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Genotypic,size and morphological diversity of virioplankton in a deep oligomesotrophic freshwater lake(Lac Pavin,France)

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Journal of Environmental sciences 2017年第3期29卷 48-59页

作者： Jonathan Colombet agnès Robin Télesphore sime-Ngando Laboratory Microorganisms:Oenome and Environment Clermont University Blaise PascalUMR CNRS 602324 avenue des LandaisBP 80026F-63171 AubiereFrance CIRAD UMR Eco&Sols2 place Viala34060 Montpellier Cedex 1France

We examined changes in morphological and genomic diversities of viruses by means of transmission electronic microscopy and pulsed field gel electrophoresis （PFGE） over a nine-month period （April-December 2005） at four different depths in the oligomesotrophic Lac Pavin. We found that the majority of viruses in this lake belonged to the family of siphouiridae or were untailed, with capsid sizes ranging from 30 to 60 nm, and exhibited genome sizes ranging from 15 to 45 kb. On average, 12 different genotypes dominated each of the PFGE fingerprints. The highest genomic viral richness was recorded in summer （mean = 14 bands per PFGE fingerprint） and in the epilimnion （mean = 13 bands per PFGE fingerprint）. Among the physico-chemical and biological variables considered, the availability of the hosts appeared to be the main factor regulating the variations in the viral diversity.

关键词： VirusLac PavinDynamicMorphological diversity Genomic diversity

Micro-alloying of Zn and Ca in vacuum induction casted bioresorbable Mg system:Perspectives on corrosion resistance,cytocompatibility,and inflammatory response

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Journal of Magnesium and Alloys 2024年第7期12卷 2812-2825页

作者： Manisha Behera agnès Denys Rajashekhara shabadi Fabrice Allain Cosmin Gruescu UnitéMatériaux et Transformations(UMET) Universitéde LilleCNRSINRAENSCLUMR 8207UMETF-59000 LilleFrance Universitéde Lille CNRSUMR 8576-UGSF-Unitéde Glycobiologie Structurale et FonctionnelleF-59000 LilleFrance

There is an increasing interest in biodegradable materials,such as magnesium,for orthopaedic *** is driven by their potential to address challenges like stress shielding and the need for secondary removal *** this study,biodegradable magnesium alloys were produced using the Vacuum Induction Casting *** impact of micro-alloying Zn and Ca in Mg-xZn-0.2Ca(x=0.1,0.2,0.3,and 0.4 wt%)alloys on corrosion resistance,cytocompatibility,and early-stage inflammatory response was *** and sEM-EDs analysis confirmed the presence of Ca_(2)Mg_(6)Zn_(3)secondary phases in all *** Mg-0.3Zn-0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 36.8 GPa,resembling that of natural *** measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion *** vitro degradation in simulated body fluid(sBF)for 21 days showed hydroxyapatite formation on alloy surfaces,aligning with electrochemical *** vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys,with Mg-0.3Zn-0.2Ca having the highest cell viability over a 6-day cell *** into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mg-0.3Zn-0.2Ca ***-alloying with 0.3 wt%Zn and 0.2 wt%Ca enhanced mechanical properties,corrosion resistance,cytocompatibility,and immunomodulatory *** positions the Mg-0.3Zn-0.2Ca alloy as a promising biodegradable implant for bone fixation applications.

关键词： Micro-alloying MgZnCa Corrosion resistance In vitro Anti-inflammatory response

Natural stilbenes effects in animal models of Alzheimer’s disease

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Neural Regeneration Research 2020年第5期15卷 843-849页

作者： Aline Freyssin Guylène Page Bernard Fauconneau agnès Rioux Bilan University of Poitiers EA3808 NEUVACOD (Neurovascular Unit and Cognitive Disorders)P?le Biologie Santé

Alzheimer’s disease is one of the most frequent neurodegenerative *** pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive *** currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic ***,stilbenes presenting multiple pharmacological effects could be good potential therapeutic *** aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s ***,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro ***,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in *** paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in *** review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive ***,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on ***,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective *** could be relevant to evaluate this molecule in clinical trials.

