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Accuracy of a predictive model for severe hepatic fibrosis or cirrhosis in chronic hepatitis C

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World Journal of Gastroenterology 2005年第46期11卷 7318-7322页

作者： agostino colli Alice Colucci Silvia Paggi Mirella Fraquelli Sara Massironi Marco Andreoletti Vittorio Michela Dario Conte Department of Internal MedicineOspedale "A.Manzoni" 23900 LeccoItaly Postgraduate School of GastroenterologyIRCCS Ospedale Maggiore 20122 MilanItaly

AIM: To assess the accuracy of a model in diagnosing severe fibrosis/cirrhosis in chronic hepatitis C virus (HCV)***: The model, based on the sequential combination of the Bonacini score (BS: ALT/AST ratio,platelet count and INR) and ultrasonography liver surface characteristics, was applied to 176 patients with chronic HCV infection. Assuming a pre-test probability of 35%,the model defined four levels of post-test probability of severe fibrosis/cirrhosis: 90% (almost absolute).The predicted probabilities were compared with the observed patients' distribution according to the histology (METAVIR).RESULTS: Severe fibrosis/cirrhosis was found in 67 patients (38%). The model discriminated patients in three comparable groups: 34% with a very high (>90%)or low (75%) or low (<10%) probability of cirrhosis, leaving only 33% of the patients still requiring liver biopsy.

关键词： Liver fibrosis Ultrasonography Bonacini score Liver biopsy Hepatitis C

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氯苄噻啶与茶碱的相互作用

药学实践与服务 1988年第3期 38-40页

作者： agostino colli 姜红

氨苄噻啶-5[(2—氯苯]甲基—4,5,6,7—四氢噻吩-[3,2—C]吡啶盐酸盐—是一种自1978年以来广泛应用于欧洲的新型抗血栓形成药,如今又在美国和加拿大进行研究中。口服后,氯苄噻啶(Ticlopidine)抑制了由于各种凝聚剂(主要是二磷酸腺苷ADP)... 详细信息

氨苄噻啶-5[(2—氯苯]甲基—4,5,6,7—四氢噻吩-[3,2—C]吡啶盐酸盐—是一种自1978年以来广泛应用于欧洲的新型抗血栓形成药,如今又在美国和加拿大进行研究中。口服后,氯苄噻啶(Ticlopidine)抑制了由于各种凝聚剂(主要是二磷酸腺苷ADP)而引起的血小板聚合。据报道氯苄噻啶可以引起某些严重的副作用:粒细胞缺乏症、血小板减少症和肝功能异常。

关键词：茶碱药代动力学清除率药物天后利尿药药物动力学空白剂安慰剂血浆浓度

K-Corruption Intermittent Attacks for Violating the Codiagnosability

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 159-172页

作者： Ruotian Liu Yihui Hu agostino Marcello Mangini Maria Pia Fanti IEEE the Department of Electrical and Information Engineering Polytechnic University of Bari the School of Automation Xi'an University of Posts and Telecommunications

In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of sites, in which each site possesses its own set of sensors, without requiring communication among sites or to any coordinators. A net is said to be codiagnosable with respect to a fault if at least one site could deduce the occurrence of this fault within finite steps. In this context, we focus on a type of malicious attack that is called stealthy intermittent replacement attack. The stealthiness demands that the corrupted observations should be consistent with the system's normal behavior, while the intermittent replacement setting entails that the replaced transition labels must be recovered within a bounded of consecutive corrupted observations(called as K-corruption intermittent attack). Particularly, there exists a coordination between attackers that are separately effected on different sites, which holds the same corrupted observation for each common transition under attacks. From an attacker viewpoint, this work aims to design Kcorruption intermittent attacks for violating the codiagnosability of systems. For this purpose, we propose an attack automaton to analyze K-corruption intermittent attack for each site, and build a new structure called complete attack graph that is used to analyze all the potential attacked paths. Finally, an algorithm is inferred to obtain the K-corruption intermittent attacks, and examples are given to show the proposed attack strategy.

