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Communication between bone marrow mesenchymal stem cells and multiple myeloma cells:Impact on disease progression

World Journal of Stem Cells 2023年第5期15卷 421-437页

作者： Daniel García-Sánchez Alberto gonzález-gonzález Ana Alfonso-Fernández Mónica Del Dujo-Gutiérrez Flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y Cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

Multiple myeloma(MM)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(BM).The interaction between MM cells and the BM microenvironment,and specifically BM mesenchymal stem cells(BM-MSCs),has a key role in the pathophysiology of this *** data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs,aiding the progression of this hematological *** relation of MM cells with the resident BM-MSCs is a two-way *** modulate the behavior of BM-MSCs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence *** turn,modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease *** interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs,long non-coding RNAs or other ***,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling ***,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

关键词： Multiple myeloma Mesenchymal stem cells Bone marrow microenvironment Soluble factors Extra-cellular vesicles Cells adhesion molecules Tunnellingnanotubes

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Biofilm and Helicobacter pylori:From environment to human host

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World Journal of Gastroenterology 2014年第19期20卷 5632-5638页

作者： Apolinaria García María José Salas-Jara Carolina Herrera Carlos gonzález Laboratorio de Patogenicidad Bacteriana Departamento de MicrobiologíaFacultad de Ciencias BiológicasUniversidad de ConcepciónConcepción 4030000Chile

Helicobacter pylori(***)is a Gram negative pathogen that selectively colonizes the human gastric *** 50%of the world population is infected with *** reaching up to 90%of infected individuals in developing *** the increased impact upon public health care,its reservoir and the transmission pathway of the species has not been clearly established *** studies allowed the detection of *** in various aquatic environments,even forming biofilm in tap water distribution systems in several countries,suggesting a role of water as a possible reservoir of the *** persistence of human infection with *** and the resistance of clinical isolates to commonly used antibiotics in eradication therapy have been related to the genetic variability of the species and its ability to develop biofilm,demonstrated both in vivo and in vitro ***,during the last years,experimental work with this pathogen has been focused in the search for biofilm inhibitors and biofilm destabilizing ***,only two *** biofilm disrupting agents have been successfully used:Curcumin-a natural dye-and N-acetyl cysteine-a mucolytic agent used in respiratory *** main goal of this review was to discuss the evidences available in the literature supporting the ability of *** to form biofilm upon various surfaces in aquatic environments,both in vivo and in *** results published and our own observations suggest that the ability of *** to form biofilm may be important for surviving under stress conditions or in the spread of the infection among humans,mainly through natural water sources and water distribution systems.

关键词： Helicobacter pylori Biofilm,Water Infection

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Physical modeling and visualization of soil liquefaction under high confining stress

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Earthquake Engineering and Engineering Vibration 2005年第1期4卷 47-57页

作者： Lenart gonzález Tarek Abdoun Mourad Zeghal Vivian Kallou Michael K.Sharp Dept.of Civil and Environmental Engineering Rensselaer Polytechnic Inst.(RPI)TroyNYUSA Mueser Rutledge Consulting Engineers 225 W 34th StreetNew YorkNYUSA US Army Engineer Research and Development Center VicksburgMSUSA

The mechanisms of seismically-induced liquefaction of granular soils underhigh confining stresses are still not fully *** of these mechanisms is generallybased on extrapolation of observed behavior at shallow *** centrifuge model tests wereconducted at RPI's experimental facility to investigate the effects of confining stresses on thedynamic response of a deep horizontal deposit of saturated *** was observed at highconfining stresses in each of the tests.A system identification procedure was used to estimate theassociated shear strain and stress time *** histories revealed a response marked byshear strength degradation and dilative *** recorded accelerations and pore pressures wereemployed to generate visual animations of the *** visualizations revealed a liquefactionfront traveling downward and leading to large shear strains and isolation of upper soil layers.

