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Neural differentiation of choroid plexus epithelial cells:role of human traumatic cerebrospinal fluid

Neural Regeneration Research 2017年第1期12卷 84-89页

作者： Elham Hashemi Yousef Sadeghi Abbas Aliaghaei afsoun seddighi Abbas Piryaei Mehdi Eskandarian Broujeni Fatemeh Shaerzadeh Abdollah Amini Ramin Pouriran Department of Anatomy and Cell Biology School of MedicineShahid Beheshti University of Medical SciencesTehranIran Shohada Tajrish Neurosurgical Center of Excellence Shahid Beheshti University of Medical SciencesTehranIran Department of Stem Cells and Regenerative Medicine Faculty of Medical BiotechnologyNational Institute of Genetic Engineering andBiotechnologyTehranIran Molecular Medicine Research Center Hormozgan Health InstituteHormozgan University of Medical SciencesBandar AbbasIran School of Medicine Shahid Beheshti University of Medical SciencesTehranIran

As the key producer of cerebrospinal fluid（CSF）,the choroid plexus（CP） provides a unique protective system in the central nervous *** components are not invariable and they can change based on the pathological conditions of the central nervous *** purpose of the present study was to assess the effects of non-traumatic and traumatic CSF on the differentiation of multipotent stem-like cells of CP into the neural and/or glial *** epithelial cells were isolated from adult male rats and treated with human non-traumatic and traumatic *** in m RNA expression of Nestin and microtubule-associated protein（MAP2）,as the specific markers of neurogenesis,and astrocyte marker glial fibrillary acidic protein（GFAP） in cultured CP epithelial cells were evaluated using quantitative real-time *** data revealed that treatment with CSF（non-traumatic and traumatic） led to increase in m RNA expression levels of MAP2 and ***,the expression of Nestin decreased in CP epithelial cells treated with non-traumatic CSF,while treatment with traumatic CSF significantly increased its m RNA level compared to the cells cultured only in DMEM/F12 as *** seems that CP epithelial cells contain multipotent stem-like cells which are inducible under pathological conditions including exposure to traumatic CSF because of its compositions.

关键词： nerve regeneration choroid plexus cerebrospinal fluid stem cells Nestin microtubule-associated protein 2 glial fibrillary acidic protein neurogenesis central nervous system neural regeneration

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