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Computational stochastic Investigations for the socio-Ecological Dynamics with Reef Ecosystems

Computers, Materials & Continua 2022年第12期73卷 5589-5607页

作者： Thongchai Botmart Zulqurnain sabir afaf s.alwabli salem Ben said Qasem Al-Mdallal Maria Emilia Camargo Wajaree Weera Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen 40002Thailand Department of Mathematical sciences United Arab Emirates UniversityP.O.Box 15551Al AinUAE Department of Mathematics and statistics Hazara UniversityMansehraPakistan Department of Biological sciences Rabigh College of Science and ArtsKing Abdulaziz UniversityJeddahSaudi Arabia Graduate Program in Administration Federal University of Santa MariaSanta Maria 93458Brazil

The motive of this work is to present a computational design using the stochastic scaled conjugate gradient(sCG)neural networks(NNs)called as sCGNNs for the socio-ecological dynamics(sED)with reef ecosystems and conservation *** mathematical descriptions of the sED model are provided that is dependent upon five categories,macroalgae M(v),breathing coral C(v),algal turf T(v),the density of parrotfish P(v)and the opinion of human opinion X(v).The stochastic sCGNNs process is applied to formulate the sEDmodel based on the sample statistics,testing,accreditation and *** different variations of the sED have been provided to authenticate the stochastic sCGNNs performance through the statics for training,accreditation,and testing are 77%,12%and 11%,*** obtained numerical performances have been compared with the Runge-Kutta approach to solve the *** reduction of mean square error(MsE)is used to investigate the numericalmeasures through the sCGNNs for solving the sED *** precision of the sCGNNs is validated through the comparison of the results and the absolute error *** reliability of the sCGNNs is performed by using the correlation values,state transitions(sTs),error histograms(EHs),MsE measures and regression analysis.

关键词： socio-ecological state conservation estimation neural networks reef ecosystems scaled conjugate gradient numerical study

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Fractional Order Environmental and Economic Model Investigations Using Artificial Neural Network

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Computers, Materials & Continua 2023年第1期74卷 1735-1748页

作者： Wajaree Weera Chantapish Zamart Zulqurnain sabir Muhammad Asif Zahoor Raja afaf s.alwabli s.R.Mahmoud supreecha Wongaree Thongchai Botmart Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand Department of Mathematics and statistics Hazara UniversityMansehraPakistan Department of Mathematical sciences UAE UniversityP.O.Box 15551Al AinUAE Future Technology Research Center National Yunlin University of Science and Technology123 University RoadSection 3DouliouYunlin64002Taiwan Department of Biological sciences Rabigh College of Science and ArtsKing Abdulaziz UniversityRabighSaudi Arabia GRC Department Faculty of Applied StudiesJeddahKing Abdulaziz UniversityRabighSaudi Arabia Institute of General Education Udon Thani Rajabhat UniversityUdon Thani41000Thailand

The motive of these investigations is to provide the importance and significance of the fractional order(FO)derivatives in the nonlinear environmental and economic(NEE)model,i.e.,FO-NEE *** dynamics of the NEE model achieves more precise by using the form of the FO *** investigations through the non-integer and nonlinear mathematical form to define the FO-NEE model are also provided in this *** composition of the FO-NEEmodel is classified into three classes,execution cost of control,system competence of industrial elements and a new diagnostics technical exclusion *** mathematical FO-NEE system is numerically studied by using the artificial neural networks(ANNs)along with the Levenberg-Marquardt backpropagation method(ANNs-LMBM).Three different cases using the FO derivative have been examined to present the numerical performances of the FO-NEE *** data is selected to solve the mathematical FO-NEE system is executed as 70%for training and 15%for both testing and *** exactness of the proposed ANNs-LMBM is observed through the comparison of the obtained and the Adams-Bashforth-Moulton database *** ratify the aptitude,validity,constancy,exactness,and competence of the ANNs-LMBM,the numerical replications using the state transitions,regression,correlation,error histograms and mean square error are also described.

关键词： Environmental and economic model artificial neural networks fractional order nonlinear Levenberg-Marquardt backpropagation

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Development of micro/nanostructured‒based biomaterials with biomedical applications

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BIOCELL 2023年第8期47卷 1743-1755页

作者： afaf ALHARTHI Department of Clinical Laboratory sciences College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia

Natural biomaterials are now frequently used to build biocarrier systems,which can carry medications and biomolecules to a target region and achieve a desired therapeutic *** and polymers are of great importance in the synthesis of *** recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi,algae,bacteria,and medicinal *** are also biodegradable,compatible with neighborhoods,and *** biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds,matrices,composites,and interpenetrating polymer networks employing microtechnology and *** review highlights how microengineered and nanoengineered biomaterials are utilized to produce efficient drug-delivery systems and biomedical and biological therapies and how innovative sources of biomaterials have been identified.

关键词： Micro/Nanoparticles Biomaterials Green synthesis Microorganisms Algae Medicinal plants

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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synthesis of new 1,2,4-oxadiazolidin-5-ylthiophenes and thienopyrimidine derivatives by aza-Wittig reaction using a thienyl carbodiimide

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Chinese Chemical Letters 2012年第4期23卷 411-414页

作者： afaf M.Abdel Hameed Chemistry Department Faculty of ScienceMinia University

Azidation of aminothiophene derivative 1 afforded the corresponding azido derivative *** latter reacted with triphenylphosphine to afford iminophosphorane derivatives *** 3 with phenylisocyanate gave the highly reactive carbodiimide intermediate 4,which was reacted with different nitrones to afford new l,2,4-oxadiazolidin-5-ylidene-aminothiophenes 5a-c. Treatment of 4 with absolute EtOH at room temperature gave methyleneamino-5-（methylthio）thiophene 7,（methylthio）-3-（3- phenylureidothiophene）-2-carboxylate 8 or thienopyrimidine 9 and 10 at refluxing *** reaction of carbodiimide intermediate 4 with different secondary amines gave the new thienopyrimidines 11a-c.

关键词： Carbodiimide Cycloaddition 1 2 4-Oxadiazolidin-5-ylideneaminothiophene derivatives Thienopynmidine Aza-Wittig reaction

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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