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A systematic review of progenitor survival and maturation in Parkinsonian models

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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soundscape Dynamics at Anuran Reproductive sites in Pannonian Biogeographical Region：Effects of Road Noise on Vocal Activity

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Asian Herpetological Research 2016年第1期7卷 34-40页

作者： András WEIPERTH ed sMITH szilvia sIMIGLA Miklòs PUKY Yezhong TANG MTA Centre Jor Ecological Research Danube Research Institute H- 1113 Budapest Karolina ut 29 Hungary Department of Psychology University of Maryland College Park MD 20742 USA Chengdu Institute of Biology Chinese Academy of Sciences # 9 of Section 4 South Renmin Road Chengdu 610041 Sichuan China

The emerging field of soundscape ecology views ecosystems in terms of biophony, geophony and anthrophony. soundscape ecology considers the effects of sound on fauna, and this research focuses on anuran breeding lek soundscapes. The sensitivity of anuran breeding leks to acoustic disturbances makes breeding leks an important venue for a comparative soundscape study. We made long-term（〉 24 h） sound recordings in three representative wetlands and short-term（〈 30 min） recordings in ten sites in the Pannonian Biogeographical Region of Hungary and around the Hungary and slovakia border. Long-term soundscapes of the floodplain stretch, where there is relatively minor anthrophonical disturbance, showed an obvious circadian change in sound intensities. The site with moderate sound contamination exhibited a disturbed pattern of circadian sound variation, while the site with heavy traffic noise displayed an apparently random temporal soundscape. At different amphibian breeding sites during mating season, our short-term recordings were dominated by anuran calls, bird songs and wind noises, while insect calls and rain were present to a lesser degree. Our study indicates that vehicle traffic noise is a severe imposition to the natural soundscape, and suggests that soundscape monitoring can provide a reliable and sensitive index of environmental change for both short-term and long-term periods.

关键词： soundscape monitoring anuran breeding site biophony geophony anthrophony

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Operational guidance for aeration and flow augmentation for the Chicago Area Waterway system—A case study

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Water science and Engineering 2023年第4期16卷 345-358页

作者： Charles s.Melching Jennifer Wasik ed staudacher Thomas Minarik Melching Water solutions LLC GreenfieldWI 53221USA Metropolitan Water Reclamation District of Greater Chicago ChicagoIL 60611USA Metropolitan Water Reclamation District of Greater Chicago CiceroIL 60804USA

The Chicago Area Waterway system(CAWs)is a 133.9 km branching network of navigable waterways controlled by hydraulic structures,in which the majority of the flow is treated wastewater effluent and there are periods of substantial combined sewer *** CAWs comprises a network of effluent dominated *** stringent dissolved oxygen(DO)standards and a reduced flow augmentation allowance have been recently applied to the ***,a carefully calibrated and verified one-dimensional flow and water quality model was applied to the CAWs to determine emission-based real-time control guidelines for the operation of flow augmentation and aeration *** goal of these guidelines was to attain DO standards at least 95%of the ***“optimal”guidelines were tested for representative normal,dry,and wet *** finally proposed guidelines were found in the simulations to attain the 95%target for nearly all locations in the CAWs for the three test *** developed operational guidelines have been applied since 2018 and have shown improved attainment of the DO standards throughout the CAWs while at the same time achieving similar energy use at the aeration stations on the Calumet River system,greatly lowered energy use on the Chicago River system,and greatly lowered discretionary diversion from Lake Michigan,meeting the recently enacted lower amount of allowed annual discretionary *** case study indicates that emission-based real-time control developed from a well calibrated model holds potential to help many receiving water bodies achieve high attainment of water quality standards.

关键词： Water quality modeling Water quality management Real-time control stream aeration Flow augmentation Dissolved oxygen

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A Nonstandard Lévy-Khintchine Formula and Lévy Processes

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Acta Mathematica sinica,English series 2008年第2期24卷 241-252页

作者： siu ah NG school of Mathematical sciences University of KwaZulu-Natal Pietermaritzburg 3209 South Africa

We use methods from nonstandard analysis to obtain a short and simple derivation of the Levy-Khintchine formula via an explicit construction of certain laws of the infinitesimal increments. Consequently, any arbitrary... 详细信息

关键词： Levy processes Levy-Khintchine formula nonstandard analysis infinitesimal hyperfinite

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synthesis of crosslinked polystyrene particles by seeded batch polymerization with monomer absorption

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Transactions of Nonferrous Metals society of China 2011年第A1期21卷 153-159页

作者： Ki-Chang LEE Han-ah WI Department of Polymer science and Engineering Engineering Research Institute Gyeongsang National University

A highly crosslinked, monodispersed polystyrene（Ps） particle was prepared by a seeded batch dispersion polymerization with a monomer absorption method. Prior to polymerization, 1,9 lam monodispersed Ps seed particles were treated under an optimum condition of monomer absorption. The effects of divinylbenzebe（DVB） concentration and polymerization temperature were examined for styrene（in Ps seed）/styrene（in the second stage） mass ratio of 1：1 in the medium range of EtOH/water mass ratio of 100/0-80/20 and 2.3 μm uniform crosslinked Ps particles containing 15%-20% （mass fraction） DVB were prepared at 60-70 ℃. The results show that monomer absorption before the second stage of polymerization is more effective to prepare highly crosslinked monodispersed Ps particles.

