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Right colon and liver hemangiomatosis:A case report and a review of the literature

World Journal of Gastroenterology 2006年第39期12卷 6405-6407页

作者： Athanasios Marinis Evi Kairi Theodosios Theodosopoulos agathi kondi-pafiti Vassilios Smyrniotis 2nd Department of Surgery Areteion University Hospital 76 Vasilisis Sofias av. Athens 11528 Greece Department of Pathology Areteion University Hospital 76 Vasilisis Sofias av. Athens 11528 Greece

Cavernous hemangiomatosis of the colon and liver in a 38-year-old woman presenting with a history of cramp like abdominal pain and a mass in the right iliac fossa are presented. Abdominal ultrasonography and computed tomography demonstrated multiple liver hemangiomas as well as a noncystic lesion in the right iliac fossa. Operative findings were suggestive of diffuse hemangiomatosis of the right colon and an extensive right hemicolectomy was performed. A review of the literature is presented, considering current diagnostic and therapeutic methods.

关键词： Hemangiomatosis Right Colon Liver

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KIT-negative gastrointestinal stromal tumors with a long term follow-up:A new subgroup does exist

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World Journal of Gastroenterology 2007年第7期13卷 1098-1102页

作者： Katerina Kontogianni-Katsarou Constantina Lariou Eugenia Tsompanaki Christina Vourlakou Evi Kairi-Vassilatou Costas Mastoris Georgia Pantazi Agatha kondi-pafiti Department of Pathology Athens Medical School Areteion University Hospital 76 Vas. Sophias Ave. Athens 11528 Greece Department of Pathology Evaggelismos General Hospital Ipsiladou 45-47 Athens 10676 Greece Department of Statistics School of Economics and Business Athens University Patision 76 Athens 10434 Greece

AIM： To investigate the incidence of KIT immunohostochemical staining in （GI） stromal tumors （GISTs）, and to analyze the clinical manifestations of the tumors and prognostic indicators. METHODS： We retrospectively analyzed 50 cases of previously diagnosed GISTs. Tissue samples were assessed with KIT （CDl17 antigen）, CD34, SMA, desmin, S-100, NSE, PCNA, Ki-67, and BCL-2 for immunohistochemical study and pathological characteristics were analyzed for prognostic factors. RESULTS： Fifteen tumors （30%） were negative in KIT staining. A significant association was observed between gender （male patients： 14/15） and KIT-negative staining （P = 0.003）.The patients＇s mean age was 56.6 years. Tumors developed in stomach （n = 8）, small intestine （n = 5）, large intestine （n = 1） and oesophagus （n = 1）. The mean tumor size was 5.72 cm. The mitotic count ranged from 0-29/50 HPF （mean： 3.4） and 73% of tumors showed no necrosis. The majority of the tumors （67%） had dual or epithelioid differentiation. Tumors were classified as very low or low risk （n = 7）, intermediate risk （n = 5）, and high risk （n = 3） groups. Twelve （80%） patients were alive without evidence of residual tumor for an average period of 40.25 mo （12-82 too）; three patients developed metastatic disease to the liver and eventually died within 2-12 mo （median survival： 8.6 too）.CONCLUSION： A small subgroup of GISTs fulfils the clinical and morphological criteria of these tumors, and lacks KIT expression. These tumors predominantly developed in the stomach, being dual or epithelioid in morphology, which are classified as low risk tumors and presented a better survival status than KIT-positive tumors. The ability to diagnose GISTs still depends on immunohistochemical staining but the research should extend in gene mutations.

关键词： Gastrointestinal stromal tumors CD 117antigen Immunohistochemistry Survival

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Surgical approaches of resectable synchronous colorectal liver metastases:Timing considerations

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World Journal of Gastroenterology 2007年第9期13卷 1431-1434页

作者： Ioannis Vassiliou Nick Arkadopoulos Theodosios Theodosopoulos Georgios Fragulidis Athanasios Marinis agathi kondi-Paphiti Lazaros Samanides Andreas Polydorou Constantinos Gennatas Dionysios Voros Vassilios Smyrniotis 2nd Department of Surgery Aretaieion HospitalUniversity of AthensSchool of Medicine AthensGreece Department of Pathology Aretaieion Hospital University of Athens School of Medicine Athens Greece Department of Oncology Aretaieion Hospital University of Athens School of Medicine AthensGreece

AIM: To compare the safety and efficacy of simultaneous versus two stage resection of primary colorectal tumors and liver metastases. METHODS: From January 1996 to May 2004, 103 colorectal tumor patients presented with synchronous liver metastases. Twenty five underwent simultaneous colorectal and liver surgery and 78 underwent liver surgery 1-3 mo after primary colorectal tumor resection. Data were retrospectively analyzed to assess and compare the morbidity and mortality between the surgical strategies. The two groups were comparable regarding the age and sex distribution, the types of liver resection and stage of primary tumors, as well as the number and size of liver metastases. RESULTS: In two-stage procedures more transfusions were required (4 ± 1.5 vs 2 ± 1.8, pRBCs, P < 0.05). Chest infection was increased after the two-stage approach (26% vs 17%, P < 0.05). The two-stage procedure was also associated with longer hospitalization (20 ± 8 vs 12 ± 6 d, P < 0.05). Five year survival in both groups was similar (28% vs 31%). No hospital mortality occurred in our series. CONCLUSION: Synchronous colorectal liver metastases can be safely treated simultaneously with the primary tumor. Liver resection should be prioritized over colon resection. It is advisable that complex liver resections with marginal liver residual volume should be dealt with at a later stage.

关键词： Synchronous colorectal liver metastases Colon resections Liver resections

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