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The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

Journal of Renewable Materials 2024年第2期12卷 245-258页

作者： Yatim Lailun Ni’mah afaf Baktir Dewi Santosaningsih Suprapto Suprapto Chemistry Department Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabayaIndonesia Chemistry Department Faculty of Science and TechnologyAirlangga UniversitySurabayaIndonesia Department Clinical Microbiology Faculty of MedicineBrawijaya UniversityMalangIndonesia

Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of *** protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity *** attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery *** aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver *** Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis ***-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric *** highlights the increased stability that tartaric acid provides in AgNP *** size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 *** second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 *** contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 *** more negative zeta potential of AgNP-tartaric acid indicates its increased *** of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against *** and *** bacteria compared with *** summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.

关键词： Tartaric acid silver nanoparticle polyvinyl pyrrolidone response surface methodology

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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF AHMED EL-SEBAIE SHERIF REFAAT afaf EL-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,p<0.001)and dominant(GT+TT ***,OR=5.4,p<0.001)*** cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Hepatobiliary manifestations in children with inflammatory bowel disease:A single-center experience in a low/middle income country

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第3期11卷 48-58页

作者： Mortada HF El-Shabrawi Sara Tarek Maha Abou-Zekri Safa Meshaal afaf enayet Engy Adel Mogahed Department of Paediatrics Kasr Alainy School of MedicineCairo UniversityCairo 11562Egypt Department of Clinical Pathology Kasr Alainy School of MedicineCairo UniversityCairo 11562Egypt

BACKGROUNDThere has been a worldwide increase in the reported incidence of inflammatorybowel disease (IBD) in children over the past 2-3 decades. The hepatobiliary (HB)manifestations of IBD have been well-studied in children in industrialized anddeveloped countries but are infrequently reported in low- and middle-incomecountries (LMIC) such as *** determine the prevalence of the HB manifestations in a cohort of Egyptianchildren with *** cross-sectional observational study was carried out over a period of 6 mo(between June 2013 to December 2013, at the Paediatric Hepatology andGastroenterology Units of Cairo University Children's Hospital, which is thelargest paediatric tertiary care centre in the *** study included 48 patients with confirmed IBD based upon clinical,laboratory, endoscopic and histopathological features, 29 (60.4%) were ***-four patients (50%) had ulcerative colitis (UC), 11 (22.9%) had Crohn'sdisease (CD) and 13 (27.1%) had unclassified-IBD (IBD-U), which was formerlyknown as indeterminate colitis. The mean age of the patients at the time ofpresentation was 8.14 (± SD 4.02) years and the mean age at the time of studyenrolment was 10.16 (± SD 4.19) years. All patients were screened for HBmanifestations by physical examination, liver function tests, imaging and liver biopsy when indicated. HB disorders were confirmed in 13 patients (27.1%).Transaminases were elevated in 3 patients (6.3%). Two patients (4.2%) hadelevated biliary enzymes (one was diagnosed as primary sclerosing cholangitis(PSC) and the other was diagnosed with PSC/autoimmune hepatitis overlapsyndrome and the third patient had hepatitis C virus infection. Ten patients(20.8%) had bright echogenic liver on ultrasound suggesting fatty infiltration as asequel of malnutrition or medication *** commonest HB disorders in Egyptian children with IBD were abnormal liverfunction tests, fatty infiltration and PSC. These HB manifestations i

关键词： Children Crohn's disease Egypt Elevated liver enzymes Hepatobiliary Inflammatory bowel disease Ulcerative colitis

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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： Hasan M Isa Fatema A Alkharsi Jawad K Khamis Sawsan A Hasan Zainab A Naser Zainab N Mohamed afaf M Mohamed Shaikha A Altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and Medical Departments of Salmaniya Medical Complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,Ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and Mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-Meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis C

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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in Saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In S

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Development of micro/nanostructured‒based biomaterials with biomedical applications

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BIOCELL 2023年第8期47卷 1743-1755页

作者： afaf ALHARTHI Department of Clinical Laboratory Sciences College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia

Natural biomaterials are now frequently used to build biocarrier systems,which can carry medications and biomolecules to a target region and achieve a desired therapeutic *** and polymers are of great importance in the synthesis of *** recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi,algae,bacteria,and medicinal *** are also biodegradable,compatible with neighborhoods,and *** biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds,matrices,composites,and interpenetrating polymer networks employing microtechnology and *** review highlights how microengineered and nanoengineered biomaterials are utilized to produce efficient drug-delivery systems and biomedical and biological therapies and how innovative sources of biomaterials have been identified.

关键词： Micro/Nanoparticles Biomaterials Green synthesis Microorganisms Algae Medicinal plants

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Preparation of ammonium nitrate-based solid composite propellants supplemented with polyurethane/nitrocellulose blends binder and their thermal decomposition behavior

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Defence Technology（防务技术） 2022年第11期18卷 2023-2033页

作者： Sabri Touidjine Moulai Karim Boulkadid Djalal Trache Samir Belkhiri Abderrahmane Mezroua Mohamed Islam Aleg afaf Belkebiche Energetic Propulsion Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj-El-Bahri16046AlgiersAlgeria Energetic Materials Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj-El-Bahri16046AlgiersAlgeria

