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Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line

Growth-inhibitory effect of neurotrophin-3-secreting adipose...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Chae-Yong Kim Young-Hoon Kim Seung Hee cho Soo Jung Lee Seung ah choi Ji Hoon Phi Seung-Ki Kim Kyu-Chang Wang Byung-Kyu cho Department of Neurosurgery Seoul National University College of Medicine Department of Neurosurgery Seoul National University Bundang Hospital Division of Pediatric Neurosurgery Seoul National University Children's Hospital

Medulloblastoma（MBL）,the most common malignant pediatric brain tumor,is incurable in about one-third of patients and can lead to long-term disabilities despite current multimodal *** purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3（NT-3） on MBL cells and to evaluate the growth-inhibitory effect of neurotrophin-3（NT-3）-secreting stem cells on tumor *** confirmed by western blotting that D283-MED cells express tyrosine kinase C,a specific receptor for *** the biological effects of NT-3 on MBL cells,we evaluated autophagy,apoptosis,senescence,and differentiation of tumor cells with *** NT-3 induced a concentrationdependent increase in apoptosis in the tumor cell line（P ＜ 0.001）.The high concentrations of NT-3 increased the expression of class III β-tubulin（P ＜ 0.001） and decreased the expression of Nestin（P ＜ 0.05）.NT-3-secreting stem cells were produced by nucleofecting ***-NT3 into human adipose tissue-derived mesenchymal stem cells（hAT-MSCs） and were confirmed by fluorescence microscopy and ***-layered co-culture experiments with the NT-3-secreting hAT-MSCs and D283-MED MBL cells were performed,and NT-3-induced cell death was studied by 3-（4,5-dimethylathiazol-2-yl）-2,5-dephenyltetrazolium bromide（MTT） ***,the high concentrations of NT-3-secreting hAT-MSCs significantly（P ＜ 0.05） increased the death of D283-MED cells in *** present study demonstrated that both apoptotic cell death and neuronal differentiation of tumor cells were the mechanisms of growth-inhibitory effect of NT-3-secreting hAT-MSCs on MBL cell line.

关键词： neurotrophin-3 adipose tissue-derived mesenchymal stem cell medulloblastoma apoptosis differentiation

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A novel off-on fluorescent probe for specific detection and imaging of cysteine in live cells and in vivo

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Chinese Chemical Letters 2020年第1期31卷 133-135页

作者： Baoxin Zhang Haijuan Zhang Miao Zhong Song Wang Qianhe Xu Dong-Hyung cho Hongdeng Qiu State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources/Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China School of Life Sciences Kyungpook National UniversityDaegu 41566Republic of Korea

Cysteine(Cys)plays a pivotal role in many physiological and pathological processes,including detoxification and protein *** abnormal levels of Cys are linked to many *** this study,a novel red-emitting off-on fluorescent probe Cys-TCF was masterly constructed for discriminative detection of *** a series of experimental assessment,Cys-TCF displayed higher selectivity and sensitivity for Cys over other biothilols with a low detection limit(0.04μmol/L).More notably,the probe was also successfully applied to image Cys in live cells and live zebrafishes with low cytotoxicity.

关键词： Cysteine Fluorescent probe Red emission Low detection limit Fluorescent imaging

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Effects of honing treatment on AIP-TiN and TiAlN coated end-mill for high speed machining

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 83-87页

作者： Jae-Young HEO Sung-Hak cho Tae-Jin JE Kwang-Ho KIM Hyung-Woo LEE Myung-Chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Nano Machining Laboratory Korea Institute of Machinery and Material (KIMM) 171 Jang-dong Yuseong-Gu Daejeon 305-343 Korea

The objective of this work is to compare the tool performance of TiN and TiA1N coated carbides end-mills deposited by an arc ion plating （ALP） method, using honing treatment to polish the cutting edge surface sleekly. The curve of surface roughness versus honing time showed a rapid improvement initially and thereafter became steady, manifesting a saturation effect. The optimal honing time related to surface roughness was determined to be approximately 20 s. As the surface roughness increased, the critical loads reduced. At an average surface roughness （ra） of 0.028 p.m, the highest critical loads of TiN and TiAlN coating layers were 98 and 114 N, respectively. Tool performances of uncoated and coated tools were conducted under high speed machining （HSM） of AISI D2 cold-worked die steel （62 HRC）. Consequently, the TiAlN coated end-mill using honing treatment showed excellent tool life under HSM conditions.

