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Performance of the EDACS-ADP incorporating high-sensitivity troponin assay:Do components of major adverse cardiac events matter?

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World Journal of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yedalm Yoo shin ahn Bora Chae Won young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

BACKGROUND:The accelerated diagnostic protocol(ADP)using the Emergency Department Assessment of Chest pain Score(EDACS-ADP),a tool to identify patients at low risk of a major adverse cardiac event(MACE)among patients presenting with chest pain to the emergency department,was developed using a contemporary troponin *** study was performed to validate and compare the performance of the EDACS-ADP incorporating high-sensitivity cardiac troponin I between patients who had a 30-day MACE with and without unstable angina(MACE I and II,respectively).METHODS:A single-center prospective observational study of adult patients presenting with chest pain suggestive of acute coronary syndrome was *** performance of EDACS-ADP in predicting MACE was assessed by calculating the sensitivity and negative predictive ***:Of the 1,304 patients prospectively enrolled,399(30.6%;95%confidence interval[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the rates of MACE I and II were 1.3%(5/399)and 1.0%(4/399),*** EDACS-ADP showed sensitivities and negative predictive values of 98.8%(95%CI:97.2%–99.6%)and 98.7%(95%CI:97.0%–99.5%)for MACE I and 98.7%(95%CI:96.8%–99.7%)and 99.0%(95%CI:97.4%–99.6%)for MACE II,***:EDACS-ADP could help identify patients as safe for early ***,when unstable angina was added to the outcome,the 30-day MACE rate among the designated lowrisk patients remained above the level acceptable for early discharge without further evaluation.

关键词： Chest pain Major adverse cardiac event Acute coronary syndrome Emergency department

Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： young Hyun shin Chul Min Park Hong Gi Kim Dong-Eun Kim Min Suk Choi Jeong-ah Kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

Convolutional Neural Network-Based Regression for Predicting the Chloride Ion Diffusion Coefficient of Concrete

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Computers, Materials & Continua 2022年第3期70卷 5059-5071页

作者： Hyun Kyu shin Ha young Kim Sang Hyo Lee Architectural Engineering Hanyang University ERICAAnsan15588Korea Graduate School of Information Yonsei UniversitySeoul03722Korea Division of Smart Convergence Engineering Hanyang University ERICAAnsan15588Korea

The durability performance of reinforced concrete(RC)building structures is significantly affected by the corrosion of the steel reinforcement due to chloride penetration,thus,the chloride ion diffusion coefficient should be investigated through experiments or theoretical equations to assess the durability of an RC *** study aims to predict the chloride ion diffusion coefficient of concrete,a heterogeneous material.A convolutional neural network(CNN)-based regression model that learns the condition of the concrete surface through deep learning,is developed to efficiently obtain the chloride ion diffusion *** the model implementation to determine the chloride ion diffusion coefficient,concrete mixes with w/c ratios of 0.33,0.40,0.46,0.50,0.62,and 0.68,are cured for 28 days;subsequently,the surface image data of the specimens are ***,the proposed model predicts the chloride ion diffusion coefficient using the concrete surface image data and exhibits an error of approximately 1.5E−12 m^(2)/*** results suggest the applicability of proposed model to the field of facility maintenance for estimating the chloride ion diffusion coefficient of concrete using images.

关键词： Chloride ion diffusion coefficient convolutional neural network deep learning

Korean Morphological Analysis for Korean-Vietnamese Statistical Machine Translation

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Journal of Electronic Science and Technology 2017年第4期15卷 413-419页

作者： Quang-Phuoc Nguyen Joon-Choul shin Cheol-young Ock Department of IT Convergence University of Ulsan Ulsan 44610 Republic of Korea

This paper describes the experiments with Korean-to-Vietnamese statistical machine translation(SMT). The fact that Korean is a morphologically complex language that does not have clear optimal word boundaries causes a major problem of translating into or from Korean. To solve this problem, we present a method to conduct a Korean morphological analysis by using a pre-analyzed partial word-phrase dictionary(PWD).Besides, we build a Korean-Vietnamese parallel corpus for training SMT models by collecting text from multilingual magazines. Then, we apply such a morphology analysis to Korean sentences that are included in the collected parallel corpus as a preprocessing step. The experiment results demonstrate a remarkable improvement of Korean-to-Vietnamese translation quality in term of bi-lingual evaluation understudy(BLEU).