关键词： Alzheimer's disease amyloid animal models cognitive impairment inflammation natural stilbenes neuroprotection resveratrol tau

Natural polyphenols effects on protein aggregates in Alzheimer＇s and Parkinson＇s prion-like diseases

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Neural Regeneration Research 2018年第6期13卷 955-961页

作者： aline freyssin guylène page bernard fauconneau agnès rioux bilan University of Poitiers EA380-8 NEUVACOD (Neurovascular Unit and Cognitive Disorders) Pole Biologie Sante Poitiers France

Alzheimer＇s and Parkinson＇s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer＇s disease, α-synuclein and synphilin-1 for Parkinson＇s disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer＇s and Parkinson＇s diseases.

关键词： natural polyphenols protein aggregates Alzheimer's disease amyloid peptide amyloid plaques hyperphosphorylated tau Parkinson's disease a-synuclein synphilin-I

Reciprocal interactions between gut microbiota and autophagy

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World Journal of Gastroenterology 2021年第48期27卷 8283-8301页

作者： Pierre Lapaquette Jean-Baptiste Bizeau Niyazi Acar Marie-agnès Bringer UMR PAM A 02.102 University Bourgogne Franche-ComtéAgrosup DijonDijon 21000France Eye and Nutrition Research Group Centre des Sciences du Goût et de l'AlimentationAgroSup DijonCNRSINRAEUniversitéBourgogne Franche-ComtéDijon 21000France

A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom *** gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this ***,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other ***,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or *** microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the *** these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and *** cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress *** of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host *** this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral ***,we describe the autophagy-related mechanisms affecting the gut *** conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

关键词： Gut microbiota Autophagy Probiotic Brain Liver Muscle

High-density single antibody electrochemical nanoarrays

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Nano Research 2023年第4期16卷 5412-5418页

作者： Khalil Chennit Yannick Coffinier shuo Li Nicolas Clément agnès Anne Arnaud Chovin Christophe Demaille UniversitéParis Cité CNRSLaboratoire d’Electrochimie MoléculaireParis F-75013France Institute of Electronics Microelectronics and NanotechnologyCNRSUniversity of LilleAvenue PoincaréBP60069Villeneuve d’Ascq 59652France IIs LIMMS/CNRS-IIS UMI2820The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

The fabrication and electrochemical interrogation of very high density single-antibody nanoarrays is *** nanodots,15 nm in diameter,arranged in large(cm2)square arrays with a pitch of 200 nm,are used as carriers for primary antibodies(immunoglobulin G(IgG)),further recognized by secondary redox-labeled detection *** scale interrogation of the antibody array by cyclic voltammetry,and nanoscale interrogation of individual nanodots by mediator tethered atomic forcescanning electrochemical microscopy(Mt/AFM-sECM),enable the occupancy of nanodots by single antibody molecules to be *** involving the competitive adsorption of antibodies of different species onto the nanodots evidence the possibility of using single-antibody nanoarrays for digital electrochemical immunoassays.

关键词： single entity electrochemistry electrochemical digital immunoassays atomic force-scanning electrochemical microscopy(AFM-sECM)

Mean-field BsDEs with jumps and dual representation for global risk measures

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Probability, Uncertainty and Quantitative Risk 2023年第1期8卷 33-52页

作者： Rui Chen Roxana Dumitrescu Andreea Minca agnès sulem INRIA Paris 2 rue Simone IffCS 4211275589 ParisCedex 12France UniversitéParis-Dauphine 75775 ParisCedex 16France Department of Mathematics King’s College LondonStrandLondon WC 2 R 2LSUK Department of Operations Research and Information Engineering Cornell University222 Rhodes HallIthacaNY 14853USA

We study mean-field BsDEs with jumps and a generalized mean-field operator that can capture higher-order *** interpret the BsDE solution as a dynamic risk measure for a representative bank whose risk attitude is influenced by the *** influence can come in a wide class of choices,including the average system state or average intensity of system *** Fenchel−Legendre transforms,our main result is a dual representation for the expectation of the risk measure in the convex *** particular,we exhibit its dependence on the mean-field operator.

关键词： Mean-field interactions BsDEs Dynamic risk measures system influence

Controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque satish s C Rao school of Medicine and Biomedical sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early Cancer Management Research Group RIsE@CI-IPO(Health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy sacral neuromodulation

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral