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Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease

World journal of Diabetes 2015年第11期6卷 1186-1197页

作者： Ramiro A Sanchez Hugo Sanabria Cecilia de los Santos agustin j ramirez Arterial Hypertension and Metabolic Unit University Hospital Fundación Favaloro Diabetes Unit Instituto Cardiovascular de Buenos Aires Santos Medical Affairs Department Boehringer Ingelheim

Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight *** animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary *** a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/*** could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive *** data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator *** the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular *** this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based *** the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 ***,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still *** this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovas

关键词： Incretins Hypertension Cardiovascular effects Dipe

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Study on Characteristics of Co-firing Ammonia/Methane Fuels under Oxygen Enriched Combustion Conditions

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journal of Thermal Science 2018年第3期27卷 270-276页

作者： XIAO Hua WANG Zhaolin VALERA-MEDINA agustin BOWEN Philip j School of Engineering Cardiff University College of Energy Xiamen University

Having a background of utilising ammonia as an alternative fuel for power generation, exploring the feasibility of co-firing ammonia with methane is proposed to use ammonia to substitute conventional natural gas. However, improvement of the combustion of such fuels can be achieved using conditions that enable an increase of oxygenation, thus fomenting the combustion process of a slower reactive molecule as ammonia. Therefore, the present study looks at oxygen enriched combustion technologies, a proposed concept to improve the performance of ammonia/methane combustion. To investigate the characteristics of ammonia/methane combustion under oxygen enriched conditions, adiabatic burning velocity and burner stabilized laminar flame emissions were studied. Simulation results show that the oxygen enriched method can help to significantly enhance the propagation of ammonia/methane combustion without changing the emission level, which would be quite promising for the design of systems using this fuel for practical applications. Furthermore, to produce low computational-cost flame chemistry for detailed numerical analyses for future combustion studies, three reduced combustion mechanisms of the well-known Konnov's mechanism were compared in ammonia/methane flame simulations under practical gas turbine combustor conditions. Results show that the reduced reaction mechanisms can provide good results for further analyses of oxygen enriched combustion of ammonia/methane. The results obtained in this study also allow gas turbine designers and modellers to choose the most suitable mechanism for further combustion studies and development.

关键词： Ammonia/Methane Oxygen-enriched Combustion Reduced Mechanism Gas Turbine

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Reviewing the Oceanic Nino Index(ONI) to Enhance Societal Readiness for El Nino’s Impacts

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International journal of Disaster Risk Science 2020年第3期11卷 394-403页

作者： Michael H.Glantz Ivan j.ramirez Consortium for Capacity Building/INSTAAR.University of Colorado BoulderCO 80309USA Department of Health and Behavioral Sciences University of Colorado DenverDenverCO 80204USA

NOAA’s Oceanic Nino Index(ONI)is used to record for historical purposes the occurrence and duration of El Nino episodes,based on the monitoring of sea surface temperatures(SSTs)in the central Pacific *** ONI is used to identify the onset of an above average SST threshold that persists for several months,encompassing both the beginning and end of an El Nino *** first appearance of an anomalous seasonal value of 0.5℃suggests with a high probability that an El Nino could emerge,but for heightened warnings,one must wait for several *** this article,we proposed that the ONI value of 0.7℃identifies a tipping point at which the El Nino event becomes locked in,which can provide additional lead time for mitigative actions to be taken by societal decision *** preliminary findings suggest that a first appearance of 0.7℃value could serve as a credible marker of El Nino’s locked-in phase,which can provide additional credibility to the current 0.5℃El Nino onset indicator for at-risk societies to get ready for El Nino’s foreseeable societal and ecological impacts.

关键词： Advisory Disasters Early warning El Nino El Nino Southern Oscillation ENSO Hydrometeorological hazards Oceanic Nino Index ONI

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Three bona fide plant-specific SAGA subunits and their regulatory function

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Molecular Plant 2021年第7期14卷 1033-1035页

作者： j.S.ramirez-Prado M.Benhamed Centre of Microbial and Plant Genetics KU Leuven3001 LeuvenBelgium lnstitute of Plant Sciences Paris-Saclay(IPS2) Universite Paris-SaclayCNRSINRAEUniv EvryOrsay 91405France Institute of Plant Sciences Paris-Saclay Universite de ParisCNRSINRAEOrsay(IPS2)91405France lnstitut Universitaire de France(IUF) ParisFrance

Nucleosomal histone tails are subject to a vast repertoire of covalent modifications that alter the physical accessibility of their associated DNA,impacting gene ***,the acetylation of histones is associated with transcriptional activation,as it has been shown to reduce their affinity for DNA(Grant,2001).The dynamic changes on histone acetylation levels throughout development are the result of active acetylation and deacetylation processes,mediated by histone acetyltransferases(HATs)and deacetylases,respectively.

