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Potential of Fisetin as a Nutri-cosmetics Material through Evaluating Anti-oxidant and Anti-adipogenic Activities

北京日化 2016年第3期 64-71页

作者： Myung-Soo Shon Ryeong-Hyeon Kim Ji-Hye Song O Jun Kwon ah-reum lee Hae-Ok Kim Seong-Soo Roh Gyo-Nam Kim Department of Food Science and Biotechnology Kyunonam University Changwon-si Gyeongsangnam-do Korea International Ginseng & Herb Research Institute Geumscm-an Chungcheongnam-do Korea Gyeongbuk Regional Industry Evaluation Daegyeong Institute for Regional Program Evaluation Gyeongsan-si Gyeongsongbuk-doKorea Department of Herbology Daegu Haany University Gyeongsan-si Gyeongsangbuk-do Korea Department of Nursing Kyungnam University Changwon-si Gyeongsangnam-do Korea

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Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

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Neuroscience Bulletin 2022年第4期38卷 373-385页

作者： Seong-ah Kim Jun Ho Jang Wheedong Kim Pa reum lee Yong Ho Kim Hue Vang Kihwan lee Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080Republic of Korea Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Gachon Pain Center and Department of Physiology College of MedicineGachon UniversityIncheon 21999Republic of Korea Tooth-Periodontium Complex Medical Research Center School of DentistrySeoul National UniversitySeoul 03080Republic of Korea

Mitochondrial reactive oxygen species(mROS)that are overproduced by mitochondrial dysfunction are linked to pathological conditions including sensory ***,we explored whether mROS overproduction induces itch through transient receptor potential canonical 3(TRPC3),which is sensitive to *** injection of antimycin A(AA),a selective inhibitor of mitochondrial electron transport chain complex III for mROS overproduction,produced robust scratching behavior in naïve mice,which was suppressed by MitoTEMPO,a mitochondria-selective ROS scavenger,and Pyr10,a TRPC3-specific blocker,but not by blockers of TRPA1 or *** activated subsets of trigeminal ganglion neurons and also induced inward currents,which were blocked by MitoTEMPO and ***,dry skin-induced chronic scratching was relieved by MitoTEMPO and Pyr10,and also by resveratrol,an *** together,our results suggest that mROS elicit itch through TRPC3,which may underlie chronic itch,representing a potential therapeutic target for chronic itch.

关键词： Mitochondria Reactive oxygen species TRPC3 Itch Dry skin Trigeminal ganglia

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Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第48期20卷 18360-18366页

作者： Eunmi ahn Ki Young Son Dong Wook Shin Min Kyu Han Hyejin lee ah reum An Eun Ho Kim Be Long Cho Department of Family Medicine Seoul National University Hospital Cancer Survivorship Clinic Seoul National University Cancer HospitalSeoul 110-744 South Korea

AIM: To evaluate perceived risk, diagnostic testing, and acceptance of a diagnosis of irritable bowel syndrome (IBS) among the Korean laypersons.

关键词： Diagnostic testing Patient attitude Positive diagnosis Functional gastrointestinal disease Irritable bowel syndrome

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Synthesis of crosslinked polystyrene particles by seeded batch polymerization with monomer absorption

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 153-159页

作者： Ki-Chang lee Han-ah WI Department of Polymer Science and Engineering Engineering Research Institute Gyeongsang National University

A highly crosslinked, monodispersed polystyrene（PS） particle was prepared by a seeded batch dispersion polymerization with a monomer absorption method. Prior to polymerization, 1,9 lam monodispersed PS seed particles were treated under an optimum condition of monomer absorption. The effects of divinylbenzebe（DVB） concentration and polymerization temperature were examined for styrene（in PS seed）/styrene（in the second stage） mass ratio of 1：1 in the medium range of EtOH/water mass ratio of 100/0-80/20 and 2.3 μm uniform crosslinked PS particles containing 15%-20% （mass fraction） DVB were prepared at 60-70 ℃. The results show that monomer absorption before the second stage of polymerization is more effective to prepare highly crosslinked monodispersed PS particles.