关键词： crosslinked polystyrene particle seeded batch dispersion polymerization monomer absorption divinylbenzene (DVB)

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Normalized residual displacement spectra for post-mains

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 403-421页

作者： saeed Amiri Alireza Garakaninezhad edén Bojórquez structural Engineering Research Center International Institute of Earthquake Engineering and Seismology(IIEES)TehranIran Department of Civil Engineering Faculty of EngineeringUniversity of JiroftJiroftKermanIran Facultad de Ingeniería Universidad Autónoma de SinaloaCalz.de las Américas y Boulevard UniversitariosCd.Universitaria80040 CuliacánMexico

Residual displacement,as a significant measure of structural inelasticity,is effectively used in post-earthquake seismic assessment of *** demand can be considered for seismic evaluation of structures under multiple *** study introduces a simple and novel index to predict the residual displacement of mainshock-damaged structures against subsequent *** proposed index is defined as a ratio between residual displacement of damaged structures against aftershock and peak inelastic displacement of intact structures under *** this study,constantstrength spectra based on the index are developed considering the effects of important structural characteristics and also significant seismic ***,analytical equations are presented to predict the proposed index for bi-linear single-degree-of-freedom(sDOF)systems considering both the effects of positive and negative polarities of ***,an equation is suggested to estimate the peak inelastic displacement of intact systems under mainshock,which is required to compute the index.

关键词： residual displacement demand mainshock-aftershock sequences peak inelastic displacement constantstrength spectra

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Comparison of Measurements for Enhanced Diffusion Problem in Chemical Reaction systems

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Chinese Journal of Chemistry 2024年第14期42卷 1659-1664页

作者： ah-Young Jee Ziyang Wen Huan Wang Beijing National Laboratory for Molecular sciences College of Chemistry and Molecular EngineeringBeijing Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationPeking UniversityBeijing100871 China

The problem of molecular diffusion in the soup of chemical reactions attracts mounting interest across fields ranging from chemistry to biophysics to material *** reactions involve bond breakup and formation,whose time scale is typically on the orders of fs to ps,while molecular diffusion occurs at time scales ofμs to *** two processes are often considered orthogonal,given the vastly different *** serial results show that the enzyme's diffusion is enhanced in a substrate-dependent manner,which was further extended to small molecule reaction systems,challenging this classical ***,the results from different groups using different techniques do not quantitatively agree,and a general mechanism is yet to be *** summarize experimental studies on diffusion problems and seek to reconcile the interpretation with understanding the limits of measurement tools and the chemical nature of reaction *** molecular diffusion in chemical reactions will provide fresh thoughts in designing chemical systems such as molecular machines that harvest work at the nanoscale in a controllable manner.

关键词： Molecular diffusion Chemical reactions Enzyme reactions Active matter Diffusion measurements single-molecule studies Fluorescence Time-resolved spectroscopy

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studies on the flow and distribution of leukocytes in mesentery microcirculation of rats

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World Journal of Gastroenterology 1999年第3期5卷 231-234页

作者： Jiang Y Liu ah Zhao Ks Mil Med Univ 1st Chinese PLA Lab Shock & Microcirculat Guangzhou 510515 Peoples R China

AIM To study the effect of leukocyteendothelium interaction (LEI) on the flow anddistribution of leukocytes in microcirculationunder physiological *** A microcirculation image multipleparameter computer analysis system (MIMPCAs)was used to study the flow and distribution ofleukocytes in mesentery microcirculation of ratsIn *** The difference of visible leukocyteflux (VLF) was as high as 131 times in thearterioles and venules with similar diameter andblood velocity. The visible leukocytes rolledalong the blood vessel wall as a" jerky"movement. The frequency distribution of thevisible leukocyte velocity (VLV) showed a "twopeak" Curve. The low peak value was at 10 pm/ s-- 15 pm/ s while the high peak fell between25 pm/ s-- 30 pm/ s. With the increase of diameterof venules, VLF increased while the VLVremained at the same level. With the increase ofRBC velocity, VLV trends to elevate and VLF tofal I *** The results herein might providea basic theory for the study on the mechanism ofLEI under physiological condition and novelmethods for the prevention and treatment of highLEI in many pathological

关键词： studies on the flow and distribution of leukocytes in mesentery microcirculation of rats flow

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An Abstract Reachability Approach by Combining HOL Induction and Multiway Decision Graphs

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Journal of Computer science & Technology 2009年第1期24卷 76-95页

作者： sa'ed Abed Otmane Ait Mohamed Ghiath Al-sammane ECE Department Concordia UniversityMontrealCanada

In this paper, we provide a necessary infrastructure to define an abstract state exploration in the HOL theorem prover. Our infrastructure is based on a deep embedding of the Multiway Decision Graphs （MDGs） theory in HOL. MDGs generalize Reduced Ordered Binary Decision Diagrams （ROBDDs） to represent and manipulate a subset of first-order logic formulae. The MDGs embedding is based on the logical formulation of an MDG as Directed Formulae （DF）. Then, the MDGs operations are defined and the correctness proof of each operation is provided. The MDG teachability algorithm is then defined as a conversion that uses our MDG theory within HOL. Finally, a set of experimentations over benchmark circuits has been conducted to ensure the applicability and to measure the performance of our approach.

关键词： HOL theorem prover multiway decision graphs correctness reachability analysis

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Thermal Efficiency for Each Zone of a solar Pond

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Chinese Physics Letters 2011年第10期28卷 281-283页

作者： BEZİR CİCEK Nalan ŞahİNŞENCAN Arzu Department of Physics Faculty of ScienceSuleyman Demirel UniversityTurkey Department of Mechanical education Technical Education FacultySüleyman Demirel UniversityTurkey

A salt gradient solar pond with a surface area of 3.5×3.5 m^(2) and a depth of 2 m is *** collapsible covers are used to reduce thermal energy loss from the surface of the solar pond during the night and to increase the thermal efficiency of the pond solar energy harvesting during *** covers can be rotated between 0 and 180°by a controlled electric motor and has insulation and reflection *** thermal efficiency for each solar pond zone is investigated theoretically and experimentally.

关键词： properties insulation harvesting

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