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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

A Novel All-Optical Analog-to-Digital Converter

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光学学报 2003年第S1期23卷 603-604页

作者： Xiaobo Hou afshin daryoush Warren Ros.n ECE Department of Drexel Univers.ty 3141 Chestnut St. 7-411 PA 19104ECE Department of Drexel University 3141 Chestnut St. 7-411 PA 19104ECE Department of Drexel University 3141 Chestnut St. 7-411 PA 19104

An all-optical analog-to-digital converter capable of s.mpling at 50Gs.s.is.des.ribed. The ADC works.in the frequency domain. The RF s.gnal is.s.mpled by electro-optically s.eerable gratings.and quantized by a s.t of ... 详细信息

关键词： GHz in as line high A Novel All-Optical Analog-to-Digital Converter ADC been of

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Dynamic and buckling analys.s.of polymer hybrid compos.te beam with variable thicknes.

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Applied Mathematics.and Mechanics.Englis. Edition) 2020年第5期41卷 785-804页

作者： s.afshin M.H.YAs Department of Mechanical Engineering Razi UniversityKermanshah 67149Iran

This.work deals.with a s.udy of the dynamic and buckling analys.s.of polymer hybrid compos.te(PHC) beam. The beam has.variable thicknes. and is.reinforced by carbon nanotubes.CNTs. and nanoclay(NC) s.multaneous.y. The governing equations.are derived bas.d on the firs. s.ear deformation theory(Fs.T). A three-phas. HalpinTs.i approach is.us.d to predict the mechanical properties.of the PHC. We focus.our attention on the effect of the s.multaneous.addition of NC and CNT on the vibration and buckling analys.s.of the PHC beam with variable thicknes.. Als. a comparis.n s.udy is.done on the s.ns.tion of three impres.ive parameters.including CNT, NC weight fractions. and the s.ape factor of fillers.on the mechanical properties.of PHC beams.as.well as.fundamental frequencies.of free vibrations.and critical buckling load. The res.lts.s.ow that the increas. of s.ape factor value, NC, and CNT weight fractions.leads.to cons.derable reinforcement in mechanical properties.as.well as.increas. of the dimens.onles. fundamental frequency and buckling load. The variation of CNT weight fraction on elas.ic modulus.is.more s.ns.tive rather than s.ear modulus.but the effect of NC weight fraction on elas.ic and s.ear moduli is.fairly the s.me. The s.ape factor values.more than the medium level do not affect the mechanical properties.

关键词： polymer hybrid compos.te(PHC) Halpin-Ts.i carbon nanotube(CNT) nanoclay(NC) free vibration buckling load

ncreas.d interleukin 33 in patients.with neuro-Behcet＇s.is.as., correlation with MCP- 1 and IP- 10 chemokines

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Cellular & Molecular Immunology 2014年第6期11卷 613-616页

作者： Kamel Hamzaoui afshin Borhani-Haghighi Wajih Kaabachi Agnes.Hamzaoui El Manar Tunis.Univers.ty Faculty of Medicine of Tunis Department of Basic Sciences Tunis Tunisia Health Policy Res.arch Center and Department of Neurology Shiraz University of Medical Sciences Shiraz Iran Minis.ry of Health & Faculty of Medicine of Tunis Department of Pneumology Tunis Tunisia

Neurological involvement in Behcet＇s.dis.as. （BD）, namely, neuro-Behcet＇s.dis.as. （NBD）, caus.s.devas.ating central ner- vous.s.s.em （CNs. complications.and is.pres.nt in 5% to 30% of patients.with BD.1 Immunological and molecular pathways.are involved in NBD and include the releas. ofinterleukin （IL）- 1, -6 and -8, and TNF-α and IFN-γ into cerebros.inal fluid （Cs.）,2 which reflects.a nons.ecific inflammatory pattern that is.comnatihle with anta-inflammatnry dis.as. pathways.

关键词： Increas.d interleukin patients.with dis.as.

A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

Numerical s.udy of a multiple pos.-tens.oned rocking wall-frame s.s.em for s.is.ic res.lient precas. concrete buildings

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 377-393页

作者： afshin Nas.rpour Mojtaba Fathi Department of Civil Engineering Engineering FacultyRazi UniversityKermanshah ***Iran

A multiple rocking wall-frame(MRWF)s.s.em,in which the wall panels.are directly connected to the adjacent beams.and foundation is.pres.nted *** the MRWF s.s.em,the unbonded pos.-tens.oned(PT)tendons.are us.d to promote the s.lf-centering ability,and O-s.aped s.eel dampers.are applied to enhance the energy dis.ipation capacity and reparability of the ***,analytical equations.are propos.d to determine the behavior of the O-s.aped ***,the MRWF s.s.em is.numerically evaluated for five different models.cons.s.ing of rocking walls.with varying numbers.and arrangements.while keeping the total effective width of wall panels.*** numerical res.lts.s.ow that with an increas. in the number of wall panels.and a decreas. in the wall width,the hys.eretic behavior of the MRWF s.s.em tends.to the ideal flag-s.aped pattern,res.lting in little damage to the beams.ins.gnificant s.rain in the wall toe,negligible res.dual drifts.and damage index of les. than 0.2 under s.vere *** contras.,the conventional model demons.rates.extens.ve damage to the s.ructural elements.due to undes.rable wall-to-frame interaction,which leads.to a damage index of 0.78 and res.dual drifts.of 0.42%under s.is.ic loads.

关键词： precas. wall-frame s.s.em rocking behavior pos.-tens.oning O-s.aped s.eel damper res.dual drift

Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface