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European cooperation to tackle the legacies of hexachlorocyclohexane(HCH)and lindane

Emerging Contaminants 2022年第1期8卷 97-112页

作者： John Vijgen Boudewijn Fokke Guido van de Coterlet Katja Amstaetter Javier Sancho Carlo Bensaïah Roland Weber International HCH and Pesticides Association(IHPA) Elmevej 14Holte2840Denmark TAUW Handelskade 37P.O.Box 1337400ACDeventerthe Netherlands CDm Smith Europe GmbH Germany SARGA Sociedad Aragonesa de Gestion AgroambientalAvenida Ranillas(ED A)5-3 PLT50018ZaragozaSpain POPs Environmental Consulting Lindenfirststr.2373527 Schw€abisch GmündGermany

Hexachlorocyclohexane(HCH)waste isomers from lindane production are the largest single POPs legacy,with an estimated 4.8 to 7.4 million tonnes of disposed *** largest part of this waste e 1.8 to 3 million tonnes e was disposed in Europe,where most producers were *** paper provides a short overview of projects supported by the European Union(EU)to address this waste legacy and to implement the Stockholm Convention for this group of POPs with associated protection of soil,ecosystems and human *** report here particularly on the results of a project financed by the EU called the“HCH in EU project”,which aimed to develop a systematic inventory of sites where HCH was handled and potentially resulted in *** compiled information provide guidance for competent authorities to further assess their national HCH inventory and to further develop a strategy to address this large POP legacy in *** systematic inventory revealed that there were at least 299 sites where HCH was *** sites include 54 former production sites,76 pesticide processing plants that used lindane,59 uncontrolled HCH waste isomer deposits,29 landfills with HCH waste,34 former or current storage sites for stocks of obsolete pesticides including technical HCH or lindane,and 16 HCH treatment or disposal ***,at 31 of the sites lindane/technical HCH was used in applications with significant risk of soil pollution,such as wood *** number of sites in this latter category is likely higher and will need further *** addition to this inventory,the“HCH in EU project”produced detailed country reports,a guidance document for how to find potentially HCHimpacted sites,and a strategy document for implementing the sustainable management of these sites EU-wide,with proposed actions at the EU,country,and site ***,the project has facilitated information exchange and e together with other related EU projects e has led to sharing info

关键词： HCH Lindane POPs Stockholm convention Contaminated sites Inventory Strategy

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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan min Yeon ah Sung Tae Hwa Kim Jae min Lee Kang Seo Park Department of Internal medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ed）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ed in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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应用伽玛刀治疗脑深部和功能区海绵状血管瘤

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立体定向和功能性神经外科杂志 1999年第4期12卷 27-29页

作者：雷鹏 LD.朗斯佛 D.康茨欧卡 JC.佛里肯哥 ah.麦兹兰州军区总医院神经外科 730050 美国匹兹堡大学医学中心神经外科

目的：探讨伽玛刀对脑深部和功能区海绵状血管瘤（ＣＡ）的治疗效果及有关问题。方法：采用伽玛刀对６７例大脑半球深部、丘脑、基底节及脑干海绵状血管瘤进行治疗。结果：随访３月～８年（平均２．６年），评价其治疗效果， ... 详细信息

目的：探讨伽玛刀对脑深部和功能区海绵状血管瘤（ＣＡ）的治疗效果及有关问题。方法：采用伽玛刀对６７例大脑半球深部、丘脑、基底节及脑干海绵状血管瘤进行治疗。结果：随访３月～８年（平均２．６年），评价其治疗效果，２例死于其他疾病，６例行手术治疗。在ＭＲＩ检查随访５９例中，病变稳定好转率达９８％，并且年再出血发生率大大降低。结论：应用伽玛刀治疗脑深部及险要部位的ＣＡ是一种无创伤、效果比较好的方法。

关键词：伽玛刀治疗脑海绵状血管瘤海绵状血管瘤

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急性角膜排斥患者的房水蛋白组学分析

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 10-10页

作者： Funding m. Vorum H. HonoréB. 陈立军 Department of Ophthalmology úrhus University Hospital Nφrebrogade 44 8000 úrhus C Denmark

Purpose: To compare the basic proteomic composition of aqueous humour (ah) fro m patients with corneal rejection (patients) with ah from patients with cataract (controls). methods: Aqueous humour was analysed for total protein concentratio n using Bradford’s method and for protein composition using two-dimensional (2 D) gel electrophoresis. Image analysis was used to detect protein spots in 2D ge ls that were increased by more than factor 2 in patients as compared with contro ls. Increased spots were identified by immunoblotting and mass spectrometry. Res ults: Aqueous humour from patients contained significantly higher total protein concentration than did ah from controls. A total of 31 spots were significantly increased in 2D gels from patients. The spots were derived from albumin, α1-an titrypsin, apolipoprotein J, cytokeratin type II, serin proteinase inhibitor and transthyretin. After correction of spot volumes by total protein concentrations , 10 spots derived from albumin, cytokeratin type II and α1-antitrypsin remain ed significantly increased. Conclusion: The proteomic composition of ah differed significantly between patients and controls. The identified proteins suggest th at the changes in ah are due to at least three different mechanisms: breakdown o f the aqueousblood barrier, enzymatic degradation, and liberation of locally syn thesized proteins.

关键词：蛋白组学蛋白印迹细胞角蛋白排斥反应白内障眼抗胰蛋白酶丝氨酸蛋白酶总蛋白含量质谱测定法载脂蛋白

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