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Aqueous Leaf Extract of Moringa oleifera (Moringaceae) Effectively Treats Induced Hemolytic Anemia in Wistar Rats

Journal of Biosciences and Medicines 2023年第8期11卷 154-168页

作者： Semado Franck Médard Tchogou Atchadé Pascal Medoatinsa Seinde Espérance Agbogba Félicienne Abissi Yollande Kassa Roxane Lokonon Jacques Ezéchiel Houngbeme Alban agbonon amegnon Gbénou Joachim Djimon Baba-Moussa Lamine Senou Maximin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin National Pharmacognosy Laboratory (LNP) Institute for Research and Experimentation in Traditional Medicine and Pharmacopoeia (IREMPT) Porto Novo Benin Laboratory of Physiology/Pharmacology Faculty of Sciences University of Lome Lome Togo Doctoral School (ED-STIM) National University of Sciences Technologies Engineering and Mathematics (UNSTIM) Abomey Benin Laboratory of Biology and Molecular Typing in Microbiology University of Abomey-Calavi Cotonou Benin

Introduction: Moringa oleifera was a medicinal plant generally used by populations in the food and therapeutic fields. It’s used to treat anemia has been observed in the Djougou Zone in northern Benin. To our knowledge, there were no scientific data available that have evaluated its efficacy in the treatment of haemolytic anemia. This was what justifies this research work in which the phytochemical analysis, extraction and evaluation of the anti-anemic effect were carried out. Methods: Five groups of five Wistar rats each were formed. All the rats were rendered anemic by injection of phenylhydrazine hydrochloride on the first two days D0 and D1 except those in the negative control group. From the second day, the anemic groups were force-fed either with the aqueous extract of Moringa oleifera leaves at 200 or 300 mg/kg body weight/day, or with vitafer, the reference drug against anemia. The positive control group (anemia) was not treated. Blood samples were taken from all the rats on different days: D0, D2, D7, D10 and D15 to evaluate the data of the hemogram and the osmotic resistance of the red blood cells. Results: Phytochemical analysis revealed the presence of tannins, flavonoids, leucoanthocyanins, saponosides, triterpenes and mucilages. A good yield was obtained at the extraction. Both the extract and the reference drug vitafer completely corrected anemia within two weeks after stimulating hemoglobin synthesis and early release of immature red blood cells into the bloodstream. Its effect seemed dose-dependent and specific. Conclusion: Moringa oleifera leaves showed good therapeutic efficacy and can be considered and exploited for transformation into improved traditional medicines (ITM) in the treatment of anemia.

关键词： Moringa oleifera Hemolytic Anemia Red Blood Cells Wistar Rats

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