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Effect of Plasma Density on Proton Acceleration in a Rectangular Waveguide

Plasma Science and Technology 2004年第5期6卷 2456-2458页

作者： Hitendra K.malik Department of Physics Indian Institute of Technology DelhiNew Delhi-110016Indianalytical studies are made for the proton acceleration during its motion in thefields of the fundamental mode excited by a high-intensity microwave in a rectangular waveguidewhen the proton is injected along the propagating direction of the mode. The trajectory of theproton is calculated and the expressions are obtained for the energy gain and acceleration gradienttogether with the effects of plasma density microwave frequency and waveguide width. Energygain of 181 keV is attained by a 50 keV proton in a 0.015m×0.020 m evacuated waveguide when0.5×10~(10)W/m~2 microwave intensity is used. However this gain increases to 1387 keV whenthe waveguide is filled with a plasma having a density of 1.0×10~(19) m~(-3). Higher accelerationgradients are achieved when the proton is injected with a higher initial energy and also when themicrowave intensity increases. The effects of the microwave frequency and width of the waveguideare found to decrease the acceleration gradient.

Analytical studies are made for the proton acceleration during its motion inthe fields of the fundamental mode excited by a high-intensity microwave in a rectangular waveguide,when the proton is injected along the propagating direction of the mode. The trajectory of theproton is calculated and the expressions are obtained for the energy gain and acceleration gradienttogether with the effects of plasma density, microwave frequency and waveguide width. Energy gain of181 keV is attained by a 50 keV proton in a 0.015m x 0.020 m evacuated waveguide when 0.5 x 10^(10)W/m^2 microwave intensity is used. However, this gain increases to 1387 keV when the waveguide isfilled with a plasma having a density of 1.0 x 10^(19) m^(-3). Higher acceleration gradients areachieved when the proton is injected with a higher initial energy and also when the microwaveintensity increases. The effects of the microwave frequency and width of the waveguide are found todecrease the acceleration gradient.

关键词： proton acceleration microwave fundamental mode

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Hopf bifurcation and chaos in a Leslie–Gower prey–predator model with discrete delays

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International Journal of Biomathematics 2020年第6期13卷 135-161页

作者： Anuraj Singh Preeti Pradeep malik ABV-Indian Institute of Information Technology and Management Gwalior M.P.India Department of Mathematics University of Petroleum Energy Studies DehradunUttarakhandIndia

In this work,a Leslie–Gower prey-predator model with two discrete delays has been *** positivity,boundedness and persistence of the delayed system have been *** system exhibits the phenomenon of Hopf bifurcation with respect to both *** conditions for occurrence of Hopf bifurcation are obtained for different combinations of *** is shown that delay induces the complexity in the system and brings the periodic oscillations,quasi-periodic oscillations and *** properties of periodic solution have been determined using central manifold and normal form ***,the global stability of the system has been established for different cases of discrete *** numerical computation has also been performed to verify analytical results.

关键词： Discrete delays limit cycle global stability Hopf bifurcation chaotic behavior

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In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog ⅢM-067

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Journal of Integrative Medicine 2023年第1期21卷 62-76页

作者： Sumera malik Mubashir J.Mintoo Chilakala Nagarjuna Reddy Rajesh Kumar Pankul Kotwal Sandip BBharate Utpal Nandi Dilip M.Mondhe Sanket K.Shukla Pharmacology Division Council of Scientific and Industrial Research(CSIR)-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002Uttar PradeshIndia Medicinal Chemistry Division CSIR-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia Pharmacokinetics-Pharmacodynamics(PK-PD) Toxicology DivisionCSIR-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia

