 Sq. Km whereas the pattern of urban settlement has been classified as clustered and linear, following the roads network. The temporal population growth also seconded these results. The population growth rate and population density increase, are based on the pixel based extraction of the data from satellite imagery for the period of 2000 to 2014, which is taken as a decision support tool. In 2000, the population of the district increased from 2,071,694 (1981 census) to 2,939,907 and then in 2013, it became 4,384,191 at a rate to 2.93% upturn per annum. Moreover, the study also reveals the extent of the growth of other land uses as well which may be taken as a reference that in an agricultural country like Pakistan, the natural resources are being wasted (by urbanization of the fertile land). There must be some master planning to avoid such things in the other cities as well.

关键词： Urban Sprawl Population Growth Spatio-Temporal Remote Sensing Land Use Pakistan

Alcohol-induced hypertension: Mechanism and prevention

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World Journal of Cardiology 2014年第5期6卷 245-252页

作者： Kazim Husain rais A Ansari Leon Ferder Department of Physiology Pharmacology and Toxicology Ponce School of Medicine and Health Sciences Ponce PR 00732 United States Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL 33314 United States

Epidemiological, preclinical and clinical studies es-tablished the association between high alcohol con-sumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been pro-posed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angio-tensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracel-lular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflamma-tion and oxidative injury of the endothelium by angio-tensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise trainingis one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme(ACE) inhibitors or angiotensin Ⅱ type 1 receptor blockers(ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the

关键词： Alcohol Hypertension Mechanisms Prevention/treatment Vascular endothelium