关键词： TiA1N arc ion plating honing treatment high speed machining tool life

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Does climate change alter the nutrient trends of Cedrela fissilis *** in the southern Brazilian Amazon?

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Ecological Processes 2023年第1期12卷 806-827页

作者： Daigard R.Ortega Rodriguez raúl Sánchez-Salguero Andrea Hevia Renata C.Bovi Marciel J.Ferreira James H.Speer Fidel A.Roig Mario Tomazello-Filho Escola Superior de Agricultura Luiz de Queiroz Departamento de Ciências FlorestaisUniversidade de São PauloAv.Pádua Dias 11PiracicabaSão Paulo 13418-900Brazil DendrOlavide-Department Sistemas Físicos Químicos y NaturalesUniversidad Pablo de OlavideCrta.Utrera Km.141013 SevilleSpain Department of Ecology Universidad de JaénCampus Las Lagunillas s/n.23009 JaénSpain Departamento de Ciência Florestal Solos e AmbienteUniversidade Estadual PaulistaAv.Universitária 3780BotucatuSão Paulo 18610-034Brazil Laboratory of Silviculture Universidade Federal do Ama-zonasAv.Gen.Rodrigo Octávio 6200ManausAmazonas 69080-900Brazil Department of Earth and Environmental Systems Indiana State UniversityTerre MauteIN 47809USA Argentine Institute of Nivology Glaciology and Environmental Sciences(IANIGLA CONICETUniversidad Nacional de Cuyo)5500 MendozaArgentina Hémera Centro de Observación de la Tierra Escuela de Ingeniería ForestalFacultad de CienciasUniversidad MayorSantiagoChile

Background The increase in the frequency and intensity of droughts is pointed out as one of the main factors altering biogeochemical cycles in the Amazon *** eco-nutritional approach using X-ray fluorescence micro-analysis(μXRF)is proposed to verify the long-and short-term effects of droughts on the growth and xylem nutrient concentrations of Cedrela fissilis *** Fourteen radii were selected from a tree-ring width chronology and X-rayed by Itrax *** of ring width,wood density,and concentrations of aluminum(Al),phosphorus(P),sulfur(S),calcium(Ca),potassium(K),manganese(Mn),iron(Fe)and strontium(Sr)together with Al/Ca,Ca/Mn,K/Ca,Sr/Ca and Mn/S ratios were constructed and correlated with precipitation,temperature,the difference between precipitation and potential evapotranspiration(P-PET)and standardized precipitation-evapotranspiration index(SPEI).Results During dry years,*** showed narrower,less dense rings,lower Al,P,S and Ca,and higher K and Fe concentrations(the opposite was found in wet years).Ring width decreased(together with Al,P,S,K,Ca,Mn,Fe,Sr,Al/Ca,K/Ca and Sr/Ca)and wood density increased(together with Ca/Mn and Mn/S),which was associated with an increase in evapotranspiration and temperature over time,mainly since *** fissilis showed a tendency to increase its capacity for resistance,and a recovery and resilience in growth over time associated with responses in Al,Ca,P and ***,it showed a risk in the capacity for recovery of the pre-drought density values,associated with unsatisfactory responses in Al,Ca,K,Fe and *** This study is the first attempt to analyze tree-ring nutritional evidences of *** trees to climate sensitivity and resilience to drought,based on long-term data from seasonal moist tropical forests of the *** data suggested that *** is undergoing alterations in the concentration,use and redistribution of nutrients associated with increasing wood density and d

关键词： Dendrochemistry μXRF Drought Tropical tree Eco-chemical indicator Resilience Resistance Recovery

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氨己烯酸治疗婴儿痉挛的疗效和安全性观察

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儿科药学杂志 2018年第7期24卷 6-9页

作者：南在元赵敏廷 A-ra Ko 姜薰澈哈尔滨市儿童医院、哈尔滨医科大学附属第二医院黑龙江哈尔滨150010 韩国延世大学医学院 Severance儿童医院韩国

目的:评价氨己烯酸治疗婴儿痉挛的疗效和安全性。方法:选择2015年4月至2016年9月于韩国Severance儿童医院诊治的46例婴儿痉挛患者给予口服氨己烯酸治疗,起始剂量为50 mg/(kg·d),第2天加至100 mg/(kg·d),如症状控制明显,则继续应用3~6... 详细信息