Objective: The current study evaluated various new colchicine analogs for their anticancer activity and to study the primary mechanism of apoptosis and in vivo antitumor activity of the analogs with selective anticancer properties and minimal toxicity to normal ***: Sulforhodamine B(SRB) assay was used to screen various colchicine analogs for their in vitro cytotoxicity. The effect of N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(pyrrolidine-1-yl)5,6,7,9-tetrahydrobenzo[a] heptalene-7-yl] acetamide(ⅢM-067) on clonogenicity, apoptotic induction, and invasiveness of A549 cells was determined using a clonogenic assay, scratch assay, and staining with 4’,6-diamidino-2-phenylindole(DAPI) and annexin V/propidium iodide. Mitochondrial membrane potential(MMP) and reactive oxygen species(ROS) levels were observed using fluorescence microscopy. Western blot analysis was used to quantify expression of proteins involved in apoptosis, cell cycle, and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR) signaling. Pharmacokinetic and in vivo efficacy studies against Ehrlich ascites carcinoma(EAC) and Ehrlich solid tumor models were conducted using Swiss albino ***: ⅢM-067 showed potent cytotoxicity and better selectivity than all other colchicine analogs screened in this study. The selective activity of ⅢM-067 toward A549 cells was higher among other cancer cell lines,with a selectivity index(SI) value of 2.28. ⅢM-067 demonstrated concentration-and time-dependent cytotoxicity against A549 cells with half-maximal inhibitory concentration values of 0.207, 0.150 and0.106 μmol/L at 24, 48 and 72 h, respectively. It also had reduced toxicity to normal cells(SI > 1) than the parent compound colchicine(SI = 1). ⅢM-067 reduced the clonogenic ability of A549 cells in a dose-dependent manner. ⅢM-067 enhanced ROS production from 24.6% at 0.05 μmol/L to 82.1% at 0.4 μmol/L and substantially decreased the MMP(100% in control to 5.6% at 0.4 μmol

关键词： Colchicine 1IIM-067 Apoptosis Antineoplastic agents Carcinoma Ehrlich tumor A549 cells

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Flow of a Jeffery-Six Constant Fluid Between Coaxial Cylinders with Heat Transfer Analysis

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Communications in Theoretical Physics 2011年第8期56卷 345-351页

作者： Muhammad Yousaf malik Azad Hussain Sohail Nadeem Department of Mathematics Quaid-i-Azam University

In the present investigation we have discussed the flow of a Jeffrey-six constant incompressible fluid betweentwo infinite coaxial cylinders in the presence of heat transfer *** governing equations of Jeffrey-six constant fluidalong with energy equation have been derived in cylindrical *** highly nonlinear equations are simplifiedwith the help of non-dimensional parameters and then solved analytically with the help of homotopy analysis method(HAM) for two fundamental flows namely Couette and Generalized Couette *** effects of emerging parametersare discussed through *** convergence of the HAM solution has been discussed by plotting h-curves.

关键词：不可压缩流体传热分析 Couette流动恒定同轴圆柱坐标系无量纲参数非线性方程

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Electromagnetic effects on anisotropic expansion-free fluid content

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Communications in Theoretical Physics 2023年第10期75卷 79-89页

作者： Z Yousaf H Asad Bander Almutairi Adnan malik Department of Mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan Department of Mathematics College of ScienceKing Saud UniversityP.O.Box 2455 Riyadh 11451Saudi Arabia School of Mathematical Sciences Zhejiang Normal UniversityJinhuaZhejiangChina

The major goal of this work is to find solutions of Einstein–Maxwell field equations for anisotropic,expansion-free,non-static,spherically distributed matter *** analytical models that highlight the major benefit of simplicity are shown and this makes it possible to use them as a toy model to illustrate how cavities ***,the transport equations,quasi-homologous constraints and the junction conditions are also evaluated along with their useful ***,the consequences of electric force on this system are summed up in the last section.

关键词： gravitation neutron stars modified gravity hydrodynamics voids

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Tocilizumab in severe COVID-19-A randomized,double-blind,placebo-controlled trial

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Infectious Medicine 2022年第2期1卷 88-94页

作者： Muhammad Irfan malik Sardar Al Fareed Zafar Fabiha Qayyum Muna malik Muhammad Sohaib Asghar Muhammad Junaid Tahir Ammarah Arshad Fatima Khalil Hafiza Shafia Naz Mudassar Aslam Jodat Saleem Abdul Aziz Mustafa Usman Azhar Muhammad Naqash Zohaib Yousaf Postgraduate Medical Institute LahorePakistan Lahore General Hospital LahorePakistan Ameer-ud-Din Medical College LahorePakistan Dow University of Health Sciences-Ojha Campus KarachiPakistan Sheikh Zayed Medical College Rahim Yar KhanPakistan Hamad Medical Corporation DohaQatar

