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Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation

International Journal of Oral Science 2012年第4期4卷 189-195页

作者： afsaneh rangiani Zheng-Guo Cao Ying Liu Anika Voisey Rodgers Yong Jiang Chun-Lin Qin Jian-Quan Feng Biomedical Sciences Baylor College of DentistryTexas A&M Health Science Center

Deletion or mutation of dentin matrix protein 1 （DMP1） leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change is a direct role of DMP1 or an indirect role of phosphate （Pi） or both. It has also been previously shown that Klotho-deficient mice, which displayed a high Pi level due to a failure of Pi excretion, causes mild defects in the dentinal structure. This study was to address the distinct roles of DMP1 and Pi homeostasis in cell differentiation, apoptosis and mineralization of dentin and enamel. Our working hypothesis was that a stable Pi homeostasis is critical for postnatal tooth formation, and that DMP1 has an antiapoptotic role in both amelogenesis and dentinogenesis. To test this hypothesis, Dmpl-null （Dmpl-/-）, Klotho-deficient （kl/kl）, Dmpl/Klotho-double-deficient （Dmpl-/-/kl/kl） and wild-type （WT） mice were killed at the age of 6 weeks. Combinations of X-ray, microcomputed tomography （I^CT）, scanning electron microscopy （SEM）, histology, apoptosis and immunohistochemical methods were used for characterization of dentin, enamel and pulp structures in these mutant mice. Our results showed that Dmpl-/- （a low Pi level） or kl/kl（a high Pi level） mice displayed mild dentin defects such as thin dentin and a reduction of dentin tubules. Neither deficient mouse line exhibited any apparent changes in enamel or pulp structure. However, the double-deficient mice （a high Pi level） displayed severe defects in dentin and enamel structures, including loss of dentinal tubules and enamel prisms, as well as unexpected ectopic ossification within the pulp root canal. TUNEL assay showed a sharp increase in apoptotic cells in ameloblasts and odontoblasts. Based on the above findings, we conclude that DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment （a high Pi level）.

关键词： apoptosis dentin dentin matrix protein 1 enamel Klotho phosphate

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Middle Jurassic palynomorphs of the Dalichai Formation, central Alborz Ranges, northeastern Iran:Paleoecological inferences

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Science China Earth Sciences 2013年第12期56卷 2107-2115页

作者： DEHBOZORGI afsaneh SAJJADI Freshteh HASHEMI Hossein Faculty of Geology College of ScienceUniversity of TehranEnghelab AvenueTehran 14155-6455Iran Department of Geology Faculty of Science and Research School of Applied SciencesKharazmi UniversityNo. 49Mofatteh AvenueTehran 15614Iran

Palynological data are used to draw paleoecological inferences for the Dalichai Formation,northeast of Semnan,northeastern *** samples examined yield well-preserved,diverse palynofloras consisting predominantly of miospores;dinoflagellate cysts,foraminiferal test linings,and fungal spores occur as minor ***-four species of spores(37 genera),18species of pollen(9 genera),and 16 species of dinoflagellate cysts(13 genera)are ***-occurrence of such miospore species with known vertical ranges as Klukisporites variegatus,Sellaspora asperata,Murospora florida,and Concavissimisporites verrucosus suggests a Middle Jurassic(Bajocian-Callovian)age for the host strata,thus corroborating the available paleozoological *** spore species as Klukisporites,Cyathidites,and Dictyophyllidites known to have been produced by Pterophyta dominate the *** the contemporaneous coastal vegetation was characterized by predominance of Pterophyta whereas representatives of Ginkgophyta,Pteridospermophyta,Lycophyta,Coniferophyta,and Bryophyta were rarely *** reconstruction implies that a moist,warm climate prevailed in northeastern Iran during the Middle Jurassic(Bajocian-Callovian).This is confirmed by occurrence of fungal spores accompanied by such warm water dinoflagellate cysts as Mendicodinium groenlandicum,Pareodinia ceratophora,and Gonyaulacysta *** of Amorphous Organic Matter(AOM)signifies a shallow,low-energy,dysoxic-anoxic depositional site for the host ***,the ratio of AOM to marine palynomorphs as well as abundance of blade-shaped to eqiudimensional opaque palynomacerals could indicate low sedimentation rate in a shallow,low-oxygenated marine ***,occurrence of chorate dinoflagellate cysts(e.g.,Adnatosphaeridium caulleryi)and acritarchs bearing relatively long processes(e.g.,Micrhystridium)possibly suggests deepening upward in the study section.