目的:评价氨己烯酸治疗婴儿痉挛的疗效和安全性。方法:选择2015年4月至2016年9月于韩国Severance儿童医院诊治的46例婴儿痉挛患者给予口服氨己烯酸治疗,起始剂量为50 mg/(kg·d),第2天加至100 mg/(kg·d),如症状控制明显,则继续应用3~6个月,定期复查脑电图;如1周后无效,则加量至150 mg/(kg·d),应用3~6个月,随访时间为3~10个月。结果:氨己烯酸单药治疗总有效率为67.4%(31/46),无发作率为19.6%(9/46),复发率6.5%(3/46),短期不良反应主要为嗜睡、纳差、激惹、多动。结论:氨己烯酸治疗婴儿痉挛症效果显著,复发率低,不良反应通常在早期出现。

关键词：婴儿痉挛氨己烯酸疗效安全性

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Lithium plating-free 1 ah-level high-voltage lithium-ion pouch battery via ambi-functional pentaerythritol disulfate

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Journal of Energy Chemistry 2023年第8期83卷 229-238,I0007页

作者： Dung Tien Tuan Vu Jinsol Im Jae-Hee Kim Jisoo Han Gyeong Jun Chung Giang Thi Huong Nguyen Junhyeok Seo Minjae Kim Eui-Hyung Hwang Young-Gil Kwon Jae Wook Shin Kuk Young cho Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science&Chemical Engineering Hanyang UniversityAnsan 15588Republic of Korea Fine Chem Co.Ltd. Daejeon 34365Republic of Korea d CSIM Co.Ltd. Yesan 32400Republic of Korea Dongwha Electrolyte Nonsan 32925Republic of Korea

Elevating the charge cut-off voltage beyond traditional 4.2 V is a commonly accepted technology to increase the energy density of Li-ion batteries(LIBs) but the risk of Li-dendrites and fire hazard increases as well. The use of ambi-functional additive, which forms stable solid electrolyte interphase(SEI) simultaneously at both cathode and anode, is a key to enabling a dendrites-free and well-working high-voltage LIB. Herein, a novel ambi-functional additive, pentaerythritol disulfate(PEDS), at 1 wt% without any other additive is demonstrated. We show the feasibility and high impacts of PEDS in forming lithium sulfateincorporated robust SEI layers at NCM523 cathode and graphite anode in 1 ah-level pouch cell under4.4 V, 25 °C and 0.1 C rate, which mitigates the high-voltage instability, metal-dissolution and cracks on NCM523 particles, and prevents Li-dendrites at graphite anode. Improved capacity retention of 83%after 300 cycles is thereby achieved, with respect to 69% with base electrolyte, offering a promising path toward the design of practical high-energy LIBs.

关键词： Lithium-ion pouch cell Lithium plating-free High-voltage Ambi-functional additive SEI layer

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基准利率对伊斯兰衍生证券的重要性

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武汉理工大学学报（信息与管理工程版） 2015年第6期37卷 779-781,785页

作者：陈晓芳 T.M AL-JALLAD ra'fat 武汉理工大学管理学院湖北武汉430070

伊斯兰金融衍生品的定价和评估同样遵循适用于传统衍生品的定价机制。定价机制的一个主要输入数据是贴现率或同等的伊斯兰金融市场的利率。货币市场基准用来表示利率,这些基准受到当地经济及伊斯兰教法的不利影响,进而要求寻求一个更合... 详细信息

伊斯兰金融衍生品的定价和评估同样遵循适用于传统衍生品的定价机制。定价机制的一个主要输入数据是贴现率或同等的伊斯兰金融市场的利率。货币市场基准用来表示利率,这些基准受到当地经济及伊斯兰教法的不利影响,进而要求寻求一个更合适的利率。利率在伊斯兰金融衍生品的定价和估值中的重要性已在伊斯兰利率互换价格的敏感度测量中得到证明。结果表明,价格对利率的任何设定误差都非常敏感。

关键词：伊斯兰金融衍生品利率互换利率曲线银行基准利率

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富集在平滑肌中的长链非编码RNA调控细胞增殖

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Ballantyne MD Pinel K Dakin R Vesey AT Diver L Mackenzie R Garcia R Welsh P Sattar N Hamilton G Joshi N Dweck MR Miano JM McBride MW Newby DE McDonald ra Baker ah 刘莉叶鹏

血管平滑肌细胞（vascularsmoothmusclecells，VSMC）从收缩到合成状态的表型转换涉及到不同的血管病变，包括动脉粥样硬化，斑块稳定和新生内膜增生。而长链非编码RNA（10ngnoncodingRNA，lncRNA）在上述过程中的作用尚未知。

关键词：血管平滑肌细胞非编码RNA 细胞增殖长链调控富集动脉粥样硬化新生内膜增生

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