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Safety evaluation in mice of the childhood immunization vaccines from two south-eastern states of Nigeria

Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 132-137页

作者： Oli Angus Nnamdi agu remigus uchenna Oli Ugochukwu Chinedum Nwoye Charles Ugochukwu Ejiofor Obiora Shedrack Esimone Charles Okechukwu Department of Pharmaceutical Microbiology and Biotechnology Faculty of Pharmaceutical SciencesNnamdi Azikiwe University Biopharmaceutics and Drug Delivery Laboratory College of Pharmacy5968 College Street.PO Box 15000Dalhousie University Departments of Chemical Pathology Nnamdi Azikiwe UniversityTeaching Hospital Departments of Hematology Nnamdi Azikiwe UniversityTeaching Hospital Department of Pediatrics Anambra State University Teaching Hospital

Objective:To check the effects of the vaccines on the hematopoietic system and weight of mice after ***:The study was done with the Expanded Programme on Immunization vaccines donated by the Ministries of Health of Abia and Imo States of *** vaccines were collected from the cold-chain stores and transported in vaccine carriers to the cold-chain facility in Nnamdi Azikiwe University Teaching Hospital within 3 hours of *** were used to immunize a total of 160 *** Ethics Committee of Nnamdi Azikiwe University Teaching Hospital,Nnewi of Anambra State,Nigeria approved the ***:Mice body weight changes test showed that the mice all had increased body weight at Days 3 and 7 post-immunization and none died during the 7 d post-immunization *** percentage weight gains of the mice compared with the control were 69%.70%,64%.63%,65%and 68%for oral polio vaccine,*** CalmetteGuerin,measles,yellow fever and hepatitis B vaccines respectively collected from Imo *** mice immunized with oral polio vaccine,*** ***,yellow fever and hepatitis B vaccines collected from Abia State had 123%.114%,121%.116%,142%and 119%weight gain respectively compared with the *** promoting toxicity test showed that none of the vaccines was able to induce proliferation of leukocytes up to ten *** toxicity test showed that all the vaccines had an leukopenic toxicity test value higher than 80%of the control(physiological saline).Conclusions:The vaccine samples tested were safe and did not affect the hematopoietic system *** storage conditions of the vaccines in the States' cold-chain stores had not compromised the safety of the vaccines.

关键词： Safety evaluation Vaccines Routine immunization Imo and Abia Nigeria

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