检索结果-南通市图书馆

All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy

Light(Science & Applications) 2018年第1期7卷 337-345页

作者： Rehman Ansari edward Z.Zhang adrien e.desjardins Paul C.Beard Department Medical Physics and Biomedical engineering University College LondonGower StreetLondon WC1E 6BTUK Wellcome/ePSRC Centre for Interventional and Surgical Sciences University College LondonCharles Bell House67-73 Riding House StreetLondon W1W 7EJUK

A miniature forward-viewing endoscopic probe that provides high-resolution 3D photoacoustic images is *** probe is of outer diameter 3.2mm and comprised of a transparent Fabry-Pérot(FP)polymer-film ultrasound sensor that is located at the distal end of a rigid optical fiber *** laser pulses are coupled simultaneously into all cores of the bundle and are transmitted through the FP sensor to provide wide-field tissue illumination at the distal *** resulting photoacoustic waves are mapped in 2D by sequentially scanning the input end of the bundle with an interrogation laser beam in order to individually address different points on the FP *** this way,the sensor acts as a high-density ultrasound array that is comprised of 50,000 individual elements,each of which is 12μm in diameter,within the 3.2mm diameter footprint of the *** fine spatial sampling that this affords,along with the wide bandwidth(f_(-3dB)=34 MHz)of the sensor,enables a high-resolution photoacoustic image to be *** measured on-axis lateral resolution of the probe was depth-dependent and ranged from 45-170μm for depths between 1 and 7 mm,and the vertical resolution was 31μm over the same depth *** system was evaluated by acquiring 3D images of absorbing phantoms and the microvascular anatomies of a duck embryo and mouse *** image fidelity was *** is anticipated that this type of probe could find application as a tool for guiding laparoscopic procedures,fetal surgery and other minimally invasive interventions that require a millimeter-scale forward-viewing 3D photoacoustic imaging probe.

关键词： optical millimeter resolution

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Bidirectional energy-controlled piezoelectric shunt damping technology and its vibration attenuation performance

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International Journal of Mechanical System Dynamics 2024年第1期4卷 63-76页

作者： Yipeng Wu Quan Yuan Kaibin Ren Xin Shen Hui Shen adrien Badel Hongli Ji Jinhao Qiu State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjingChina College of Mechanical and electrical engineering Qingdao UniversityQingdaoChina SYMMe Laboratory Universite Savoie Mont BlancAnnecy le VieuxFrance

Piezoelectric material-based semi-active vibration control systems may effectively suppress vibration amplitude without any external power supply,or even harvest electrical *** bidirectional electrical energy control phenomenon is theoretically introduced and validated in this paper.A flyback transformer-based switching piezoelectric shunt circuit that can extract energy from or inject energy into piezoelectric elements is *** analytical expressions of the controlled energy and the corresponding vibration attenuation are therefore derived for a classical electromechanical cantilever *** predictions validated by the experimental results show that the structure vibration attenuation can be tuned from−5 to−25 dB under the given electrical quality factor of the circuit and figure of merit of the electromechanical structure,and the consumed power is in the range of−13 to 25 mW,which is a good theoretical basis for the development of self-sensing,self-adapting,and self-powered piezoelectric vibration control systems.

关键词： vibration control piezoelectric shunt damping electromechanical energy

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具有半子模式欧拉拓扑绝缘体的声学观测

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Science Bulletin 2024年第11期69卷 1653-1659页

作者：姜斌 adrien Bouhon 吴世巧孔泽霖林志康 Robert-Jan Slager 蒋建华 Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China TCM Group Cavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK NORDITA Stockholm University and KTH Royal Institute of TechnologyStockholm SE-10691Sweden

Topological band theory has conventionally been concerned with the topology of bands around a single gap. Only recently non-Abelian topologies that thrive on involving multiple gaps were studied, unveiling a new horizon in topological physics beyond the conventional paradigm. Here, we report on the first experimental realization of a topological euler insulator phase with unique meronic characterization in an acoustic metamaterial. We demonstrate that this topological phase has several nontrivial features:First, the system cannot be described by conventional topological band theory, but has a nontrivial euler class that captures the unconventional geometry of the Bloch bands in the Brillouin ***, we uncover in theory and probe in experiments a meronic configuration of the bulk Bloch states for the first time. Third, using a detailed symmetry analysis, we show that the topological euler insulator evolves from a non-Abelian topological semimetal phase via. the annihilation of Dirac points in pairs in one of the band gaps. With these nontrivial properties, we establish concretely an unconventional bulk-edge correspondence which is confirmed by directly measuring the edge states via. pump-probe techniques. Our work thus unveils a nontrivial topological euler insulator phase with a unique meronic pattern and paves the way as a platform for non-Abelian topological phenomena.

