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Beyond reproduction：the role of progesterone in neuropathic pain after spinal cord injury

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Neural Regeneration Research 2016年第8期11卷 1238-1240页

作者： Susana Laura gonzález María Florencia Coronel Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquimica Humana Buenos Aires Argentina Laboratorio de Nocicepcion y Dolor Neuropatico Instituto de Biologia y Medicina Experimental CONICET Buenos Aires Argentina

Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic *** particular,neuropathic pain is a very frequent s... 详细信息

关键词： progesterone intractable Beyond contributor reproduction neuronal NMDAR glial synaptic targeting

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Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2023年第2期12卷 147-157页

作者： Antonio García-Hermoso Robinson Ramírez-Vélez Javier Díez Arantxa gonzález Mikel Izquierdo Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)University Hospital of NavarraPamplona 310008Spain CIBER of Frailty and Healthy Aging(CIBERFES) Carlos Ⅲ Institute of HealthMadrid 28029Spain Institute for Health Research of Navarra(IDISNA) Pamplona 31008Spain Program of Cardiovascular Diseases Center for Applied Medical ResearchUniversity of NavarraPamplona 31008Spain Centre for Biomedical Research in Cardiovascular Disease Network Carlos Ⅲ Institute of HealthMadrid 28029Spain Departments of Nephrology and Cardiology University of Navarra ClinicPamplona 31008Spain

Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise ***:A systematic search for relevant studies was performed in 3 *** controlled trials investigating the effects of exercise training on at least one of the following exerkines were included:adiponectin,apelin,brain-derived neurotrophic factor,fetuin-A,fibroblast growth factor-21,follistatin,ghrelin,interleukin(IL)-6,IL-8,IL-10,IL-15,IL-18,leptin,myostatin,omentin,resistin,retinol-binding protein 4,tumor necrosis factor-α,and ***:Forty randomized controlled trials were selected for data extraction(n=2160).Exercise training induces changes in adiponectin,fetuin-A,fibroblast growth factor-21,IL-6,IL-10,leptin,resistin,and tumor necrosis factor-a levels but has no significant effects on apelin,IL-18,and ghrelin compared to *** exercise training favored large and positive changes in pooled exerkines(i.e.,an overall effect size calculated from several exerkine s)(Hedge’s g=1.02,95%confidence interval(95%CI):0.76-1.28),which in turn were related to changes in glycated hemoglobin(mean difference(MD)=-0.81%,95%CI:-0.95%to-0.67%),fasting glucose(MD=-23.43 mg/dL,95%CI:-30.07 mg/dL to-16.80 mg/dL),waist circumference(MD=-3.04 cm,95%CI:-4.02 cm to-2.07 cm),and body mass(MD=-1.93 kg,95%CI:-2.00 kg to-1.86 kg).Slightly stronger effects were observed with aerobic,resistance,or high-intensity interval protocols at moderate-to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per ***:Exercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

关键词： Adipokines Exercise training Hepatokines Myokines

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Review of natural products with hepatoprotective effects

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World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-gonzález María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-gonzález Manuel García-Luna y gonzález-Rubio J Leopoldo Aguilar-Faisal José A Morales-gonzález Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera L Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

The ecological scale mediates whether trees experience drought legacies in radial growth

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Forest Ecosystems 2023年第3期10卷 298-306页

作者： Héctor Hernández-Alonso Jaime Madrigal-gonzález Fernando Silla Area of Ecology Faculty of BiologyUniversidad de SalamancaE-37007SalamancaSpain iuFOR-EiFAB Campus de SoriaUniversidad de ValladolidE-42004SoriaSpain

The impact of lag effects produced by disturbances on primary production has been a major concern among ecologists during the last *** and extreme climatic events are imposing drastic reductions in radial growth of trees as evidenced in tree-rings series Dendrochronological samples are obtained at tree level but analyzed at an aggregated scale(i.e.,mean chronologies),although aggregating tree-ring chronology on a regional scale may reduce the possibility of studying the variability of individual tree response to drought,by amplifying the average population ***,we conducted experimental research in which 370 trees of 5 species were analyzed to assess the potential statistical and scaling issues that may occur when using regressionbased methods to analyze ecosystem responses to *** legacy effects were quantified using individual and aggregated ***,lag effects were validated using confidence and prediction intervals to identify values falling outside the certainty of the climate-growth model Individual scale legacy effects contrasted with confidence intervals were commonly distributed across species but were scarce when compared with prediction *** analysis of aggregated scale legacies detected significant growth reductions when validated using prediction intervals;however,individual scale legacy lag effects were not *** finding directly contrasts the results obtained when using an aggregated *** results provide empirical evidence on how aggregating ecological data to infer processes that emerge from an individual scale can lead to distorted *** therefore encourage the use of individual based statistical and ecological procedures to analyze tree rings as a means of further understanding the ecosystem responses to disturbances.