关键词： palynomorphs Middle Jurassic paleoecology Alborz Ranges Dalichai Formation

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Solvent-less synthesis of zinc oxide nanostructures from Zn(salen) as precursor and their optical properties

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Particuology 2012年第6期10卷 759-764页

作者： Ali Kazemi Babaheydari Masoud Salavati-Niasari afsaneh Khansari Islamic Azad University Shahrekord BranchShahre KordIran Institute of Nano Science and Nano Technology University of KashanP.O.Box 87317-51167KashanIran Department of Inorganic Chemistry Faculty of ChemistryUniversity of GuilanP.O.Box 413354-1914RashtIran

ZnO nanoparticles, 10-20 nm in size, were synthesized by heat treatment in air at 500 ℃ for 5 h., using [N,N＇-bis（salicylaldehydo） ethylene diamine]zinc（II）, i.e., Zn（salen）, as precursor, which was obtained by a solvent-flee solid-solid reaction. Heat-treated products were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy. Room temperature photoluminescence spectra of ZnO nanostructures are dominated by green emission attributed to oxygen vacancy related donor-acceptor transition.

关键词： ZnO Nanostructures Solvent-free synthesis Semiconductor

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A Novel All-Optical Sensor Design Based on a Tunable Resonant Nanocavity in Photonic Crystal Microstructure Applicable in MEMS Accelerometers

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Photonic Sensors 2021年第4期11卷 457-471页

作者： Mojtaba HOSSEINZADEH SANI Hamed SAGHAEI Mohammad Amin MEHRANPOUR afsaneh ASGARIYAN TABRIZI Department of Electrical Engineering Imam Reza International UniversityMashhad ***Iran Department of Electrical Engineering Shahrekord BranchIslamic Azaci UniversityShahrekord ***Iran Department of Electrical Engineering Sari BranchIslamic Azad UniversitySari ***Iran Academic Center for Education Cultureand Research(ACECR)Tabriz ***Iran

In view of the large scientific and technical interest in the microelectromechanical system(MEMS)accelerometer sensor and the limitations of capacitive,resistive piezo,and piezoelectric methods,we focus on the measurement of the seismic mass displacement using a novel design of the all-optical sensor(AOS).The proposed AOS consists of two waveguides and a ring resonator in a two-dimensional rod-based photonic crystal(PhC)microstructure,and a holder which connects the central rod of a nanocavity to a proof *** photonic band structure of the AOS is calculated with the plane-wave expansion approach for TE and TM polarization modes,and the light wave propagation inside the sensor is analyzed by solving MaxwelFs equations using the finite-difference time-domain *** results of our simulations demonstrate that the fundamental PhC has a free spectral range of about 730 nm covering the optical communication *** also show that the AOS has the resonant peak of 0.8 at 1.644μm,quality factor of 3288,full width at half maximum of 0.5nm,and figure of merit of ***,for the maximum 200nm nanocavity displacements in the x-or y-direction,the resonant wavelengths shift to 1.618μm and 1.547μm,*** also calculate all characteristics of the nanocavity displacement in positive and negative directions of the jc-axis and *** small area of 104.35μm^(2)and short propagation time of the AOS make it an interesting sensor for various applications,especially in the vehicle navigation systems and aviation safety tools.

