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Numerical analysis on zone-divided deep excavation in soft clays using a new small strain elasto–plastic constitutive model

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Underground Space 2022年第1期7卷 19-36页

作者： afnan younis tanoli Bin Yan Yong-lin Xiong Guan-lin Ye Usama Khalid Zhong-hua Xu Department of Civil Engineering State Key Laboratory of Ocean Engineering and ShanghaiKey Laboratory for Digital Maintenance of Buildings and InfrastructureShanghai Jiao Tong UniversityShanghai 200240China Institute of Geotechnical Engineering Ningbo UniversityNingbo 315211China Department of Civil Engineering Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan 64200Pakistan East China Architectural Design&Research Institute Shanghai 200002China

Accurate prediction of displacements associated with deep excavations is essential to ensure safety and stability of the excavation and to prevent any damage and distress to the adjoining *** paper presents a numerical approach for prediction of ground displacements related to a zone-divided deep excavation construction executed in Shanghai soft clays based on a new elasto–plastic con-stitutive model(small-strain Shanghai model)that incorporates small strain *** model can describe the mechanical properties and structural and over-consolidated characteristics of natural *** model is implemented into a finite element analysis *** analysis on the deep excavation in Shanghai using zone-divided method is conducted.A comparison between monitored and simulated results of horizontal displacements along the diaphragm wall,the settlements in the surroundings,and the effects on the adjoin-ing metro tunnel due to excavation construction is carried *** attention is paid to the stiffness degradation of representative elements in the *** simulated displacements show a good agreement with the monitored ***,this study provides an integrated solution for predicting displacements related to deep excavation in soft clays.

关键词： Deep excavation Soft clays Small strain Elasto-plastic model Ground displacements Metro tunnels

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基于小应变上海土本构模型的基坑工程数值模拟

基于小应变上海土本构模型的基坑工程数值模拟

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作者： afnan younis tanoli 上海交通大学

学位级别：硕士

在软土城市进行深基坑开挖施工时,往往会对周边环境造成扰动,因此在工程开始前评估施工的环境影响效应是非常重要的。由于基坑周边地层变形是在小应变范围内,高精度的数值评估必须采用考虑小应变刚度的本构模型。本文基于上海土统一本... 详细信息

在软土城市进行深基坑开挖施工时,往往会对周边环境造成扰动,因此在工程开始前评估施工的环境影响效应是非常重要的。由于基坑周边地层变形是在小应变范围内,高精度的数值评估必须采用考虑小应变刚度的本构模型。本文基于上海土统一本构模型开展基坑工程的数值分析,探讨深基坑分区开挖施工对周围环境的影响规律。首先介绍了小应变上海土统一本构模型,该模型能够准确描述上海软土在小应变及大应变下的力学性质;然后分别针对邻近地铁隧道的基坑和邻近历史保护建筑物的基坑开展数值分析,在验证计算正确性的同时,探讨相关施工措施的有效性。本文的主要成果如下:(1)编制了小应变上海土模型的用户子程序,并给出了详细使用说明。模拟三轴试验和简单基坑开挖,验证了该用户子程序的正确性。与未考虑小应变刚度相比,基坑开挖引起的墙体变形和地面沉降的计算结果更符合实际,显示新本构模型适合于深基坑开挖变形的数值分析。(2)以邻近地铁隧道的分区开挖基坑为对象,选取典型断面建立有限元模型,计算结果与现场监测结果对比,表明地下连续墙最大水平位移的最大值、最大水平位移发生位置,以及周边地表沉降变化,都与监测结果非常接近,邻近隧道的变形最终计算值也与监测值接近。进一步分析土体剪切应变变化规律,证明了考虑小应变刚度的重要性。并探讨了分区开挖对减少周边环境影响的有效性。(3)以邻近历史保护建筑物的基坑工程为对象,建模进行数值分析,计算结果与现场监测结果对比验证本构模型的有效性。通过对比计算,揭示了邻近建筑物的存在将增加基坑围护变形和地表沉降。综上所述,小应变上海土本构模型可以适用于软土深基坑工程的数值模拟,并且能有效、准确地预测深基坑的围护结构变形及周边地表沉降,今后应进一步推广应用。

关键词：深基坑软土小应变本构模型分区开挖历史保护建筑

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Modelling of debris-flow susceptibility and propagation: a case study from Northwest Himalaya

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Journal of Mountain Science 2024年第1期21卷 200-217页