关键词： centrifuge modeling high confining stress liquefaction system identification visualization

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Macrocystic serous cystadenoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 587-589页

作者： Patricia Pastor Pérez Francisco Miguel gonzález Valverde Francisco Pastor Quirante Department of General Surgery Reina Sofia General University Hospital University of Murcia

Cystic pancreatic lesions are common,and about 90%of these lesions are pseudocysts or retention *** cysts of the pancreas are *** majority of pancreatic serous cystadenomas are *** serous cystadenoma is an unusual and essentially benign pancreatic *** radiologic features of this subtype may resemble a pseudocyst or a mucinous ***,it is often difficult to make a correct diagnosis[1,2].Herein,we report on a macrocystic serous cystadenoma of the pancreas in a 46-year-old female patient,with a preoperative diagnosis of pancreatic pseudocyst by radiologic imaging.

关键词： pancreas adenoma diagnosis

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Experimental study on lightweight expanded clay at particle level:Breakage of isolated grains

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1846-1858页

作者： Elías Roces-Alonso Jose Estaire Miriam Martín-Ruiz Jesús gonzález-Galindo ETS de Ingenieros de Caminos Universidad Politécnica de MadridSpain Laboratorio de Geotecnia CEDEXMadridSpain

In this study,more than 1500 particles of lightweight expanded clay aggregate(LECA)are individually loaded up to breakage,following different patterns of contact(from 2 to 7)using a purpose-built ***,a statistical model for predicting the number of fragments into which a grain breaks as a function of the number of contacts and their diameter is *** number of fragments is found to follow a statistical binomial-type distribution function that depends on the number of *** addition,a model based on Bayesian networks,capable of assessing the number of fragments and their size(measured as normalized weight)as a function of the number of contacts,is *** proposed method is applicable when performing discrete element method(DEM)simulations on granular media in which grain breakage plays a relevant role.

关键词： Lightweight expanded clay aggregate(LECA) Grain fragmentation Grain breakage Biaxial grain load

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A novel viewpoint in glaucoma therapeutics: enriched environment

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Neural Regeneration Research 2022年第7期17卷 1431-1439页

作者： María F.gonzález Fleitas Damián Dorfman Ruth E.Rosenstein Laboratory of Retinal Neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Glaucoma is one of the world’s most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their *** glaucoma’s most accepted risk factor is increased intraocular pressure(IOP),the mechanisms behind the disease have not been fully *** date,IOP lowering remains the gold standard;however,glaucoma patients may still lose vision regardless of effective IOP ***,the exclusive IOP control apparently is not enough to stop the disease progression,and developing new resources to protect the retina and optic nerve against glaucoma is a goal of vast clinical *** pharmacological treatments,environmental conditions have been shown to prevent neurodegeneration in the central nervous *** this review,we discuss current concepts on key pathogenic mechanisms involved in glaucoma,the effect of enriched environment on these mechanisms in different experimental models,as well as recent evidence supporting the preventive and therapeutic effect of enriched environment exposure against experimental glaucomatous ***,we postulate that stimulating vision may become a non-invasive and rehabilitative therapy that could be eventually translated to the human disease,preventing glaucoma-induced terrible sequelae resulting in permanent visual disability.

关键词： brain-derived neurotrophic factor chondroitin sulfate enriched environment glaucoma optic nerve axons optic nerve glia retinal ganglion cells visual stimulation

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Peripheral refraction of myopic eyes with spectacle lenses correction and lens free emmetropes during accommodation

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Eye and Vision 2021年第1期8卷 454-461页

作者： António Queirós Alejandro Cerviño JoséManuel gonzález‑Méijome Clinical&Experimental Optometry Research Lab(CEORLab) Center of Physics(Optometry)University of MinhoCampus de Gualtar4710‑057 BragaPortugal Optometry Research Group Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValenciaSpain

Purpose:To measure axial and off-axis refraction patterns in myopic eyes with spectacle lenses correction and lens free emmetropes in young healthy subjects at different target distances from 2.00 m(0.50 D)to 0.20 m(5.00 D)in terms of sphere,astigmatism,and spherical equivalent ***:Refraction was measured at the center,20 and 40 degrees from the line of sight both nasally and temporally in 15 emmetropic and 25 myopic young healthy subjects with an open field,binocular,infrared autorefractor(Grand Seiko WAM-5500,Hiroshima,Japan).Fixation target was a Maltese cross set at 2.00,0.50,0.33 and 0.20 m from the corneal *** in off-axis refraction with accommodation level were normalized with respect to distance axial values and compared between myopic eyes with spectacle lenses correction and lens free ***:Off-axis refraction in myopic eyes with spectacle lenses correction was significantly more myopic in the temporal retina compared to lens free emmetropes except for the closest target *** off-axis refractive error changed significantly with accommodation when compared to axial refraction particularly in the myopic *** change in the negative direction was due to changes in the spherical component of refraction that became more myopic relative to the center at the 0.20 m distance as the J0 component of astigmatism was significantly reduced in both emmetropes and myopes for the closest ***:Accommodation to very near targets(up to 0.20 m)makes the off-axis refraction of myopes wearing their spectacle correction similar to that of lens free emmetropes.A significant reduction in off-axis astigmatism was also observed for the 0.20 m distance.

关键词： Off-axis refraction Refractive error Accommodation Myopia progression

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Building health monitoring in the old town of Madrid:applicability of SAR Imagery to the monitoring of underground works through classification indexes

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International Journal of Digital Earth 2021年第3期14卷 271-287页

作者： Adrian Jesus Garcia Beatriz gonzález-Rodrigo Sara Martinez Ruben Martinez Miguel Marchamalo Topography and Geomatics Lab ETSI CaminosCanales y PuertosUniversidad Politécnica de MadridMadridSpain ETS de Ingeniería Civil Universidad Politécnica de MadridMadridSpain

The old city centers of many major cities represent a great challenge from a constructive point of view since the foundations of the buildings consist of an aggregation of previous *** endorses thorough monitoring activities during any underground *** capabilities of the persistent scatterer interferometry(PSI)can be exploited to cope with these monitoring ***,the old city centers represent a very challenging urban scenario since the rooftops are usually filled with air conditioning systems and due to the fact that the streets are usually *** work assesses the applicability of the PSI technique under this challenging ***,it proposes a set of novel classification indexes that allow an objective assessment of the building’s health and the impact derived from any *** can be applied in deformation monitoring and risk evaluation in urban *** applicability of the technique and the proposed indexes is validated in the monitoring of underground construction works in the old city center of Madrid comparing the results against on-ground measurements and identifying the potential and the limitation of the technique.

关键词： Satellite-based monitoring historical city center building health monitoring persistent scatterer interferometry urban planning

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Hepatoprotective effect of Geranium schiedeanum against ethanol toxicity during liver regeneration

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World Journal of Gastroenterology 2015年第25期21卷 7718-7729页

作者： Eduardo Madrigal-Santillán Mirandeli Bautista Juan A Gayosso-De-Lucio Yadira Reyes-Rosales Araceli Posadas-Mondragón ángel Morales-gonzález Marvin A Soriano-Ursúa Jazmín García-Machorro Eduardo Madrigal-Bujaidar Iselaálvarez-gonzález JoséA Morales-gonzález Laboratorio de Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónMéxico DF 11340México área Académica de Farmacia ICSaUniversidad Autónoma del Estado de HidalgoPachuca de Sotoestado de HidalgoCP 42000México Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Departamento de Fisiología Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónColonia Casco de Santo TomasDel.Miguel HidalgoMéxico DF 11340México Laboratorio de Genética Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalAv.Wilfrido MassieuUnidad A.López MateosZacatencoMéxico DF 07700México