关键词： Photonic crystal MEMS accelerometer sensor tunable resonator finite-difference time-domain method

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Stem cell therapy in retinal diseases

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Neural Regeneration Research 2023年第7期18卷 1478-1485页

作者： Audrey Voisin Amaury Pénaguin afsaneh Gaillard Nicolas Leveziel Laboratoire de Neurosciences Expérimentales et Cliniques Universitéde PoitiersINSERM 1084PoitiersFrance Department of Ophthalmology CHU PoitiersPoitiersFrance Laboratoires Thea Clermont-FerrandFrance

Alteration of the outer retina leads to various diseases such as age-related macular degeneration or retinitis pigmentosa characterized by decreased visual acuity and ultimately *** intensive research in the field of retinal disorders,there is currently no curative *** therapeutic approaches such as cell-based replacement and gene therapies are currently in *** the context of cell-based therapies,different cell sources such as embryonic stem cells,induced pluripotent stem cells,or multipotent stem cells can be used for *** the vast majority of human clinical trials,retinal pigment epithelial cells and photoreceptors are the cell types considered for replacement cell *** this review,we summarize the progress made in stem cell therapies ranging from the pre-clinical studies to clinical trials for retinal disease.

关键词： age-related macular degeneration cell transplantation clinical trial retinal disease retinal dystrophy stem cell

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The efficient synthesis of 14-alkyl or aryl 14H-dibenzo[a,j] xanthenes catalyzed by bismuth(Ⅲ)chloride under solvent-free conditions

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Chinese Chemical Letters 2011年第8期22卷 927-930页

作者： Ebrahim Soleimani Mohammad Mehdi Khodaei afsaneh Taheri Kal Koshvandi Department of Chemistry Razi UniversityKermanshah 67149Iran

An efficient method for the synthesis of 14-alkyl or aryl 14H-dibenzo[a,j]xanthene derivatives by the reaction of β-naphthol,and aldehydes in the presence of a catalytic amount of bismuth（Ⅲ） chloride（BiCl_3） under solvent-free conditions at 110℃is *** and aromatic aldehydes were used in the reaction and in all cases the desired products were synthesized *** reaction was studied under different temperatures;the maximum yield was obtained in a short reaction period at 110℃.The method offers the advantages of high yields,short reaction times,simplicity and easy workup compared to the conventional method of syntheses.

关键词： Bismuth(Ⅲ) chloride 14H-Dibenzo[a j]xanthenes β-Naphthol

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Evaluating the different boundary conditions to simulate airflow and heat transfer in Double-Skin Facade

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Building Simulation 2022年第5期15卷 799-815页

作者： Javad Ahmadi Mohammadjavad Mahdavinejad Olena Kalyanova Larsen Chen Zhang afsaneh Zarkesh Somayeh Asadi Highperformance Architecture Laboratory Department of ArchitectureTarbiat Modares UniversityJalal-e Al Ahmad HighwayNasr bridgeTehranIran Department of Built Environment Faculty of Engineering and ScienceDivision of Architectural EngineeringAalborg UniversityAalborgDenmark Department of Architectural Engineering Pennsylvania State UniversityPA 16801USA

The CFD simulation accuracy mostly depends on the appropriate setting of boundary conditions and numerical simulation *** study shows the influence of two types of boundary condition settings on the CFD simulation results of Double-Skin Facade(DSF)for a specific *** two boundary settings are the constant temperature on the DSF surfaces called Boundary A,and Boundary B is defined via solar radiation using the Discrete Ordinate radiation Model(DOM).The paper verified both the numerical simulations using the experimental *** the numerical results of two types of boundaries with experimental data shows that both cases underestimated the values lower than 5.2 K and 0.1 m/s for the temperature and velocity respectively at the regarded measured *** A gives more accurate temperature prediction results,while Boundary B shows velocity magnitude closer to the measurements in the middle height of the cavity;the average temperature and velocity differences between the two boundary types are 0.6 K and 0.003 m/s respectively which are ***,the selection of boundary conditions depends on study purposes,however,when the DSF is equipped with blinds and if there is not enough data in hand but the exact value of solar irradiation,using the Boundary B approach is suggested;it can provide reasonable results associated with multi-type of thermal boundary conditions at the same ***,if the goal is to investigate the flow pattern in the DSF,Boundary B is argued to perform better than the constant temperature boundary condition.