关键词： euler insulators Meronic waves Acoustic metamaterials Topological phases of matter

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凝固的历史蒙特利尔Maisonneuve图书馆

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室内设计与装修 2024年第11期 78-83页

作者： [加拿大]eVOQ Architectúre adrien Williams(摄影) 沙漏(编译) eVOQ Architecture

蒙特利尔作为加拿大的第二大城市,以其繁荣的文化景象和丰富的建筑遗产而闻名。在过去的20年里,当城市设计师们忙于重新定义街道生活时,建筑师们则忙于建设或翻新众多公共设施,如剧院、体育设施和图书馆。这一变革过程中最引人注目的项... 详细信息

蒙特利尔作为加拿大的第二大城市,以其繁荣的文化景象和丰富的建筑遗产而闻名。在过去的20年里,当城市设计师们忙于重新定义街道生活时,建筑师们则忙于建设或翻新众多公共设施,如剧院、体育设施和图书馆。这一变革过程中最引人注目的项目之一是Maisonneuve图书馆,它自1981年以来便坐落在一座曾经小巧但是颇具声望的市政厅内,这座市政厅曾是短命的Maisonneuve市的标志性建筑。

关键词：体育设施建筑遗产公共设施大城市标志性建筑变革过程蒙特利尔图书馆

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Modeling strain rate sensitivity and high temperature deformation of Mg-3Al-lZn alloy

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Journal of Magnesium and Alloys 2019年第3期7卷 433-443页

作者： adrien Chapuis Qing Liu College of Materials Science and engineering Chongqing UniversityChongqing 400044China

Increasing the plastic deformation temperature of Mg alloys results in higher strain rate sensitivity,easier activation of secondary slip modes,and impeded *** this study,the strain rate sensitivity is estimated for each deformation mode,and visco-plastic self-consistent modeling is used to reproduce the plastic deformation behavior of an Mg-3Al-lZn O-temper plate from 150 to 450℃.Twinning and basal slip have relatively low strain rate sensitivity,whereas secondary slip modes are highly strain rate sensitive at high *** texture evolution and plastic anisotropy are modeled at different temperatures and strain *** show that when the strain rate sensitivity is taken into account,compared with rate independent critical resolved shear stresses,the material parameters and predictions are *** particular,this study shows that,for hot deformation,there is a critical strain rate above which secondary slip modes predominate,and beyond which tension twinning is activated.A similar transition is expected for modes that have different strain rate sensitivity.

关键词： Magnesium alloy AZ31 Crystal plasticity VPSC Visco-plastic

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The interferon inducing pathways and the hepatitis C virus

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World Journal of Gastroenterology 2007年第17期13卷 2446-2454页

作者： eliane F Meurs adrien Breiman Pasteur Institute Hepacivirus Unit F-75015 Paris cedex France Imperial College Faculty of Medicine Department of Virology London W2 1PG United Kingdom

The innate immune response is triggered by a variety of pathogens, including viruses, and requires rapid induction of typeⅠ?interferons (IFN), such as IFNβ and IFNα. IFN induction occurs when specific pathogen motifs bind to specific cellular receptors. In non-professional immune, virally-infected cells, IFN induction is essentially initiated after the binding of dsRNA structures to TLR3 receptors or to intracytosolic RNA helicases, such as RIG-Ⅰ/MDA5. This leads to the recruitment of specific adaptors, such as TRIF for TLR3 and the mitochondrial-associated IPS-1/VISA/MAVS/CARDIF adapter protein for the RNA helicases, and the ultimate recruitment of kinases, such as MAPKs, the canonical IKK complex and the TBK1/IKKε kinases, which activate the transcription factors ATF-2/ c-jun, NF-κB and IRF3, respectively. The coordinated action of these transcription factors leads to induction of IFN and of pro-inflammatory cytokines and to the establishment of the innate immune response. HCV can cleave both the adapters TRIF and IPS-1/VISA/MAVS/ CARDIF through the action of its NS3/4A protease. This provokes abrogation of the induction of the IFN and cytokine pathways and favours viral propagation and presumably HCV chronic infection.

关键词： Toll-like receptor RNA helicase Mitochondrialadapter Cardif TBK1/IKKepsilon Interferon induction HCV NS3A protease

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Somatic mutant clone screening: scan for novel NASH target genes in mouse liver

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3902-3903页

作者： Tian Lan adrien Guillot Frank Tacke Lab of Gastroenterology and Hepatology State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Gastroenterology West China HospitalSichuan UniversityChengduChina Department of Hepatology&Gastroenterology Charité-Universitätsmedizin BerlinCampus Virchow-Klinikum and Campus CharitéMitteBerlinGermany

In a landmark study recently published in Cell,Wang et *** a novel method of somatic adeno-associated virus(AAV)-transposon in vivo clonal screening(termed MOSAICS),which is capable to generate multiple mutant hepatocyte clones within the same tissue and thereby to scan for non-alcoholic steatohepatitis(NASH)target genes(Fig.1).1 Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease affecting about 20–30%of the global population and associated with metabolic *** can progress to NASH,characterized by liver inflammation,steatosis and hepato-cyte ballooning,and NAFLD/NASH can lead to fibrosis,cirrhosis,and ultimately liver *** decades,researchers have been seeking to understand its pathogenesis and to discover ther-apeutic strategies to treat NAFLD/***,up to now,there is still no specific pharmacotherapy available.

