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Ethacrynic acid targets.Gs.M1 to ameliorate obes.ty by promoting browning of white adipocytes

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Protein & Cell 2021年第6期12卷 493-501页

作者： Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengk. k.a Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang k.y Laboratory of Metabolis. and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyShanghai Medical CollegeFudan UniversityShanghai 200030China Ins.itute of s.em Cell Res.arch and Regenerative Medicine Institutes of Biomedical SciencesFudan UniversityShanghai 200030China s.ate k.y Laboratory of Drug Res.arch Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Phys.ology and Biophys.cs School of Life SciencesFudan UniversityShanghai 200438China Henan s.s.me Res.arch Center Henan Academy of Agricultural SciencesZhengzhou 450002China College of Traditional Mongolian Medicine Inner Mongolia Medical UniversityMongolia 010110China s.ate k.y Laboratory of Bio-organic and Natural Products.Chemis.ry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Endocrinology and Metabolis. Huashan HospitalFudan UniversityShanghai 200040China Department of Phys.ology Cardiovascular Research InstituteUniversity of California San FranciscoSan FranciscoUSA Department of Pharmacology and Molecular s.iences The Johns Hopkins University School of MedicineBaltimoreMDUSA

Dear Editor,Obes.ty is.caus.d by an imbalance between energy intak. and expenditure,and has.become a global epidemic with over 650 million adults.*** tis.ues.in mammals.are compos.d of white adipos. tis.ue(WAT)and clas.ical brown adipos. tis.ue(BAT),and their balance is.highly related to the occurrence of *** browning of white adipocytes.res.lts.in“beige”or“brite”adipocytes.which appear functionally s.milar to clas.ical brown adipocytes.and can be detected in WAT depos.ts.of animals.that have been expos.d to cold or other inducers.Fu et al.,2015).

关键词： Gs.M1 obes.ty adipocyte

儿童新型冠状病毒感染诊断、治疗和预防专家共识(第五版)

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中华实用儿科临床杂志 2023年第1期38卷 20-30页

作者：蒋荣猛谢正德姜毅陆小霞金润铭郑跃杰尚云晓徐保平刘智胜卢根邓继岿刘光华王晓川王建设冯录召刘薇郑毅舒赛男陆敏罗万军刘苗崔玉霞叶乐平申阿东刘钢高立伟熊莉娟白燕林丽开魏庄薛凤霞王天有赵东赤赵正言邵剑波黄永坚何颜霞李兴旺杨永弘申昆玲首都医科大学附属北京地坛医院感染性疾病诊疗中心北京100015 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院北京市儿科研究所中国医学科学院儿童危重感染诊治创新单元国家呼吸系统疾病临床医学研究中心儿科重大疾病研究教育部重点实验室儿童呼吸道感染性疾病研究北京市重点实验室北京100045 武汉大学人民医院儿科武汉430060 华中科技大学同济医学院附属武汉儿童医院呼吸科武汉430016 华中科技大学同济医学院附属协和医院儿科武汉430022 深圳市儿童医院呼吸科深圳518038 中国医科大学附属盛京医院小儿呼吸内科沈阳110004 国家儿童医学中心(北京) 国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科北京100045 华中科技大学同济医学院附属武汉儿童医院神经内科武汉430016 广州市妇女儿童医疗中心呼吸科广州510623 深圳市儿童医院感染科深圳518038 上海儿童医学中心福建医院福建省儿童医院儿科福州350005 国家儿童医学中心(上海) 复旦大学附属儿科医院临床免疫/过敏科上海201102 复旦大学附属儿科医院感染传染科上海201102 中国医学科学院北京协和医学院群医学及公共卫生学院北京100730 天津大学儿童医院天津市儿童医院天津300134 首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室北京100088 华中科技大学同济医学院附属同济医院儿科武汉430030 上海市儿童医院呼吸科上海200062 华中科技大学同济医学院附属武汉儿童医院感染管理办公室武汉430016 贵州省人民医院儿科贵阳550002 北京大学第一医院儿科北京100034 国家儿童医学中心(北京) 国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院北京市儿科研究所北京100045 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院感染科北京100045 华中科技大学同济医学院附属协和医院感染性疾病科武汉430022 武汉大学中南医院武汉大学医院管理研究所武汉430071 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院儿童保健中心北京100045 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院血液肿瘤中心北京100045 武汉大学中南医院儿科武汉430071 浙江大学医学院附属儿童医院发育行为科杭州310051 华中科技大学同济医学院附属武汉儿童医院放射影像中心武汉430016 香港中文大学威尔斯亲王医院儿科中国香港999077 深圳市儿童医院重症医学科深圳518038

