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Pharmacological insights into Chukrasia velutina bark:Experimental and computer-aided approaches

Animal Models and Experimental Medicine 2022年第4期5卷 377-388页

作者： Israt Jahan Shahenur alam Sakib Najmul alam Mohuya Majumder Sanjida Sharmin A.S.M.Ali Reza Department of Pharmacy International Islamic University ChittagongChittagongBangladesh Department of Pharmacy East West UniversityDhakaBangladesh

Background:Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal *** present study aimed to explore the pharmacological activities of bark methanol extract using in vitro,in vivo and in silico ***:The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark(MECVB)through in vitro,in vivo and in silico *** activity was tested using formalin-i nduced nociception and acetic acid-i nduced writhing assays while the antipyretic effect was tested using yeast-i nduced hyperthermia in mice *** antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality *** addition,in silico studies were conducted using computer aided ***:In the acetic acid-i nduced writhing assay,the extract showed 28.36%and 56.16%inhibition of writhing for doses of 200 and 400 mg/kg,***,a dose-dependent formalin-i nduced licking response was observed in both early and late *** yeast-i nduced pyrexia,the MECVB exhibited(p<0.05)antipyretic *** extract demonstrated an ICvalue of 78.86μg/ml compared with ascorbic acid(IC23.53μg/ml)in the DPPH scavenging *** compounds sitosterol,5,7-dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX-I(2OYE),COX-II(6COX)and human peroxiredoxin 5(1HD2).In ADME/T analysis,5,7-dimethoxycoumarin and scopoletin satisfied Lipinski’s rule of five and thus are potential drug ***:The bark of Chukrasia velutina showed significant analgesic and antipyretic properties and is a potential source of natural anti-oxidative agents.

关键词： anti-nociceptive antioxidant antipyretic Chukrasia velutina cytotoxicity

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A Novel Krill Herd Based Random Forest Algorithm for Monitoring Patient Health

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Computers, Materials & Continua 2023年第5期75卷 4553-4571页

作者： Md.Moddassir alam Md Mottahir alam Muhammad Moinuddin Mohammad Tauheed Ahmad Jabir Hakami Anis Ahmad Chaudhary Asif Irshad Khan Tauheed Khan Mohd Department of Health Information Management and Technology University of Hafr Al-BatinSaudi Arabia Department of Electrical and Computer Engineering Faculty of EngineeringKing AbdulazizJeddah21589Saudi Arabia Center of Excellence in Intelligent Engineering Systems King Abdul Aziz UniversityJeddahSaudi Arabia College of Medicine King Khalid UniversityAbhaSaudi Arabia Department of Physics College of ScienceJazan UniversityP.O.Box.114Jazan45142Saudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11623Saudi Arabia Computer Science Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Math and Computer Science Augustana CollegeIL61201United States

Artificial Intelligence(AI)is finding increasing application in healthcare *** learning systems are utilized for monitoring patient health through the use of IoT sensor,which keep track of the physiological state by way of various health ***,early detection of any disease or derangement can aid doctors in saving patients’***,there are some challenges associated with predicting health status using the common algorithms,such as time requirements,chances of errors,and improper *** propose an Artificial Krill Herd based on the Random Forest(AKHRF)technique for monitoring patients’health and eliciting an optimal prescription based on their health *** begin with,various patient datasets were collected and trained into the system using IoT *** a result,the framework developed includes four processes:preprocessing,feature extraction,classification,and result ***,preprocessing removes errors,noise,and missing values from the dataset,whereas feature extraction extracts the relevant ***,in the classification layer,we updated the fitness function of the krill herd to classify the patient’s health status and also generate a *** found that the results fromthe proposed framework are comparable to the results from other state-of-the-art techniques in terms of sensitivity,specificity,Area under the Curve(AUC),accuracy,precision,recall,and F-measure.

关键词： Healthcare system health monitoring clinical decision support internet of things artificial intelligence machine learning diagnosis

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Surface settlement induced by horizontal directional drilling

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Underground Space 2023年第1期8卷 94-108页

作者： Asif Ahmed Md Azijul Islam Md Zahangir alam Hashmi S.Quazi College of Engineering State University of New York Polytechnic Institute(SUNY Poly)UticaNY 13502USA Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX 76019USA Department of Civil Engineering Bangladesh University of Engineering and Technology(BUET)Dhaka 1000Bangladesh Converse Consultants RedlandsCA 92373USA