关键词： Double-Skin Facade boundary conditions thermal performance airflow irradiation

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An active and selective heterogeneous catalytic system for Michael addition

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Chinese Chemical Letters 2012年第5期23卷 537-540页

作者： Hoda Keipour Mohammad A.Khalilzadeh Abolfazl Hosseini afsaneh Pilevar Daryoush Zareyee Department of Chemistry Science and Research BranchIslamic Azad UniversityMazandaranIran Department of Chemistry Qaemshahr BranchIslamic Azad UniversityQaemshahrIran

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple *** produ... 详细信息

关键词： Michael addition Potassium fluoride Natural zeolite Heterogeneous catalytic system

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Biopharmaceuticals for prevention of COVID-19:A scoping review

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Asian Pacific Journal of Tropical Medicine 2022年第6期15卷 245-265页

作者： afsaneh Farjami Soheila Montazersaheb Saiedeh Razi Soofiyani Parvin Akbarzadehlaleh Sara Salatin Food and Drug Safety Research Center Tabriz University of Medical ScienceTabrizIran Pharmaceutical Analysis Research Center Tabriz University of Medical ScienceTabrizIran Molecular Medicine Research Center Tabriz University of Medical ScienceTabrizIran Department of Molecular Medicine Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran Clinical Research Development Unit Sina Educational Research and Treatment CenterTabriz University of Medical SciencesTabrizIran Department of Pharmaceutical Biotechnology Faculty of PharmacyTabriz University of Medical ScienceTabrizIran Neurosciences Research Center(NSRC) Tabriz University of Medical SciencesTabrizIran

The COVID-19 epidemic caused by SARS-CoV-2 virus has turned into a worldwide ***,health officials all around the world have strived for developing efficient preventive and treatment methods to deal with this global *** them,monoclonal antibodies,anti-TNFs,and convalescent plasma appear to be effective against this *** addition,clinical trials are currently being conducted for viral targeting *** review summarizes major advances using biopharmaceuticals in the treatment and prevention strategies against COVID-19 that have occurred in the global medicinal system from its introduction until March 2022.

关键词： COVID-19 SARS-CoV-2 Biopharmaceuticals Monoclonal antibodies Anti-TNFs Convalescent plasma Vaccine

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The research and development on the antioxidants in prevention of diabetic complications

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 801-808页

作者： Mohammad Rahimi-Madiseh afsaneh Malekpour-Tehrani Mahmoud Bahmani Mahmud Rafieian-kopaei Medical Plants Research Center Shahrekord University of Medical Sciences Department of Social Medicine Shahrekord University of Medical Sciences Faculty of Medicine and Clinical Microbiology Research Center

Diabetes mellitus can damage the eyes,kidneys,nerves and *** and macrovascular disorders are the leading causes of morbidity and mortality in diabetic *** can increase the indicators of lipid peroxidation and oxidative stress in which free radicals have the main role in the pathogenesis of these ***,antioxidants which combat oxidative stress should be able to prevent and repair free radicals induced *** free radicals contribute to kidney damage,atherosclerosis,diabetes,heart disease,nephrotoxicity and hepatotoxicity; however,clinical trials do not uniquely confirm a substantial impact on diabetic *** seems that antioxidants in vegetables,fruits and grains help preventing diabetes complications; however,there is little evidence that taking single antioxidants such as vitamin E or vitamin C protect these *** findings about combination antioxidants are also complicated and not entirely *** this review paper we tried to present the role of oxidative stress on microvascular complications of type2 diabetes *** objective of this paper is to review the new findings about the role of various antioxidants on prevention and treatment of diabetes mellitus as well as its complications including retinopathy,nephropathy and neuropathy.

关键词： Diabetic Nephropathy Natural antioxidants Diabetes complications Nephropathy Neuropathy Retinopathy

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