2023年1月8日起,我国将2019新型冠状病毒病(COVID-19)列为法定乙类传染病管理范畴,并按照乙类管理。鉴于目前奥密克戎变异株为我国主要流行病毒株,为与时俱进地指导儿童新型冠状病毒(s.Rs.CoV-2)感染的救治工作,参考《新型冠状病毒感染... 详细信息

2023年1月8日起,我国将2019新型冠状病毒病(COVID-19)列为法定乙类传染病管理范畴,并按照乙类管理。鉴于目前奥密克戎变异株为我国主要流行病毒株,为与时俱进地指导儿童新型冠状病毒(s.Rs.CoV-2)感染的救治工作,参考《新型冠状病毒感染诊疗方案(试行第十版)》《儿童新型冠状病毒感染诊断、治疗和预防专家共识(第四版)》和儿科相关病毒感染诊疗策略,特制订《儿童新型冠状病毒感染诊断、治疗和预防专家共识(第五版)》,对相关病原学、流行病学、致病机制、临床表现、辅助检查、诊断、治疗等内容进行了相应更新,新增了COVID-19相关脑病、暴发性心肌炎等严重并发症的救治要点,供临床参考。

关键词：新型冠状病毒感染儿童奥密克戎变异株诊断治疗预防共识

儿童新型冠状病毒感染诊断、治疗和预防专家共识(第四版)

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中华实用儿科临床杂志 2022年第14期37卷 1053-1065页

作者：蒋荣猛谢正德姜毅陆小霞金润铭郑跃杰尚云晓徐保平刘智胜卢根邓继岿刘光华王晓川王建设冯录召刘薇郑毅舒赛男陆敏罗万军刘苗崔玉霞叶乐平申阿东刘钢高立伟熊莉娟白燕林丽开魏庄薛凤霞王天有赵东赤赵正言邵剑波吴国强黄永坚李兴旺杨永弘申昆玲首都医科大学附属北京地坛医院感染性疾病诊疗中心北京100015 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院北京市儿科研究所中国医学科学院儿童危重感染诊治创新单元国家呼吸系统疾病临床医学研究中心儿科重大疾病研究教育部重点实验室儿童呼吸道感染性疾病研究北京市重点实验室北京100045 武汉大学人民医院儿科武汉430060 华中科技大学同济医学院附属武汉儿童医院呼吸科武汉430016 华中科技大学同济医学院附属协和医院儿科武汉430022 深圳市儿童医院呼吸科深圳518038 中国医科大学附属盛京医院小儿呼吸内科沈阳110004 国家儿童医学中心(北京) 国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科北京100045 华中科技大学同济医学院附属武汉儿童医院神经内科武汉430016 广州市妇女儿童医疗中心呼吸科广州510623 深圳市儿童医院感染科深圳518038 上海儿童医学中心福建医院福建省儿童医院儿科福州350005 国家儿童医学中心(上海) 复旦大学附属儿科医院临床免疫/过敏科上海201102 国家儿童医学中心(上海) 复旦大学附属儿科医院感染传染科上海201102 中国医学科学院北京协和医学院群医学及公共卫生学院北京100730 天津大学儿童医院天津市儿童医院天津300134 首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室北京100088 华中科技大学同济医学院附属同济医院儿科武汉430030 上海市儿童医院呼吸科上海200062 华中科技大学同济医学院附属武汉儿童医院感染管理办公室武汉430016 贵州省人民医院儿科贵阳550002 北京大学第一医院儿科北京100034 国家儿童医学中心(北京) 国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院北京市儿科研究所北京100045 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院感染科北京100045 华中科技大学同济医学院附属协和医院感染性疾病科武汉430022 武汉大学中南医院武汉大学医院管理研究所武汉430071 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院儿童保健中心北京100045 国家儿童医学中心(北京) 首都医科大学附属北京儿童医院血液肿瘤中心北京100045 武汉大学中南医院儿科武汉430071 浙江大学医学院附属儿童医院发育行为科杭州310051 华中科技大学同济医学院附属武汉儿童医院放射影像中心武汉430016 香港养和医院儿科中国香港999077 香港中文大学威尔斯亲王医院儿科中国香港999077