Background:The therapeutic effectiveness of interleukin-6 receptor inhibitor in critically ill hospitalized patients with coronavirus disease 2019(COVID-19)is ***:To evaluate the efficacy and safety of the outcome as recovery or death of tocilizumab for severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection,we conducted a randomized,double-blinded,placebo-controlled phase 2 trial in critically ill COVID-19 adult *** patients were randomly assigned in a 4:1 ratio to receive standard medical treatment plus the recommended dose of either tocilizumab or the placebo *** was *** primary outcome was the recovery or death after administration of tocilizumab or a placebo *** secondary outcomes were clinical recovery or worsening of the patients’symptoms and inflammatory markers and discharge from the ***:Of 190 patients included in this study,152 received tocilizumab,and 38 received a *** duration of hospital stay of the interventional group was 12.9±9.2,while the placebo group had a more extended hospital stay(15.6±8.8).The mortality ratio for the primary outcome,ie,mortality or recovery in the tocilizumab group was 17.8%;p=0.58 by log-rank test).The mortality ratio in the placebo group was 76.3%;p=0.32 by log-rank test).The inflammatory markers in the tocilizumab group significantly declined by day 16 compared to the placebo ***:The use of tocilizumab was associated with decreased mortality,earlier improvement of inflamma-tory markers,and reduced hospital stay in patients with severe COVID-19.

关键词： Inflammatory Infectious Immunosuppression COVID-19 Therapy Trial

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Secure Model to Generate Path Map for Vehicles in Unusual Road Incidents Using Association Rule Based Mining in VANET

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Journal of Electronic Science and Technology 2018年第2期16卷 153-162页

作者： Arun malik Babita Pandey Chia-Chun Wu Department of Industrial Engineering and Management National Quemoy UniversityQuemoy 89250

Logical behavioral arrangements are a class of conventional arrangements to illustrate the happening of incidents in an appropriate and structured approach in vehicular ad hoc network （VANET）. These incidents are characterized as a list of path segments that are passed through by the vehicles for the duration of their journeys from a pre-decided local source to a local destination in a structured manner. A set of proper description illustrating the paths traversed by the vehicles as logical behavioral arrangements is describedin this paper. The data gathering scheme based on secure authentication to gather the data from the vehicles is proposed in this paper. This proposed data gathering scheme based on secure authentication is compared with the existing data gathering schemes by using veins framework and the results of analysis reflect that the proposed scheme outperforms among others. The data collected from the vehicles by the proposed data gathering scheme is stored at distributed road side units （RSUs）. From these collected paths, the common and frequent paths opted by the vehicles in a certain region are determined by using frequent arrangement mining approach. An estimation model is used to decidethe next path and the whole path map opted by the vehicles in unusual situations like accident, jams, or a particular time of day. The proposed scheme will helpthe society in reducing the waiting time in vent of emergency or normal working days.

关键词： Confidence motion arrangements support vehicular ad hoc network(VANET) vehicle-toroad side unit(V2R) vehicle-to-vehicle(V2V)

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Antiacanthamoebic properties of natural and marketed honey in Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 967-972页

作者： Farzana Abubakar Yousuf malik Hassan Mehmood Abdul malik Ruqaiyyah Siddiqui Naveed Ahmed Khan Department of Biological and Biomedical Sciences Aga Khan University Department of Biological Sciences Faculty of Science and Technology Sunway University

