检索结果-南通市图书馆

HPLC-UV method for simultaneous determination of irbesartan, candesartan, gliquidone and pioglitazone in formulations and in human serum

引用

Journal of Chinese Pharmaceutical Sciences 2018年第4期27卷 273-280页

作者： agha zeeshan mirza Science and Technology Unit Umm Al-Qura University Makah 21955 KSA

In this study, we reported and validated a novel and sensitive reversed-phase liquid chromatographic method for the simultaneous determination of irbesartan, candesartan, gliquidone and pioglitazone. Separation was performed at 230 nm using a mobile phase consisting of methanol–water(90:10, v/v) with a flow rate of 1 mL/min. p H was adjusted to 3.5 with phosphoric acid. The concentration-response relationship was found linear over a concentration range of 5–25 μg/mL for all of the analytes tested. The limits of detection and quantification were 0.83 and 2.78 for irbesartan, 0.30 and 1.01 for candesartan, 1.11 and 3.93 for gliquidone, and 0.41 and 1.41 μg/mL for pioglitazone, respectively. Described method permitted the successful determination of these drugs in human serum. The developed method was simple, rapid, and it did not require extensive sample purification.

关键词： Candesartan Gliquidone Irbesartan Pioglitazone RP-HPLC Method development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and antibacterial activities of metal complexes of norfloxacin

引用

Journal of Chinese Pharmaceutical Sciences 2021年第10期30卷 838-844页

作者： Ahsan Zamir Siddiqi Muneeba Akhtar agha zeeshan mirza Research Institute of Pharmaceutical Sciences Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity of KarachiKarachi-75270Pakistan Highnoon Laboratories Limited LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversity of Central PunjabLahore-54782Pakistan Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia

The metal complexes of norfloxacin were prepared, and their structures were characterized using spectroscopic techniques like IR, 1H NMR, UV, atomic absorption, and CHN analysis. The solubility, melting point, and conductance measurements were also performed. These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom. The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method. It was observed that the complexes of norfloxacin with magnesium, calcium, cobalt, nickel, and copper showed improved activity compared with the stated drug.

关键词： Norfloxacin Metal complexes Characterization Antibacterial activities

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk,Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies

引用

Journal of Analysis and Testing 2020年第4期4卷 281-290页

作者： Faiza Akhtar Somia Gul Salman Ashfaq Iqra Rehman agha zeeshan mirza Department of Pharmaceutical Chemistry Faculty of PharmacyJinnah University for WomenKarachi 74600Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyZiauddin UniversityKarachi 75600Pakistan Department of Pharmaceutics Faculty of PharmacyUniversity of KarachiKarachi 75270Pakistan Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMecca 21955Saudi Arabia

A simple,easy and cost-efficient UV spectroscopic method was developed and validated for glibenclamide,the second generation of sulfonylureas,using 0.1 N NaOH as a *** proposed method is linear(R^(2)>0.999)with the range 5-25μg mL^(−1),accurate(99.60%),precise(inter and intraday variation 0.241 and 0.019%,respectively)and robust(<1%).The quantification and detection limit were 1.46 and 0.48μg mL^(−1),*** validated method was applied for in vitro interaction studies of glibenclamide(GLB)with commonly prescribed quinolones(ciprofloxacin,levofloxacin,moxifloxacin,and gemifloxacin)and nonsteroidal anti-inflammatory drugs(NSAIDs)(diclofenac sodium,ibuprofen,mefenamic acid,and aspirin)using UV *** in vitro interaction studies were carried out in different artificially prepared physiological buffers at 37°C for 2 *** showed raised level of glibenclamide when interacted with gemifloxacin(pH 7.4),levofloxacin(pH 9),ciprofloxacin(pH 4.5)and with moxifloxacin(pH 4.5,7.4 and 9).Interaction with NSAIDs results in increased%availability of glibenclamide in the presence of diclofenac sodium,ibuprofen,and mefenamic acid at pH *** anticipated method can be successfully applied for the routine analysis and also for the interaction of glibenclamide with other drugs.

关键词： Glibenclamide Interaction Quinolones NSAIDS UV spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis and antibacterial studies of ciprofloxacin-metal complexes

引用

Journal of Chinese Pharmaceutical Sciences 2019年第6期28卷 422-429页

作者： Najma Sultana M.Saeed Arayne Ahsan Zamir Siddiqi agha zeeshan mirza Research Institute of Pharmaceutical Sciences Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity ofKarachiKarachi-75270Pakistan Department of Chemistry University of Karachi Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia Research Laboratories Centre Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia

Metal complexes of ciprofloxacin were synthesized to study the effect of the drug on the metals present in the body or metals co-administered as multivitamin therapy. These complexes were then characterized by IR, UV, 1 H NMR, CHN and AA analyses. It was found that the metals coordinated through the β-keto carboxylic group, forming four coordinated complexes having square planar geometry. The effect of the antibacterial activity of these complexes with respect to parent drug was also studied against 14 different Gram + ve and Gram – ve organisms by the disk susceptibility technique. Some complexes showed improve activity as compared with the stated drug.

关键词： Ciprofloxacin IR UV ~1H NMR CHN AA analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：