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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

WAVE COMPUTATION ON ThE hYPERBOLIC DOUBLE DOUGhNUT

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Journal of Computational Mathematics 2010年第6期28卷 790-806页

作者： agnes Bachelot-Motet Universite de Bordeaux Institut de Mathematiques

We compute the waves propagating on the compact surface of constant negative curvature and genus 2 that is a toy model in quantum chaos theory and cosmic topology. We adopt a variational approach using finite elements. We have to implement the action of the fuchsian group by suitable boundary conditions of periodic type. Despite the ergodicity of the dynamics that is quantum weak mixing, the computation is very accurate. A spectral analysis of the transient waves allows to compute the spectrum and the eigenfunctions of the Laplace-Beltrami operator. We test the exponential decay due to a localized dumping satisfying the assumption of geometric control.

关键词： Wave equation hyperbolic manifold Finite elements Quantum chaos.

Variations in shoot and root growth of three provenances of Faidherbia albida in clay and sand soil

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Journal of Forestry Research 2016年第1期27卷 59-66页

作者： agnes Gachuiri Catherine Muthuri Jonathan K.Muriuki Ramni h.Jamnadass Fergus Sinclair World Agroforestry Centre (ICRAF) United Nations Avenue Gigiri

The variation in shoot and root seedling growth traits was compared among three Faidherbia albida （Del）. A. Chev. provenances originating from Kenya （Taveta）, Malawi （Bolero） and Ghana （Bolgatanga）; representing east, south and west Africa, respectively. Bulked seeds from three provenances were grown in two soil types （clay and sand） at the World Agroforestry Centre nursery, Nairobi. Seedlings grown in clay soil had high shoot growth and shoot to root ratios but shorter root length, lower number of nodules and specific root length compared to seedlings in sand soil. Shoot to root ratios reduced with time and this was more pronounced in sand soil. Overall, the Bolero and Taveta provenances had higher growth than the Bolgatanga provenance. This was probably because plants grown in nutrient-rich clay soil invest more in shoot growth as compared to root growth. Longer root growth in sand soil shows a better adaptive mechanism that increases competitive ability and survival in nutrient-poor systems. Variations observed among the seedling variables such us shoot and root growth could be used for early selection for reforestation and agroforestry in predominantly clay and sand soil areas.

关键词： Faidherbia albida Provenance Soil type Shoot and root growth

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Biomaterials for spinal cord repair

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Neuroscience Bulletin 2013年第4期29卷 445-459页

作者： agnes E. haggerty Martin oudega Departments of Bioengineering University of Pittsburgh Departments of the Center for the Neural Basis of Cognition University of Pittsburgh Departments of Physical Medicine and Rehabilitation University of Pittsburgh Departments of Neurobiology University of Pittsburgh

Spinal cord injury （SCI） results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCI.

关键词： spinal cord injury axon regeneration biodegradable materials extracellular matrix proteins functionalrecovery growth factor guidance injury and repair spinal motor neuron

Attention-deficit/hyperactivity disorder and suicide:A systematic review

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World Journal of Psychiatry 2017年第1期7卷 44-59页

作者： Judit Balazs agnes Kereszteny Vadaskert Child and Adolescent Psychiatry hospital Institute of Psychology Eotvos Loránd University School of Ph.D. Studies Semmelweis University

AIM To investigate suicidality and attention-deficit/hyperactivity disorder(ADhD), this paper aims to systematically review the literature as an extension of previous *** We searched five databases(Ovid MEDLINE, Psychinfo, PubM ed, Scopus, Web of Science) with two categories of search terms:(1) suicide; suicidal; suicide behavior; suicide attempt; suicidal thought; and(2) ADhD. RESULTS The search resulted 26 articles. There is a positive association between ADhD and suicidality in both sexes and in all age groups. Comorbid disorders mediate between suicidality and ADhD. CONCLUSION Recognizing ADhD, comorbid conditions and suicidality is important in prevention.

关键词： Attention-deficit/hyperactivity disorder Suicide Systematic review

Geological applications using geospatial standards-an example from OneGeology-Europe and GeoSciML

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International Journal of Digital Earth 2010年第S01期3卷 31-49页

作者： John Laxton Jean-Jacques Serrano agnes Tellez-Arenas British Geological Survey Murchison HouseWest Main Rd.Edinburgh EH93LAUK BRGM 3 Avenue Claude-GuilleminBP 36009Orleans 45060France

The Geoscience Markup Language(GeoSciML)has been developed to enable the interchange of geoscience information,principally that portrayed on geological maps as well as boreholes.A GeoSciML testbed was developed both to test the implementation of the data model and its application in web *** OneGeology-Europe project aims to use the GeoSciML data model,and build on the experience of the GeoSciML testbed,in implementing a geoportal for a harmonised geological map of Europe at 1:1 million *** involves the integration of web services from 20 participating *** important objective of OneGeology-Europe is to contribute to Infrastructure for Spatial Information in the European Community(INSPIRE),both through the development of a geological data specification and the use of the INSPIRE technical *** and the OneGeology-Europe project are also steps towards incorporating geoscience data into a Digital *** the development of GeoSciML and the implementation of web services for GeoSciML and OneGeology-Europe,have followed a standards-based *** technical architecture comprises a geoportal providing access to a Catalogue Service for the Web for metadata describing both the data and services ***-Europe will provide bothWeb Map Services view andWeb Feature Services download services,which aim to be compliant with the INSPIRE implementing rules.

关键词： data exchange model web services spatial data standards INSPIRE digital earth geoinformatics geology

“Classical Realism” and the Problematic of Marxist Literary Criticism-An Examination of Wu Zuxiang's Review on Dream of the Red Chamber

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2019年第4期13卷 546-562页

作者： agnes Zhuo LIU Institute of Literature Chinese Academy of Social SciencesBeijing 100732China

The term of“Classical Realism”was derivate from the dominate discourse of realism and used for studies of Chinese ancient vernacular novels ever since *** Zuxiang took this term and organized his analysis of Dream of the Red Chamber with the Marxist literary ***'s adoption of realism principle might be defended as a strategic cover for that the discussion of literary skills would be labeled as bourgeois in that *** paper attempts to argue that the framework of Marxist literary criticism had indicated the transformation of scientific method of literature *** Wu's remark of Dream of the Red Chamber as the“great work of Classical Realism”is rather a conclusion from his consistent reflection on new literature after May Fourth,rather than the influence of ideological construction.

关键词： Classical Realism Wu Zuxiang Dream of the Red Chamber Marxist literary criticism