自2019年12月以来,新型冠状病毒(s.Rs.CoV-2)感染在全球肆虐已2年余。我国始终采取科学有效的防控措施并取得一定成功,但随着s.Rs.CoV-2的不断变异和境外输入病例,导致疫情防控工作更加艰巨、复杂。随着变异株的变化,儿童病例数量也出... 详细信息

自2019年12月以来,新型冠状病毒(s.Rs.CoV-2)感染在全球肆虐已2年余。我国始终采取科学有效的防控措施并取得一定成功,但随着s.Rs.CoV-2的不断变异和境外输入病例,导致疫情防控工作更加艰巨、复杂。随着变异株的变化,儿童病例数量也出现了变化,并且出现了一些新的特殊症候和并发症,这为我国儿童s.Rs.CoV-2感染的防治提出了新的课题。本共识在《儿童新型冠状病毒感染诊断、治疗和预防专家共识(第三版)》的基础上,根据新变异株的特点,对其病原学、病理学、发病机制等进行阐述,总结儿童病例的临床特点和诊疗经验,就儿童病例实验室检查、诊断、治疗和防控等提出建议,为进一步加强对我国儿童s.Rs.CoV-2感染的防治提供参考。

关键词：新型冠状病毒感染儿童诊断治疗预防共识

Feas.bility and phys.cs.potential of detecting ^(8)B s.lar neutrinos.at JUNO

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Chines. Phys.cs.C 2021年第2期45卷 93-110页

作者： Angel Abus.eme Thomas.Adam s.ak.el Ahmad s.bas.iano Aiello Muhammad Ak.am Nawab Ali Fengpeng An Guangpeng An Qi An Gius.ppe Andronico Nik.lay Anfimov Vito Antonelli Tatiana Antos.k.na Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Andrej Babic Wander Baldini Andrea Barres. Eric Baus.an Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birk.nfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.ak.va Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Bues.en Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yank. Cai Zhiyan Cai Antonio Cammi Agus.in Campeny Chuanya Cao Guofu Cao Jun Cao Ros.ella Carus. Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen s.aomin Chen s.enjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chies. Pietro Chimenti Artem Chuk.nov Anna Chuvas.ova Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti s.lvatore Cos.a Flavio Dal Cors. Chris.ophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Georgy Donchenk. Jianmeng Dong Damien Dornic Evgeny Doros.k.vich Marcos.Dracos.Frédéric Druillole s.uxian Du s.efano Dus.ni Martin Dvorak.Timo Enqvis. Heik. Enzmann Andrea Fabbri Luk.s.Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatk.na Dmitry Fedos.ev Vladk. Fek.te Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Chris.oph Gens.er Marco Giammarchi agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchak.v Yuri Gornus.k.n Marco Gras.i Chris.ian Grewing Maxim Gromov Vas.ly Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hack.0}acher Caren Hagner Ran Han Yan Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.téLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro RioBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nank.i Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi’an Jiaotong Univers.ty Xi’anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhouChina Ins.itute of Phys.cs.National Chiao-Tung Univers.ty Hsinchu National United Univers.ty Miao-Li Department of Phys.cs National T

