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Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer

World Journal of Gastroenterology 2009年第44期15卷 5568-5572页

作者： John Griniatsos Hara Gakiopoulou Eugenia Yiannakopoulou Nikoletta Dimitriou Gerasimos Douridas afrodite nonni Theodoros Liakakos Evangelos Felekouras 1st Department of Surgery University of AthensMedical School LAIKO HospitalGR 115-27AthensGreece Department of Pathology University of AthensMedical SchoolLAIKO HospitalGR 115-27AthensGreece 3rd Department of Surgery University of AthensMedical SchoolATTIKO HospitalGR 115-27Athens Greece

AIM： To evaluate routine modified D2 lymphadenectomy in gastric cancer, based on immunohistochemicaUy detected skip micrometastases in level 11 lymph nodes. METHODS： Among 95 gastric cancer patients who were routinely submitted to curative modified D2 lymphadenectomy, from January 2004 to December 2008, 32 were classified as pN0. All level I lymph nodes of these 32 patients were submitted to immunohistochemistry for micrometastases detection. Patients in whom micrometastases were detected in the level Ⅰ lymph node stations （n = 4） were excluded from further analysis. The level 11 lymph nodes of the remaining 28 patients were studied immunohistochemically for micrometastases detection and constitute the material of the present study. RESULTS： Skip micrometastases in the level Ⅱ lymph nodes were detected in 14% （4 out of 28） of the patients. The incidence was further increased to 17% （4 out of 24） in the subgroup of T1-2 gastric cancer patients. All micrometastases were detected in the No. 7 lymph node station. Thus, the disease was upstaged from stage Ⅰ A to Ⅰ B in one patient and from stage Ⅰ B to Ⅱ in three patients. CONCLUSION： In gastric cancer, true R0 resection may not be achieved without modified D2 lymphadenectomy. Until D2＋/D3 lymphadenectomy becomes standard, modified D2 lymphadenectomy should be performed routinely.

关键词： Gastric cancer D2 gastrectomy D2 lymphadenectomy Micrometastases Skip metastases Skip micrometastases

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Formation mechanism and application potential of carbon dots synthesized from palm kernel shell via microwave assisted method

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Carbon Resources Conversion 2022年第2期5卷 150-166页

作者： Thivyah Balakrishnan Wei Lun Ang Ebrahim Mahmoudi Abdul Wahab Mohammad nonni Soraya Sambudi Department of Chemical and Process Engineering Faculty of Engineering&Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Centre for Sustainable Process Technology Faculty of Engineering&Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Department of Chemical Engineering Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia

The present study systematically investigated the influence of synthesis conditions(duration,reaction medium,and doping concentration)and formation mechanism of carbon dots(CDs)derived from low-cost and abundant biomass palm kernel shell(PKS).Surprisingly,the dopant(urea)did not enhance the photoluminescence of CDs as expected,which could be attributed to the low reactivity between the dopant and PKS *** of synthesis duration from 30 to 120 s clearly indicated the formation mechanism of CDs,involving the stages of dehydration,carbonization,and *** CDs with the highest photoluminescent intensity and quantum yield was obtained at synthesis duration of 90 s,aligned well with the perfect spherical shape of CDs and the synergistic effects of both surface and carbogenic core *** the formation mechanism could be used to optimize the synthesis of CDs,and hence linked to quantum yield and fluorescent *** terms of application potential,the CDs illuminated well as fluorescent ink and in bacteria cells *** potential of CDs as sensing material has also been proven with the quenching of fluorescence in the presence of metal *** linear range for detection of Cu2+ions was 0.1–0.5 mM with a detection limit as low as 0.05 *** signifies the potential of CDs fabricated from PKS as a low-cost and easily available material for Cu2+ions detection in aqueous *** CDs possessed reasonable photo stability as indicated by its consistent fluorescence level even after exposure to UV radiation for a prolonged period of 180 ***,a simple,straightforward,and fast method is developed to synthesis strong blue emissive CDs from green PKS that are potentially suitable for Cu2+ions sensing in real application.

关键词： Carbon dots Microwave radiation Palm kernel shell Cell imaging Metal ions detection

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Clinicopathological differences and correlations between right and left colon cancer

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World Journal of Clinical Cases 2020年第8期8卷 1424-1443页

作者： Ioannis Kalantzis Afroditi nonni Kitty Pavlakis Eumorphia-Maria Delicha Konstantinos Miltiadou Christos Kosmas Nikolaos Ziras Konstantinos Gkoumas Harikleia Gakiopoulou Department of Gastroenterology Korgialenio-Mpenakeio Hellenic Red Cross HospitalAthens 11526Greece Department of Oncology Metaxa Anticancer HospitalPiraeus 18537Greece First Department of Pathology National and Kapodistrian University of AthensMedical SchoolAthens 11527Greece Independent Biostatistical Consultant ASTATStatistics in Clinical ResearchGlyfada 16675Greece Hepatogastroenterology Unit Second Department of Internal MedicineAttikon University General HospitalAthens 12462Greece

BACKGROUND The differences in histopathology and molecular biology between right colon cancer(RCC)and left colon cancer(LCC)were first reported in the literature by Bufill in *** then,a large number of studies have confirmed their differences in epidemiology,clinical presentation,comorbidities and biological behaviours,which may be related to the difference in prognosis and overall survival(OS)between the two *** To investigate statistically significant differences between Greek patients with LCC and *** The present observational study included 144 patients diagnosed with colon cancer of any stage who received chemotherapy in a Greek tertiary oncology hospital during a 2.5-year *** information,comorbidities,histopathologic characteristics and molecular biomarkers were collected from the patients’medical records retrospectively,while administered chemotherapy regimens,targeted agents,progression-free survival(PFS)periods with first-and second-line chemotherapy and OS were recorded retroactively and *** analysis was performed with the SPSS statistical *** Eighty-six males and 58 females participated in the *** hundred(69.4%)patients had a primary lesion in the left colon,and 44(30.6%)patients had a primary lesion in the right *** with RCC were more likely to display anaemia than patients with LCC[odds ratio(OR)=3.09],while LCC patients were more likely to develop rectal bleeding(OR=3.37)and a feeling of incomplete evacuation(OR=2.78)than RCC *** comorbidities,RCC patients were more likely to suffer from diabetes(OR=3.31)and coronary artery disease(P=0.056)than LCC *** mucinous differentiation rate was higher in the right-sided group than in the left-sided group(OR=4.49),as was the number of infiltrated lymph nodes(P=0.039),while the percentage of high-grade differentiation was higher in the group of patients with left-sided colon cancer than in RCC patients(OR=2.78)

关键词： Colorectal neoplasm Epidermal growth factor Vascular endothelial growth factor Histology Molecular biology Metabolic syndrome

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