关键词： Factored translation models Korean-Vietnamese parallel corpus morphological analysis statistical machine translation(SMT)

Computed tomography coronary angiography after excluding myocardial infarction:high-sensitivity troponin versus risk score-guided approach

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World Journal of Emergency Medicine 2023年第6期14卷 428-433页

作者： Won Jae Yoo shin ahn Bora Chae Won young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republicof Korea

BACKGROUND:Patients with suspected acute coronary syndrome (ACS) in whom myocardial infarction has been ruled out are still at risk of having obstructive coronary artery disease (CAD).This rate is higher among patients with intermediate high-sensitivity troponin I (hsTnI) concentrations (5 ng/L to 99th percentile) than low concentrations (<5 ng/L).Therefore,an intermediate concentration has been suggested as a candidate for downstream investigation with computed tomography coronary angiography(CTCA).We tried to compare the HEART score-guided ***-guided approach for identifying obstructive ***:From a prospective cohort study of patients presenting to the emergency department with suspected ACS,433 patients without elevated hsTnI who also underwent CTCA were selected and *** performances of hsTnI concentration and HEART score were compared using sensitivity,specificity,positive predictive value (PPV),and negative predictive value (NPV).RESULTS:Overall,120 (27.7%) patients had obstructive *** with intermediate hsTnI concentrations were more likely to have obstructive CAD than those with low hsTnI concentrations(40.0%vs.18.1%);patients with non-low-risk HEART scores (≥4 points) were also more likely to have obstructive CAD than those with low-risk scores (0 to 3 points)(41.0%vs.7.6%).The HEART score had higher sensitivity and NPV for detecting obstructive CAD in each classification than hsTnI concentration (sensitivity:89.2%vs.63.3%;NPV:92.4%vs.81.9%,respectively).CONCLUSION:After excluding myocardial infarction in patients with suspected ACS,adding the HEART score for selecting candidates for CTCA could improve patient risk stratification more accurately than relying on hsTnI concentration.

关键词： Chest pain Coronary artery disease Acute coronary syndrome Troponin HEART score

Characterization of plasma electrolytic oxide formed on AZ91 Mg alloy in KMnO_4 electrolyte

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中国有色金属学会会刊：英文版 2009年第4期19卷 829-834页

作者： Duck-young HWANG Ki-Ryong shin Bongyoung YOO Dong-Heon LEE Deok-Yong PARK Dong-Hyuk shin Department of Metallurgy and Materials Science Hanyang University Ansan 426-791 Korea Department of Applied Materials Engineering Hanbat National University Daejon 305-719 Korea 不详

The aim of this work is to investigate microstructure,corrosion resistance characteristics and nanohardness of the oxide layer on AZ91 Mg alloy by applying different voltage with KMnO4 contained *** are lots of closed pores that are filled with another oxide compound compared with the typical surface morphology with pore coated until 350 V of coating *** thickness of oxide layer increases with increasing coating *** oxide layer formed on AZ91 Mg alloy in electrolyte with potassium permanganate consists of MgO and *** potential of the oxide layer on AZ91 Mg alloy obtained at different plasma electrolytic oxidation(PEO) reaction stages increases with increasing coating *** corrosion resistance of AZ91 Mg alloy depends on the existence of the manganese oxide in the oxide *** inner barrier layer composed of the MgO and Mn2O3 may serve as diffusion barrier to enhance the corrosion resistance and may partially explain the excellent anti-corrosion performance in corrosion *** values increase with increasing coating *** increase in the nanohardness may be due to the effect of manganese oxide in the oxide layer on AZ91 Mg alloy coated from electrolyte containing KMnO4.

关键词： AZ91镁合金等离子体电解高锰酸钾氧化特性电解液氧化层厚度纳米硬度耐腐蚀性

Influence of potassium pyrophosphate in electrolyte on coated layer of AZ91 Mg alloy formed by plasma electrolytic oxidation

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中国有色金属学会会刊：英文版 2009年第4期19卷 824-828页

作者： Jin-young CHO Duck-young HWANG Dong-H eon LEE Bongyoung YOO Dong-Hyuk shin Department of Metallurgy and Materials Scienc e Hanyang University