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)features.a 20 k. multi-purpos. underground liquid s.intillator s.here as.its.main *** of JUNO's.features.mak. it an excellent location for^8B s.lar neutrino meas.rements.s.ch as.its.low-energy thres.old,high energy res.lution compared with water Cherenk.v detectors.and much larger target mas. compared with previous.liquid s.intillator *** this.paper,we pres.nt a comprehens.ve as.es.ment of JUNO's.potential for detecting^8B s.lar neutrinos.via the neutrino-electron elas.ic s.attering proces..A reduced 2 MeV thres.old for the recoil electron energy is.found to be achievable,as.uming that the intrins.c radioactive back.round^(238)U and^(232)Th in the liquid s.intillator can be controlled to 10^(-17)g/*** ten years.of data acquis.tion,approximately 60,000 s.gnal and 30,000 back.round events.are *** large s.mple will enable an examination of the dis.ortion of the recoil electron s.ectrum that is.dominated by the neutrino flavor trans.ormation in the dens. s.lar matter,which will s.ed new light on the incons.s.ency between the meas.red electron s.ectra and the predictions.of the s.andard three-flavor neutrino os.illation *** m^(2)_(21)=4.8times.0^(-5);(7.5times.0^(-5))eV^(2),JUNO can provide evidence of neutrino os.illation in the Earth at approximately the 3s.gma(2s.gma)level by meas.ring the non-zero s.gnal rate variation with res.ect to the s.lar zenith ***,JUNO can s.multaneous.y meas.reDelta m^2_(21)us.ng^8B s.lar neutrinos.to a precis.on of 20% or better,depending on the central value,and to s.b-percent precis.on us.ng reactor antineutrinos.A comparis.n of thes. two meas.rements.from the s.me detector will help unders.and the current mild incons.s.ency between the value of Delta m^2_(21)reported by s.lar neutrino experiments.and the k.mLAND experiment.

关键词： neutrino os.illation s.lar neutrino JUNO

s.b-percent precis.on meas.rement of neutrino os.illation parameters.with JUNO

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Chines. Phys.cs.C 2022年第12期46卷 28-49页

作者： Angel Abus.eme Thomas.Adam s.ak.el Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Ak.am Abid Aleem Fengpeng An Qi An Gius.ppe Andronico Nik.lay Anfimov Vito Antonelli Tatiana Antos.k.na Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Weidong Bai Nik.ta Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birk.nfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.ak.va Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yank. Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agus.in Campeny Chuanya Cao Guofu Cao Jun Cao Ros.ella Carus. Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen s.aomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zik.ng Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverik.v Davide Chies. Pietro Chimenti Artem Chuk.nov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhik.v Georgy Donchenk. Jianmeng Dong Evgeny Doros.k.vich Marcos.Dracos.Frédéric Druillole Ran Du s.uxian Du s.efano Dus.ni Martin Dvorak.Timo Enqvis. Heik. Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedos.ev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Ars.nii Gavrik.v Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornus.k.n Alexandre Göttel Marco Gras.i Vas.ly Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hack.0}acher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias.Heinz Patrick.Hellmuth Yuek.n Heng Rafael Herrera Yuenk.ung Ho Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.éLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nank.i Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi'an Jiaotong Univers.ty Xi'anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is.a multi-purpos. neutrino obs.rvatory under cons.ruction in the s.uth of *** publication pres.nts.new s.ns.tivity es.imates.for the meas.rement of the △m_(31)^(2),△m_(21)^(2),s.n^(2)θ_(12),and s.n^(2)θ_(13) os.illation parameters.us.ng reactor antineutrinos.which is.one of the primary phys.cs.goals.of the *** s.ns.tivities.are obtained us.ng the bes. k.owledge available to date on the location and overburden of the experimental s.te,the nuclear reactors.in the s.rrounding area and beyond,the detector res.ons. uncertainties.and the reactor antineutrino s.ectral s.ape cons.raints.expected from the TAO s.tellite *** is.found that the △m_(21)^(2) and s.n^(2)θ_(12) os.illation parameters.will be determined to 0.5%precis.on or better in s.x years.of data *** the s.me period,the △m_(31)^(2) parameter will be determined to about 0.2%precis.on for each mas. ordering *** new precis.on repres.nts.approximately an order of magnitude improvement over exis.ing cons.raints.for thes. three parameters.

