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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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基于神经网络模型的原子核基态自旋分布的随机相互作用研究

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原子核物理评论 2024年第1期41卷 385-395页

作者：刘登 alam Noor A 肖越雷杨覃珍珍西南科技大学数理学院四川绵阳621010 西南科技大学国防科技学院四川绵阳621010

利用神经网络模型学习、模拟随机两体系综(TBRE)下的原子核基态自旋分布,并对学习后的模型输入特征进行了分析。这是核物理中利用神经网络模型进行分类的典型应用。研究表明,采用本工作的单隐藏层神经网络模型,精确地描述每个随机相互... 详细信息

利用神经网络模型学习、模拟随机两体系综(TBRE)下的原子核基态自旋分布,并对学习后的模型输入特征进行了分析。这是核物理中利用神经网络模型进行分类的典型应用。研究表明,采用本工作的单隐藏层神经网络模型,精确地描述每个随机相互作用系综内的样本仍比较困难。然而,神经网络模型却能够相对较好地描述基态自旋的统计性质,这可能是因为神经网络模型学习到了TBRE中基态自旋分布的经验规律。

关键词：神经网络随机两体系综原子核基态自旋

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Structure Design of Underwater Micro Robot

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Modern Mechanical Engineering 2024年第1期14卷 12-24页

作者： Md Shahriar Sujan Joy Howlader Md Jahangir alam Md Al Imran Tapu College of Harbor Coastal & Offshore Engineering Hohai University Nanjing China Department of Computer Science and Information Technology College of Computer and Information Hohai University Nanjing China College of Civil and Transportation Engineering Hohai University Nanjing China

A submergible robot model has been presented, and for 3D printing measures, their parts have been modified enough. It has been shown in our design that using printable connectors—a few engines and weight arrangements can be carried out, permitting distinctive moving prospects. After presenting our configuration and delineating a bunch of potential structures, a helpful model dependent on open-source equipment and programming arrangements has been presented conditionally. The model can be effectively tried in a few makes-a plunge streams and lakes throughout the planet. The unwavering quality of the printed models can be strained distinctly in generally shallow waters. Nonetheless, we accept that their accessibility will inspire the overall population to construct and test submerged robots, subsequently accelerating the improvement of imaginative arrangements and applications.

关键词： Submergible Robot Thruster Adapter Raspberry Pi 3D Printer Open Source Software

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Design and Analysis of Power and Transmission System of Downhole Pure Electric Command Vehicle

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Journal of Transportation Technologies 2024年第1期14卷 31-52页

作者： Md Jahangir alam Md Shahriar Sujan Md. Al Imran Tapu Joy Howlader College of Civil and Transportation Engineering Hohai University Nanjing China College of Harbor Coastal & Offshore Engineering Hohai University Nanjing China Department of Computer Science and Technology College of Computer and Information Hohai University Nanjing China

Electric vehicles use electric motors, which turn electrical energy into mechanical energy. As electric motors are conventionally used in all the industry, it is an established development site. It’s a mature technology with ideal power and torque curves for vehicular operation. Conventional vehicles use oil and gas as fuel or energy storage. Although they also have an excellent economic impact, the continuous use of oil and gas threatened the world’s reservation of total oil and gas. Also, they emit carbon dioxide and some toxic ingredients through the vehicle’s tailpipe, which causes the greenhouse effect and seriously impacts the environment. So, as an alternative, electric car refers to a green technology of decarbonization with zero emission of greenhouse gases through the tailpipe. So, they can remove the problem of greenhouse gas emissions and solve the world’s remaining non-renewable energy storage problem. Pure electric vehicles (PEV) can be applied in all spheres, but their special implementation can only be seen in downhole operations. They are used for low noise and less pollution in the downhole process. In this study, the basic structure of the pure electric command vehicle is studied, the main components of the command vehicle power system, namely the selection of the drive motor and the power battery, are analyzed, and the main parameters of the drive motor and the power battery are designed and calculated. The checking calculation results show that the power and transmission system developed in this paper meets the design requirements, and the design scheme is feasible and reasonable.