关键词： crosslinked polystyrene particle seeded batch dispersion polymerization monomer absorption divinylbenzene (DVB)

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Digital exchange attributes and the risk of closure

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Blockchain(Research and Applications) 2023年第2期4卷 136-145页

作者： Seung ah lee George Milunovich Department of Actuarial Studies and Business Analytics Macquarie UniversitySydneyNSW2109Australia

Presently,there are over 500 cryptocurrency exchanges worldwide and more than 19,700 different *** the fact that cryptocurrency trading is possible via private peer-to-peer transactions,more than 90%of trading occurs on organised exchanges,which provide convenience and ***,centralised cryptocurrency exchanges are regarded as high-value targets by criminals and are often victims of *** this paper,we investigate the risk of cryptocurrency exchange closures and develop predictive models to forecast which markets will close down and which ones will remain active using publicly available *** models perform well and reach a high level of classification *** trading volume,the availability of public information on exchange staff,exchange lifetime,and several cybersecurity features are identified as key attributes in predicting exchange ***,our models do not account for all sources of risk,e.g.,potential fraud and mismanagement of client funds committed by the exchanges themselves,and market participants are encouraged to carefully consider where and how they store their digital assets.

关键词： Cryptocurrency markets Digital exchange Closure Classification Predictive models

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The anti-tubercular activity of Melia azedarach L. and Lobelia chinensis Lour. and their potential as effective anti-Mycobacterium tuberculosis candidate agents

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 830-835页

作者： Won Hyung Choi In ah lee Department of Biomedical Science School of Medicine Kyung Hee University Department of Medical Zoology School of Medicine Kyung Hee University Department of Chemistry College of Natural Science Kunsan National University

Objective: To evaluate the anti-mycobacterial activity of Melia azedarach L.(M. azedarach) and Lobelia chinensis Lour.(L. chinensis) extracts against the growth of Mycobacterium tuberculosis(M. tuberculosis).Methods: The anti-M. tuberculosis activity of M. azedarach and L. chinensis extracts were evaluated using different indicator methods such as resazurin microtiter assay(REMA) and mycobacteria growth indicator tube(MGIT) 960 system assay. The M. tuberculosis was incubated with various concentrations(50–800 mg/m L) of the extracts for 5 days in the REMA, and for 4 weeks in MGIT 960 system ***: M. azedarach and L. chinensis extracts showed their anti-M. tuberculosis activity by strongly inhibiting the growth of M. tuberculosis in a concentration-dependent manner in the REMA and the MGIT 960 system assay. Particularly, the methanol extract of M. azedarach and n-hexane extract of L. chinensis consistently exhibited their effects by effectively inhibiting the growth of M. tuberculosis in MGIT 960 system for 4 weeks with a single-treatment, indicating higher anti-M. tuberculosis activity than other extracts,and their minimum inhibitory concentrations were measured as 400 mg/m L and 800 mg/m L, ***: These results demonstrate that M. azedarach and L. chinensis extracts not only have unique anti-M. tuberculosis activity, but also induce the selective antiM. tuberculosis effects by consistently inhibiting or blocking the growth of M. tuberculosis through a new pharmacological action. Therefore, this study suggests the potential of them as effective candidate agents of next-generation for developing a new anti-tuberculosis drug, as well as the advantage for utilizing traditional medicinal plants as one of effective strategies against tuberculosis.

关键词： Lobelia chinensis Lour. Melia azedarach L. MGIT 960 system Drug susceptibility Tuberculosis

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Recognition of Association Between Blood Stasis Syndrome and Traumatic Injury among Doctors of Korean Medicine:A Cross-Sectional Observation Study

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Chinese Journal of Integrative Medicine 2018年第4期24卷 254-259页

作者： Jeeyoun Jung Mi Mi Ko Ju ah lee Myeong Soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome（BSS） patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. Methods： Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine（DKMs） determined the diagnosis of BSS or non-BSS based on the subjects＇ signs and symptoms. The scores assigned to BSS symptoms and DKMs＇ reasons for diagnosing BSS in patients with traumatic injury were investigated. Both medication and herbal prescription records from a 3-month period were collected for all patients diagnosed with BSS by both DKMs. Results： A total of 169 of 204（82.8%） patients received consistent diagnosis related to BSS by two DKMs. Among them, 54.4%（92 cases） were diagnosed with BSS, and 45.6%（77 cases） were not diagnosed with BSS. DKMs most frequently cited symptoms of recent traumatic injury as justifications for BSS diagnoses, and also selected pain-related indicators such as abdominal pain, sharp pain and nocturnal pain as important reasons in diagnosing BSS. In addition, an inconsistency in the pattern identification theory with respect to traumatic injury was observed. Although only 92 cases（54.4%） of patients were diagnosed with BSS, 77.6% of them were prescribed decoctions for BSS. Conclusions： DKMs considered traumatic injury could cause BSS, and utilized decoction for BSS in patients with traumatic injury without confirming a diagnosis of BSS because they assumed the main symptoms or pathologies of traumatic injury to be closely related to BSS.