The effect of potassium pyrophosphate in the electrolyte on plasma electrolytic oxidation(PEO) process for AZ91 Mg alloy was *** morphologies and chemical compositions of the coating layer on the AZ91 Mg alloy were evaluated and corrosion resistance was also estimated by potentiodynamic polarization *** coating layer on AZ91 Mg alloy coated from the Bath 2 containing 0.03 mol/L of potassium pyrophosphate for 360 s exhibited considerably dense structure and contained 11%-18%(mass fraction) of *** higher content of phosphorous of coating layer coated from Bath 2 could be detected at the bottom of oxide layer,which strongly implied that the phosphorous ion might be concentrated at the barrier *** potential of coating layer of AZ91 Mg alloy increased and corrosion current density decreased with increasing the concentration of potassium *** polarization resistance(Rp) of coating layer of AZ91 Mg alloy coated from Bath 2 was 4.65×107 Ω/cm2,which was higher than that(Rp=3.56×104 Ω/cm2) of the sample coated from electrolyte without potassium *** coating layer coated from Bath 2 containing 0.03 mol/L potassium pyrophosphate exhibited the best corrosion resistance.

关键词： AZ91镁合金合金涂层焦磷酸钾电解氧化等离子体电解质腐蚀电流密度耐腐蚀性

Distinctive characteristics and functions of multiple mitochondrial Ca^(2+) influx mechanisms

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Science China(Life Sciences) 2011年第8期54卷 763-769页

作者： Shi PAN shin-young RYU Shey-shing SHE~ Center for Translational Medicine Department of Medieine Thomas Jefferson University Philadelphia PA 19107 USA Department of Physiology Seoul National University College of Medicine Seoul 110-799 Republic of Korea

Intracellular Ca2+ is vital for cell *** of Ca2+ homeostasis contributes to human diseases such as heart failure,neuron-degeneration,and *** ensure an effective intracellular Ca2+ dynamics,various Ca2+ transport proteins localized in different cellular regions have to work in *** central role of mitochondrial Ca2+ transport mechanisms in responding to physiological Ca2+ pulses in cytosol is to take up Ca2+ for regulating energy production and shaping the amplitude and duration of Ca2+ transients in various *** the discovery that isolated mitochondria can take up large quantities of Ca2+ approximately 5 decades ago,extensive studies have been focused on the functional characterization and implication of ion channels that dictate Ca2+ transport across the inner mitochondrial *** mitochondrial Ca2+ uptake sensitive to non-specific inhibitors ruthenium red and Ru360 has long been considered as the activity of mitochondrial Ca2+ uniporter(MCU) .The general consensus is that MCU is dominantly or exclusively responsible for the mitochondrial Ca2+ *** multiple Ca2+ influx mechanisms(e.g.L-,T-,and N-type Ca2+ channel) have their unique functions in the plasma membrane,it is plausible that mitochondrial inner membrane has more than just MCU to decode complex intracellular Ca2+ signaling in various cell *** the last decade,four molecular identities related to mitochondrial Ca2+ influx mechanisms have been *** are mitochondrial ryanodine receptor,mitochondrial uncoupling proteins,LETM1(Ca2+ /H+ exchanger) ,and MCU and its Ca2+ sensing regulatory subunit ***,we briefly review recent progress in these and other reported mitochondrial Ca2+ influx pathways and their differences in kinetics,Ca2+ dependence,and pharmacological *** potential physiological and pathological implications are also discussed.

关键词： mitochondrial calcium channels calcium transport mitochondria heart ryanodine receptor

Process simulation and economic analysis of reactor systems for perfluorinated compounds abatement without HF effluent

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Frontiers of Chemical Science and Engineering 2016年第4期10卷 526-533页

作者： Boreum Lee Sunggeun Lee Ho young Jung shin-Kun Ryi Hankwon Lim Department of Advanced Materials and Chemical Engineering Catholic University of Daegu Gyeongbuk 38430 Korea Department of Environment and Energy Engineering C-honnam National University-Gwangju 61186 Korea Korea Institute of Energy Research Daejeon 34129 Korea

New and efficient proposed to treat perfluorinated reactor systems were compounds via catalytic decomposition. One system has a single reactor （S-1）, and another has a series of reactors （S-2）. Both systems are capable of producing a valuable CaF2 and eliminating toxic HF effluent and their feasibility was studied at various temperatures with a commercial process simulator, Aspen HYSYS. They are better than the conventional system, and S-2 is better than S-1 in terms of CaF2 production, a required heat for the system, natural gas usage and CO2 emissions in a boiler, and energy consumption. Based on process simulation results, preliminary economic analysis shows that cost savings of 12.37% and 13.55% were obtained in S-2 at 589.6 and 621.4℃compared to S-1 at 700 and 750 ℃, respectively, for the same amount of CaF2 production.

关键词： perfluorinated compounds (PFCs) CF4 pro-cess simulation economic analysis