作者： Hamza DAUD Javed Iqbal tanoli Sardar Muhammad ASIF Muhammad QASIM Muhammad ALI Junaid KHAN Zahid Imran BHATTI Ishtiaq Ahmad Khan JADOON Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan 430074China Department of Earth Sciences COMSATS University IslamabadAbbottabad Campus 22010Pakistan Department of Earth Sciences Sultan Qaboos UniversityAl-KhoudMascat 123Oman Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China Department of Earth Sciences Abbottabad University of Science and TechnologyHavelian 22500Pakistan

The geological and geographical position of the Northwest Himalayas makes it a vulnerable area for mass movements particularly landslides and debris flows. Mass movements have had a substantial impact on the study area which is extending along Karakorum Highway(KKH) from Besham to Chilas. Intense seismicity, deep gorges, steep terrain and extreme climatic events trigger multiple mountain hazards along the KKH, among which debris flow is recognized as the most destructive geohazard. This study aims to prepare a field-based debris flow inventory map at a regional scale along a 200 km stretch from Besham to Chilas. A total of 117 debris flows were identified in the field, and subsequently, a point-based debris-flow inventory and catchment delineation were performed through Arc GIS analysis. Regional scale debris flow susceptibility and propagation maps were prepared using Weighted Overlay Method(WOM) and Flow-R technique sequentially. Predisposing factors include slope, slope aspect, elevation, Topographic Roughness Index(TRI), Topographic Wetness Index(TWI), stream buffer, distance to faults, lithology rainfall, curvature, and collapsed material layer. The dataset was randomly divided into training data(75%) and validation data(25%). Results were validated through the Receiver Operator Characteristics(ROC) curve. Results show that Area Under the Curve(AUC) using WOM model is 79.2%. Flow-R propagation of debris flow shows that the 13.15%, 22.94%, and 63.91% areas are very high, high, and low susceptible to debris flow respectively. The propagation predicated by Flow-R validates the naturally occurring debris flow propagation as observed in the field surveys. The output of this research will provide valuable input to the decision makers for the site selection, designing of the prevention system, and for the protection of current infrastructure.

关键词： North Pakistan Debris flow Flow-R Propagation Susceptibility mapping Debris-flow inventory Weighted Overlay Method

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SynergyFinder Plus:Toward Better Interpretation and Annotation of Drug Combination Screening Datasets

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 587-596页

作者： Shuyu Zheng Wenyu Wang Jehad Aldahdooh Alina Malyutina Tolou Shadbahr Ziaurrehman tanoli Alberto Pessia Jing Tang Research Program in Systems Oncology Faculty of MedicineUniversity of HelsinkiHelsinki 00290Finland

Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The Synergy Finder R package is a software used to analyze pre-clinical drug combination datasets. Here, we report the major updates to the Synergy Finder R package for improved interpretation and annotation of drug combination screening results. Unlike the existing implementations, the updated Synergy Finder R package includes five main innovations. 1) We extend the mathematical models to higher-order drug combination data analysis and implement dimension reduction techniques for visualizing the synergy landscape. 2) We provide a statistical analysis of drug combination synergy and sensitivity with confidence intervals and P values. 3)We incorporate a synergy barometer to harmonize multiple synergy scoring methods to provide a consensus metric for synergy. 4) We evaluate drug combination synergy and sensitivity to provide an unbiased interpretation of the clinical potential. 5) We enable fast annotation of drugs and cell lines, including their chemical and target information. These annotations will improve the interpretation of the mechanisms of action of drug combinations. To facilitate the use of the R package within the drug discovery community, we also provide a web server at www.s *** as a user-friendly interface to enable a more fexible and versatile analysis of drug combination data.

关键词： SynergyFinder Drug combination Synergy modeling Drug discovery Drug combination sensitivity analysis

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Debris flow susceptibility analysis based on the combined impacts of antecedent earthquakes and droughts： a case study for cascade hydropower stations in the upper Yangtze River, China

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Journal of Mountain Science 2017年第9期14卷 1712-1727页

作者： HU Gui-sheng CHEN Ning-sheng tanoli Javed Iqbal LIU Mei LIU Rong-Kun CHEN Kun-Ting Key Lab of Mountain Hazards and Surface Processes Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Department of Earth Sciences COMSATS Institute of Information Technology Abbottabad 22060 Pakistan School of Environment and Natural Resources The Ohio State University Columbus OH 43210 USA