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Innovative Services for Electric Mobility Based on Virtual Sensors and Petri Nets

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IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1845-1859页

作者： agostino Marcello Mangini Michele Roccotelli Department of Electrical and Information Engineering Polytechnic University of BariBari 70126Italy

About 60%of emissions into the earth’s atmosphere are produced by the transport sector,caused by exhaust gases from conventional internal combustion *** effective solution to this problem is electric mobility,which significantly reduces the rate of urban *** use of electric vehicles(EVs)has to be encouraged and facilitated by new information and communication technology(ICT)*** help achieve this goal,this paper proposes innovative services for electric vehicle users aimed at improving travel and charging *** goal is to provide a smart service to allow drivers to find the most appropriate charging solutions during a trip based on information such as the vehicle’s current position,battery type,state of charge,nearby charge point availability,and *** particular,the drivers are supported so that they can find and book the preferred charge option according to time availability and the final cost of the charge points(CPs).To this purpose,two virtual sensors(VSs)are designed,modeled and simulated in order to provide the users with an innovative service for smart CP searching and *** particular,the first VS is devoted to locate and find available CPs in a preferred area,whereas the second VS calculates the charging cost for the EV and supports the driver in the booking phase.A UML activity diagram describes VSs operations and cooperation,while a UML sequence diagram highlights data exchange between the VSs and other electromobility ecosystem actors(CP operator,EV manufacturer,etc.).Furthermore,two timed Petri Nets(TPNs)are designed to model the proposed VSs,functioning and interactions as discrete event *** Petri Nets are synchronized by a single larger TPN that is simulated in different use cases and scenarios to demonstrate the effectiveness of the proposed VSs.

关键词： Charge point booking electric mobility EV charging Petri Net virtual sensor

Maximizing Convergence Speed for Second Order Consensus in Leaderless Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 259-269页

作者： Gianvito Difilippo Maria Pia Fanti agostino Marcello Mangini Department of Electrical and Information Engineering Polytechnic University of BariBari 70125Italy IEEE

The paper deals with the consensus problem in a leaderless network of agents that have to reach a common velocity while forming a uniformly spaced ***,the final common velocity(reference velocity)is determined by the agents in a distributed and leaderless ***,the consensus protocol parameters are optimized for networks characterized by a communication topology described by a class of directed graphs having a directed spanning tree,in order to maximize the convergence rate and avoid *** advantages of the optimized consensus protocol are enlightened by some simulation results and comparison with a protocol proposed in the related *** presented protocol can be applied to coordinate agents such as mobile robots,automated guided vehicles(AGVs)and autonomous vehicles that have to move with the same velocity and a common inter-space gap.

关键词： Consensus protocols directed spanning tree multiagent systems networked systems second-order consensus

INNOVATIVE SOLUTIONS BASED ON SIMULATION COMBINED WITH OPTIMIZATION TECHNIQUES FOR MAINTENANCE SERVICE MANAGEMENT WITHIN COMPLEX SYSTEMS

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第2期3卷 19-41页

作者： agostino BRUZZONE ENRICO BOCCA MISS DIME University of Genoa Via Opera Pia 15 16145 GenovaItaly MAST Srl Via Biga 2616144 GenovaItaly

The research proposes a simulation model combined with smart optimizer based onArtificial Intelligence techniques, in order to support service and maintenance of poolswithin Complex Systems, such as power plants or vessel/aircraft *** authors propose an innovative methodology allowing the evaluation and theoptimization of service and maintenance policies in order to improve inventory management and scheduling operations within complex systems. This methodology is based onthe development of a simulator combined with an intelligent *** authors proposed a new metrics to evaluate the real performance of pool servicemanagement of the whole complex system and support the optimization processes.

关键词： Simulation power plants maintenance decision support system complex system optimization.

Topography, exhumation, and drainage network evolution of the Apennines

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Episodes 2003年第3期26卷 212-216页

作者： CarloBartolini NicolaD‘agostino FrancescoDramis DepartmentofEarthSciences UniversityofFlorenceViaGiorgioLaPira4-50121Florence.Italv INGV-NationalInstituteofGeophysicsandVolcanoiogy ViadiVignadiVignaMurata605-00143RomeItaly DepartmentofGeologicalSciences "RomaThe"UniversityLargoSanLeonardoMurialdo1-00146RomeItaly

The present-day topography of the Italian peninsula results from the interactions between crustal-mantle and surface processes occurring since the Late Miocene. Analysis of exhumation and cooling of crustal rocks, together with Quaternary drainage evolution,helps to unravel the tectonic-morphologic evolution of the Apennines by distinguishing end-member models,and hence describing the orogenic belt evolution. The pattern of regional topography, erosional history and present-day distribution of active deformation suggests that the eastward migrating extensional-compressional paired deformation belts may still control the topogra-phy of the northern Apennines, albeit at slower rates than in the past. Conversely, Quaternary drainage evo-lution in the central and southern Apennines suggests that the topography of these regions underwent a Quaternary regional arching, which is only partly con-sistent with the persisting migration of the compres-sional-extensional pair.

关键词：地形学排水网络亚平宁山脉意大利成因地质特征剥蚀作用

Morphodynamics and sediment connectivity index in an unmanaged,debris-flow prone catchment:a through time perspective

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Journal of Mountain Science 2023年第4期20卷 891-910页

作者： Loris TORRESANI Guillaume PITON Vincenzo D’agostino Department of Land EnvironmentAgriculture and ForestryUniversity of PadovaAgripolisViale dell'Università1635020 Legnaro(PD)Italy UniversitéGrenoble Alpes INRAECNRSIRDGrenoble INPIGE38000 GrenobleFrance

Torrential processes are among the main actors responsible for sediment production and mobility in mountain *** this reason,the understanding of preferential pathways for sediment routing has become a priority in hazard assessment and *** this context,the sediment Connectivity Index(IC)enables to analyse the existing linkage between sediment sources and the selected target(channel network or catchment outlet).The IC is a grid-based index that allows fast computation of sediment connectivity based on landscape information derived from a single Digital Terrain Model(DTM).The index computation is based on the log-ratio between an upslope and a downslope component,including information about drainage area,slope,terrain roughness,and distance to the analysis target(***).The output is a map that highlights the degree of structural connectivity of sediment pathways over analysed *** now,these maps are however rarely used to help defining debris-flow hazard maps,notably due to a lack of guidelines to interpret the IC spatial *** paper proposes an exploitation procedure along profiles to extract more information from the analysis of mapped IC *** methodology relies on the analysis of the IC and its component variables along the main channel profile,integrated with information about sediment budgeting derived from Difference of DEMs(DoD).The study of connectivity was applied in the unmanaged sub-catchment(without torrent control works)of the Rio Soial(Autonomous Province of Trento–NE Italy)to understanding the geomorphic evolution of the area after five debris flows(in ten years)and the related changes of sediment *** a recent DTM as validation,we demonstrated how an IC analysis over the older DTM can help predicting geomorphic changes and associated *** results show an IC aptitude to capture geomorphic trajectories,anticipate debris flow deposits in a specific channel location,and depict pre

关键词： Sediment Connectivity Index Debris flow Hazard assessment Digital Elevation Model Geomorphic evolution DEMs of Difference

Downwash modelling for three-lifting-surface aircraft configuration design

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Chinese Journal of Aeronautics 2023年第6期36卷 161-173页

作者： Salvatore CORCIONE Giordana BONAVOLONTÃ agostino DE MARCO Fabrizio NICOLOSI Department of Industrial Engineering University of Naples“FedericoⅡ”Naples 8125Italy School of Aerospace Transport&Manufacturing Cranfield UniversityBedford MK43 OALUnited Kingdom

This paper introduces a semi-empirical model to predict the downwash gradient at the horizontal tail of a three-lifting-surface *** superposition principle applied to well established formulations valid for two lifting surfaces is not a reasonable approach to calculate the downwash of a canard-wing-tail layout,and this paper demonstrates that such a basic technique leads to incorrect ***,an ad hoc prediction model is proposed that considers the combined nonlinear effects of canard and main wing inductions on tail downwash,being based on a full factorial design sweep of CFD simulations obtained by varying the main geometrical parameters of the three lifting surfaces.A suitable analytical formula for the downwash gradient is established through a process of data analysis and factor *** presented model extends the validity of the available models for traditional two-lifting-surface designs by means of a correction *** engineering estimation method introduced here exhibits an acceptable accuracy,as well as relatively small prediction errors,and it is suitable for conceptual and preliminary studies of threesurface *** value of this methodology is confirmed by the validation with the results of numerical and experimental investigations on a case study aircraft.

关键词： Aerodynamic modelling Aircraft design Design of experiments Downwash Three-lifting-surface