关键词： expression. SAGA transcriptional

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Introducing System Identification Strategy into Model Predictive Control

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journal of Systems Science & Complexity 2020年第5期33卷 1402-1421页

作者： WANG jianhong RICARDO A.ramirez-Mendoza jORGE de j Lozoya Santos School of Electronic Engineering and Automation Jiangri University of Science and TechnologyGanzhou343000China School of Engineering and Sciences Tecnologico de MonterreyMonterreyAve.Eugenio Garza Sada 2501MonterreyN.L.64849Merico

As system identification theory and model predictive control are belonged to two different research fields separately,so one gap exists between these two *** alleviate this gap between them,one new idea proposed in this paper is to introduce system identification theory into model predictive *** the most important element in model predictive control is the prediction of the output value for a nonlinear system,then the problem of deriving the prediction of the output value can be achieved by system identification *** specifically,a Bayesian approach is applied for the nonparametric estimation by modeling the prediction as realizations of zero mean random *** comparing this kind of prediction corresponding to this Bayesian approach and the former direct weight optimization identification for nonlinear system,the authors see that if the unknown weights are chosen appropriately,these two approaches are equivalent to each *** on the obtained prediction of the output value,the authors substitute this prediction of the output value into one cost function of model predictive control,and then a quadratic programming problem with inequality constraints is *** to solve this quadratic programming problem,a detailed process about how to derive its dual form is *** the dual problem has a simple constraint set,it is amenable to the use of the common Gauss-Seidel algorithm,whose convergence can be shown ***,one simulation example confirms the proposed theoretical results.

关键词： Equivalence model predictive control nonparametric estimation system identification

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Complementarity of electric vehicles and pumped-hydro as energy storage in small isolated energy systems:case of La Palma,Canary Islands

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journal of Modern Power Systems and Clean Energy 2016年第4期4卷 604-614页

作者： Alfredo ramirez-DIAZ Francisco j.RAMOS-REAL Gustavo A.MARRERO Departamento de Economı´a Contabilidad y FinanzasFacultad de Economı´aEmpresa y TurismoUniversidad de La Laguna38071 La LagunaSpain Instituto Universitario de Ciencias Polı´ticas y Sociales Universidad de La Laguna38071 La LagunaSpain Instituto Universitario de Desarrollo Regional Universidad de La Laguna38071 La LagunaSpain

Isolated energy systems in archipelagos are characterized for having a great dependence on fossil sources due to isolation and territorial *** island of La Palma is situated on the northwest of the Canary Islands,and its electric system is very *** policies planned by local authorities are aimed to increase the share of renewable energies and the reduction of fossil ***,intermittence and the concentration of unmanageable renewable energies in few locations may hinder the operation of the *** order to solve these problems,energy storage plays an essential *** aim of this paper is to analyse the effects of the introduction of two possible alternatives as a way of energy storage:pumped hydro storage and electric *** this,we use a simulation model adapted to the features of La Palma,considering different *** show that,in the most favourable scenario,the installation of an additional 25 MW from renewables(more than double the current power),supported by 20 MW of pumped hydro storage and a fleet of 3361 electric vehicles,would allow the current share of renewables to increase from11%(in 2015)to 49%.Furthermore,this would mean a 26%reduction in CO2 emissions,10%in costs of generated k Wh and 19%in energy dependence.

关键词： Energy storage Electric vehicles Vehicle-to-grid Grid-for-vehicles Pumped-hydro energy storage Isolated systems

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Towards rapid and automated vulnerability classification of concrete buildings

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 309-332页

作者： Lissette Iturburu jean Kwannandar Shirley j.Dyke Xiaoyu Liu Xin Zhang julio ramirez Lyles School of Civil Engineering Purdue UniversityWest LafayetteIN 47907United States School of Mechanical Engineering Purdue UniversityWest LafayetteIN 47907United States

With the overwhelming number of older reinforced concrete buildings that need to be assessed for seismic vulnerability in a city,local governments face the question of how to assess their building *** leveraging engineering drawings that are stored in a digital format,a well-established method for classification reinforced concrete buildings with respect to seismic vulnerability,and machine learning techniques,we have developed a technique to automatically extract quantitative information from the drawings to classify *** this technique,stakeholders will be able to rapidly classify buildings according to their seismic vulnerability and have access to information they need to prioritize a large building *** approach has the potential to have significant impact on our ability to rapidly make decisions related to retrofit and improvements in our *** the Los Angeles County alone it is estimated that several thousand buildings of this type *** Hassan index is adopted here as the method for automation due to its simple application during the classification of the vulnerable reinforced concrete *** paper will present the technique used for automating information extraction to compute the Hassan index for a large building inventory.