AIM: To evaluate the effect of an extract of Geranium schiedeanum(Gs) as a hepatoprotective agent against ethanol(Et OH)-induced toxicity in rats. METHODS: Male Wistar rats weighing 200-230 g were subjected to a 70% partial hepatectomy(PH); they were then divided into three groups(groups 1-3). During the experiment, animals in group 1 drank only water. The other two groups(2-3) drank an aqueous solution of Et OH(40%, v/v). Additionally, rats in group 3 received a Gs extract daily at a dose of 300 mg/kg body weight intragastically. Subsequently, to identify markers of liver damage in serum, alanine aminotransferase, aspartate aminotransferase, albumin and bilirubin were measured by colorimetric methods. Glucose, triglyceride and cholesterol concentrations were also determined. In addition, oxidative damage was estimated by measuring lipid peroxidation [using thiobarbituric-acid reactive substances(TBARS)] in both plasma and the liver and by measuring the total concentration of antioxidants in serum and the total antioxidant capacity in the liver. In addition, a liver mass gain assessment, total DNA analysis and a morpho-histological analysis of the liver from animals in all three groups were performed and compared. Finally, the number of deaths observed in the three groups was ***: Administration of the Geranium shiedeanum extract significantly reduced the unfavorable effect of ethanol on liver regeneration(restitution liver mass: PHEt OH group 60.68% vs PH-Gs-Et OH group 69.22%). This finding was congruent with the reduced levels of hepatic enzymes and the sustained or increased levels of albumin and decreased bilirubin in serum. The extract also modified the metabolic processes that regulate glucose and lipid levels, as observed from the serum measurements. Lower antioxidant levels and the liver damage induced by Et OH administration appeared to be mitigated by the extract, as observed from the TBARs(PH-Et OH group 200.14 mmol/mg vs PH-Gs-Et OH group 5

关键词： Geranium schiedeanum Liver regeneration Ethanol Free radicals Nuclear factor erythroid-2-relatedfactor 2

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Acute esophageal variceal bleeding:Current strategies and new perspectives

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World Journal of Hepatology 2010年第7期2卷 261-274页

作者： Salvador Augustin Antonio gonzález Joan Genescà Liver Unit Department of Internal MedicineHospital Universitari Vall d’HebronInstitut de RecercaUniversitat Autònoma de Barc elona

Management of acute variceal bleeding has greatly improved over recent years. Available data indicates that general management of the bleeding cirrhotic patient by an experienced multidisciplinary team plays a major role in the f inal outcome of this complication. It is currently recommended to combine pharmacological and endoscopic therapies for the initial treatment of the acute bleeding. Vasoactive drugs (preferable somatostatin or terlipressin) should be started as soon as a variceal bleeding is suspected (ideally during transfer to hospital) and maintained afterwards for 2-5 d. After stabilizing the patient with cautious fluid and blood support, an emergency diagnostic endoscopy should be done and, as soon as a skilled endoscopist is available, an endoscopic variceal treatment (ligation as f irst choice, sclerotherapy if endoscopic variceal ligation not feasible) should be performed. Antibiotic prophylaxis must be regarded as an integral part of the treatment of acute variceal bleeding and should be started at admission and maintained for at least 7 d. In case of failure to control the acute bleeding, rescue therapies should be immediately started. Shunt therapies (especially tran sjugular intrahepatic portosystemic shunt) are very effective at controlling treatment failures after an acute variceal bleeding. Therapeutic developments and increasing knowledge in the prognosis of this complication may allow optimization of the management strategy by adapting the different treatments to the expected risk of complications for each patient in the near future. Theoretically, this approach would allow the initiation of early aggressive treatments in high-risk patients and spare low-risk individuals unnecessary proce dures. Current research efforts will hopefully clarify this hypothesis and help to further improve the outcomes of the severe complication of cirrhosis.

关键词： Portal hypertension Variceal bleeding Complic ations of cirrhosis

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