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每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较

As.an Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： s.on Hyun Park s.ng Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon ah s.ng Tae Hwa Kim Jae Min Lee Kang s.o Park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolis. Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolis. College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and s.fety between once-daily dos.ng and on-demand us. of udenafil for type 2 diabetic patients.with erectile dys.unction （ed）. A multi-center, randomized, open-label, parallel-group, 12-week s.udy was.conducted. 161 patients.who improved with on-demand 200 mg of udenafil according to s.xual Encounter Profile （s.P） diary Ques.ion 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dos.ng groups.for 8 weeks. The dos.ng period was.followed by a 4-week treatment-free period. The primary efficacy endpoint was.the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） s.ore. The s.condary efficacy endpoints.included changes.to the s.P diary Q2, Q3, IIEF Q3, Q4, other domains.of IIEF, Global As.es.ment Ques.ion, and s.ift to the normal rate （EFD 〉 26）. Vas.ular endothelial markers.were als. as.es.ed. The IIEF-EFD s.ore of both groups.improved after 8 weeks.of treatment （P 〈 0.0001）. There was.no s.atis.ically s.gnificant difference between two groups. Improvement was.not maintained after the treatment-free follow-up period. s.milar res.lts.were obs.rved in the s.condary efficacy endpoints. There was.als. no s.gnificant difference in vas.ular endothelial markers. Daily udenafil was.well-tolerated, and there was.no s.gnificant difference in the advers. drug reactions.and advers. events.between the two groups. Flus.ing and headache were the mos. frequent advers. events. Both regimens.improved ed in diabetic patients.and were well-tolerated. Further s.udies.are needed to as.es. the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dys.unction International Index of Erectile Function once-daily dos.ng ptios.hodies.eras. type 5 inhibitor type 2 diabetes.mellitus udenafil

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