关键词： balloon NAFLD inflammation

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中桥

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城市环境设计 2024年第1期147卷 168-173页

作者：宫原贤次名城俊树田中浩介今井博康 adrien Fritz 堀越圭晋中尾孝佑 SS

中桥是一座步行桥，代表了隈研吾事务所自2013年开始参与南三陆市复兴设计的努力。桥身连接南三陆市Sun Sun商业街和复兴祈愿公园（前身是防灾办公室），成为一个祈祷的场所。中桥以不同形式连接了不同空间。从前防灾办公室穿过桥梁，...

中桥是一座步行桥，代表了隈研吾事务所自2013年开始参与南三陆市复兴设计的努力。桥身连接南三陆市Sun Sun商业街和复兴祈愿公园（前身是防灾办公室），成为一个祈祷的场所。中桥以不同形式连接了不同空间。从前防灾办公室穿过桥梁，会到达上山八幡宫神社。在日本神社中，道路与神社之间的桥梁被用来区分和联系人界与神界。中桥优雅的桥拱与神社前典型的太鼓桥相似。

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A Clinical Study to Assess the effectiveness of Oral Combination Kit Therapy in Syndromic Management of Abnormal Vaginal Discharge (FeMINe Study) in Kinshasa, Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 193-208页

作者： Feruzi Michel Mangala Muela Andy Mbangama Di-Mosi-Nkoy Roger Wumba Ambis Joëlle Lumaya Nkongolo Freddy Muamba Tshitadi Jean Mukendi Ndombasi Neilda Lemba Otem Christian Ndesanzim Nkashama Bienvenu Kazadi Banza Jesual Lotoy Umba adrien Tandu Mushengezi Dieudonné Sengeyi Mwimba Roger Mbungu Department of Gynecology and Obstetrics University Clinics of Kinshasa Kinshasa DR Congo Congolese Society of Gynecology and Obstetrics Kinshasa DR Congo Department of Gynecology and Obstetrics Kinshasa Provincial General Reference Hospital Kinshasa DR Congo Departement of Tropical Medicine University Clinics of Kinshasa Kinshasa DR Congo

Background: Vaginal discharge is one of most common and nagging problems that women face. About 20% - 25% of women who visit gynecology department complain of vaginal discharge and leucorrhoea. An orally administered combination kit, containing 2 g secnidazole, 1 g azithromycin and 150 mg fluconazole (Azimyn FS Kit), has been successfully evaluated in clinical trials and used in several countries for management syndromic vaginal discharge due to infections. Methods: This is a longitudinal study which aimed to verify the clinical efficacy of the combined oral kit containing secnidazole, azithromycin and fluconazole (Azimyn FS Kit®) in the syndromic treatment of abnormal vaginal discharge in patients received in outpatient consultations in Kinshasa/DR Congo from March to September 2023. Results: Majority of patients had whitish vaginal discharge (51.6%) of average abundance (56.2%), accompanied by pruritus in 72.1% of cases, and dyspareunia in 23.5% of cases and hypogastralgia in 40.2% of cases. One week after treatment with the Azimyn FS® combined kit, at the greatest majority of patients (97.3%), abnormal vaginal discharge had decreased by more than 50% (84.1%). Two weeks after treatment with the Azimyn FS® combined kit, almost all patients (97.3%) no longer had abnormal vaginal discharge which had completely disappeared. Conclusion: A single dose of secnidazole, azithromycin and fluconazole in the form of an oral combi-kit (Azimyn FS Kit) has shown excellent therapeutic effectiveness in the syndromic treatment of abnormal vaginal discharge wherein patients were treated without diagnostic confirmation.

关键词： Oral Combination Kit Therapy Syndromic Management Abnormal Vaginal Discharge

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Implementation of Presolving and Interior-Point Algorithm for Linear & Mixed Integer Programming: SOFTWARe

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Journal of Systems Science and Information 2020年第3期11卷 195-223页

作者： adrien NDAYIKeNGURUTSe Siming HUANG School of Management Science and engineering Institute of Science and DevelopmentChinese Academy of SciencesBeijing 100190China Chinese Academy of Sciences Beijing 100190China

Linear and mixed integer programming are very popular and important methods to make efficient scientific management *** large size of real application data,the use of linear-mixed integer programming is facing problems with more complexity;therefore,preprocessing techniques become very *** aims to check and delete redundant information from the problem *** is a collection of techniques that reduce the size of the problem and try to strengthen the *** and effective preprocessing techniques are very important and essential for solving linear or mixed integer programming *** this paper,we demonstrate a set of techniques to presolve linear and mixed integer programming *** results showed that when preprocessing is well done,then it becomes easier for the solver;we implemented interior-point algorithm for computational ***,preprocessing is not enough to reduce the size and total nonzero elements from the constraints ***,we also demonstrate the impact of minimum degree reordering on the speed and storage requirements of a matrix *** techniques mentioned above are presented in a multifunctional software to facilitate users.

关键词： integer programming formulation

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