To improve the performance of solid composite propellants(SCPs)supplemented with ammonium nitrate(AN)as an oxidizer,the incorporation of energetic ingredients such as explosives,energetic binders or catalysts is a common effective *** this purpose,polyurethane(PU),a typical inert binder,was mixed with nitrocellulose(NC)as an energetic *** composite solid propellant compositions based on AN and NC-modified polyurethane binder with different NC ratios were *** prepared formulations were characterized using Fourier transform infrared spectroscopy(FTIR),RAMAN spectroscopy,X-ray diffraction(XRD),electron densimetry,thermogravimetric(TG)analysis,and differential scanning calorimetry(DSC).A kinetic study was then performed using the iterative KissingerAkahira-Sunose(It-KAS),Flynn-Wall-Ozawa(It-FWO),and non-linear Vyazovkin integral with compensation effect(VYA/CE)*** theoretical performances,such as theoretical specific impulse,adiabatic flame temperature,and ideal exhaust gaseous species,were also determined using the NASA Lewis Code,Chemical Equilibrium with Application(CEA).Spectroscopic examinations revealed the existence of NC and full polymerization of PU in the prepared *** to density tests,the density of the propellant increases as the nitrocellulose component *** to the thermal analysis and kinetics study,the increase in NC content catalyzed the thermal decomposition of the AN-based composite solid *** on the theoretical study,increasing the amount of NC in the propellant increased the specific impulse and,as a result,the overall performance.

关键词： Composite propellants Polyurethane Nitrocellulose Ammonium nitrate Decomposition kinetics Thermal decomposition

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Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis

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Food Bioscience 2022年第3期47卷 918-927页

作者： afaf Kheroufi María E.Brassesco Débora A.Campos Halima Boughellout Manuela E.Pintado Laboratoire de Génie Agro-alimentaire équipe Génie des Procédés AlimentairesBiodiversité et Agro environnementInstitut de la Nutritionde l’Alimentation et des Technologies Agroalimentaires INATAAUniversité Frères Mentouri Constantine 1BP 325 Route de Ain El BeyConstantineAlgeria CBQF – Centro de Biotecnologia e Química Fina – Laboratório Associado Escola Superior de BiotecnologiaUniversidade Católica Portuguesa/PortoRua de Diogo Botelho 13274169-005PortoPortugal

Enzymatic whey proteins concentrates (WPC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WPC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FPLC),Tricine SDS-PAGE,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other *** showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and *** results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other *** hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients.

关键词： Whey proteins Ficin Hydrolysis Antioxidant Solubility

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Computational Stochastic Investigations for the Socio-Ecological Dynamics with Reef Ecosystems

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Computers, Materials & Continua 2022年第12期73卷 5589-5607页

作者： Thongchai Botmart Zulqurnain Sabir afaf S.Alwabli Salem Ben Said Qasem Al-Mdallal Maria Emilia Camargo Wajaree Weera Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen 40002Thailand Department of Mathematical Sciences United Arab Emirates UniversityP.O.Box 15551Al AinUAE Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Department of Biological Sciences Rabigh College of Science and ArtsKing Abdulaziz UniversityJeddahSaudi Arabia Graduate Program in Administration Federal University of Santa MariaSanta Maria 93458Brazil

The motive of this work is to present a computational design using the stochastic scaled conjugate gradient(SCG)neural networks(NNs)called as SCGNNs for the socio-ecological dynamics(SED)with reef ecosystems and conservation *** mathematical descriptions of the SED model are provided that is dependent upon five categories,macroalgae M(v),breathing coral C(v),algal turf T(v),the density of parrotfish P(v)and the opinion of human opinion X(v).The stochastic SCGNNs process is applied to formulate the SEDmodel based on the sample statistics,testing,accreditation and *** different variations of the SED have been provided to authenticate the stochastic SCGNNs performance through the statics for training,accreditation,and testing are 77%,12%and 11%,*** obtained numerical performances have been compared with the Runge-Kutta approach to solve the *** reduction of mean square error(MSE)is used to investigate the numericalmeasures through the SCGNNs for solving the SED *** precision of the SCGNNs is validated through the comparison of the results and the absolute error *** reliability of the SCGNNs is performed by using the correlation values,state transitions(STs),error histograms(EHs),MSE measures and regression analysis.

关键词： Socio-ecological state conservation estimation neural networks reef ecosystems scaled conjugate gradient numerical study

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Open Journal of Therapy and Rehabilitation 2023年第1期11卷 1-16页

作者： afaf Ahmed Mohamed Shaheen Department of Health Rehabilitation Sciences College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia Basic Science Department Faculty of Physical Therapy Cairo University Cairo Egypt

Health related-physical fitness (HRPF) is critical for maintaining and enhancing health and quality of life. Purposes: To estimate the reference values and predictive equations for frequently used clinical field HRPF measures in a sample of Saudi female college students aged 18 - 24 years. Methods: In this cross-sectional study, body fat percentage (BF %) was estimated. Curl-up test (CUT) and sit and reach test (SRT) were applied in 216 students. The Queen’s College Step Test (QCST) was used to predict maximal oxygen consumption (VO2 max). Physical activity (PA) level was also measured using International Physical Activity Questionnaire (IPAQ). Results: The mean of BF %, SRT, CUT, and predicted VO2 max were 23.98% ± 6.13%, 17.10 ± 7.50 cm, 28.17 ± 7.72 number/min, and 39.58 ± 4.01 ml/kg/min respectively. There was no significant effect of age on all HRPF measures except for BF % (F (6,215) = 3.25, p (6,215) = 4.01, p strated that BMI was the predictor for BF % and SRT and explained 65% and 4% of total variance respectively. IPAQ score, age, and height were the predictors of CUT counting 17% of total variance. While, BMI and IPAQ score were the predictors for VO2 max and explained 13% of the total variance. Conclusion: Reference values can be used clinically in the evaluation of HRPF, in the rehabilitation process as well as in designing a program to improve the HRPF for female college students with consideration of age, height, BMI, and PA level for a particular population.

关键词： Physical Activity Health Related Physical Fitness Female College Students Saudi Arabia

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