关键词： Legacy effects Drought disturbances Tree growth Tree-ring width Dendrochronology Individual scale Mountainous forests

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An explanation of the △_(D35)（1930） as a ρ△ bound state

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Chinese Physics C 2009年第12期33卷 1267-1272页

作者： P. gonzlez E. Oset J. Vijande Departamento de Física Teórica Universidad de Valencia (UV) e IFIC (UV - CSIC) Spain Departamento de Física Atómica Molecular y Nuclear Universidad de Valencia (UV) e IFIC (UV - CSIC) Spain

Constituent quark models based on two-body potentials systematically overpredict the mass of △D35(1930). A possible solution to this problem comes out from the application of a schematic hybrid model, containing three-quark as well as meson-baryon components, to the light-quark baryon spectrum. The △D35(1930) and its partners △D33(1940) and △S31(1900) are found to contain a significant ρ△ component. Then, through the use of the hidden gauge formalism, it is shown that these resonances can be dynamically generated from the ρ-△ interaction. In particular △D35(1930) can be interpreted as being essentially a ρ△bound state. This interpretation suggests that the inclusion of ρ△as an effective inelastic channel in data analyses could improve the extraction and identification of the resonance.

关键词： Baryon spectra dynamically generated resonances quark model

Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第23期13卷 3221-3227页

作者： FJ Vizoso M Rodriguez A Altadill ML gonzález-Diéguez A Linares LO gonzález S Junquera F Fresno-Forcelledo MD Corte L Rodrigo Unidad de Investigación. Fundación Hospital de Jove. Gijón Spain Gastroenterology Service. Hospital Universitario Central de Asturias. Oviedo Spain Instituto Universitario de Oncología del Principado de Asturias. Oviedo Spain Pathology Service. Hospital Universitario Central de Asturias. Oviedo Spain

AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies.

关键词： Androgen Estrogen Progesterone and Apolipoprotein D receptors Hepatocellular carcinoma Tissue micro-arrays

Coyote(Canis latrans)in South America:potential routes of colonization

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Integrative Zoology 2020年第6期15卷 471-481页

作者： Octavio MONROY-VILCHIS JoséF.gonzÁlez-MAYA Ángel BALBUENA-SERRANO Fausto ELVIR Martha M.ZARCO-gonzÁlez Clarita RODRÍGUEZ-SOTO Centro de Investigación en Ciencias Biológicas Aplicadas Universidad Autónoma del Estado de MéxicoInstituto Literario 100TolucaMéxico50000México Instituto de Ecología Universidad Nacional Autónoma de MéxicoCoyoacánMéxico The Sierra to Sea Institute and ProCAT Colombia Las AlturasCoto BrusPuntarenasCosta Rica Fundación Investigación en Ciencias para el Estudio y Conservación de la Biodiversidad Instituto de Ciencia para el Estudio y Conservación de la Biodiversidadfrente a la Escuela República de JapónTegucigalpaHonduras Facultad de Geografía Universidad Autónoma del Estado de MéxicoInstituto Literario 100TolucaMéxico50000México

During the last century,the coyote(Canis latrans)has increased its distribution in Central *** the 1980s,it had not been recorded in *** records show that coyotes have crossed the Panama Canal,indicating that continues to expand;therefore,there is a possibility that it will reach northern South *** objectives were to identify potential coyote colonization routes to South America,and the variables that favor its *** hypothesized that habitat fragmentation benefits coyote *** applied 7 algorithms to model the potential distribution of the coyote,using 196 presence records and 12 *** models with better performance were used to generate a consensus *** our consensus model and the areas with highest probability of presence,a potential colonization route was generated between Central America and northern South *** route lies through southern Costa Rica,along the Pacific coast of Panama to the south,to the Andean mountains in northern *** variables that explained potential coyote distribution were human population density,altitude,and percentage of crops with positive influence,and tropical broadleaf forests with negative *** results indicate that human activities and deforestation are related to coyote distribution *** can be implemented within the identified route to improve environmental management,in order to avoid the presence of the coyote in the ecosystems of northern South America.