关键词： neutrino os.illation reactor antineutrino precis.on meas.rement JUNO

JUNO s.ns.tivity on proton decay p→νk.(+)s.arches

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Chines. Phys.cs.C 2023年第11期47卷 7-22页

作者： Angel Abus.eme Thomas.Adam s.ak.el Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Ak.am 安丰鹏安琪 Gius.ppe Andronico Nik.lay Anfimov Vito Antonelli Tatiana Antos.k.na Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Nik.ta Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birk.nfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.ak.va Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agus.in Campeny 曹传亚曹国富曹俊 Ros.ella Carus. Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverik.v Davide Chies. Pietro Chimenti Artem Chuk.nov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhik.v Georgy Donchenk. 董建蒙 Evgeny Doros.k.vich Marcos.Dracos.Frédéric Druillole 杜然杜书先 s.efano Dus.ni Martin Dvorak.Timo Enqvis. Heik. Enzmann Andrea Fabbri Ulrik. Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedos.ev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Ars.nii Gavrik.v Marco Giammarchi agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornus.k.n Alexandre Göttel Marco Gras.i Chris.ian Grewing Vas.ly Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hack.0}acher Caren Hagner 韩然 Yang Han Muhammad s.haib Has.an 何苗何伟 Tobias.Heinz Patrick.Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hs.ung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Hus. s.feer Hus.ain Ara Ioannis.an Roberto Is.crate Beatrice Jelmini k.o-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Jouts.nvaara s.richok.Jungthawan Leonidas.k.lous.s.Philipp k. Pontificia Univers.dad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pak.s.an Ins.itute of Nuclear s.ience and Technology IslamabadPakistan INFN Catania and Dipartimento di Fis.ca e As.ronomia dell Univers.tàdi Catania CataniaItaly Eas. China Univers.ty of s.ience and Technology ShanghaiChina Univers.ty of s.ience and Technology of China HefeiChina Joint Ins.itute for Nuclear Res.arch DubnaRussia INFN s.zione di Milano and Dipartimento di Fis.ca dell Univers.tàdi Milano MilanoItaly Department of Phys.cs Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Phys.cs.and Earth s.ience University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and Univers.ty of Milano Bicocca MilanoItaly INFN s.zione di Padova PadovaItaly III.Phys.k.lis.hes.Ins.itut B RWTH Aachen UniversityAachenGermany Eberhard k.rls.Univers.tät Tübingen Physikalisches InstitutTübingenGermany Ins.itute of High Energy Phys.cs BeijingChina s.BATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Phys.cs National Taiwan UniversityTaipei Dipartimento di Fis.ca e As.ronomia dell’Univers.tàdi Padova and INFN s.zione di Padova PadovaItaly Univers.ty of Roma Tre and INFN s.zione Roma Tre RomaItaly Aix Mars.ille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan Univers.ty WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United Univers.ty Miao-Li Dongguan Univers.ty of Technology DongguanChina Ts.nghua Univers.ty BeijingChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Ins.itute of Phys.cs National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power Univers.ty BeijingChina s.n Yat-s.n Univers.ty GuangzhouChina Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Univers.dade Es.adual de Londrina LondrinaBrazil INFN s.z

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)is.a large liquid s.intillator detector des.gned to explore many topics.in fundamental *** this.s.udy,the potential of s.arching for proton decay in the p→νk.(+)mode with JUNO is.*** k.on and its.decay particles.feature a clear three-fold coincidence s.gnature that res.lts.in a high efficiency for ***,the excellent energy res.lution of JUNO permits.s.ppres.ion of the s.zable back.round caus.d by other delayed *** on thes. advantages.the detection efficiency for the proton decay via p→νk.(+)is.36.9%±4.9%with a back.round level of 0.2±0.05(s.s.)±0.2(s.at)events.after 10 years.of data *** es.imated s.ns.tivity bas.d on 200 k.on-years.of expos.re is.9.6×1033 years.which is.competitive with the current bes. limits.on the proton lifetime in this.channel and complements.the us. of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid s.intillator detector