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Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

World Journal of Hepatology 2011年第11期3卷 278-284页

作者： adriano m pellicelli massimo marignani Valerio Zoli mario Romano Aldo morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio mecenate Ettore mazzoni Ignazio majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini Liver Unit Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense 8700149 Rome Italy Department of Digestive and Liver Disease Azienda Ospedaliera Sant’AndreaVia Grottarossa 1035/1039000189 Rome Italy Hematology and Bone marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Liver Unit Ospedale Sandro PertiniVia dei Monti Tiburtini 38500157 Rome Italy Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense87 00149 Rome Italy medicine of migration National Institute for Migrant Health and Poverty Via di S. Gallicano 25/a 00153Rome Italy Department of medical Pathophysiology University of Rome "La Sapienza" Viale del Policlinico 15500161 Rome Italy Liver Unit Campus Biomedico UniversityVia álvaro del Portillo 21 00128Rome Italy Histopathology Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149Rome Italy Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Department of Infectious and Tropical Disease University of Rome"La Sapienza"Viale del Policlinico155 00161 Rome Italy Liver Unit Ospedale Villa BetaniaVia Niccolò Piccolomini 2700165 RomeItaly Liver Unit Policlinico CasilinoVia Casilina104900169 Rome Italy Hematology and Bone marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Infectious and Parasitic Diseases Policlinico San Matteo P.zzale Golgi 2 2710 PaviaItaly

AIm:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management ***:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and *** with DLBCL were managed with the standard of care of *** with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course *** outcomes of the different approaches were ***:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent *** of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL *** lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection.

关键词： Hepatitis C virus infection Diffuse large B cell lymphoma Indolent lymphoma Pegylated interferon Lymphomagenesis

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‘Les liaisons dangereuses’: Hepatitis C, Rituximab and B-cell non-Hodgkin’s lymphomas

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第2期3卷 21-28页

作者： massimo marignani michela di Fonzo Paola Begini Elia Gigante Ilaria Deli adriano m pellicelli Sara Gallina Emanuela de Santis Gianfranco Delle Fave m Christina Cox Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy Liver Unit Azienda Ospedaliera San Camillo Forlanini 000149 Rome Italy Department of Haematology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Rituximab has provided a revolutionary contribution to the treatment of B-cell non-Hodgkin’s lymphomas (NHL). A high prevalence of hepatitis C virus (HCV) infection has been described in B-cell NHL patients. Cases of liver dysfunction in HCV-positive patients have been reported with Rituximab-containing regimens. In this paper we review the recent data regarding the effects of Rituximab in NHL patients with HCV infection. We also added a section devoted to improving communication between oncohaematologists and hepatologists. Furthermore, we propose a common methodological ground to study hepatic toxicity emerging during chemotherapy.

关键词： Rituximab B-cell non-Hodgkin’s lymphoma Hepatitis C virus Immunochemotherapy methodology

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Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

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World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo massimo De Luca Vincenzo De maria massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo marrone Ettore mazzoni Vincenzo messina Roberto monarca Vincenzo Narciso Lorenzo Nosotti adriano maria pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi mario Romano Angelo Rossini maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal medicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San matteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital Depart-ment of Internal medicine Umberto I Hospital Internal medicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of medical Day Hospital "Rummo" Hospital Internal medicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino medicine and Health Unit for Prisoners Belcolle Hospital Internal medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIm: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. mETHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin

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