Objective: To determine antiacanthamoebic activity of natural and marketed honey ***: Natural honey samples were collected directly from the bee hive and marketed honey samples were purchased from the local market in Karachi, Pakistan. Both honey samples were tested for their flavonoid content(quercetin equivalent per gram of the extract) and phenolic content(gallic acid equivalent per gram). Furthermore, their antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl. Using amoebistatic and amoebicidal assays, the effects of honey samples were tested against growth and viability of Acanthamoeba ***: Natural honey exhibited potent amoebistatic and amoebicidal effects, in a concentration-dependent manner. Honey-treated Acanthamoeba castellanii showed loss of acanthopodia, following which amoebae detached, rounded up, reduced in size,decreased in cytoplasmic mass and they were observed floating in the culture ***, honey-treated amoebae did not revive when inoculated in fresh growth medium, however, glycerol-treated amoebae exhibited viable trophozoite and active growth. In contrast, marketed honey samples varied in their efficacy against Acanthamoeba castellanii. The proportion of flavonoid, as determined by quercetin measurements and the proportion of phenolic, as determined by gallic acid measurements was higher in natural honey compared with marketed honey. Similarly, the antioxidant activity, as determined by 2,2-diphenyl-1-picrylhydrazyl scavenging activity was higher in natural honey vs. marketed ***: This study shows that natural honey has antiacanthamoebic properties and possesses higher flavonoid, phenolic and antioxidant properties compared with the marketed honey. These findings are of concern to the public, health officials, and to the manufacturers regarding production of honey for medical applications.

关键词： Honey Acanthamoeba Amoebicidal Amoebistatic

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Mountain highway stability threading on the fragile terrain of upper Ganga catchment(Uttarakhand Himalaya),India

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Journal of Mountain Science 2022年第12期19卷 3407-3425页

作者： S.P.SATI Shubhra SHARMA Girish Ch.KOTHYARI Maria ASIM Y.P.SUNDRIYAL Kapil malik Ayush JOSHI Harsh DOBHAL Naresh RANA Navin JUYAL Department of Basic and Social Science(CoF) VCSGU University of Horticulture&Forestry BharsarPauri Garhwal 246123India Geosciences Division Physical Research LaboratoryAhmedabad 380005India Department of Geography Instituteof ScienceBanaras Hindu UniversityVaranasi 221005India Department of Petroleum Engineering&Earth Sciences University of Petroleum and Energy StudiesDehradun 248007India Department of Geology HNBG harwal UniversitySrinagar 246174India Institute of Seismological Research Gandhinagar 382009India School of Media and Communication Studies Doon UniversityDehradun 248001India Department of Geology Universityof DelhiDelhi-110007India Kabir Enclave BopalAhmedabad 380058India

Roads are the most critical means of connectivity in Himalayan ***,the terrain is inherently fragile with varied geological,geomorphological,ecological,and climate regimes,that result in frequent slope failure and disruption in *** risk is further to be increased by extreme events-generated hazards,which are expected to rise in frequency and magnitude with ongoing intervention,however,can improve the sustainability of road *** present study attempts to analyse and quantify the impacts of a major road widening project initiated in 2018 in the upper Ganga catchment,Uttarakhand Himalaya which has destabilised valley slopes along the widened ***,a large quantity of excavated sediments is dumped down slopes,which is posing a threat to aquatic *** estimates are based on Google Earth imagery of a few representative road segments recently widened in the upper Ganga catchment,which indicate a substantial increase in the landslide and unstable slope area following the road *** increase in unstable slope area is attributed to improper road widening approaches and poor slope management in seismically active Himalayan ***,the mean velocity plots of Persistent Scatterer Interferometric Synthetic Aperture Radar(PSInSAR)indicate that the segments undergoing road widening are coherent with areas of significant earth surface change.A broad correlation between the road width and sediment yield indicates that even a slight increase in road width can result in a large-scale mass removal from the toe of the hillslope,inflicting cascading impact on *** study recommends a more flexible road construction approach based on the environmental and geological aspects of the terrain for sustainable road ***,the impact of climate change is looming over the Himalayas,and the relation between climate change and its potential effects on the stability of slopes remains an open issue.

关键词： Himalaya Disaster resilient road Landslide Flash flood Road-widening

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Analytical Treatment of an Oldroyd 8-constant Fluid Between Coaxial Cylinders with Variable Viscosity

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Communications in Theoretical Physics 2011年第11期56卷 933-938页

作者： Muhammad Yousaf malik Azad Hussain Sohail Nadeem Department of Mathematics Quaid-i-Azam University

The flow of an Oldroyd 8-constant fluid between coaxial cylinders with variable viscosity is *** heat transfer analysis is also taken into *** analytical solution of the non-linear problem is obtained usinghomotopy an... 详细信息

关键词：流体流动变粘度同轴恒定非线性问题传热分析同伦分析

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