Horizontal directional drilling(HDD)is a widely used trenchless method for underground utility *** associated ground settlement triggered by HDD depends on the size,types,and surface texture of pipe,diameter of borehole,and soil *** pre-sent study investigates the surface settlement due to the construction of a 1067 mm diameter HDD,which will replace an existing sewer siphon under the SR-60 highway in Chino,California using empirical,and numerical *** on the results obtained from the subsurface investigation,an empirical analysis was conducted *** by numerical modeling of the HDD using PLAXIS 2D soft-ware.A careful comparison between two different methods indicated closer values of surface settlement between the empirical method(7.3 mm)and the numerical modeling(4.6 mm).In addition,the shape of surface settlement and horizontal settlement curves for the empirical and numerical methods was found to be *** minor discrepancy between the two methods resulted as the numerical model can host several soil layers whereas the empirical equation can use only one type of ***,a parametric study was conducted to evaluate the effect of borehole cover depth,size,and soil parameters on surface *** was observed that soil strength param-eters yielded a greater effect on surface movement,whereas modulus of elasticity has a relatively smaller influence with zero contribution from Poisson’s ratio.

关键词： Horizontal directional drilling(HDD) Surface settlement Cover depth Soil arching Borehole

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One-dimensional numerical investigation on multicylinder gasoline engine fueled by micro-emulsions,CNG,and hydrogen in dual fuel mode

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Chinese Journal of Aeronautics 2023年第5期36卷 57-65页

作者： Ufaith QADIRI D.SIVA KRISHNA REDDY Amjad ALI PASHA Mohammad IRFAN alam Department of Mechanical Engineering Sreenidhi UniversityYamnampetGhatkesar Hyderabad 501301India School of Mechanical Engineering SRM Institute of Science and TechnologyKattankulathurChennai 603203India Aerospace Engineering Department King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Aerospace Engineering VIT Bhopal UniversitySehore 466665India

This research work is the novel state-of-the-art technology performed on multi-cylinder SI engine fueled compressed natural gas,emulsified fuel,and hydrogen as dual *** work predicts the overall features of performance,combustion,and exhaust emissions of individual fuels based on AVL Boost simulation *** types of alternative fuels have been compared and *** results show that hydrogen produces 20%more brake power than CNG and 25%more power than micro-emulsion fuel at 1500 r/min,which further increases the brake power of hydrogen,CNG,and micro-emulsions in the range of 25%,20%,and 15%at higher engine speeds of 2500-4000 r/min,*** addition,the brake-specific fuel consumption is the lowest for 100%hydrogen,followed by CNG 100%and then micro-emulsions at 1500 r/*** 2500-5000 r/min,there is a significant drop in brake-specific fuel consumption due to a lean mixture at higher engine *** CO,HC,and NOx emissions significantly improve for hydrogen,CNG,and micro-emulsion *** fuel shows zero CO and HC emissions and is the main objective of this research to produce 0%carbon-based emissions with a slight increase in NOx emissions,and CNG shows 30%lower CO emissions than micro-emulsions and 21.5%less hydrocarbon emissions than micro-emulsion fuel at stoichiometric air/fuel ratio.

关键词： CNG Emissions Hydrogen Ignition Micro-emulsions Performance

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Performance of hot-mix asphalt using polymer-modified bitumen and marble dust as a filler

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第3期10卷 385-398页

作者： Diyar Khan Rawid Khan Muhammad Tariq Khan Muhammad alam Tanveer Hassan Department of Civil Engineering University of Engineering and TechnologyPeshawarPakistan Faculty of Transport and Aviation Engineering Silesian University of TechnologyKatowice 40-019Poland Department of Civil Engineering University of Engineering and TechnologyMardanPakistan Department of Built Environment and Architecture London South Bank UniversityLondon SE10AAUK

Marble dust waste powder generated by the marble cutting industry has a high *** this research,the use of marble dust(MD)as a mineral filler substitute in hot mixed asphalt(HMA)was *** Marshall mix design was used to determine the optimum bitumen content(OBC)for all of the *** each of the four MD contents,i.e.,0,2%,4%,and 6%by weight of the total aggregates,four different bitumen percentages were *** results of the Marshall stability test showed that the optimum filler content was 4%*** were prepared with 0 MD in the control mix and varying percentages of MD as an alternate *** addition,MD aided in increasing the Marshall stability,rutting resistance,and permanent deformation and reduced the fatigue life of asphalt *** the percentage of MD increases,the rutting resistance and stiffness at high temperatures both *** the percentage of MD increases,the fatigue life *** resistance in high-temperature conditions can be improved by using MD in HMA as a partial substitute for stone dust(SD).In areas where extensive MD waste is present,MD can be incorporated into HMA mixtures instead of conventional fillers.

关键词： Asphalt mixture Marble dust Wheel tracker test Dynamic modulus test Four-point fatigue beam test

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