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Influence of mixed organosilane coatings with variable RGD surface densities on the adhesion and proliferation of human osteosarcoma Saos-2 cells to magnesium alloy AZ31

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Bioactive Materials 2017年第1期2卷 35-43页

作者： Xiaoxi Yang afrah al hegy Eric R.Gauthier Joy Gray-Munro Dept.of Chemistry and Biochemistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

In the last decade,the use of magnesium and its alloys as biodegradable implant materials has become increasingly ***,surface modification of these materials to control the degradation rate in the early stages of healing and improve their biocompatibility is crucial to the successful implementation of magnesium alloy implants in *** adhesion and proliferation at the implant surface is a vital factor for successful integration of a biomaterial within the *** accomplish this task by binding to ligands such as the arginine-glycine-aspartic acid peptide sequence(RGD)commonly found on adhesive proteins present in the extracellular *** this paper,we report a biomimetic surface modification strategy involving deposition of a mixed organosilane layer on Mg AZ31 followed by covalent immobilization of RGD peptides through a heterobifunctional cross-linker *** results indicate that with optimized deposition conditions uniform organosilane coatings were successfully deposited on the Mg AZ31 ***,we have demonstrated that the surface density of immobilized RGD can be varied by depositing organosilane layers from solutions containing two different organosilanes in specified *** in cell adhesion and cell proliferation were observed on the surface modified substrates.

关键词： Magnesium alloys Biodegradable Biomimetic RGD peptide Surface modification Cell adhesion Organosilane

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Investigation of a cyanine dye assay for the evaluation of the biocompatibility of magnesium alloys by direct and indirect methods

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Bioactive Materials 2020年第1期5卷 26-33页

作者： afrah al hegy Ryan Smith Eric R.Gauthier Joy E.Gray-Munro Dept.of Chemistry and Biochemistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

Magnesium and its alloys are promising candidates for a new generation of biodegradable metals in orthopaedic applications due to their excellent biocompatibility,biodegradability,and mechanical properties that are similar to natural ***,direct in vitro assessment of these materials in the presence of cells is complicated by degradation products from the alloy that lead to a false positive for the most commonly used cell adhesion and cell proliferation *** this paper,a cyanine dye was used to quantitatively evaluate the in vitro biocompatibility of a Mg AZ31 alloy by both direct and indirect *** cytotoxicity of the corrosion products was evaluated via an indirect method;a 25%decrease in cell viability compared to control samples was ***,direct assessment of cell adhesion and proliferation showed a statistically significant increase in cell number at the surface after 72 *** addition,the degradation rate and surface characteristics of the Mg AZ31 alloy were evaluated for both direct and indirect *** degradation rate was unaffected by the presence of cells while evidence of an increase in calcium phosphate deposition on the magnesium alloy surface in the presence of cells was *** study demonstrates that a cyanine dye based assay provides a more accurate assessment of the overall in vitro biocompatibility of biodegradable metals than the more commonly used assays reported in the literature to date.

关键词： Magnesium alloys Biocompatibility Direct method Indirect method Cyanine dye Cell adhesion Cell proliferation Cytotoxicity

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钢笔写字VS硬笔书法

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中国钢笔书法 2007年第1期 56-59页

作者：周继中张燕玉李迎春静心路鸿峰杨卫列伦强黄玉华梅林天下行者 hegy 佩之刘英杰朱一夫刘明帅

主持人从一开始产生的“钢笔写字”概念,到现在的“硬笔书法”艺术一说,已走过了20多年的风雨之路。对钢笔写字和硬笔书法,很多人仍然模糊,并徘徊在硬笔书法和写字之间,误认为字写得好看就是硬笔书法艺术,甚至无法理解、欣赏和接受真正... 详细信息

主持人从一开始产生的“钢笔写字”概念,到现在的“硬笔书法”艺术一说,已走过了20多年的风雨之路。对钢笔写字和硬笔书法,很多人仍然模糊,并徘徊在硬笔书法和写字之间,误认为字写得好看就是硬笔书法艺术,甚至无法理解、欣赏和接受真正意义上的“硬笔书法”作品。《中国钢笔书法》杂志“e网传真”栏目委托中国硬笔论坛网站,在此邀请诸位书家书友对之展开讨论:什么是钢笔写字?什么是硬笔书法?它们之间有什么必然联系?谁更重要?如何进行互补和转化?

关键词： VS 结体书如其人论坛网站艺术语言书写者力感艺术之林莎木情感抒发

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