The upper Yangtze River region is one of the most frequent debris flow areas in China. The study area contains a cascade of six large hydropower stations located along the river with total capacity of more than 70 million kilowatts. The purpose of the study was to determine potential and dynamic differences in debris flow susceptibility and intensity with regard to seasonal monsoon events. We analyzed this region's debris flow history by examining the effective peak acceleration of antecedent earthquakes,the impacts of antecedent droughts, the combined effects of earthquakes and droughts, with regard to topography, precipitation, and loose solid material conditions. Based on these factors, we developed a debris flow susceptibility map. Results indicate that the entire debris flow susceptibility area is 167,500 km^2, of which 26,800 km^2 falls within the high susceptibility area, with 60,900 km^2 in medium and 79,800 km^2 are in low susceptibility areas. Three of the six large hydropower stations are located within the areas with high risk of debris flows. The synthetic zonation map of debris flow susceptibility for the study area corresponds with both the investigation data and actual distribution of debris flows. The results of debris flow susceptibility provide base-line data for mitigating, assessing, controlling and monitoring of debris flows hazards.

关键词： Hydropower stations Debris flow susceptibility Earthquake Drought Geological Information System(GIS) Upper Yangtze River

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Long-term Activity of Earthquake-induced Landslides: A Case Study from Qionghai Lake basin, Southwest of China

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Journal of Mountain Science 2014年第3期11卷 607-624页

作者： WEI Xue-li CHEN Ning-sheng CHENG Qian-gong HE Na DENG Ming-feng tanoli Javed Iqbal Faculty of Geosciences and Environmental Engineering Southwest Jiaotong Universit Institute of Mountain Hazards and Environment Chinese Academy of Sciences

Earthquake-triggered landslides are a major geological hazard in the eastern Tibetan Plateau, and have prolonged impact on earth surface processes and fluvial system. To determine how long co-seismic landslides affect basins, a massive number of landslides existing in Qionghai Lake Basin were investigated for landslide distribution characteristics and geomorphological evidences, with further comparison and analysis using historic seismic analog method. The landslides found in Qionghai Lake Basin showed clear features of seismic triggering with strongly controlled by Zemuhe fault. These landslides are still active at present. Some new slides generally occur in ancient slope failure zones causing serious secondary hazards in recent years. In this study we strengthen the idea that the landslides triggered by the 185o Xichang earthquake （Ms7.5） have long term activity and prolonged impact on the mountain disasters with a period of more than 16o years. Our results support growing evidence that coseismic landslides have a prolonged effect on secondary disasters in a basin, and invite more careful consideration of the relationship between current basin condition and landslide history for a longer period.

关键词： Qionghai Lake Earthquake Landslide Debris flow Sediment yield

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高极化^3He MRI对100例连续研究对象的生理检测观察和安全性评估

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国际医学放射学杂志 2008年第5期31卷 408-408页

作者： B.A. Lutey S.S. Lefrak J.C. Woods T. tanoli J.D. Quirk A. Bashir 郭雪梅（译）唐光健（校） Divisions of Pulmonary and Critical Care Medicine Washington University School of Medicine 510 S Kingshighway Blvd St Louis MO 63110 USA. 不详

目的评价高极化氦3（^3He）MR成像的安全性。方法本研究经伦理审查委员会批准并取得受试者的知情同意。100例连续受试者[男57例，女43例；平均年龄（52±14）岁1在进行高极化^3HeMR成像之前、过程中及之后分别采集生理检测数据。受试者... 详细信息

目的评价高极化氦3（^3He）MR成像的安全性。方法本研究经伦理审查委员会批准并取得受试者的知情同意。100例连续受试者[男57例，女43例；平均年龄（52±14）岁1在进行高极化^3HeMR成像之前、过程中及之后分别采集生理检测数据。受试者吸入含有300～500mL的^3He和0～2700mL的N2的混合气体10L，在MR检查中屏气长达15S。在每次检查中采用脉冲血氧监测仪连续检测心率、心律和血红蛋白氧饱和度（SpO2）。分别评价^3HeMR成像对于生命体征和SpO2的影响，以及SpO2最低观测值与肺功能、药物剂量、临床分类（正常志愿者、哮喘病人、大剂量吸烟者、因为严重肺气肿而行肺部减容手术的病人以及肺癌病人）的关系。

关键词：安全性评估生理检测极化 MRI 伦理审查委员会 MR成像 MR检查 SpO2

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