关键词： blood stasis syndrome Korean medicine traumatic injury herbal medicine diagnosis pattern identification

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Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review

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World Journal of Gastroenterology 2024年第15期30卷 2087-2090页

作者： ah Young lee Joo Young Cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135Korea

Upper gastrointestinal(GI)hemorrhage presents a substantial clinical *** management typically involves resuscitation and endoscopy within 24 h,although the benefit of very early endoscopy(leeding,preventing rebleeding,and using a multimodal approach encompassing endoscopic,pharmacological,angiographic,and surgical *** agents such as vasopressin,prostaglandins,and proton pump inhibitors are effective,but the increase in antithrombotic use has increased GI bleeding *** hemostasis,particularly for nonvariceal bleeding,employs techniques such as electrocoagu-lation and heater probes,with concerns over tissue injury from monopolar *** methods such as Hemospray and Endoclot show promise in creating mechanical tamponades but have ***,the first-line therapy includes thermal probes and hemoclips,with over-the-scope clips emerging for larger ulcer *** gold probe,combining bipolar electrocoagulation and injection,offers targeted coagulation but has faced device-related *** advancements involve combining techniques and improving endoscopic imaging,with studies exploring combined approaches showing *** research is crucial for developing standardized and effective hemorrhage management strategies.

关键词： Upper gastrointestinal bleeding Hemostasis Endoscopy Probe Spray Clip

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Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases

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Chinese Journal of Integrative Medicine 2018年第10期24卷 752-757页

作者： Jeeyoun Jung Mi Mi Ko Myeong Soo lee So Min lee Ju ah lee Korea Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the important diagnostic indicators for blood stasis syndrome （BSS） in patients of childbearing age with gynaecological diseases. Methods： A partial least squared-discriminant analysis （PLS-DA） were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine （DKMs） among BSS patients with gynaecological diseases were also investigated. Results： A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63 （61.7%） and 40 （38.8%） were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion： DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases.

关键词： blood stasis syndrome diagnosis gynaecological disease pattern identification

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Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1127-1138页

作者： In-ah lee Alan Kamba Daren Low Emiko Mizoguchi Gastrointestinal Unit Department of Medicine Harvard Medical School Center for the Study of Inflammatory Bowel Disease Massachusetts General Hospital Harvard Medical School

Family 18 chitinases have a binding capacity with chitin, a polymer of N-acetylglucosamine. Recent studies strongly suggested that chitinase 3-like 1(CHI3L1, also known as YKL-40) and acidic mammalian chitinase, the two major members of family 18 chitinases, play a pivotal role in the pathogenesis of inflammatory bowel disease(IBD), bronchial asthma and several other inflammatory disorders. Based on the data from highthroughput screening, it has been found that three methylxanthine derivatives, caffeine, theophylline, and pentoxifylline, have competitive inhibitory effects against a fungal family 18 chitinase by specifically interacting with conserved tryptophans in the active site of this protein. Methylxanthine derivatives are also known as adenosine receptor antagonists, phosphodiesterase inhibitors and histone deacetylase inducers. Anti-in-flammatory effects of methylxanthine derivatives have been well-documented in the literature. For example, a beneficial link between coffee or caffeine consumption and type 2 diabetes as well as liver cirrhosis has been reported. Furthermore, theophylline has a long history of being used as a bronchodilator in asthma therapy, and pentoxifylline has an immuno-modulating effect for peripheral vascular disease. However, it is still largely unknown whether these methylxanthine derivativemediated anti-inflammatory effects are associated with the inhibition of CHI3L1-induced cytoplasmic signaling cascades in epithelial cells. In this review article we will examine the above possibility and summarize the biological significance of methylxanthine derivatives in intestinal epithelial cells. We hope that this study will provide a rationale for the development of methylxanthine derivatives, in particular caffeine,-based antiinflammatory therapeutics in the field of IBD and IBDassociated carcinogenesis.

关键词： Adherent-invasive Escherichia coli Chitinase 3-like 1 Chitinase inhibitors Intestinal epithelial cells Host-microbial interactions Inflammatory bowel disease

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