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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 56-56页

作者： agostoni p. Kedhi E. Verheye S. 马超 Antwerp Cardiovascular Center Middelheim AZ Middelheim Antwerp Belgium

本文讨论2例非闭塞性亚急性(或晚期)支架血栓形成患者,其中1例在西罗莫司洗脱支架置入后12d时被准确诊断(借助血管内超声检查),另1例在裸金属支架置入后17d时被错误漏诊,其血栓在随后6周进展至支架完全闭塞。作者相信对接受西罗莫司洗... 详细信息

本文讨论2例非闭塞性亚急性(或晚期)支架血栓形成患者,其中1例在西罗莫司洗脱支架置入后12d时被准确诊断(借助血管内超声检查),另1例在裸金属支架置入后17d时被错误漏诊,其血栓在随后6周进展至支架完全闭塞。作者相信对接受西罗莫司洗脱支架

关键词：支架血栓患者西罗莫司洗脱支架金属支架置入

紫杉醇洗脱支架置入后应用阿司匹林辅以噻氯匹啶与氯吡格雷的比较:TRUE(Taxus紫杉醇洗脱支架实际应用评价)研究结果

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 57-57页

作者： Biondi-Zoccai G.G.L. agostoni p. Sangiorgi G.M. A. Colombo 郭俊 EMO Centro Cuore Columbus Via Buonarroti 48 20145 Milan Italy

Thienopyridines and aspirin are beneficial in patients undergoing bare-metal stent implantation, and aspirin and clopidogrel treatment have also been proved effective after drug-eluting stent(DES) implantation. However, despite the common substitution of clopidogrel with ticlopidine because of cost or patient intolerance, there are no data on the comparison of ticlopidine vs. clopidogrel after DES implantation. We hereby compare ticlopidine vs. clopidogrel after paclitaxel-eluting stent implantation in subjects enrolled in the prospective multicenter Taxus in Real-life Usage Evaluation(TRUE) Study. Across the 505 analyzed patients(112 treated with ticlopidine and 393 with clopidogrel), similar rates of early and mid-term(7 months) adverse thrombotic events were found with either antiplatelet regimen, with the notable exception of 2 cases of late stent thrombosis in patients who had prematurely withdrawn ticlopidine treatment just 3 months after the procedure. These findings thus support the overall safety and effectiveness of ticlopidine after DES implantation, and also confirm the increased risk of late thrombosis when premature withdrawal of thienopyridines occurs.

关键词：药物洗脱支架噻氯匹啶氯吡格雷阿司匹林紫杉醇噻吩并吡啶金属支架置入有效治疗

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Effect of the timing of gluten introduction on the development of celiac disease

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World Journal of Gastroenterology 2010年第16期16卷 1939-1942页

作者： Marco Silano Carlo agostoni Stefano Guandalini Unit of Human Nutrition and Health Italian National Institute of Health Department of Maternal and pediatric Sciences University of MilanFondazione IRCCS Ca' Granda-Ospedale Maggiore PoliclinicoMilano 20122Italy Department of pediatrics Section of Gastroenterology Hepatology and NutritionUniversity of Chicago

Celiac disease(CD) is a permanent auto-immune enteropathy,triggered in genetically predisposed individuals by the ingestion of dietary *** is the alcohol-soluble protein component of the cereals wheat,rye and *** is a multifactorial condition,originating from the interplay of genetic and environmental *** necessary environmental trigger is gluten,while the genetic predisposition has been identified in the major histocompatibility complex region on chromosome 6p21,with over 90% of CD patients expressing HLA DQ2 and the remaining celiac patients express *** fact that only about 4% of DQ2/8positive individuals exposed to gluten develop CD,has led to the recognition that other genetic and environmental factors are also *** the last few years,several epidemiological studies have suggested that the timing of the introduction of gluten,as well as the pattern of breastfeeding,may play an important role in the subsequent development of ***,we present and review the most recent evidences regarding the effect of timing of gluten introduction during weaning,the amount of gluten introduced and simultaneous breastfeeding,on the development of CD.

关键词： Celiac disease Gluten Weaning Breastfeeding prevention Autoimmunity Anti-transglutaminase antibody Duodenal biopsy

Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions

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Chinese Medical Journal 2007年第7期120卷 545-551页

作者： GE Lei John Cosgrave Ioannis Iakovou QIAN Ju-ying pierfrancesco agostoni Giuseppe M. Sangiorgi Flavio Airoldi Iassen Michev Alaide Chieffo Nicola Corvaja Antonio Colombo GE Jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China EMO Centro Cuore Columbus and San Raffaele Hospital Milan Italy

Background The safety and efficacy of drug-eluting stents （DES） implantation in unprotected left main （LM） bifurcation lesions has yet to be determined. The aim of the present report was to evaluate the long-term outcome following implantation of DES in unprotected LM bifurcation lesions.Methods We identified 70 consecutive patients treated with DES in unprotected LM bifurcation lesions from April 2003 to January 2005. Of them, 42 patients were treated with sirolimus-eluting stent （SES） and 28 patients were treated with paclitaxel-eluting stent （pES）. Results Stents to the left anterior descending and to the circumflex were implanted in 62 patients. During 1-year follow-up, 3 （4.3%） patients died of cardiac causes. One of them had myocardial infarction and adjudicated as possibly due to stent thrombosis. Angiographic follow-up was available in 80% of patients. The per lesion restenosis rate was 13.4% in the entire cohort, of which 10.7% occurred in lesions treated with SES and 16.1% in those treated with pES （p=0.58）. All restenosis was focal and occurred in the lesions treated with a stent with stent size to post-procedural reference vessel diameter ratio 〈1.0 （17.6% vs 0, p=0.04）. The per patient target lesion revascularization rate at 1 year was 17.1%. One year survival free from major adverse cardiac events was 77.1%. Conclusions Treatment of LM bifurcation lesions using DES is a safe and feasible way with a low one-year mortality. The need for revascularization in 17% of patients demands for improvement.

关键词： stents revascularization restenosis thrombosis

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