关键词： Canis latrans carnivore distribution expansion invasive management species distribution model

Areas of research and clinical approaches to the study of liver abscess

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World Journal of Gastroenterology 2017年第2期23卷 357-365页

作者： Gregorio gonzález-Alcaide Jorge Peris José Manuel Ramos Department of History of Science and Documentation University of Valencia Deparment of Internal Medicine Hospital Universitario Sant Joan d’Alacant Departament of Clinical Medicine Universidad Miguel Hernández de Elche Department of Internal Medicine Hospital General Universitario de Alicante

AIMTo analyze the research activity on liver abscess (LA) and identify the main topic clusters in the *** identified all documents using the medical subject heading “LA” indexed in the MEDLINE database between 2001 and 2015. We performed a descriptive bibliometric analysis, characterizing the evolution of scientific activity, the publication types of the documents, the document categories of clinical interest (case reports, clinical trials, evaluation studies, meta-analysis, observational studies, practice guidelines and validation studies) and the geographic distribution of the research. We also carried out an analysis of networks and research clusters in order to identify the main topic areas of *** search yielded a total of 1278 documents, showing a stable scientific production over the study period and a marked multidisciplinary nature. The research was dominated by case reports (65.9% of the documents analyzed). In terms of geographic distribution, researchers from the United States led in the number of signatures (n = 229), followed by those from Taiwan (n = 185), India (n = 145), Japan (n = 144), South Korea (n = 100), and China (n = 84). With regard to amebic LA, the top-producing countries were India and Mexico (n = 69 each), followed by the United States (n = 29). In the case of pyogenic LA, Taiwan Residents researchers led scientific production (n = 71), followed by the United States (n = 39) and China (n = 29). The most active areas of research in the field are diagnosis via computerized tomography scan, differential diagnosis with regard to liver cancer, treatment with antimicrobial agents, and Klebsiella infections (including bacteremia).CONCLUSIONClinical case reports associated with diagnosis and treatment are the main topic of study, highlighting the importance of this document type in advancing knowledge.

关键词： Liver abscess Cluster analysis Amebic abscess Pyogenic abscess Bibliometrics

Seed loss before seed predation: experimental evidence of the negative effects of leaf feeding insects on acorn production

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Integrative Zoology 2018年第3期13卷 238-250页

作者： Tara CANELO Álvaro GAYTÁN Guillermo gonzÁlez-BORNAY Raul BONAL Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain CREAF Cerdanyola del VallèsCataloniaSpain

Insect herbivory decreases plant fitness by constraining plant growth,survival and reproductive *** studies on the effects of herbivory in trees rely on correlational inter-individual comparisons and could,thus,be affected by confounding factors linked to both herbivory and plant *** the Mediterranean Holm oak(Quercus ilex)as a study model,we followed an experimental approach in which leaf-feeding insects(mainly Lepidoptera caterpillars)were excluded from some shoots in all study *** subjected to herbivore exclusion exhibited lower defoliation rates and produced more acorns than control *** constrained shoot growth throughout the study period,but had no effect on the number of female flowers produced per *** production was,however,lower in control shoots due to their higher abortion rates,and also to their greater mortality risk during summer drought,as shoots with fewer leaves were less likely to *** reaction to herbivory inhibits certain physiological pathways involved in plant growth,which,together with the effects of physical damage,reduces the amount and efficiency of the photosynthetic *** increases their vulnerability to environmental stresses,such as water deficit,which limit resource *** is likely a key factor affecting oak regeneration,as it may be a significant source of seed loss prior to pre-dispersal acorn *** experimental studies could help to elucidate its effects in contrasting *** Mediterranean regions,the harsher droughts predicted by climate change models could worsen the effects of insect herbivory on oak reproductive output.

关键词： drought stress insect defoliation oak seed abortion shoot mortality