关键词： Pure Electric Vehicles Transmission Gears Electronic Differential Control Algorithms

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An Analysis of the Lifestyle and Mental Health Status of Adult People Living in Dhaka City: A Cross-Sectional Study in Post COVID-19 Era

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Advances in Infectious Diseases 2024年第2期14卷 393-410页

作者： Tania Ahmed Chowdhury Nasrin Akhter Ishrat Hossain Rezwana Jahan Pallabi Sultana Mohammad Jahangir alam Radda MCH-FP Centre Dhaka Bangladesh Center for Higher Studies and Research (CHSR) Bangladesh University of Professionals (BUP) Dhaka Bangladesh

Introduction: The Novel Coronavirus or COVID-19 affected all the megacities of the world and made the mental health and lifestyle of people paralyzed. According to different studies, such difficulties were different in scale in different cities depending on the demographic attributes of the people. This phenomenon has created the essence of the current study to examine the health conditions in terms of their mental health, lifestyle, and demographic attributes during and immediate past of the COVID-19 era. Method: It was a cross-sectional study covering the people of Dhaka City Corporation. For this purpose, a multistage sampling method was applied, under which the respondents were selected randomly and a self-administered structured questionnaire was used to collect data. The questionnaire was developed based on the DASS 21, as it was suitable to measure the components of mental health in the form of depression, anxiety, and stress. Descriptive analysis and cross-tabulation were applied to find out the association between dependent and independent variables, whereas, a chi-square test was performed to examine the hypothesis. Finally, multivariate analysis was done to find out the risk factors. Three logistic regression models were developed for three dependent variables. Result: The findings of the analysis revealed that the lifestyle of people had severely influenced the components of their mental health conditions during and immediate past of COVID-19 in the Dhaka City Corporation, which varies to some extent depending on the demographic attributes of those. Conclusion: The above findings are statistically significant enough to conclude about the essence of taking preventive measures regarding mental health issues in the future. However, the limitations of this study-keeping it within the urban areas and the educated people, have also created the venue for future researchers to move with their research endeavors in the rural areas nationwide and thus generalize t

关键词： Lifestyle Mental Health Depression Stress Anxiety Dhaka City DASS 21 COVID-19

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Evaluation of AVNRT & AVRT by Different Criteria: Old & New

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World Journal of Cardiovascular Surgery 2024年第7期14卷 95-106页

作者： Abdul Hamid Tahmina alam Sonali Rizwan Rehan Pijous Biswas Subas Caandro Datta Asif Zaman Department of Cardiology Chattagram Medical College Hospital Chattagram Bangladesh Chattagram Medical College Hospital Chattagram Bangladesh Department of Cardiology National Institute of Cardiovascular Disease Dhaka Bangladesh Department of Cardiology Bangamata Sheikh Fozilatunnesa Mujib General Hospital Sirajganj Bangladesh Department of Cardiology Evercare Hospital Dhaka Bangladesh

The two most frequent causes of paroxysmal SVT are atrioventricular tachycardia (AVRT) and atrioventricular nodal re-entrant tachycardia (AVNRT). The purpose of this study was to assess the diagnostic efficacy of traditional and newly proposed ECG criteria in the identification of Avnrt and Avrt. Aim of the Study: The aim of this study was to evaluate Atrioventricular Nodal Reentrant Tachycardia (AVNRT) and Atrioventricular Re-entrant Tachycardia (AVRT) using both traditional and novel criteria. Methods: This prospective observational study was conducted at the Electrophysiology Unit, Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD) in Dhaka, from February 2019 to January 2020. A total of 62 patients with Supraventricular Tachycardia (SVT) undergoing electrophysiology study (EPS) were included. Standard ECG criteria were applied for the differential diagnosis, and electrophysiological diagnoses were made using established criteria. Statistical analysis, including descriptive statistics and appropriate tests, was performed using SPSS 23.0. Result: In our study of 62 patients with Supraventricular Tachycardia (SVT), we found that 66.1% had AVNRT and 33.9% had AVRT. The mean age in AVNRT was higher than AVRT (41.3 ± 9.7 vs. 38.5 ± 14.3, p = 0.36) with statistically no significant difference, with similar gender distribution between AVNRT and AVRT groups. Classical AVNRT criteria were present in 30.6% of patients, and 45.2% showed a Pseudo R' wave in aVR. Additionally, 30.6% had an RP interval ≥100ms, more prevalent in AVRT patients (66.7%). Conclusion: Integrating traditional and novel criteria, including lead aVR analysis, enhances the electrocardiographic diagnosis of AVNRT and AVRT, offering a pathway to refined patient care.

关键词： SVT (Supraventricular Tachycardia) AVNRT (Atrioventricular Nodal Re-Entrant Tachycardia) AVRT (Atrioventricular Re-Entrant Tachycardia) ECG Criteria Electrophysiology

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Analyzing the Impact of Scene Transitions on Indoor Camera Localization through Scene Change Detection in Real-Time

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Intelligent Automation & Soft Computing 2024年第3期39卷 417-436页

作者： Muhammad S.alam Farhan B.Mohamed Ali Selamat Faruk Ahmed AKM B.Hossain Department of Emergent Computing School of ComputingUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia Malaysia-Japan International Institute of Technology(MJIIT) Universiti Teknologi MalaysiaKuala Lumpur54100Malaysia Media and Game Innovation Centre of Excellence(MaGICX) Universiti Teknologi MalaysiaJohor Bahru81310Malaysia Department of Engineering Technology University of MemphisMemphisTN38152USA Department of Computer Science and Artificial Intelligence College of Computing and Information TechnologyUniversity of BishaBisha61922Saudi Arabia School of Computing Faculty of EngineeringUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia Department of Information System and Cyber Security College of Computing and Information TechnologyUniversity of BishaBisha61922Saudi Arabia

Real-time indoor camera localization is a significant problem in indoor robot navigation and surveillance *** scene can change during the image sequence and plays a vital role in the localization performance of robotic applications in terms of accuracy and *** research proposed a real-time indoor camera localization system based on a recurrent neural network that detects scene change during the image *** annotated image dataset trains the proposed system and predicts the camera pose in *** system mainly improved the localization performance of indoor cameras by more accurately predicting the camera *** also recognizes the scene changes during the sequence and evaluates the effects of these *** system achieved high accuracy and real-time *** scene change detection process was performed using visual rhythm and the proposed recurrent deep architecture,which performed camera pose prediction and scene change impact ***,this study proposed a novel real-time localization system for indoor cameras that detects scene changes and shows how they affect localization performance.

关键词： Camera pose estimation indoor camera localization real-time localization scene change detection simultaneous localization and mapping(SLAM)

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Chiral symmetry restoration and deconfinement in the contact interaction model of quarks with parallel electric and magnetic fields

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Chinese Physics C 2021年第7期45卷 111-121页

作者： aftab Ahmad Institute of Physics Gomal University29220D.I.KhanKhyber PakhtunkhawPakistan

We study the impact of steady,homogeneous,and external parallel electric and magnetic field strengths(eE||eB)on the chiral symmetry breaking-restoration and confinement-deconfinement phase *** also sketch the phase diagram of quantum chromodynamics(QCD)at a finite temperature T and in the presence of background *** unified formalism for this study is based on the Schwinger-Dyson equations,symmetry preserving vector-vector contact interaction model of quarks,and an optimal time regularization *** T=0,in the purely magnetic case(i.e.,eE→0),we observe the well-known magnetic catalysis ***,in a pure electric field background(eB→0),the electric field tends to restore the chiral symmetry and deconfinement above the pseudo-critical electric field eE^(x,C)_(c).In the presence of both eE and eB,we determine the magnetic catalysis effect in the particular region where eB dominates over eE,whereas we observe the chiral inhibition(or electric chiral rotation)effect when eE overshadows *** finite T,in the pure electric field case,the phenomenon of inverse electric catalysis appears to exist in the proposed ***,for a pure magnetic field background,we observe the magnetic catalysis effect in the mean-field approximation and inverse magnetic catalysis with eB-dependent *** combined effects of eE and eB on the pseudo-critical T^(x,C)_(c)yields an inverse electromagnetic catalysis,with and without an eB-dependent effective coupling of the *** findings of this study agree well with the already predicted results obtained via lattice simulations and other reliable effective models of QCD.