关键词： object detection segmentation U-Net vulnerability hazards earthquakes reinforced concrete building inventories and databases

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Current status and trends of carbon-based electrodes for fully solution-processed perovskite solar cells

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journal of Energy Chemistry 2022年第5期31卷 222-246页

作者： Laura MGonzález Daniel ramirez Franklin jaramillo Centro de Investigación Innovacióny Desarrollo de MaterialesCIDEMATFacultad de IngenieríaUniversidad de Antioquia UdeACalle 70 No.52-21Medellín 050010Colombia

Perovskite solar cells(PSCs) have revolutionized photovoltaic research. As a result, a certified power conversion efficiency(PCE) of 25.5% was recorded in late 2020. Although this efficiency is comparable with silicon solar cells;some issues remain partially unsolved, such as lead toxicity, instability of perovskite materials under continuous illumination, moisture and oxygen, and degradation of the metallic counter electrodes. As an alternative to tackle this last concern, carbon materials have been recently used, due to their good electrical and thermal conductivity, and chemical stability, which makes them one of the most promising materials to replace metallic counter electrodes in the fabrication of PSCs. This review highlights the recent advances of carbon-based PSCs, where the carbon electrode(CE) is the main *** have become very promising candidates for PSCs;they are mainly fabricated using a simple combination of graphite and carbon black powders embedded in a binder matrix, giving a paste that is then solution-processable, resulting in devices with improved quality stability, when compared to metallic electrodes. In this review, CE’s composition is emphasized, since it can give both, high and lowtemperature processed electrodes, compatible with different device configurations. Finally, the tendencies and opportunities to use CE in PSCs devices are presented.

关键词： Perovskite solar cells Carbon electrodes Scaling up Stability Solution processing

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Improved frost forecast using machine learning methods

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Artificial Intelligence in Geosciences 2023年第1期4卷 164-181页

作者： jos´e Roberto Rozante Enver ramirez Diego ramirez Gabriela Rozante Center for Weather Forecast and Climate Studies National Institute for Space ResearchCachoeira PaulistaSPBrazil University of Sao Paulo(EEL/USP) LorenaSPBrazil Sao Paulo State University(UNESP) BauruSPBrazil

Frosts are one of the atmospheric phenomena with one of the larger negative effects on the agricultural sector in the southern region of Brazil,therefore,an earlier forecast can minimize their *** the present work,artificial neural networks(ANNs)techniques were applied in order to improve the predicting capabilities of frost events in southern *** the study,two multilayer perceptron(MLP)ANNs were built,one with ADAM optimizer and the other with *** input parameters MLP-ANNs were numerical predictions of the Eta *** ANNs were trained using four years(2012-2015),while validation and testing were performed using 2016 and 2017,*** episode of frost that occurred on May 21st,2018,related to an intense cold air mass,was also utilized to evaluate the performance of the *** best configurations(topologies and hyperparameters)of the ANNs were identified through experiments,using the highest accuracy obtained during the validation period as a *** results of the ANNs with ADAM and SGD optimizers were compared with the predictions of the Eta *** the case study,an additional comparison against the operational frost index(IG)from the National Institute for Space Research(INPE)was also *** performance of both ANNs(properly configured)with ADAM and SGD optimizers are comparable one to the *** both are significantly better compared to the Eta *** ANNs were able to drastically reduce the underestimation trends of frost events caused by the warm bias of the Eta *** ANNs also indicated more satisfactory performances when compared to the INPE *** general,the ANNs were able to identify deficiencies in Eta predictions,and consequently improve their *** this sense,the use of ANNs to predict frost events can be a very useful tool in an operational environment.

关键词： Frost Artificial neural networks Multilayer perceptron frost index Deep learning

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Europium recovery process by means of polymeric nanoparticles functionalized with acrylic acid,curcumin and fumaramide

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journal of Rare Earths 2024年第10期42卷 1950-1959页

作者： P.A.Martínez-Montoya j.M del Río A.de j.Morales-ramirez M.Corea Escuela Superior de Ingeniería Química e Industrias Extractivas ESIQIE-IPNDepartamento de Ingeniería Metalúrgica UPALM S/N Col.LindavistaGustao A.MaderoCDMXC.P.07738Mexico Escuela Superior de Ingenieria Química e Industrias Extractivas ESIQIE-IPNLaboratorio de Investigación en Polímeros y NanomaterialesUPALM S/N Col.LindavistaGustavoA.MaderoCDMXC.P.07738Mexico Centra de Investigación e Innovación Tecnológica CIITEC-IPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P.02250CDMXMexico

Polymeric nanoparticles of poly(methyl methacrylate)were obtained by emulsion polymerization techniques in a proce ss of two *** particles were functionalized with acrylic acid,curcumin,and fumaramide and three series of polymeric particles were *** incorporation of functional groups was confirmed by Fourier transform-infrared spectrosocopy(FT-IR)and ultraviolet-visible(UV-Vis)*** spherical morphology of particles with an average diameter of 100 nm was observed by scartning electron microscopy(SEM).The polymeric materials were used for recovery of[Eu]from synthetic *** nanoparticles show excellent chelation capacity to trap rare-earth ions,because they recover more than 85%of[Eu]at pH of *** images of SEM after extraction process show arrays between particles with larger average particle sizes to 1.5 *** addition,the particles have a good stripping capacity,exceeding 50%of it,maintaining their homogeneity in morphology and good stability in dispersion for the recovery and stripping processes.A pseudo-second model order is obtained for the extraction and stripping processes while the best results of stripping process are obtained at pH of 6.

关键词： [Eu]recovery Chelating effect Extraction process Stripping process Emulsion polymerization Rare earths

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