关键词： chiral symmetry breaking confinement electric and magnetic fields schwinger-dyson equations QCD phase diagram

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Utilizing the γ-Irradiated Sodium Alginate as a Plant Growth Promoter for Enhancing the Growth,Physiological Activities,and Alkaloids Production in Catharanthus roseus L.

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Agricultural Sciences in China 2011年第8期10卷 1213-1221页

作者： Mohd Idrees Mohd Naeem Masidur alam Tariq aftab Nadeem Hashmi Mohd Masroor Akhtar Khan Moinuddin Lalit Varshney Department of Botany Aligarh Muslim University Bhabha Atomic Research Centre

Sodium alginate is a polysaccharide that is largely obtained from the brown algae （Sargassum sp.）.It has been used as a wonderful growth promoting substance in its depolymerized form for various *** aim of this study was to find out the effects of various concentrations of γ-irradiated sodium alginate （ISA）,viz.,deionized water （control,T0）,20 （T1）,40 （T2）,60 （T3）,80 （T4）,and 100 ppm （T5） on the agricultural performance of Catharanthus roseus L.（Rosea） in terms of growth attributes,photosynthesis,physiological activities,and alkaloid *** present work revealed that ISA applied as leaf-sprays at concentrations from 20 to 100 ppm might improve growth,photosynthesis,physiological activities,and alkaloid production in *** *** the various ISA concentrations,80 ppm proved to be the best one compared to other concentrations applied.

关键词： γ-irradiated sodium alginate plant growth promoter chlorophyll and carotenoids content carbonic anhydrase and nitrate reductase activities growth attributes photosynthesis

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Chemical modification of acetaminophen：PASS assisted in vivo antiinflammatory activity of chalcones,flavanones and Schiff bases

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Journal of Chinese Pharmaceutical Sciences 2017年第8期26卷 611-620页

作者： Syed Misbahul Hasan Shah alam Khan Kavita Golani Jaswinder Lamba aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and Research Jamia Hamdard (Hamdard University)New Delhi 110062 India Faculty of Pharmacy Integral University Lucknow UP 226026 India Department of Pharmacy Oman Medical College PO Box 620 Postal code-130 Muscat Sultanate of Oman Health Information Technology Department Jeddah Community College King Abdulaziz University deddah Kingdom of Saudi Arabia

In the present study,synthetic chalcones,flavanones and Schiff bases were prepared starting from paraceamol,and evaluated their anticipated anti-inflammatory *** were synthesized by reacting 3-acetyl-4-hydroxy acetanilide and aromatic aldehydes in alcoholic potassium hydroxide(KOH) solution under Claisen-Schmidt condensation *** chalcones were cyclized in the presence of piperidine in isoamyl alcohol to obtain flavonone *** bases were synthesized by condensing 3-acetyl-4-hydroxy anilines with aromatic aldehydes in the presence of *** Schiff bases were further reacted with other aromatic aldehydes in alcoholic KOH *** cheminformatics software was used to predict the anti-inflammatory activity of synthesized *** software predicted that chalcone-based Schiff bases 6a–d contained structural features that can exhibit anti-inflammatory *** the prepared derivatives of acetaminophen exhibited moderate to excellent in vivo anti-inflammatory activity in carrageenan-induced edema in rat *** the Schiff bases coupled chalcones showed good anti-inflammatory activity compared with the reference drug,*** evaluation of their therapeutic potential and safety profile is required in the future study.

关键词： p-Acetaminophen Anti-inflammatory Chalcone Flavanone

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